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Peng, Y. Terpenoid Metabolism. Encyclopedia. Available online: https://encyclopedia.pub/entry/61434 (accessed on 12 November 2026).
Peng Y. Terpenoid Metabolism. Encyclopedia. Available at: https://encyclopedia.pub/entry/61434. Accessed November 12, 2026.
Peng, Yu. "Terpenoid Metabolism" Encyclopedia, https://encyclopedia.pub/entry/61434 (accessed November 12, 2026).
Peng, Y. (2026, October 25). Terpenoid Metabolism. In Encyclopedia. https://encyclopedia.pub/entry/61434
Peng, Yu. "Terpenoid Metabolism." Encyclopedia. Web. 25 October, 2026.

Terpenoid Metabolism

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Terpenoid metabolism is the network of reactions that produces and transforms compounds derived from isoprenoid precursors. Formation of isopentenyl diphosphate and dimethylallyl diphosphate supplies five-carbon units for synthesis of longer prenyl diphosphates [1]. Terpene synthases then generate distinct skeletons through cyclization or rearrangement, followed by enzymatic reactions that elaborate their functional groups [2]. Branch-point reactions distribute shared precursors among products, while regulation of enzyme expression and activity adjusts their accumulation within cells [3]. In plant diterpenoid pathways, geranylgeranyl diphosphate connects precursor metabolism to multiple product branches, and the structures of the participating enzymes govern their substrate and product specificity. Cellular compartmentation and metabolite transport link these reactions across the locations in which precursor production, skeleton formation, and subsequent modification occur [4][5].

terpenoids isoprenoid metabolism prenyl intermediates metabolic regulation
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References

  1. Eva Vranová; Diana Coman; Wilhelm Gruissem; Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis. Annu. Rev. Plant Biol. 2013, 64, 665-700. [CrossRef]
  2. Jiachen Zi; Sibongile Mafu; Reuben J. Peters; To Gibberellins and Beyond! Surveying the Evolution of (Di)Terpenoid Metabolism. Annu. Rev. Plant Biol. 2014, 65, 259-286. [CrossRef]
  3. Susan C Roberts; Production and engineering of terpenoids in plant cell culture. Nat. Chem. Biol. 2007, 3, 387-395. [CrossRef]
  4. Zhibiao Wang; David R. Nelson; Juan Zhang; Xiangyuan Wan; Reuben J. Peters; Plant (di)terpenoid evolution: from pigments to hormones and beyond. Nat. Prod. Rep. 2022, 40, 452-469. [CrossRef]
  5. Ke Jin; Hongzhi Xia; Yanfeng Liu; Jianghua Li; Guocheng Du; Xueqin Lv; Long Liu; Compartmentalization and transporter engineering strategies for terpenoid synthesis. Microb. Cell Fact. 2022, 21, 1-12. [CrossRef]
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Subjects: Biochemistry & Molecular Biology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Yu Peng
View Times: 7
Entry Collection: Biosynthesis and Synthetic Biology
Revisions: 2 times (View History)
Update Date: 25 Oct 2026
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