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1 Yu Peng -- 153 2026-09-24 08:11:41 |
2 format correct Catherine Yang -9 word(s) 144 2026-09-28 08:28:54 |

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Peng, Y. Biosynthetic Gene Cluster (BGC). Encyclopedia. Available online: https://encyclopedia.pub/entry/60457 (accessed on 05 October 2026).
Peng Y. Biosynthetic Gene Cluster (BGC). Encyclopedia. Available at: https://encyclopedia.pub/entry/60457. Accessed October 05, 2026.
Peng, Yu. "Biosynthetic Gene Cluster (BGC)" Encyclopedia, https://encyclopedia.pub/entry/60457 (accessed October 05, 2026).
Peng, Y. (2026, September 24). Biosynthetic Gene Cluster (BGC). In Encyclopedia. https://encyclopedia.pub/entry/60457
Peng, Yu. "Biosynthetic Gene Cluster (BGC)." Encyclopedia. Web. 24 September, 2026.
Biosynthetic Gene Cluster (BGC)
Edit

A biosynthetic gene cluster (BGC) is a contiguous, functionally coordinated genomic locus that encodes the enzymatic and regulatory machinery required for the biosynthesis of a specialized natural product or a defined family of structurally related metabolites. In microbial genomes, a BGC commonly includes one or more core biosynthetic genes encoding scaffold-forming enzymes, together with genes for tailoring enzymes that modify the molecular scaffold, transport proteins, pathway-specific regulators, precursor-supply functions, and, where relevant, self-resistance or immunity mechanisms [1][2]. The coordinated expression and activity of these genes direct the conversion of primary metabolites into a characteristic natural-product scaffold and its subsequent chemical diversification. BGCs are recognized as genomic units through the physical co-localization of genes whose protein products collectively constitute a biosynthetic pathway; their boundaries encompass the genes contributing directly to metabolite assembly, modification, regulation, export, or producer protection [1][3].

specialized metabolism natural products microbial genomics biosynthetic enzymes

References

  1. Marnix H Medema; Renzo Kottmann; Pelin Yilmaz; Matthew Cummings; John B Biggins; Kai Blin; Irene de Bruijn; Yit Heng Chooi; et al. Minimum Information about a Biosynthetic Gene cluster. Nat. Chem. Biol. 2015, 11, 625-631. [CrossRef]
  2. Peter Cimermancic; Marnix H. Medema; Jan Claesen; Kenji Kurita; Laura C. Wieland Brown; Konstantinos Mavrommatis; Amrita Pati; Paul A. Godfrey; Michael Koehrsen; Jon Clardy; Bruce W. Birren; Eriko Takano; Andrej Sali; Roger G. Linington; Michael A. Fischbach; Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters. Cell 2014, 158, 412-421. [CrossRef]
  3. Barbara R Terlouw; Kai Blin; Jorge C Navarro-Muñoz; Nicole E Avalon; Marc G Chevrette; Susan Egbert; Sanghoon Lee; David Meijer; et al. MIBiG 3.0: A Community-Driven Effort to Annotate Experimentally Validated Biosynthetic Gene Clusters. Nucleic Acids Res. 2022, 51, D603-D610. [CrossRef]
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Subjects: Pharmacology & Pharmacy
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Yu Peng
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Update Date: 28 Sep 2026
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