Environmental Factors in Water Systems

Version	Summary	Created by	Modification	Content Size	Created at	Operation
1		Michele Arienzo	--	2157	2023-07-26 08:44:48	\|
2	format correct	Catherine Yang	Meta information modification	2157	2023-07-26 08:59:21	\|

This entry is adapted from the peer-reviewed paper 10.3390/jmse11071437

Microplastics, MPs, in aquatic environments pose serious threats when associated with other pollutants, such as pharmaceuticals, PHs. MPs and PHs are considered emerging and ubiquitous contaminants in water bodies, and their interaction has a complex chain effect.

microplastics contamination water sediments

1. Effect of Temperature

Temperature can modify solubility, surface tension, and sorption thermodynamics and hence the interaction. High temperatures, during ageing may favour the presence of oxygen-rich functional groups C–O, C–OH, and CO ^[1] and the interaction with hydrophilic PHs as well as their desorption ^[2].

2. Effect of pH

Among all the environmental factors regulating the interaction, pH represents is largely dominant, since it affects MP surface charges and drug speciation as well ^[3]. A significant group of drugs, such as antibiotics, are polar and ionizable, and thus speciation is driven by pH. Drugs can be cationic, anionic, and zwitterionic species and will be sorbed depending on the surface charge ^[4]. They are 85–95% ionizable and weak acids or bases ^[5]. The electrostatic interaction is the main sorption mechanism of PHs by MPs. This is a physical mechanism driven by the pH of the aquatic system, normally 5–9, when the surface charge of the MPs varies among positive, negative, or neutral, and the polymers tend to aggregate ^[3]. However, at the common pH value of estuaries and coastal water, 8.1, there would be a tendency for many PHs to desorb from the MPs due to the repulsion ^[6].

The point of zero charges, pH PZC, of MPs is below 7, and hence, at the common pH of water systems, the surface is negatively charged. The pH dependence of the surface charge was shown by the point of zero charges, PZC, experiments: When the pH of the system was above the PZC of PE, PP, and PS, the polymers carried negative charges ^[7]^[8]. The effect of solution pH on the sorption of tetracycline by PE, PP, and PS was studied by Xu et al. ^[7]. Tetracycline is present in cations at low pHs, anions at high pHs, and zwitterions at pH 5–7, with the highest electrostatic attractions for the zwitterionic species and the maximum sorption at a pH level of 6. When the pH increased, sorption decreased as tetracycline and polymers became negatively charged and repulsed. In the same way, Guo et al. ^[9] showed that the sorption of sulfamethoxazole increased with pH from 3 to 5; at pH 5–7, sulfamethoxazole is neutral and sorbed by hydrophobic interactions with the non-polar polymer surface. At pH > 7, sulfamethoxazole is anionic and is repulsed by the increased electronegativity of the polymer. This is explained by the electrostatic and hydrophobic attractions since the antibiotics became positively charged in an acidic pH, whereas the electrostatic interaction became less significant at an alkaline pH as the antibiotics became negatively charged. Zwitterionic or neutral drugs interact with non-polar plastic surfaces through hydrophobic and van der Waals forces at a neutral pH. At a high pH, as in marine environments, drugs are present as anions, which enhances their electrostatic repulsion with polymer surfaces. Thus, the pH of the aqueous system affects zwitterionic strength and electrostatic repulsion. Other similar results are shown in the literature. Guo et al. ^[10] studied the sorption of Tylenol on PS, PVC, PE, and PP. They found that the sorption capacity in the case of PS and PVC decreased gradually with the increment of pH from 3.0 to 7.0, while PE and PP showed a minimal difference. This is likely due to the electrostatic attraction. In another study ^[11], the pH decreased to less than 3.0, and protonation of PE and PS surfaces and enhanced adsorption of PFOS, perfluoro octane sulfonic acid, was observed. Thus, the pH is critical in influencing the sorption process between MPs and PHs depending on their surface charges ^[12]. Elizalde-Velázquez et al. ^[13] studied the sorption of three non-steroidal, anti-inflammatory drugs, ibuprofen, naproxen, and diclofenac, on PS, ultra-high-molecular weight PE, average molecular weight, medium density PE, and PP. The sorption process was pH-dependent, probably due to the molecular equilibrium effects that affect not only MPs’ surface charge but the compound’s speciation as well. Only under acidic conditions were the pharmaceuticals highly sorbed onto the MPs, a process ruled by hydrophobic interactions. Thus, solution pH affects overall chemical reactivity, biochemical and physicochemical properties, equilibrium condition, and toxicity ^[14]. McDougall et al. ^[15] studied the desorption of three groups of PHs, cationic, anionic, and neutral, from PE-simulating gastric and intestinal fluids. The pH of the solution was the most important factor driving PH desorption, influencing speciation of the active compounds and MP surface charge. The desorption of the cationic compounds in gastric fluids was more evident and up to 50% due to the reduced surface charge of the polymers under low pH, revealing that PHs sorbed to MPs can be bioavailable ^[15].

