Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Ver. Summary Created by Modification Content Size Created at Operation
1 -- 3511 2023-06-17 03:45:16 |
2 layout -87 word(s) 3424 2023-06-19 05:39:15 |

Video Upload Options

Do you have a full video?


Are you sure to Delete?
If you have any further questions, please contact Encyclopedia Editorial Office.
Yang, Y.; Hu, N.; Deng, J.; Yang, J. Electrochemical Sensing of Vitamins. Encyclopedia. Available online: (accessed on 10 December 2023).
Yang Y, Hu N, Deng J, Yang J. Electrochemical Sensing of Vitamins. Encyclopedia. Available at: Accessed December 10, 2023.
Yang, Yanting, Ning Hu, Jinan Deng, Jun Yang. "Electrochemical Sensing of Vitamins" Encyclopedia, (accessed December 10, 2023).
Yang, Y., Hu, N., Deng, J., & Yang, J.(2023, June 17). Electrochemical Sensing of Vitamins. In Encyclopedia.
Yang, Yanting, et al. "Electrochemical Sensing of Vitamins." Encyclopedia. Web. 17 June, 2023.
Electrochemical Sensing of Vitamins

Vitamins are a group of complex chemical compounds with very low content in the human body but extremely important functions. Compared with traditional analytical methods, electrochemical techniques, with the advantages of low cost, high sensitivity, flexible detection strategies, easy integration, and miniaturization, have gradually become the main tools in vitamin detection.

vitamin electrochemical sensor nanomaterials

1. Electrochemical Sensors for Water-Soluble Vitamins

1.1. Vitamin B1 Sensors

Adsorptive chronopotentiometric stripping analysis (AdCSA) and non-specific adsorption of VB1 onto a mercury film electrode were used for VB1 determination [1]. Under an optimal experimental condition, the linear detection range of VB1 was 5–50 mg L−1 with a LOD (limit of detection) of 1.64 mg L−1. This method was applied for the analysis of VB1 in pharmaceutical products.

1.2. Vitamin B2 Sensors

Various sensitive and accurate electrochemical detection methods were developed for VB2 detection [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. For example, Wu et al. grew a covalent-organic framework nanobelt (COFTFPB-Thi) vertically on three-dimensional porous carbon (3DKSC) to achieve double signal ratiometric electrochemical detection of RF [21]. Due to the reduction of COFTFPB-Thi and its conjugate structure, when two different response signals were used, the linear ranges were 0.13 μM–0.23 mM and 0.30 μM–0.23 mM, respectively, and the LODs were 44 nM and 90 nM respectively. Double signal-based detection can correct the measurement results and improve their reliability.
The combination of nanocomposites and the screen-printed electrode (SPE) was conducive to the construction of highly sensitive miniaturized RF sensing devices. The screen-printed carbon electrode (SPCE) was modified with Ni/NiO nanocomposites, and the sensor could achieve high detection performance after optimizing the parameters, such as the proportion of nanocomposites. In Britton Robinson (BR) buffer, the linear range was 0.5–75 μM, and the LOD was 0.15 μM [22].
Using binary transition metal oxides (ZnO-MnO) to construct core-shell nanocomposites, its unique structural morphology could improve the specific surface area and increase the number of active sites [23], thus showing a superior electron transfer rate. Based on this electrode, a wider linear range (0.05–1102 μM) could be achieved in RF detection, and the LOD also decreased to 13 nM.

1.3. Vitamin B3 Sensors

A graphite paste microelectrode (GPE) modified with 5,10,15,20-tetrakis(4-methoxyphenyl)21H,23H-porphine cobalt (II) (CoTMPP) was used to detect NA, and a wide linear detection range (1.00 × 10−7–1.00 × 10−4 M) with a LOD of 3.03 × 10−8 M could be achieved [24].

1.4. Vitamin B6 Sensors

Many methods have been used to quantify VB6 accurately. [25][26][27][28][29][30][31]. Based on the high recognition ability of MIP (3-amino benzoic acid), good selectivity and sensitivity could be obtained when VB6 is detected on MIP modified carbon fiber paper electrode (CFPE). Its linear detection range was 0.6 μM to 700 μM with a LOD of 0.010 μM [32].
The glassy carbon electrode was modified with nickel zeolite/carbon black to form a special durable layer [33]. The synergistic effect produced by the unique characteristics of zeolite material and carbon black provides excellent repeatability and short-term stability, as well as good reproducibility and advanced electrical performance. When determining VB6 with DPV, the linear range was 0.050–1.0 mg L−1 with a LOD of 15 μg L−1.
Using the unique properties of different materials will help to improve the sensitivity and specificity of VB6 detection. Vu et al. electrodeposited poly(1,8-diaminonaphthalene) onto graphene/GCE using potential cycling technology [34]. Then the electrode was immersed in copper (II) aqueous solution to adsorb copper ions onto poly(1,8-diaminonaphthalene)/graphene-modified GCE. The synthetic materials not only obtained the ability of graphene to promote electron transfer but also had the electrocatalytic capacity of copper for the oxidation of pyridoxine. In SWV detection within 0.1 M phosphate buffer solution (pH 7.4), the linear detection range of pyridoxine was 0.58–24.51 μM, and the LOD was 0.3 μM.

1.5. Vitamin B9 Sensors

In order to achieve highly sensitive and accurate electrochemical sensing detection of FA, special recognition elements are often required [35][36][37][38]. Ali et al. developed a FA sensor based on UV-Vis spectroelectrochemical technology using Ni-tipped carbon nanofibers (Ni-CNFs) anchored over a transparent ITO electrode, which could simultaneously detect the electrochemical response of FA oxidized by Ni-CNF electrocatalyst and the optical sensing signal of FA oxidation products [39]. In the presence of interfering molecules, the linear detection range of the FA sensor was 1–100 μg mL−1 with LOD 0.14 μg mL−1.
Because UV-Vis spectroelectrochemistry can simultaneously obtain complementary information from both electrochemistry and spectroscopy, as well as the unique electrical activity and optical characteristics of FA, this method has significant application value in FA quantitative analysis. Olmo et al. [40] used this method to quantitatively analyze FA concentration under various conditions and obtained ideal results (the linear detection range of the FA sensor was 5–100 μM with LOD ~1 μM). Especially, spectral analysis can more accurately capture the dynamic electrochemical response signals of FA, providing conditions for real-time analysis.

