One-pot synthesis is the execution of two or more successive chemical transformations in a single reaction vessel without isolating the intermediates between those transformations [1]. The reagents may be present from the outset or introduced sequentially, and the temperature, atmosphere, solvent composition, or catalyst may change during the sequence, provided that the reacting material is not transferred to a separate vessel. The category includes cascade, domino, tandem, multicomponent, and stepwise single-vessel procedures, but these terms are not synonyms: a cascade or domino sequence is internally triggered, whereas a one-pot stepwise synthesis can require deliberate addition of a new reagent or alteration of the conditions [1][2]. Operational continuity distinguishes one-pot synthesis from an ordinary multistep route in which an intermediate is isolated or purified. It also differs from simple telescoping when the latter involves transfer to another reactor, even if no intermediate purification occurs.
Synthesis of Organic Compounds • Pharmacology • Medicine • Health Sciences