3. Effect of Ionic Strength

The role of ionic strength on PH sorption depends on the type of adsorbent, adsorbate, electrolyte, and solution chemistry ^[16]. Sorption decreases with ionic strength, as was the case of ciprofloxacin ^[16], sulfamethoxazole ^[4] and sulfamethazine. Polymers are normally negatively charged and hence hydrophilic and influenced by the levels of cations, such as Na⁺ and Ca²⁺, in an aqueous medium that can bind electrostatically, disturbing the charge equilibrium of surfaces. Salts also increase the viscosity and density of water, hindering the mass transfer of drugs with ions being sorbed more easily ^[10]. Wan et al. ^[17] observed that MgCl₂ promoted the aggregation of PS and hence decreased tetracycline sorption via electrical double-layer compression or elimination and modulating repulsive forces and reducing accessibility to PHs ^[16].

An opposite effect of ionic strength can be also observed: the so-called salting-out and ionic complexation effect ^[18]. Lu et al. ^[6] observed a threefold increased sorption of 17β-estradiol and 17α-ethynylestradiol when the salinity of seawater was doubled and explained using solubility decreases of hydrophobic PHs with an increase of salts and the enhanced hydrophobic interactions of drugs with MPs. The presence of ions also promotes cationic bridging, especially with multivalent ions. On the other hand, polyvalent ions may favour the formation of ternary complexes through the bonding of the drugs with specific PH functional groups of the adsorbent, which enhances the sorption properties ^[19]. In the case of non-steroidal, anti-inflammatory drugs, NSAIDs, Elizalde Velasquez ^[13] reported higher sorption of ibuprofen, diclofenac, and naproxen on PP, PS, and PE in freshwater than that in seawater due to the high salinity content of seawater. The increase in salinity affects the aggregation state of the polymer. In parallel, it also increases the hydrophobic interaction between the drug and the polymer via the salting effect, i.e., decreasing the concentration of PHs in the solution ^[20].

4. Effect of Dissolved Organic Matter

The effects of dissolved organic matter, DOM, the fraction of organic matter in a solution that passes through a 0.45 μm filter, on the binding of drugs are poorly studied ^[13]. DOM can induce contrasting effects on PH sorption by MPs in the function of their properties enhancing or reducing sorption ^[7]. Few studies show increased sorption. Zhang et al. ^[21] studied the sorption of oxytetracycline on beached polystyrene foams in the presence of humic acid, HA, and fulvic acid, FA, as the two representative dissolved organic materials and showed increasing sorption with DOM. They found that fulvic acid promoted significant oxytetracycline sorption to the beached foams due to the complexation role of humic acid, acting as a bridge with both the beached foam surfaces and oxytetracycline molecules. Lu et al. ^[6] recently observed increased sorption of hormonal steroid compounds by MPs due to DOM–MPs complexation. Chen et al. ^[22] showed the formation of a copolymer between the carbonyl group of DOM and the aromatic moieties of the polymer through π–π interaction, which enhanced the electrostatic sorption of the positively charged oxytetracycline to the copolymer. Migration and stability of MPs might be considerably aided by DOM ^[23] due to the formation of a coating, eco-corona layer on the MPs, which inhibits the aggregation of plastic particles via electrostatic repulsion and steric forces ^[23]. However, mobility and stability can be reduced with the presence of DOM, as they can create a coating layer on the plastic surface. There are studies by Xu et al. ^[7] reporting decreased sorption of tetracycline on PS, PP, and PE when DOM increased due to complexation with the hydrophobic or hydrophilic DOM parts, which changes the partitioning between the polymer surface and water ^[24]. DOM and drugs may compete for the limited sorption sites on MPs ^[25] with the desorption of PHs from MPs ^[26] or can block the pores on the MPs’ surface with their large molecules, hindering the access of drugs ^[27]. Another interactive role is played by the concomitant presence of polyvalent metals: Through PHs, stable ternary complexes can form in the water metal cations and DOM ^[28].