1.6. Vitamin B12 Sensors

The determination of VB12 in human plasma, urine, food and drugs is of great significance in the diagnosis and treatment of metabolic diseases [41][42][43][44]. Guo [45] et al. modified the GCE with a nanocomposite of Au and polypyrrole nanoparticles and functionalized carbon nanotubes (Au-PPy NPs@f-CNTs), and conducted electrochemical detection using DPV and amperometric techniques. Due to the high conductivity of Au NPs, PPy NPs, and f-CNTs, as well as the uniform distribution of electrochemically active sites on CNTs, the stable and strong electrochemical signals could be obtained, and the linear range, LOD, and sensitivity of electrochemical detection of VB12 were respectively 0–85 μM, 0.9 nM and 4.3597 μA μM−1.

1.7. Vitamin C Sensors

The electrochemical AA sensor is mainly divided into enzyme sensors and non-enzyme sensors [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71]. The enzyme sensor uses the super ability of biological enzymes in recognition and catalysis, with high sensitivity and selectivity, but it still has limitations in cost and preservation. The non-enzymatic method is the focus of current research [72]. Common bare electrodes are gradually replaced by various modified electrodes due to their low electrical activity and easy passivation by electrochemical reactants, and nanomaterials have become the most commonly used modifiers [73][74][75][76][77].
Transition metal oxides have high electrochemical activity and are common modifiers for electrochemical electrodes. Sampathkumar et al. used a molybdenum disulfide (MoS2) modified GCE to determine AA electrochemically [78]. The linear range of detection was 90 to 590 nM, the sensitivity was 5.83 × 10−2 μA μM−1, and the LOD was 41 nM. It could achieve excellent detection effects in artificial urine samples with complex components.
Tortolini et al. studied the effect of different nanostructured modified gold electrodes on the electrochemical detection of AA [79]. Using CV and EIS, the developed sensor had strong electrocatalytic activity against the oxidation of AA. Compared with the bare gold electrode (1.0 × 10−2 μA μM−1 cm−2), the detection sensitivity of gold single-walled carbon nanotubes (Au/SWCNT) and gold modified electrode with high nanoporous gold (h-nPG) film was improved to 1.2 × 10−2 μA μM−1 cm−2 and 2.5 × 10−2 μA μM−1 cm−2, respectively. The h-nPG electrode was also successfully used to determine AA in human urine.
Compared with ordinary nanomaterials, nanocomposites have more advantages in porosity and synergistic effect of various electrochemical active substances. Ahmed et al. [80] developed an AA electrochemical sensor based on porous silicon-mesoporous carbon nanocomposites (PSi-MC NCs) modified GCE, which could measure AA in a very wide range (0.5–2473 μM) in PBS with a sensitivity of 0.1982 μA μM−1 cm−2 and a LOD of 30.0 ± 0.1 nM. The detection of AA in human blood showed good anti-interference ability and high selectivity.
Gold nanoparticles (Au NPs), chicken egg white (CEW), copper phosphate (Cu3(PO4)2), and graphene oxide (GO) were assembled together to form organic/inorganic hybrid nanoflowers (Au-CEW-Cu3(PO4)2-GO HNFs) [81]. When HNFs-modified GCE was used for electrochemical detection of AA, a linear range of 8–300 μM, the LOD of 2.67 μM, and a high sensitivity of 6.01 × 10−3 μA μM−1 cm−2 could be achieved due to many reasons, such as the high conductivity of Au NPs, the large specific surface area of GO, the strong electrocatalytic activity of HNFs, and so on.
Combined with the outstanding electrical activity of transition element oxides and the superior performance of nanostructures on the surface, Atacan et al. studied the electrochemical sensing of AA with Au-MoS2/NiO modified GCE [82]. The detection linear range and LOD were 2–50 μM and 0.13 μM, respectively, realizing the detection of AA in vitamin C tablets.
Zhao et al. designed a photoelectrochemical (PEC) sensor based on Dy-OSCN for the detection of AA [83]. Dy-OSCN single crystal has a regular microstructure, which accelerates the separation and transmission of internal carriers under light excitation, and can effectively improve the sensing performance. Under the best conditions, the linear range of AA sensing detection was from 7.94 μM to 1.113 × 104 μM, and LOD was 3.35 μM. The analysis of human urine samples was realized.

1.8. Vitamin P Sensors

Rutin is an effective antioxidant polyphenol with an important protective effect [84][85]. In BR electrolyte, it was determined by differential pulse stripping voltammetry (DPSV) using GCE modified with graphene oxide nanocomposite reduced (rGO) by ferric oxide containing cerium (Ce) and chromium (Cr) [86]. The integration of Ce4+, Cr3+, and rGO has a synergistic effect on the sensor performance and excellent activity. Under the optimized construction conditions of the nanocomposite, the linear range of rutin detection was 0.075–12.00 μM, and the LOD was 52 nM.
Elancheziyan et al. developed a highly porous graphitic-activated carbon-coated iron oxide nanocomposite (Fe2O3/GAC) and then deposited it on an SPE to construct Fe2O3-GAC/SPE for electrochemical detection of rutin [87]. The synergistic effect of Fe2O3 and GAC can enhance the electrocatalytic reaction ability. A wide linear detection range (0.1–130 μM) could be obtained by DPV, and the LOD was 0.027 μM.

