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Kang, H. Micellar Chromatography. Encyclopedia. Available online: https://encyclopedia.pub/entry/60722 (accessed on 12 November 2026).
Kang H. Micellar Chromatography. Encyclopedia. Available at: https://encyclopedia.pub/entry/60722. Accessed November 12, 2026.
Kang, Helena. "Micellar Chromatography" Encyclopedia, https://encyclopedia.pub/entry/60722 (accessed November 12, 2026).
Kang, H. (2026, October 09). Micellar Chromatography. In Encyclopedia. https://encyclopedia.pub/entry/60722
Kang, Helena. "Micellar Chromatography." Encyclopedia. Web. 09 October, 2026.

Micellar Chromatography

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Micellar chromatography comprises chromatographic modes in which surfactant micelles, present above the critical micelle concentration, constitute a mobile or pseudostationary phase that participates directly in solute retention. In micellar liquid chromatography, solutes distribute among bulk mobile phase, micelles, and a packed stationary phase; association with micelles and adsorption of surfactant on the packing modify both elution strength and selectivity [1]. In micellar electrokinetic chromatography, charged micelles migrate electrophoretically at a velocity different from the electroosmotic flow, creating a moving pseudostationary phase into which neutral and ionic solutes partition [2]. The defining equilibrium is reversible solute–micelle association, characterized by micellar composition and concentration. The concept excludes conventional reversed-phase chromatography without micelles, ion-pair chromatography below the critical micelle concentration, and separations using unrelated vesicles or nanoparticles. Essential features are a surfactant concentration above its critical micelle concentration, stable micelles under the separation conditions, and retention or migration that depends measurably on micellar partitioning.

micellar chromatography surfactant micelles pseudostationary phase critical micelle concentration
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References

  1. María José Ruiz‐Ángel; María Celia García‐Álvarez‐Coque; Alain Berthod; New Insights and Recent Developments in Micellar Liquid Chromatography. Sep. Purif. Rev. 2009, 38, 45-96. [CrossRef]
  2. Sami El Deeb; Mohammed Abu Iriban; Ronald Gust; MEKC as a powerful growing analytical technique. Electrophor. 2010, 32, 166-183. [CrossRef]
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Entry Collection: Analytical Chemistry
Revision: 1 time (View History)
Update Date: 21 Oct 2026
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