5. Effect of Biofouling

Biofouling is the process of microbe colonization of MPs through extracellular polymeric substances, EPS. This induces changes in morphology and physicochemical properties ^[29]. There is still very limited knowledge on the effect of biofouling on MPs–MPs interatom. PHs must pass from the water into the biofilm and then to the polymer material ^[30]. PHs interact via hydrophobic partitioning into the biopolymer or through binding onto the sorption sites of the heterogenic EPS ^[31]. EPS is rich in ionizable functional groups, such as carboxyl, phosphoryl, amino, and hydroxyl, that increase the sorption of metal ions via MPs ^[32], and in this way, metals have a synergistic effect on the sorption by forming a PHs–metal–EPS complex through an ionic bridging effect ^[33].

6. Effect of MP Ageing

MPs in water are exposed to physical and chemical weathering, such as photooxidation, temperature variations, friction, and saltwater corrosion. They crack into smaller particles with reduced hydrophobicity ^[3]. Ageing occurs through ultraviolet-induced photodegradation, physical impacts, and biodegradation ^[34]. Many kinetic models and batch sorption data reveal how modified MPs have a higher sorption capacity than pristine polymers ^[3]. Weathering processes increase surface area, accessible binding sites, and hence PHs sorption ^[34]. In this regard, however, the data are not always in agreement, Table 1. Huang et al. ^[34] studied the role of MP ageing, PS, on the interaction with sulfamethoxazole, SMX, and the β-blocker propranolol (PRP) and using red tilapia as the model fish. The authors reported a 0.27- and 0.16-fold increase in the specific surface area and average pore volume, respectively, and the formation of more carbonyl on the aged PS. Ageing increased PRP accumulation by 82.3% in the brain, whereas it decreased the SMX level by 46.1% in the gills. Even the response of the model was different: In the case of PS–PRP, the stress was alleviated by the ageing with reduced neurotoxicity and lipid peroxidation damages, whereas in the case of SMX-aged PS, co-exposure resulted in higher inhibition of cytochrome P450 enzyme activities. Thus, the interactive effect of MPs and the drug varies with the intrinsic features of the drug, exposure strategy, selected endpoints, biological models, and environmental conditions. One key issue, as stated by Huang et al. ^[34], is that there is no significant literature on the interactive effects of aged MPs and drugs on aquatic organisms where the experiments are carried out with commercially pristine MPs, that is, with homogeneous size distribution and regular shape. If ageing in laboratory settings has shown evident increases of SSA and the oxygen load and consequently more intensive drug sorption on polymers, it is very likely to hypothesize side chain effects of the toxicological interaction between MPs and drugs.

Table 1. Interactive effects of MPs–PHs on various aquatic organisms.

Drug	MPs	Organism	Effect	Reference
Roxithromycin	PS (10–100 µg/L)	Red tilapia	Reduced inhibitory effect	^[35]
Cephalexin	No-specified (0.184 mg/L)	Polatoschistus microps	Increased inhibitory effect	^[36]
Procainamide	No-specified (0.75–48 mg/L)	algae	Increased inhibitory effect	^[37]
Venlafaxine	PVC (50 mg/L)	loach	Increased inhibitory effect	^[38]
Propranolol	PS (10 µg/L)	Red tilapia	Reduced inhibitory effect	^[34]
Sulfamethoxazole	PS (50 µg/L)	Red tilapia	Increased inhibitory effect	^[34]

The effects of the biotic and abiotic degradation events depend on the chemical nature of the plastic, the loads, the hydrophilicity of the surfaces, and the environmental conditions ^[39].