1.9. Simultaneous Analysis of Multiple Water-Soluble Vitamins

Since various vitamins in the body have their own unique and important functions, it is of great significance to detect and analyze them [88][89][90][91][92][93][94]. Simultaneous detection of multiple vitamins can greatly improve detection efficiency, which is also a research hotspot in recent years. Based on the requirements of the electrochemical detection environment, vitamin samples that can be detected at the same time basically have similar solubility. There are two common detection and discrimination methods for different water-soluble vitamins. One is to rely on the difference of electrochemical response signals of a specific electrode material to different vitamins, such as different detection peak positions. The other is to select or design electrode materials with selectivity for each of several target vitamins and then combine them in a certain means to detect and discriminate their mixtures.
In B vitamins, VB2 and VB6 play an essential role in the normal function of the body and are interrelated, so Buleandra tried to detect and analyze them simultaneously by electrochemical method [95]. Preliminary cyclic voltammetry analysis showed that VB2 underwent a quasi-reversible electron transfer reaction in BR buffer with a pH of 5.0, the oxidation of VB6 was irreversible, and their electrochemical properties were of obvious differences. Therefore, PGE and SWV could be used to determine both of them simultaneously. For VB2, the two linear concentration ranges of 1.00 × 10−7–5.00 × 10−5 M and 5.00 × 10−5–7.50 × 10−4 M were achieved, and for VB6, the linear range was 2.50 × 10−5–2.50 × 10−3 M. The detection limits of VB2 and VB6 were 7.38 × 10−8 M and 1.10 × 10−5 M, respectively. The method was further realized in the simultaneous determination of VB2 and VB6 in tablets. Using magnetite nanoparticles to improve the detection sensitivity of disposable electrochemical paper-based analysis equipment, Pereira et al. also realized simultaneous quantitative analysis of VB2 and VB6 [96]. The calibration plot for VB2 was in the range of 2.0 to 20.0 μM with a detection limit of 0.25 μM, and the calibration plot for VB6 was in the range of 0.2 to 2.0 mM with a detection limit of 29.5 μM.
Porada et al. used a nickel zeolite/carbon black modified GCE (NiZCBGCE) to determine VB2, VB9, VB12, and VB3 simultaneously [97]. Based on the enhancement of zeolite and carbon black on the vitamin reduction signal, the linear response range of vitamin detection was 0.008–0.24 mg L−1, 0.004–0.22 mg L−1, 0.003–0.1 mg L−1, and 0.15–10 mg L−1, and LOD was 2.3 μg L−1, 1.3 μg L−1, 1.092 μg L−1 and 45 μg L−1 for VB2, VB9, VB12, and VB3 respectively. Chitosan, in which nitrogen and sulfur co-doped graphene quantum dots are immobilized, was used to modify GCE for monitoring a variety of B vitamins [98]. Using the optimized parameters, vitamins B2, B6 and B12 were detected by SWV with detection limits of 0.30, 30.1, and 0.32 nM, respectively, and vitamins in energy drinks could be quantified.

2. Electrochemical Sensors for Fat-Soluble Vitamins

Like water-soluble vitamins, fat-soluble vitamins are essential nutrients in the human body and play an important role in human growth and development. It is also important to effectively detect their concentrations in the human body and supplementary nutrients. However, compared with water-soluble vitamins, there are relatively few electrochemical studies on fat-soluble vitamins. The use of various organic solvents requires higher chemical inertness of various devices, and the selection of organic materials is often limited by the physical and chemical properties of vitamins to be tested. Due to the non-polar characteristics of organic solutions, the charge movement is far inferior to the polar water environment. Therefore, the detection and exploration of various fat-soluble vitamins are still of great concern.

2.1. Vitamin D Sensors

Serum 25 hydroxyvitamin D (25-OHD) has been considered a new biomarker of vitamin D deficiency, and its concentration analysis is the focus of vitamin D-related electrochemical detection [99][100][101]. Immunological methods are often used for this purpose. Anusha et al. proposed a label-free impedimetric immunosensor, using a carbodiimide chemical method to covalently immobilize Ab-25-OHD antibody on GCN-b-CD@Au/GCE for specific recognition of 25-OHD in the serum [102]. The combination of antigen and antibody was detected by EIS, and the linear concentration range was 0.1–500 ng mL−1 with a LOD of 0.01 ng mL−1. Zirconia nanoparticles modified with L-cysteine functionalized gold (Cys-Au@ZrO2 NPs) were electrodeposited onto ITO substrate to enhance the electrochemical behavior, stability, and availability of covalent binding of functional groups and biomolecules [103]. Immunosensing analysis of 25-OHD3 could be realized by further modifying the electrode with its antibody (Ab-25-OHD3). Its sensitivity was increased to 2.01 μA ng−1 mL cm−2, and the linear detection range and LOD were 1–50 ng mL−1 and 3.54 ng mL−1, respectively. Polli et al. modified the graphite SPE with cysteamine-functionalized core-shell magnetic nanoparticles and then fixed the 25-OHD3 antibody through glutaraldehyde cross-linking [104]. Utilizing DPV, the linear detection range was between 7.4 and 70 ng mL−1, and the LOD was 2.4 ng mL−1.
Aptamers are also widely used in the highly sensitive and selective electrochemical analysis. Yin et al. fixed the DNA tetrahedron on the gold surface and then assembled the hairpin DNA probe-25-OHD3 complex [105]. Its electrochemical detection showed a wide linear range of 0.1–1000 nM, and the LOD was 0.026 nM. Park et al. prepared heterogeneous nanostructures composed of molybdenum disulfide and an electrochemically reduced graphene oxide composite to modify the electrode for amplifying the electrochemical signal [106]. Then, 1,2,4-triazol-3,5-dione (MB-TAD) labeled with methylene blue was modified on the electrode, where MB was used as the redox mediator to generate electrons, and TAD could combine with 25-OHD3 to form the aptamer/25-OHD3/MB-TAD complex. The binding of the aptamer to 25-OHD3 was detected by DPV. At the same time, 1,6-hexanedithiol was modified to avoid nonspecific adsorption and reduce the steric hindrance between aptamers. The linear range of 0.1–150 ng mL−1 could be obtained by electrochemical detection, and the LOD was 0.02 ng mL−1.
Similarly, as an important specificity analysis technology, molecular imprinting is also used in vitamin D determination. GCE was modified with CuCo2O4/nitrogen-doped carbon nanotubes and phosphorus-doped oxygraphene nanocomposites and then coated by electropolymerization of 25-OHD3 imprinted polypyrrole to construct a specific recognition electrochemical sensor [107]. Using ferricyanide as the signal mediator, the signal was significantly reduced after recombining 25-OHD3 on the electrode, and the linear sensing detection range and LOD were 0.002–10 μM and 0.38 nM, respectively.
Vitamin D (such as VD3) can be directly detected by electrochemical analysis in biological samples [108][109][110]. For example, Bora et al. used nitrogen doped carbon nanotubes to improve the hydrophilicity and specific surface area of the working electrode, thereby improving the electrochemical detection performance [111]. The VD3 sensor based on it could provide high performance in the concentration range of 0–10 nM, with a LOD of 16 pM, and the sensitivity value 0.000495 mA cm−2 nM−1 was achieved.

