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Peng, Y. Translational Frameshifting. Encyclopedia. Available online: https://encyclopedia.pub/entry/60958 (accessed on 02 November 2026).
Peng Y. Translational Frameshifting. Encyclopedia. Available at: https://encyclopedia.pub/entry/60958. Accessed November 02, 2026.
Peng, Yu. "Translational Frameshifting" Encyclopedia, https://encyclopedia.pub/entry/60958 (accessed November 02, 2026).
Peng, Y. (2026, October 14). Translational Frameshifting. In Encyclopedia. https://encyclopedia.pub/entry/60958
Peng, Yu. "Translational Frameshifting." Encyclopedia. Web. 14 October, 2026.

Translational Frameshifting

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Translational frameshifting is a change in the nucleotide register used by a ribosome to decode messenger RNA, causing subsequent codons to be read in an alternative frame. The resulting polypeptide contains an initial sequence translated before the shift and a downstream sequence specified by the new frame [1]. Programmed frameshifting is promoted by particular messenger-RNA signals, commonly a shift-prone sequence together with a nearby structured region [2]. In minus-one frameshifting, the ribosome moves into a frame displaced by one nucleotide toward the RNA's 5′ end. A downstream pseudoknot can obstruct entry of RNA into the ribosome and generate tension during translocation [3]. Contacts among the pseudoknot, ribosome, and transfer RNA stabilize intermediate conformations associated with this change in reading frame [4][5].

reading frame ribosomal recoding programmed frameshifting mRNA translation
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References

  1. John F. Atkins; Gary Loughran; Pramod R. Bhatt; Andrew E. Firth; Pavel V. Baranov; Ribosomal Frameshifting and Transcriptional Slippage: From Genetic Steganography and Cryptography to Adventitious Use. Nucleic Acids Res. 2016, 44, 7007-7078. [CrossRef]
  2. Neva Caliskan; Frank Peske; Marina V. Rodnina; Changed in Translation: mRNA Recoding by −1 Programmed Ribosomal Frameshifting. Trends Biochem. Sci. 2015, 40, 265-274. [CrossRef]
  3. Pramod R. Bhatt; Alain Scaiola; Gary Loughran; Marc Leibundgut; Annika Kratzel; Romane Meurs; René Dreos; Kate M. O’cOnnor; Angus McMillan; Jeffrey W. Bode; Volker Thiel; David Gatfield; John F. Atkins; Nenad Ban; Structural Basis of Ribosomal Frameshifting during Translation of the SARS-CoV-2 RNA Genome. Science 2021, 372, 1306-1313. [CrossRef]
  4. Olivier Namy; Stephen J. Moran; David I. Stuart; Robert J. C. Gilbert; Ian Brierley; A Mechanical Explanation of RNA Pseudoknot Function in Programmed Ribosomal Frameshifting. Nat. 2006, 441, 244-247. [CrossRef]
  5. Olivier Namy; Stephen J. Moran; David I. Stuart; Robert J. C. Gilbert; Ian Brierley; A Mechanical Explanation of RNA Pseudoknot Function in Programmed Ribosomal Frameshifting. Nat. 2006, 441, 244-247. [CrossRef]
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Subjects: Biochemistry & Molecular Biology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Yu Peng
View Times: 7
Entry Collection: Molecular Biology and Gene Expression Regulation
Revisions: 2 times (View History)
Update Date: 24 Oct 2026
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