In water, the excess of hydrogen atoms favours the formation of a phenolic hydroxyl group on aged MP surfaces ^[40]. Through chemical transformation, the richness of oxygen-containing functional groups increases, carboxyl, hydroxyl, ketone, and ester, and this confers polymers hydrophilic properties ^[41], making them capable of more adsorb the hydrophilic molecules of PHs ^[42]. If the weathering process increases, the negative charges of the polymer surfaces and the sorption of cationic PHs via electrostatic interaction increases ^[3]. The increased hydrophilicity was highlighted by Liu et al. ^[43] who showed functional group alteration on PS and PVC via UV irradiation and ciprofloxacin sorption increase. Zhang et al. ^[21] also showed a twofold increase in the adsorption capacity of beached PS foams for oxytetracycline, OTC, concerning virgin PS foams, and the adsorption included electrostatic interaction, multivalent cationic bridging mechanisms, and H-bonding interaction. In the same way, ageing can also sustain other mechanisms, such as π–π, electrostatic interaction, hydrogen bonding, ion exchange, and complexation ^[21]. Other authors, reported decreased desorption of atorvastatin and amlodipine from weathered PS due to the increased electrostatic interaction ^[12].

Ageing also modifies polymer crystallinity since the weathering process enhances the percentage of the crystallization region and reduces the amorphous plastic portion, but the effects on PHs sorption are poorly known ^[44].