2.2. Vitamin E Sensors

Jashari et al. used the SWV method to simultaneously detect three natural isomers of tocopherol (α, γ, and δ) [112]. Under optimized conditions, there were similar linear detection ranges (3.0 × 10−6–1.0 × 10−5 M) for these isomers. For α, γ, and δ-tocopherol, quantification limits were 11.28, 2.70, and 3.67 × 10−6 M, and LODs were 3.72, 0.89, and 1.21 × 10−6 M, respectively. This method achieved the same detection effect as the popular chromatographic methods.

2.3. Vitamin K Sensors

Rostami-Javanroudi et al. modified PGE by electrodepositing silver nanoparticles and 2-amino-5chloro benzophenone [113]. Utilizing their electro-catalytic performance for the reduction of VK1, the sensor could achieve a linear detection range of 50–700 nM with an LOD of 16.58 nM, and it was applied in the quantifying of VK1 in human blood serums.

2.4. Simultaneous Analysis of Multiple Fat-Soluble Vitamins

Similar to water-soluble vitamins, it has outstanding application value in detecting multiple fat-soluble vitamins simultaneously [114][115]. Avan et al. modified GCE by using a β-cyclodextrin/multi-wall carbon nanotube and constructed an electrochemical sensor for the detection of various fat-soluble vitamins (VA, VD3, VE, and VK1) in an aqueous media of micellar solutions [116]. In the BR buffer at pH 5.0, the linear calibration curves of VA, VD3, VE, and VK1 could be obtained as 8–100, 0.8–60, 0.5–60, and 0.1–20 µM, respectively. The detection results have high reproducibility and selectivity.

3. Simultaneous Detection of Vitamins and Non-Vitamin Substances

In actual biomedical samples (such as serum), besides vitamins, there are often many other substances related to health. Simultaneous quantitative analysis of biological components concerned is an important goal of inspection science, and it is also the goal of many new electrochemical sensors [117][118][119][120][121][122][123][124][125].
Based on Pt-Pd nanoparticles/chitosan/nitrogen-doped graphene (N-Gra) nanocomposite, Luo et al. established an electroanalytical method for the simultaneous detection of AA, sulfite, and oxalic acid (OA) [126]. The nanocomposites have remarkable electrochemical activity for the electrooxidation of sulfite and OA. At the same time, the full separation of multiple oxidation peaks ensured high electrochemical resolution, allowing simultaneous quantification of three substances of interest. The linear ranges of AA, sulfite, and OA measured by DPV were 2–400 μM, 8–600 μM, and 1.5–500 μM, respectively. Accordingly, the LODs were 0.97 μM, 5.5 μM, and 0.84 μM, respectively.
GCE modified by Zn-Al layered double hydroxide (Zn-Al LDH) and methyl red (PMR) polymer film [127] has a high electrocatalytic activity for the oxidation of AA and aspirin (ASA). There were well-spaced anodic peaks in the CV sensing detection spectrum, which could simultaneously identify trace AA and ASA. The anode peak current and the concentration of AA and ASA were of good linear range in 0.10–53.17 μM, and LODs were 1.26 and 1.27 μM, respectively. Meanwhile, the quantification limits of AA and ASA were 4.21 and 4.25 μM, respectively. On the other hand, according to the DPV method, the LODs of AA and ASA oxidation were 0.47 and 0.21 μM, respectively.
The GCE modified with sunset yellow (SY) food dye could be used to simultaneously detect AA, dopamine (DA), and uric acid (UA) [128]. Under the optimal conditions, the linear ranges of AA, DA, and UA electrochemical detection were 7–320, 0.2–45, and 0.2–50 μM, respectively, the LODs were low (4.78, 0.12, 0.12 μM, respectively), and the stability was high.
The electrochemical sensor constructed by molecular imprinted polymer (MIP) could realize the simultaneous determination of paracetamol, AA, and uric acid mixture in pharmaceutical samples [129]. Good linearity at μM level, LOD (1–24 μM), and repeatability could be obtained.
A summary of various types of electrochemical vitamin sensors is shown in Table 1.


