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Peng, Y. Recombinant Enzymes. Encyclopedia. Available online: https://encyclopedia.pub/entry/60830 (accessed on 12 November 2026).
Peng Y. Recombinant Enzymes. Encyclopedia. Available at: https://encyclopedia.pub/entry/60830. Accessed November 12, 2026.
Peng, Yu. "Recombinant Enzymes" Encyclopedia, https://encyclopedia.pub/entry/60830 (accessed November 12, 2026).
Peng, Y. (2026, October 11). Recombinant Enzymes. In Encyclopedia. https://encyclopedia.pub/entry/60830
Peng, Yu. "Recombinant Enzymes." Encyclopedia. Web. 11 October, 2026.

Recombinant Enzymes

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Recombinant enzymes are catalytically active proteins produced through expression of engineered DNA that encodes the enzyme in a biological host. The coding sequence is incorporated into an expression construct whose regulatory elements support transcription and translation in the selected organism. The encoded protein may retain a naturally occurring sequence or contain deliberately introduced sequence changes [1]. Formation of an active recombinant enzyme can require folding, assembly of subunits, incorporation of cofactors, proteolytic processing, or other post-translational modifications [2][3]. These requirements interact with the biochemical capabilities of the expression host [2]. The enzyme may accumulate within cells or enter a secretion pathway, and its mature molecular form depends on both the encoded sequence and host-mediated processing [4]. The term identifies the recombinant origin of the enzyme and does not specify a single catalytic reaction, protein family, or expression organism [1][2].

recombinant expression catalytic proteins expression host protein maturation
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References

  1. Marie Deckers; Dieter Deforce; Marie-Alice Fraiture; Nancy H.C. Roosens; Genetically Modified Micro-Organisms for Industrial Food Enzyme Production: An Overview. Foods 2020, 9, 326. [CrossRef]
  2. Antonio Milton Vieira Gomes; Talita Souza Carmo; Lucas Silva Carvalho; Frederico Mendonça Bahia; Nádia Skorupa Parachin; Comparison of Yeasts as Hosts for Recombinant Protein Production. Microorganisms 2018, 6, 38. [CrossRef]
  3. Dujuan Liu; Sandra Garrigues; Ronald P. de Vries; Heterologous Protein Production in Filamentous Fungi. Appl. Microbiol. Biotechnol. 2023, 107, 5019-5033. [CrossRef]
  4. Chun Liu; Yaping Zhang; Liu Yang; Fengguang Zhao; Shuangyan Han; Reinforcement Strategies of Chassis Cell Secretory Pathway for Improving Heterologous Protein Production. Microbe 2024, 3, 100092. [CrossRef]
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Subjects: Biochemistry & Molecular Biology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Yu Peng
View Times: 7
Entry Collection: Biosynthesis and Synthetic Biology
Revisions: 2 times (View History)
Update Date: 24 Oct 2026
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