References

Ding, L.; Mao, R.; Ma, S.; Guo, X.; Zhu, L. High temperature depended on the ageing mechanism of microplastics under different environmental conditions and its effect on the distribution of organic pollutants. Water Res. 2020, 174, 115634.
Zhang, F.; Zhang, H.; Cao, R.; Fan, Y.; Xu, P.; Chen, J. Release and transformation of BTBPE during the thermal treatment of flame-retardant ABS plastics. Environ. Sci. Technol. 2019, 53, 185–193.
Vieira, Y.; Lima, E.C.; Foletto, E.L.; Dotto, G.L. Microplastics physicochemical properties, specific adsorption modeling and their interaction with pharmaceuticals and other emerging contaminants. Sci. Total Environ. 2021, 753, 141981.
Guo, X.; Wang, J. Sorption of antibiotics onto aged microplastics in freshwater and seawater. Mar. Pollut. Bull. 2019, 149, 110511.
Karlsson, M.V.; Carter, L.J.; Agatz, A.; Boxall, A.B.A. Novel approach for characterizing pH-dependent uptake of ionizable chemicals in aquatic organisms. Environ. Sci. Technol. 2017, 51, 6965–6971.
Lu, J.; Wu, J.; Wu, J.; Zhang, C.; Luo, Y. Adsorption and desorption of steroid hormones by microplastics in seawater. Bull. Environ. Contam. Toxicol. 2020, 107, 730–735.
Xu, B.; Liu, F.; Brookes, P.C.; Xu, J. Microplastics play a minor role in tetracycline sorption in the presence of dissolved organic matter. Environ. Pollut. 2018, 240, 87–94.
Sposito, G. On points of zero charge. Environ. Sci. Technol. 1998, 32, 2815–2819.
Guo, X.; Chen, C.; Wang, J. Sorption of sulfamethoxazole onto six types of microplastics. Chemosphere 2019, 228, 300–308.
Guo, X.; Liu, Y.; Wang, J. Sorption of sulfamethazine onto different types of microplastics: A combined experimental and molecular dynamics simulation study. Mar. Pollut. Bull. 2019, 145, 547–554.
Wang, F.; Shih, K.M.; Li, X.Y. The partition behaviour of per fluorooctanesulfonate (PFOS) and per fluorooctanesulfonamide (FOSA) on microplastics. Chemosphere 2015, 119, 841–847.
Liu, P.; Wu, X.; Liu, H.; Wang, H.; Lu, K.; Gao, S. Desorption of pharmaceuticals from pristine and aged polystyrene microplastics under simulated gastrointestinal conditions. J. Hazard. Mater. 2020, 392, 122346.
Elizalde-Velázquez, A.; Subbiah, S.; Anderson, T.A.; Green, M.J.; Zhao, X.; Cañas-Carrell, J.E. Sorption of three common nonsteroidal anti-inflammatory drugs (NSAIDs) to microplastics. Sci. Total Environ. 2020, 715, 136974.
Marion, G.M.; Millero, F.J.; Camoes, M.F.; Spitzer, P.; Feistel, R.; Chen, C.T.A. PH of seawater. Mar. Chem. 2011, 126, 89–96.
McDougall, L.; Thomson, L.; Brand, S.; Wagstaff, A.; Lawton, L.A.; Petrie, P. Adsorption of a diverse range of pharmaceuticals to polyethylene microplastics in wastewater and their desorption in environmental matrices. Sci. Total Environ. 2022, 808, 152071.
Atugoda, T.; Vithanage, M.; Wijesekara, H.; Bolan, A.; Sarmah, A.K.; Bank, M.S.; You, S.; Ok, Y.S. Interactions between microplastics, pharmaceuticals and personal care products: Implications for vector transport. Environ. Internat. 2021, 149, 106367.
Wan, T.; Lu, S.; Cheng, W.; Ren, J.; Wang, M.; Hu, B.; Jia, Z.; Li, Y.; Sun, Y. A spectroscopic and theoretical investigation of interaction mechanisms of tetracycline and polystyrene nanospheres under different conditions. Environ. Pollut. 2019, 249, 398–405.
Ma, J.; Zhao, J.; Zhu, Z.; Li, L.; Yu, F. Effect of microplastic size on the adsorption behavior and mechanism of triclosan on polyvinyl chloride. Environ. Pollut. 2019, 254, 113104.
MacKay, A.A.; Canterbury, B. Oxytetracycline sorption to organic matter by metal-bridging. J. Environ. Qual. 2005, 34, 1964–1971.
Liu, G.; Zhu, Z.; Yang, Y.; Sun, Y.; Yu, F.; Ma, J. Sorption behavior and mechanism of hydrophilic organic chemicals to virgin and aged microplastics in freshwater and seawater. Environ. Pollut. 2019, 246, 26–33.
Zhang, H.; Wang, J.; Zhou, B.; Zhou, Y.; Dai, Z.; Zhou, Q.; Chriestie, P.; Luo, Y. Enhanced adsorption of oxytetracycline to weathered microplastic polystyrene: Kinetics, isotherms and influencing factors. Environ. Pollut. 2018, 243, 1550–1557.
Chen, W.; Ouyang, Z.Y.; Qian, C.; Yu, H.Q. Induced structural changes of humic acid by exposure of polystyrene microplastics: A spectroscopic insight. Environ. Pollut. 2018, 233, 1–7.
Dong, Z.; Zhu, L.; Zhang, W.; Huang, R.; Lv, X.; Jing, X.; Yang, Z.; Wang, J.; Qiu, Y. Role of surface functionalities of nanoplastics on their transport in seawater saturated sea sand. Environ. Pollut. 2019, 255, 113177.
Seidensticker, S.; Zarfl, C.; Cirpka, O.A.; Fellenberg, G.; Grathwohl, P. Shift in mass transfer of wastewater contaminants from microplastics in the presence of dissolved substances. Environ. Sci. Technol. 2017, 51, 12254–12263.
