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Kang, H. Fourier Transform Mass Spectrometry. Encyclopedia. Available online: https://encyclopedia.pub/entry/60689 (accessed on 12 November 2026).
Kang H. Fourier Transform Mass Spectrometry. Encyclopedia. Available at: https://encyclopedia.pub/entry/60689. Accessed November 12, 2026.
Kang, Helena. "Fourier Transform Mass Spectrometry" Encyclopedia, https://encyclopedia.pub/entry/60689 (accessed November 12, 2026).
Kang, H. (2026, October 08). Fourier Transform Mass Spectrometry. In Encyclopedia. https://encyclopedia.pub/entry/60689
Kang, Helena. "Fourier Transform Mass Spectrometry." Encyclopedia. Web. 08 October, 2026.

Fourier Transform Mass Spectrometry

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Time-domain image-current or related ion signals that are converted by Fourier transformation into a frequency-domain mass spectrum constitute Fourier transform mass spectrometry (FTMS). The frequency of ion motion—cyclotron frequency in an ICR cell or axial oscillation frequency in an electrostatic (Orbitrap) trap—is a precise function of mass-to-charge ratio, so that long, coherent transients yield high resolving power [1]. Space charge shifts those frequencies and must be accounted for in mass calibration [2]. Collisional or electron-based activation of trapped multiply charged ions can be performed inside the same analyzer, linking the FTMS measurement to tandem structural analysis [3]. Conceptual boundaries exclude scanning beam instruments (magnetic sector, quadrupole) and time-of-flight analyzers that do not record a Fourier-transformed transient, and they include both FT-ICR and Orbitrap implementations as members of the FTMS class [4]. Essential features are ion trapping that supports periodic motion, broadband detection of that motion, and a Fourier-transform conversion from time to mass-to-charge ratio.

Fourier transform mass spectrometry FTMS ion trap mass-to-charge ratio
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References

  1. Michaela Scigelova; Martin Hornshaw; Anastassios Giannakopulos; Alexander Makarov; Fourier Transform Mass Spectrometry. Mol. Cell. Proteom. 2011, 10, M111.009431. [CrossRef]
  2. Edward B. Ledford; Don L. Rempel; M. L. Gross; Space charge effects in Fourier transform mass spectrometry. II. Mass calibration. Anal. Chem. 1984, 56, 2744-2748. [CrossRef]
  3. Michael W. Senko; J. Paul. Speir; Fred W. McLafferty; Collisional Activation of Large Multiply Charged Ions Using Fourier Transform Mass Spectrometry. Anal. Chem. 1994, 66, 2801-2808. [CrossRef]
  4. Luca Fornelli; Daniel Ayoub; Konstantin Aizikov; Alain Beck; Yury O. Tsybin; Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry. Anal. Chem. 2014, 86, 3005-3012. [CrossRef]
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Entry Collection: Analytical Chemistry
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Update Date: 21 Oct 2026
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