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Peng, Y. Radiation-Induced Mutagenesis. Encyclopedia. Available online: https://encyclopedia.pub/entry/61444 (accessed on 02 November 2026).
Peng Y. Radiation-Induced Mutagenesis. Encyclopedia. Available at: https://encyclopedia.pub/entry/61444. Accessed November 02, 2026.
Peng, Yu. "Radiation-Induced Mutagenesis" Encyclopedia, https://encyclopedia.pub/entry/61444 (accessed November 02, 2026).
Peng, Y. (2026, October 25). Radiation-Induced Mutagenesis. In Encyclopedia. https://encyclopedia.pub/entry/61444
Peng, Yu. "Radiation-Induced Mutagenesis." Encyclopedia. Web. 25 October, 2026.

Radiation-Induced Mutagenesis

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Radiation-induced mutagenesis is the production of stable genetic changes following exposure to radiation. Ionizing radiation can generate DNA damage that is retained as deletions or chromosome rearrangements after cellular processing [1]. Ionizing radiation also produces clustered DNA lesions containing damaged bases and strand breaks. During replication, specialized DNA polymerases can synthesize across damaged templates with characteristic error rates [2][3]. Ultraviolet radiation generates pyrimidine dimers, and errors introduced during lesion bypass can contribute to mutations at the damaged sequence [4]. A permanent mutation emerges when replication or repair converts an initial lesion into an altered sequence or chromosome structure. Surviving cells can then transmit that change during subsequent divisions. Dose, radiation quality, repair capacity, and cellular state contribute to the observed mutation spectrum [5]. 

radiation DNA damage mutagenesis DNA repair
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References

  1. Sam Behjati; Gunes Gundem; David C. Wedge; Nicola D. Roberts; Patrick S. Tarpey; Susanna L. Cooke; Peter Van Loo; Ludmil B. Alexandrov; Manasa Ramakrishna; Helen Davies; Serena Nik-Zainal; Claire Hardy; Calli Latimer; Keiran M. Raine; Lucy Stebbings; Andy Menzies; David Jones; Rebecca Shepherd; Adam P. Butler; Jon W. Teague; Mette Jorgensen; Bhavisha Khatri; Nischalan Pillay; Adam Shlien; P. Andrew Futreal; Christophe Badie; Ultan McDermott; G. Steven Bova; Andrea L. Richardson; Adrienne M. Flanagan; Michael R. Stratton; Peter J. Campbell; Mutational signatures of ionizing radiation in second malignancies. Nat. Commun. 2016, 7, 12605. [CrossRef]
  2. Toshiro Matsuda; Katarzyna Bebenek; Chikahide Masutani; Fumio Hanaoka; Thomas A. Kunkel; Low fidelity DNA synthesis by human DNA polymerase-η. Nature 2000, 404, 1011-1013. [CrossRef]
  3. Melanie Gulston; Jonathan Fulford; Terry Jenner; Catherine De Lara; Peter O'Neill; Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites. Nucleic Acids Res. 2002, 30, 3464-3472. [CrossRef]
  4. Scott D. McCulloch; Robert J. Kokoska; Chikahide Masutani; Shigenori Iwai; Fumio Hanaoka; Thomas A. Kunkel; Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity. Nature 2004, 428, 97-100. [CrossRef]
  5. Helen H Evans; David M DeMarini; Ionizing radiation-induced mutagenesis: radiation studies in Neurospora predictive for results in mammalian cells. Mutat. Res. Rev. Mutat. Res. 1999, 437, 135-150. [CrossRef]
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Subjects: Biochemistry & Molecular Biology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Yu Peng
View Times: 6
Entry Collection: Molecular Biology and Gene Expression Regulation
Revisions: 2 times (View History)
Update Date: 25 Oct 2026
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