Radiation-induced mutagenesis is the production of stable genetic changes following exposure to radiation. Ionizing radiation can generate DNA damage that is retained as deletions or chromosome rearrangements after cellular processing [1]. Ionizing radiation also produces clustered DNA lesions containing damaged bases and strand breaks. During replication, specialized DNA polymerases can synthesize across damaged templates with characteristic error rates [2][3]. Ultraviolet radiation generates pyrimidine dimers, and errors introduced during lesion bypass can contribute to mutations at the damaged sequence [4]. A permanent mutation emerges when replication or repair converts an initial lesion into an altered sequence or chromosome structure. Surviving cells can then transmit that change during subsequent divisions. Dose, radiation quality, repair capacity, and cellular state contribute to the observed mutation spectrum [5].
- radiation
- DNA damage
- mutagenesis
- DNA repair
Radiation Effects and Dosimetry·Food Science·Agricultural and Biological Sciences·Life Sciences
References
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