  1. Brezo-Borjan, T.; Stojanovic, Z.; Suturovic, Z.; Kos, J.; Kravic, S.; Durovic, A. A simple adsorptive chronopotentiometric stripping method for determination of vitamin B-1 in pharmaceutical products. Monatsh. Chem. 2020, 151, 285–291.
  2. Pushpanjali, P.A.; Manjunatha, J.G.; Hareesha, N.; Amrutha, B.M.; Raril, C.; Alothman, Z.A.; Alanazi, A.M.; Pandith, A. Fabrication of poly(L-Aspartic acid) Layer on graphene nanoplatelets paste electrode for riboflavin sensing. Mater. Chem. Phys. 2022, 276, 125392.
  3. Prinith, N.S.; Manjunatha, J.G.; Tigari, G.; Alothman, Z.A.; Alanazi, A.M.; Pandith, A. Mechanistic insights into the voltammetric determination of riboflavin at poly (serine) modified graphite and carbon nanotube composite paste electrode. Chemistryselect 2021, 6, 10746–10757.
  4. Arul, P.; Gowthaman, N.S.K.; Narayanamoorthi, E.; John, S.A.; Huang, S.T. Synthesis of homogeneously distributed gold nanoparticles built-in metal free organic framework: Electrochemical detection of riboflavin in pharmaceutical and human fluids samples. J. Electroanal. Chem. 2021, 887, 115143.
  5. Charithra, M.M.; Manjunatha, J.G. Fabrication of poly (Evans blue) modified graphite paste electrode as an electrochemical sensor for sensitive and instant riboflavin detection. Moroc. J. Chem. 2021, 9, 7–17.
  6. Dokur, E.; Gorduk, O.; Sahin, Y. Selective electrochemical sensing of riboflavin based on functionalized multi-walled carbon nanotube/gold nanoparticle/pencil graphite electrode. ECS J. Solid State Sci. Technol. 2020, 9, 121003.
  7. Grace, A.A.; Thillaiarasi, S.; Dharuman, V. Binary metal oxide adsorbed graphene modified glassy carbon electrode for detection of riboflavin. Electroanalysis 2021, 33, 993–1006.
  8. Hareesha, N.; Manjunatha, J.G. A simple and low-cost poly (DL-phenylalanine) modified carbon sensor for the improved electrochemical analysis of Riboflavin. J. Sci. 2020, 5, 502–511.
  9. Manoj, D.; Manigandan, R.; Rajendran, S.; Ponce, L.C. Self-assembled dendrite-like 3D-CeO2 nanostructures for non-enzymatic vitamin B2 sensor. Mater. Lett. 2021, 295, 129834.
  10. Rajkumar, C.; Kim, H. Interface engineering of ruthenium-supported sulfur-doped graphitic carbon nitride for ultrasensitive electrochemical determination of riboflavin. J. Taiwan Inst. Chem. Eng. 2022, 138, 104470.
  11. Girija, S.; Sankar, S.S.; Kundu, S.; Wilson, J. Microfibers of embellished cobalt-zeolite imidazole framework for vitamin-B(2)detection. J. Electrochem. Soc. 2020, 167, 137511.
  12. Lin, J.X.; Mei, Q.W.; Duan, Y.C.; Yu, C.H.; Ding, Y.P.; Li, L. A highly sensitive electrochemical sensor based on nanoflower-like MoS2-Ag-CNF nanocomposites for the detection of VB2. J. Nanopart. Res. 2020, 22, 274.
  13. Monnappa, A.B.; Manjunatha, J.G.G.; Bhatt, A.S.; Ananda, P.P. Fabrication of a sensitive and selective electrochemical sensing platform based on poly-l-leucine modified sensor for enhanced voltammetric determination of Riboflavin. J. Food Meas. Charact. 2020, 14, 3633–3643.
  14. Sharma, A.; Khosla, A.; Arya, S. Synthesis of SnO2 nanowires as a reusable and flexible electrode for electrochemical detection of riboflavin. Microchem. J. 2020, 156, 104858.
  15. Vijayaprasath, G.; Habibulla, I.; Dharuman, V.; Balasubramanian, S.; Ganesan, R. Fabrication of Gd2O3 nanosheet-modified glassy carbon electrode for nonenzymatic highly selective electrochemical detection of vitamin B2. ACS Omega 2020, 5, 17892–17899.
  16. Stefanov, C.; Negut, C.C.; Gugoasa, L.A.D.; van Staden, J.F. Sensitive voltammetric determination of riboflavin in pharmaceutical and biological samples using FSN-Zonyl-Nafion modified carbon paste electrode. Microchem. J. 2020, 155, 104729.
  17. Derakhshan, M.; Shamspur, T.; Molaakbari, E.; Mostafavi, A.; Saljooqi, A. Fabrication of a novel electrochemical sensor for determination of riboflavin in different drink real samples. Russ. J. Electrochem. 2020, 56, 181–188.
  18. Hareesha, N.; Manjunatha, J.G. Elevated and rapid voltammetric sensing of riboflavin at poly(helianthin dye) blended carbon paste electrode with heterogeneous rate constant elucidation. J. Iran. Chem. Soc. 2020, 17, 1507–1519.
  19. Tigari, G.; Manjunatha, J.G. A surfactant enhanced novel pencil graphite and carbon nanotube composite paste material as an effective electrochemical sensor for determination of riboflavin. J. Sci. 2020, 5, 56–64.
  20. Sangavi, R.; Keerthana, M.; Malini, T.P. Design of an electrochemical sensor for the determination of riboflavin using cobalt doped dysprosium oxide nanocubes modified glassy carbon electrode. Chemistryselect 2022, 7, e202201661.
