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Peng, Y. Rate Limiting Enzyme. Encyclopedia. Available online: https://encyclopedia.pub/entry/61438 (accessed on 12 November 2026).
Peng Y. Rate Limiting Enzyme. Encyclopedia. Available at: https://encyclopedia.pub/entry/61438. Accessed November 12, 2026.
Peng, Yu. "Rate Limiting Enzyme" Encyclopedia, https://encyclopedia.pub/entry/61438 (accessed November 12, 2026).
Peng, Y. (2026, October 25). Rate Limiting Enzyme. In Encyclopedia. https://encyclopedia.pub/entry/61438
Peng, Yu. "Rate Limiting Enzyme." Encyclopedia. Web. 25 October, 2026.

Rate Limiting Enzyme

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A rate limiting enzyme is an enzyme whose activity substantially constrains flux through a metabolic pathway under specified conditions. Metabolic control analysis quantifies this relationship by measuring how a change in enzyme activity changes the flux of the connected system [1]. Control can be distributed among several reactions and can shift when the metabolic state changes [2]. Regulatory circuits that coordinate expression with intracellular metabolites can alter the balance between precursor supply and downstream conversion [3]. In particular settings, regulation of one biosynthetic enzyme can exert strong control over production of a required metabolite pool [4]. The designation therefore requires evidence about the whole pathway under the conditions examined. Enzyme abundance, kinetic parameters, and reaction reversibility alone do not establish its quantitative contribution to pathway control [5].

metabolic control pathway flux enzyme capacity flux control coefficient
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References

  1. Marta Cascante; Laszlo G. Boros; Begoña Comin-Anduix; Pedro de Atauri; Josep J. Centelles; Paul W.-N. Lee; Metabolic control analysis in drug discovery and disease. Nat. Biotechnol. 2002, 20, 243-249. [CrossRef]
  2. Lu Shen; Martha Kohlhaas; Junichi Enoki; Roland Meier; Bernhard Schönenberger; Roland Wohlgemuth; Robert Kourist; Felix Niemeyer; David van Niekerk; Christopher Bräsen; Jochen Niemeyer; Jacky Snoep; Bettina Siebers; A combined experimental and modelling approach for the Weimberg pathway optimisation. Nat. Commun. 2020, 11, 1-13. [CrossRef]
  3. William R. Farmer; James C. Liao; Improving lycopene production in Escherichia coli by engineering metabolic control. Nat. Biotechnol. 2000, 18, 533-537. [CrossRef]
  4. John T. Cunningham; Melissa V. Moreno; Alessia Lodi; Sabrina M. Ronen; Davide Ruggero; Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer. Cell 2014, 157, 1088-1103. [CrossRef]
  5. Michael J. Berridge; The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease. Physiol. Rev. 2016, 96, 1261-1296. [CrossRef]
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Subjects: Biochemistry & Molecular Biology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Yu Peng
View Times: 9
Entry Collection: Biosynthesis and Synthetic Biology
Revisions: 2 times (View History)
Update Date: 25 Oct 2026
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