Teuten, E.L.; Saquing, J.M.; Knappe, D.R.; Barlaz, M.A.; Jonsson, S.; Bjorn, A.; Rowland, S.J.; Thompson, R.C.; Galloway, T.S.; Yamashita, R.; et al. Transport and release of chemicals from plastics to the environment and to wildlife. Philos. Trans. R. Soc. 2009, 364, 2027–2045.
Daugherty, M. Adsorption of Organic Pollutants to Microplastics. The Effects of Dissolved Organic Matter. Ph.D. Thesis, Northwest University, Evanston, IL, USA, 2016; pp. 1–27.
Velzeboer, I.; Kwadijk, C.J.A.F.; Koelmans, A.A. Strong sorption of PCBs to nanoplastics, microplastics, carbon nanotubes, and fullerenes. Environ. Sci. Technol. 2014, 48, 4869–4876.
Aristilde, L.; Sposito, G. Binding of ciprofloxacin by humic substances: A molecular dynamics study. Environ. Toxicol. Chem. 2010, 29, 90–98.
Glaser, A.J. The Importance of Biofilms to the Fate and Effects of Microplastics. In Bacterial Biofilms; Dincer, S., Özdenefe, M.S., Arkut, A., Eds.; IntechOpen: London, UK, 2020; p. 360.
Endo, S.; Koelmans, A.A. Sorption of Hydrophobic Organic Compounds to Plastics in the Marine Environment: Equilibrium. In Handbook of Environmental Chemistry; Springer: Berlin/Heidelberg, Germany, 2016; pp. 185–204.
Writer, J.H.; Ryan, J.N.; Barber, L.B. Role of biofilms in sorptive removal of steroidal hormones and 4-nonylphenol compounds from streams. Environ. Sci. Technol. 2011, 45, 7275–7283.
Guan, J.; Qi, K.; Wang, J.; Wang, W.; Wang, Z.; Lu, N.; Qu, J. Microplastics as an emerging anthropogenic vector of trace metals in freshwater: Significance of biofilms and comparison with natural substrates. Water Res. 2020, 184, 116205.
Wang, Y.; Wang, X.; Li, Y.; Li, J.; Wang, F.; Xia, S.; Zhao, J. Biofilm alters tetracycline and copper adsorption behaviors onto polyethylene microplastics. Chem. Eng. J. 2020, 392, 123808.
Huang, Y.; Ding, J.; Zhang, G.; Liu, S.; Zou, H.; Wang, Z.; Zhu, W.; Geng, J. Interactive effects of microplastics and selected pharmaceuticals on red tilapia: Role of microplastic aging. Sci. Total Environ. 2021, 752, 142256.
Zhang, S.; Ding, J.; Razanajatovo, R.M.; Jiang, H.; Zou, H.; Zhu, W. Interactive effects of polystyrene microplastics and roxithromycin on bioaccumulation and biochemical status in the freshwater fish red tilapia (Oreochromis niloticus). Sci. Total Environ. 2019, 648, 1431–1439.
Fonte, E.; Ferreira, P.; Guilhermino, L. Temperature rise and microplastics interact with the toxicity of the antibiotic cefalexin to juveniles of the common goby (Pomatoschistus microps): Post-exposure predatory behaviour, acetylcholinesterase activity and lipid peroxidation. Aquat. Toxicol. 2016, 180, 173–185.
Prata, J.C.; Lavorante, B.R.; Maria da Conceição, B.S.M.; Guilhermino, L. Influence of microplastics on the toxicity of the pharmaceutical’s procainamide and doxycycline on the marine microalgae Tetraselmis chuii. Aquat. Toxicol. 2018, 197, 143–152.
Qu, H.; Ma, R.; Wang, B.; Yang, J.; Duan, L.; Yu, G. Enantiospecific toxicity, distribution and bioaccumulation of chiral antidepressant venlafaxine and its metabolite in loach (Misgurnus anguillicaudatus) co-exposed to microplastic and the drugs. J. Hazard. Mater. 2019, 370, 203–211.
Kedzierski, M.; D’Almeida, M.; Magueresse, A.; Le Grand, A.; Duval, H.; César, G.; Sire, O.; Bruzaud, S.; Tilly, V.L. Threat of plastic ageing in marine environment. Adsorption/desorption of micropollutants. Mar. Pollut. Bull. 2018, 127, 684–694.
Mao, H.; Yang, H.; Xu, Z.; Yang, Y.; Zhang, X.; Huang, F.; Wei, L.; Li, Z. Microplastics and co-pollutant with ciprofloxacin affect interactions between free-floating macrophytes. Environ. Pollut. 2023, 316, 120546.
Barnes, D.K.A.; Galgani, F.; Thompson, R.C.; Barlaz, M. Accumulation and fragmentation of plastic debris in global environments. Philos. Trans. R. Soc. B Biol. Sci. 2009, 364, 1985–1998.
Mohana, A.A.; Rahman, M.; Sarker, S.K.; Haque, N.; Gao, L.; Pramanik, B.K. Nano/microplastics: Fragmentation, interaction with co-existing pollutants and their removal from wastewater using membrane processes. Chemosphere 2022, 309, 136682.
Liu, F.F.; Liu, G.Z.; Zhu, Z.L.; Wang, S.C.; Zhao, F.F. Interactions between microplastics and phthalate esters as affected by microplastics characteristics and solution chemistry. Chemosphere 2019, 214, 688–694.
McGivney, E.; Cederholm, L.; Barth, A.; Hakkarainen, M.; Hamacher-Barth, E.; Ogonowski, M.; Gorokhova, E. Rapid physicochemical changes in microplastic induced by biofilm formation. Front. Bioeng. Biotechnol. 2020, 8, 205.

© Text is available under the terms and conditions of the Creative Commons Attribution (CC BY) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.

Upload a video for this entry

Information

Subjects: Environmental Sciences

Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :

Michele Arienzo

Carlo Donadio

View Times: 423

Entry Collection: Environmental Sciences

Update Date: 26 Jul 2023

Table of Contents

Video Upload Options

Confirm