  21. Wu, N.; Wang, L.Y.; Xie, Y.; Du, Y.; Song, Y.H.; Wang, L. Double signal ratiometric electrochemical riboflavin sensor based on macroporous carbon/electroactive thionine-contained covalent organic framework. J. Colloid Interface Sci. 2022, 608, 219–226.
  22. Ognjanovic, M.; Stankovic, D.M.; Jacimovic, Z.K.; Kosovic-Perutovic, M.; Mariano, J.; Krehula, S.; Music, S.; Antic, B. Construction of sensor for submicromolar detection of riboflavin by surface modification of SPCE with thermal degradation products of nickel acetate tetrahydrate. Electroanalysis 2022, 34, 1431–1440.
  23. Ganesamurthi, J.; Shanmugam, R.; Chen, S.M. Electrochemical evaluation of vitamin B-2 through a portable electrochemical sensor based on binary transition metal oxide in various biological and vegetable samples. J. Electrochem. Soc. 2022, 169, 096505.
  24. Negut, C.C.; Stefanov, C.; Gugoasa, L.A.D.; van Staden, J.F. Rapidly renewable graphite paste electrode modified with 5,10,15,20-tetrakis(4-methoxyphenyl)-21H,23H-porphine cobalt(II) for electrochemical determination of nicotinic acid. J. Electroanal. Chem. 2020, 863, 114063.
  25. Rison, S.; Mathew, A.T.; George, L.; Maiyalagan, T.; Hegde, G.; Varghese, A. Pt nanospheres decorated graphene-beta-CD modified pencil graphite electrode for the electrochemical determination of vitamin B6. Top. Catal. 2022.
  26. Moustafa, A.; El-Kamel, R.S.; Abdelgawad, S.; Fekry, A.M.; Shehata, M. Electrochemical determination of vitamin B-6 (pyridoxine) by reformed carbon paste electrode with iron oxide nanoparticles. Ionics 2022, 28, 4471–4484.
  27. Cui, M.; Long, L.K.; Wu, Y.H.; Gao, D.; Wang, Y.D. Electrochemical biosensor based on reduced graphene oxide and CMC/silica sol-gel hybrid membranes for the detection of VB6. Funct. Mater. 2021, 28, 605–611.
  28. Dokur, E.; Gorduk, O.; Sahin, Y. Cost-effective and Facile Production of a Phosphorus-doped Graphite Electrode for the Electrochemical Determination of Pyridoxine. Electroanalysis 2021, 33, 1657–1667.
  29. Zabolestani, H.; Sarhadi, H.; Beitollahi, H. Electrochemical sensor based on modified screen printed electrode for vitamin B-6 detection. Surf. Eng. Appl. Electrochem. 2021, 57, 277–285.
  30. Sadeghi, H.; Shahidi, S.A.; Raeisi, S.N.; Ghorbani-HasanSaraei, A.; Karimi, F. Electrochemical determination of vitamin B-6 in water and juice samples using an electrochemical sensor amplified with NiO/CNTs and Ionic liquid. Int. J. Electrochem. Sci. 2020, 15, 10488–10498.
  31. Rejithamol, R.; Beena, S. Electrochemical quantification of pyridoxine (VB6) in human blood from other water-soluble vitamins. Chem. Pap. 2020, 74, 2011–2020.
  32. Cherian, A.R.; Benny, L.; Varghese, A.; John, N.S.; Hegde, G. Molecularly imprinted scaffold based on poly (3-aminobenzoic acid) for electrochemical sensing of vitamin B-6. J. Electrochem. Soc. 2021, 168, 077512.
  33. Porada, R.; Fendrych, K.; Bas, B. Electrochemical sensor based on Ni-exchanged natural zeolite/carbon black hybrid nanocomposite for determination of vitamin B-6. Microchim. Acta 2021, 188, 323.
  34. Vu, T.V.; Nguyen, M.T.T.; Do, T.T.; Nguyen, H.L.; Nguyen, V.A.; Nguyen, D.T. Adsorption of copper ions onto poly(1,8-diaminonaphthalene)/graphene film for voltammetric determination of pyridoxine. Electroanalysis 2022, 34, 1478–1486.
  35. Porada, R.; Fendrych, K.; Bas, B. Development of novel Mn-zeolite/graphite modified Screen-printed Carbon Electrode for ultrasensitive and selective determination of folic acid. Measurement 2021, 179, 109450.
  36. Zare, M.; Sarhadi, H. A novel vitamin B9 sensor based on modified screen-printed electrode. J. Electrochem. Sci. Eng. 2021, 11, 1–9.
  37. Winiarski, J.P.; Rampanelli, R.; Bassani, J.C.; Mezalira, D.Z.; Jost, C.L. Multi-walled carbon nanotubes/nickel hydroxide composite applied as electrochemical sensor for folic acid (vitamin B-9) in food samples. J. Food Compos. Anal. 2020, 92, 103511.
  38. Mani, V.; Balamurugan, T.S.T.; Huang, S.T. Rapid one-pot synthesis of polydopamine encapsulated carbon anchored with Au nanoparticles: Versatile electrocatalysts for chloramphenicol and folic acid sensors. Int. J. Mol. Sci. 2020, 21, 2853.
  39. Ali, H.; Verma, N. A hybrid UV-Vis spectroelectrochemical approach for measuring folic acid using a novel Ni-CNF/ITO electrode. Electrochim. Acta 2022, 428, 140920.
  40. Olmo, F.; Rodriguez, A.; Colina, A.; Heras, A. UV/Vis absorption spectroelectrochemistry of folic acid. J. Solid State Electrochem. 2022, 26, 29–37.
  41. Antherjanam, S.; Saraswathyamma, B.; Krishnan, R.G.; Gopakumar, G.M. Electrochemical sensors as a versatile tool for the quantitative analysis of Vitamin B-12. Chem. Pap. 2021, 75, 2981–2995.
  42. Tian, C.; Zhao, N.; Jiang, X.Y.; Wan, D.J.; Xie, Y.Q. Facile detection of vitamin B12 with copper oxide nanocrystal graphenic composite electrode. Water 2021, 13, 1790.
