Your browser does not fully support modern features. Please upgrade for a smoother experience.
Micellar Chromatography: History
Please note this is an old version of this entry, which may differ significantly from the current revision.
Contributor: Helena Kang

Micellar chromatography comprises chromatographic modes in which surfactant micelles, present above the critical micelle concentration, constitute a mobile or pseudostationary phase that participates directly in solute retention. In micellar liquid chromatography, solutes distribute among bulk mobile phase, micelles, and a packed stationary phase; association with micelles and adsorption of surfactant on the packing modify both elution strength and selectivity [1]. In micellar electrokinetic chromatography, charged micelles migrate electrophoretically at a velocity different from the electroosmotic flow, creating a moving pseudostationary phase into which neutral and ionic solutes partition [2]. The defining equilibrium is reversible solute–micelle association, characterized by micellar composition and concentration. The concept excludes conventional reversed-phase chromatography without micelles, ion-pair chromatography below the critical micelle concentration, and separations using unrelated vesicles or nanoparticles. Essential features are a surfactant concentration above its critical micelle concentration, stable micelles under the separation conditions, and retention or migration that depends measurably on micellar partitioning.

  • micellar chromatography
  • surfactant micelles
  • pseudostationary phase
  • critical micelle concentration

Analytical Chemistry and Chromatography • Spectroscopy • Chemistry • Physical Sciences

References

  1. María José Ruiz‐Ángel; María Celia García‐Álvarez‐Coque; Alain Berthod; New Insights and Recent Developments in Micellar Liquid Chromatography. Sep. Purif. Rev. 2009, 38, 45-96, 10.1080/15422110802178876.
  2. Sami El Deeb; Mohammed Abu Iriban; Ronald Gust; MEKC as a powerful growing analytical technique. Electrophor. 2010, 32, 166-183, 10.1002/elps.201000398.
More
This entry is offline, you can click here to edit this entry!
Write an Entry