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Zhong, J. Magnetic Solid Phase Extraction. Encyclopedia. Available online: https://encyclopedia.pub/entry/60563 (accessed on 05 October 2026).
Zhong J. Magnetic Solid Phase Extraction. Encyclopedia. Available at: https://encyclopedia.pub/entry/60563. Accessed October 05, 2026.
Zhong, Jack. "Magnetic Solid Phase Extraction" Encyclopedia, https://encyclopedia.pub/entry/60563 (accessed October 05, 2026).
Zhong, J. (2026, September 28). Magnetic Solid Phase Extraction. In Encyclopedia. https://encyclopedia.pub/entry/60563
Zhong, Jack. "Magnetic Solid Phase Extraction." Encyclopedia. Web. 28 September, 2026.
Magnetic Solid Phase Extraction
Edit

Magnetic solid phase extraction is a sample preparation procedure in which a magnetic sorbent is dispersed in a liquid sample, allowed to take up the target analytes, and then separated from the liquid with an external magnet instead of by filtration or centrifugation. The sorbent is usually an iron oxide core coated with a phase that does the actual retaining, so the selectivity comes from the coating while the separation comes from the core [1]; covalent triazine frameworks grown on a cobalt ferrite have been examined for this [2]. The procedure has been taken up for natural products, where the matrix is complex and the analytes are present at trace level [3]. Determining steroid estrogens in fish tissue shows the combination with liquid chromatography [4]. Dispersing the sorbent without a separate conditioning step shortens the procedure, and dispersive variants of the technique recover synthetic phosphodiesterase inhibitors from a complex matrix [5].

magnetic sorbent sample preparation iron oxide core dispersive extraction analyte recovery matrix effect liquid chromatography

References

  1. Capriotti, A.L.; Cavaliere, C.; La Barbera, G.; Montone, C.M.; Piovesana, S.; Laganà, A. Recent Applications of Magnetic Solid-phase Extraction for Sample Preparation. Chromatographia 2019, 82, 1251-1274. [CrossRef]
  2. Yan, Z.; He, M.; Chen, B.; Hu, B. Covalent triazine frameworks/cobalt composites for magnetic solid phase extraction of pyrethroids from food samples followed by gas chromatography-flame ionization detection. Advances in Sample Preparation 2022, 1, 100006. [CrossRef]
  3. Chen, L.; Yang, F. Applications of magnetic solid‐phase extraction in the sample preparation of natural product analysis (2020–2023). Journal of Separation Science 2024, 47, 2400082. [CrossRef]
  4. Xue, B.; Xu, M.; Bai, Z.; Hu, C. The determination of estrogens in fish samples by magnetic solid phase extraction coupled to high performance liquid chromatography-diode array detector. Advances in Sample Preparation 2024, 11, 100120. [CrossRef]
  5. Oller-Ruiz, A.; Campillo, N.; Fenoll, J.; Hernández-Córdoba, M.; Viñas, P. Dispersive magnetic solid-phase extraction for synthetic PDE-5 inhibitors determination by high-performance liquid chromatography with tandem mass spectrometry. Advances in Sample Preparation 2023, 7, 100071. [CrossRef]
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