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Peng, Y. Glycerophospholipid Biosynthesis. Encyclopedia. Available online: https://encyclopedia.pub/entry/61425 (accessed on 12 November 2026).
Peng Y. Glycerophospholipid Biosynthesis. Encyclopedia. Available at: https://encyclopedia.pub/entry/61425. Accessed November 12, 2026.
Peng, Yu. "Glycerophospholipid Biosynthesis" Encyclopedia, https://encyclopedia.pub/entry/61425 (accessed November 12, 2026).
Peng, Y. (2026, October 25). Glycerophospholipid Biosynthesis. In Encyclopedia. https://encyclopedia.pub/entry/61425
Peng, Yu. "Glycerophospholipid Biosynthesis." Encyclopedia. Web. 25 October, 2026.

Glycerophospholipid Biosynthesis

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Glycerophospholipid biosynthesis is the enzymatic formation of membrane lipids containing a glycerol backbone, hydrophobic chains, and a phosphate-associated polar region. Phosphatidic acid is a central intermediate connecting synthetic reactions with regulation of phospholipid production [1]. Branches involving diacylglycerol and activated head-group donors generate several major phospholipid classes, while additional reactions form or exchange particular polar groups. The CDP-choline pathway is linked to phospholipid transfer and the maintenance of Golgi membrane composition [2][3]. Another branch activates phosphatidic acid with CTP to form CDP-diacylglycerol. The integral membrane enzyme catalyzing this step binds the water-soluble nucleotide from the cytoplasm and the lipid substrate from the membrane. Subsequent transfer reactions connect this activated lipid intermediate to formation of specific glycerophospholipid head groups [4].

glycerophospholipids phosphatidic acid acyltransferases lipid remodeling
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References

  1. George M. Carman; Gil-Soo Han; Regulation of Phospholipid Synthesis in the Yeast Saccharomyces cerevisiae. Annu. Rev. Biochem. 2011, 80, 859-883. [CrossRef]
  2. H V Bosch; Phosphoglyceride Metabolism. Annu. Rev. Biochem. 1974, 43, 243-277. [CrossRef]
  3. Ann E. Cleves; Todd P. McGee; Eric A. Whitters; Kathleen M. Champlon; Jacqueline R. Altken; William Dowhan; Mark Goebl; Vytas A. Bankaitis; Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein. Cell 1991, 64, 789-800. [CrossRef]
  4. Xiuying Liu; Yan Yin; Jinjun Wu; Zhenfeng Liu; Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis. Nat. Commun. 2014, 5, 4244. [CrossRef]
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Subjects: Biochemistry & Molecular Biology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Yu Peng
View Times: 3
Entry Collection: Biosynthesis and Synthetic Biology
Revisions: 2 times (View History)
Update Date: 25 Oct 2026
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