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Kang, H. One-Pot Synthesis. Encyclopedia. Available online: https://encyclopedia.pub/entry/60367 (accessed on 03 October 2026).
Kang H. One-Pot Synthesis. Encyclopedia. Available at: https://encyclopedia.pub/entry/60367. Accessed October 03, 2026.
Kang, Helena. "One-Pot Synthesis" Encyclopedia, https://encyclopedia.pub/entry/60367 (accessed October 03, 2026).
Kang, H. (2026, September 23). One-Pot Synthesis. In Encyclopedia. https://encyclopedia.pub/entry/60367
Kang, Helena. "One-Pot Synthesis." Encyclopedia. Web. 23 September, 2026.
One-Pot Synthesis
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One-pot synthesis is the execution of two or more successive chemical transformations in a single reaction vessel without isolating the intermediates between those transformations [1]. The reagents may be present from the outset or introduced sequentially, and the temperature, atmosphere, solvent composition, or catalyst may change during the sequence, provided that the reacting material is not transferred to a separate vessel. The category includes cascade, domino, tandem, multicomponent, and stepwise single-vessel procedures, but these terms are not synonyms: a cascade or domino sequence is internally triggered, whereas a one-pot stepwise synthesis can require deliberate addition of a new reagent or alteration of the conditions [1][2]. Operational continuity distinguishes one-pot synthesis from an ordinary multistep route in which an intermediate is isolated or purified. It also differs from simple telescoping when the latter involves transfer to another reactor, even if no intermediate purification occurs.

one-pot synthesis telescoping sequential transformation intermediate compatibility

References

  1. Yujiro Hayashi; Pot economy and one-pot synthesis. Chem. Sci. 2016, 7, 866-880. [CrossRef]
  2. Xiaoming Ma; Wei Zhang; Recent developments in one-pot stepwise synthesis (OPSS) of small molecules. iScience 2022, 25, 105005. [CrossRef]
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Subjects: Chemistry, Organic
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Helena Kang
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Update Date: 23 Sep 2026
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