  43. Sharma, A.; Arya, S.; Chauhan, D.; Solanki, P.R.; Khajuria, S.; Khosla, A. Synthesis of Au-SnO2 nanoparticles for electrochemical determination of vitamin B-12. J. Mater. Res. Technol 2020, 9, 14321–14337.
  44. Pereira, D.F.; Santana, E.R.; Piovesan, J.V.; Spinelli, A. A novel electrochemical strategy for determination of vitamin B-12 by Co(I/II) redox pair monitoring with boron-doped diamond electrode. Diamond Relat. Mater. 2020, 105, 107793.
  45. Guo, L.; Yang, Z.Y. Electrochemical sensors based on Au-PPy nanocomposite modified glassy carbon electrode for determination of Vitamin B12 as a key agent in human motion coordination. Int. J. Electrochem. Sci. 2021, 16, 211029.
  46. Tiris, G.; Khoshnavaz, Y.; Oven, E.N.; Mehmandoust, M.; Erk, N. A sensitive voltammetric sensor for specific recognition of vitamin C in human plasma based on MAPbl(3) perovskite nanorods. J. Electrochem. Sci. Eng. 2022, 12, 175–183.
  47. Alhazimeh, H.; Al-Fandi, M.G.; Al-Ebbini, L.M.K. Development of an inkjet-printed electrochemical nanosensor for ascorbic acid detection. Sensor Rev. 2022, 42, 342–353.
  48. Bettazzi, F.; Ingrosso, C.; Sfragano, P.S.; Pifferi, V.; Falciola, L.; Curri, M.L.; Palchetti, I. Gold nanoparticles modified graphene platforms for highly sensitive electrochemical detection of vitamin C in infant food and formulae. Food Chem. 2021, 344, 128692.
  49. Ghanbari, M.H.; Mashhadizadeh, M.H.; Norouzi, Z. Introducing a novel nanocomposite consisting of TiO2 oxide/reduced graphene oxide for the electrocatalytic sensing of ascorbic acid. J. Iran. Chem. Soc. 2021, 18, 1329–1341.
  50. Ikram, M.; Sajid, M.M.; Javed, Y.; Afzal, A.M.; Shad, N.A.; Sajid, M.; Akhtar, K.; Yousaf, M.I.; Sharma, S.K.; Aslam, H.; et al. Crystalline growth of tungsten trioxide (WO3) nanorods and their development as an electrochemical sensor for selective detection of vitamin C. J. Mater. Sci.-Mater. Electron. 2021, 32, 6344–6357.
  51. Khand, N.H.; Palabiyik, I.M.; Buledi, J.A.; Ameen, S.; Memon, A.F.; Ghumro, T.; Solangi, A.R. Functional Co3O4 nanostructure-based electrochemical sensor for direct determination of ascorbic acid in pharmaceutical samples. J. Nanostruct. Chem. 2021, 11, 455–468.
  52. Kong, L.J.; Chen, J.H.; Peng, Z.H.; Zhang, J.W.; Gao, Y.; Yan, S.C. Synthesis of Ag-Cu alloy nanosheets for ascorbic acid detection. Mater. Express 2021, 11, 1001–1006.
  53. Sudeep, M.; Manjunatha, C.; Aan, M.P.S.; Ashoka, S.; Suresh, R.; Ujwal, S.M. Development of nano copper sulfide (CuS) structures for electrochemical detection of vitamin C. J. Nanostruct. 2021, 11, 628–637.
  54. Suriyaprakash, J.; Shan, L.W.; Gupta, N.; Wang, H.; Wu, L.J. Janus 2D-carbon nanocomposite-based ascorbic acid sensing device: Experimental and theoretical approaches. Compos. Pt. B-Eng. 2022, 245, 110233.
  55. Alam, M.M.; Asiri, A.M.; Rahman, M.M.; Islam, M.A. Selective detection of ascorbic acid with wet-chemically prepared CdO/SnO2/V2O5 micro-sheets by electrochemical approach. SN Appl. Sci. 2020, 2, 1953.
  56. Alam, M.M.; Balkhoyor, H.B.; Asiri, A.M.; Karim, M.R.; Chani, M.T.S.; Rahman, M.M. Fabrication of ascorbic acid sensor with Co3O4 center dot Fe2O3 nanosphere materials by electrochemical technique. Surf. Interfaces 2020, 20, 100607.
  57. de Faria, L.V.; Lisboa, T.P.; de Farias, D.M.; Araujo, F.M.; Machado, M.M.; de Sousa, R.A.; Matos, M.A.C.; Munoz, R.A.A.; Matos, R.C. Direct analysis of ascorbic acid in food beverage samples by flow injection analysis using reduced graphene oxide sensor. Food Chem. 2020, 319, 126509.
  58. Duzmen, S.; Baytak, A.K.; Aslanoglu, M. A novel voltammetric platform composed of poly(aminopyrazine), ZrO2 and CNTs for a rapid, sensitive and selective determination of ascorbic acid in pharmaceuticals and food samples. Mater. Chem. Phys. 2020, 252, 123170.
  59. Gurusamy, T.; Murugan, R.; Durairaj, A.; Ramanujam, K. Confinement catalysis of non-covalently functionalized carbon nanotube in ascorbic acid sensing. Electroanalysis 2020, 32, 2481–2492.
  60. Ibarlucea, B.; Roig, A.P.; Belyaev, D.; Baraban, L.; Cuniberti, G. Electrochemical detection of ascorbic acid in artificial sweat using a flexible alginate/CuO-modified electrode. Microchim. Acta 2020, 187, 520.
  61. Navadeepthy, D.; Thangapandian, M.; Viswanathan, C.; Ponpandian, N. A nanocomposite of NiFe2O4-PANI as a duo active electrocatalyst toward the sensitive colorimetric and electrochemical sensing of ascorbic acid. Nanoscale Adv. 2020, 2, 3481–3493.
  62. Shen, T.Y.; Liu, T.C.; Mo, H.Q.; Yuan, Z.C.; Cui, F.; Jin, Y.X.; Chen, X.J. Cu-based metal-organic framework HKUST-1 as effective catalyst for highly sensitive determination of ascorbic acid. RSC Adv. 2020, 10, 22881–22890.
  63. Alkhawaldeh, A.K. Platinum nanoparticle electrode modified iodine using cyclic voltammetry and chronoamperometry for determination of ascorbic acid. Anal. Bioanal. Electrochem. 2020, 12, 780–792.
  64. Zhu, S.C.; Xie, A.J.; Wei, B.Y.; Tao, X.; Zhang, J.H.; Peng, W.H.; Liu, C.Y.; Gu, L.Y.; Xu, C.F.; Luo, S.P. Construction and application of a nonenzymatic ascorbic acid sensor based on a NiO1.0/polyaniline(3.0) hybrid. New J. Chem. 2020, 44, 9288–9297.
  65. Brainina, K.Z.; Bukharinova, M.A.; Stozhko, N.Y.; Sokolkov, S.V.; Tarasov, A.V.; Vidrevich, M.B. Electrochemical sensor based on a carbon veil modified by phytosynthesized gold nanoparticles for determination of ascorbic acid. Sensors 2020, 20, 1800.
  66. Gu, Y.N.; Liu, J.J.; Zhou, M. Amperometric ascorbic acid sensor based on disposable facial tissues derived carbon aerogels. Chem. Res. Chin. Univ. 2020, 36, 139–144.
  67. Kumar, A.; Furtado, V.L.; Goncalves, J.M.; Bannitz-Fernandes, R.; Netto, L.E.S.; Araki, K.; Bertotti, M. Amperometric microsensor based on nanoporous gold for ascorbic acid detection in highly acidic biological extracts. Anal. Chim. Acta 2020, 1095, 61–70.
  68. Lopez-Pastor, J.A.; Martinez-Sanchez, A.; Aznar-Poveda, J.; Garcia-Sanchez, A.J.; Garcia-Haro, J.; Aguayo, E. Quick and cost-effective estimation of vitamin C in multifruit juices using voltammetric methods. Sensors 2020, 20, 676.
  69. Osman, A.M.; Abulkibash, A.M.; Atieh, M.A. Time-biased square wave differential electrolytic potentiometry for determination of ascorbic acid in a complex matrix at multi-walled carbon nanotubes modified silver electrodes. Arabian J. Chem. 2020, 13, 2955–2963.
  70. Loguercio, L.F.; Thesing, A.; Noremberg, B.D.; Lopes, B.V.; Maron, G.K.; Machado, G.; Pope, M.A.; Carreno, N.L.V. Direct laser writing of poly(furfuryl alcohol)/graphene oxide electrodes for electrochemical determination of ascorbic acid. Chemelectrochem 2022, 9, e202200334.
  71. Low, S.C.; Shaimi, R. Amperometric sensor using nylon-6-film-modified carbon electrode for low-cost detection of ascorbic acid. Monatsh. Chem. 2022, 153, 551–560.
  72. Roncevic, I.S.; Skroza, D.; Vrca, I.; Kondza, A.M.; Vladislavic, N. Development and optimization of electrochemical method for determination of vitamin C. Chemosensors 2022, 10, 283.
  73. Zhu, K.; Wang, J.; Luo, Y.H.; Zhang, Y.; Cai, X.Q.; Liu, B.T.; Zhang, Q.Y.; Wu, H.Y.; Liu, Z.Z.; Zhang, D.E. Facile synthesis of bowknot-like cerous phosphate as a bifunctional sensor for ascorbic acid detection. J. Solid State Chem. 2022, 307, 122745.
  74. Singh, P.; Singh, K.R.B.; Singh, J.; Prasad, P.; Singh, R.P. Bioinspired triangular ZnO nanoclusters synthesized by Argyreia nervosa nascent leaf extract for the efficient electrochemical determination of vitamin C. RSC Adv. 2021, 11, 25752–25763.
  75. Banavath, R.; Abhinav, A.; Srivastava, R.; Bhargava, P. Highly sensitive ascorbic acid sensors from EDTA chelation derived nickel hexacyanoferrate/ graphene nanocomposites. Electrochim. Acta 2022, 419, 140335.
  76. Li, Y.Q.; Pan, F.; Yin, S.Y.; Tong, C.Y.; Zhu, R.L.; Li, G.X. Nafion assisted preparation of prussian blue nanoparticles and its application in electrochemical analysis of L-ascorbic acid. Microchem. J. 2022, 177, 107278.
  77. Shayanfar, F.; Sarhadi, H. Determination of vitamin C at modified screen printed electrode: Application for sensing of vitamin C in real samples. Surf. Eng. Appl. Electrochem. 2021, 57, 487–494.
  78. Sampathkumar, P.; Sudalaimani, S.; Giribabu, K.; Suresh, C. Nanomolar detection of vitamin C in artificial urine using a glassy carbon electrode modified with molybdenum disulfide. J. Electrochem. Soc. 2021, 168, 087507.
  79. Tortolini, C.; Tasca, F.; Venneri, M.A.; Marchese, C.; Antiochia, R. Gold nanoparticles/carbon nanotubes and gold nanoporous as novel electrochemical platforms for L-ascorbic acid detection: Comparative performance and application. Chemosensors 2021, 9, 229.
  80. Ahmed, J.; Faisal, M.; Harraz, F.A.; Jalalah, M.; Alsareii, S.A. Porous silicon-mesoporous carbon nanocomposite based electrochemical sensor for sensitive and selective detection of ascorbic acid in real samples. J. Taiwan Inst. Chem. Eng. 2021, 125, 360–371.
  81. Gao, J.J.; Liu, H.; Wu, K.X.; Yan, J.F.; Tong, C. A novel nonenzymatic ascorbic acid electrochemical sensor based on gold nanoparticals-chicken egg white-copper phosphate-graphene oxide hybrid nanoflowers. Nanotechnology 2021, 32, 325504.
  82. Atacan, K.; Guy, N.; Ozacar, M. Preparation of gold decorated MoS2/NiO nanocomposite in the production of a new electrochemical sensor for ascorbic acid detection. Korean J. Chem. Eng. 2022, 39, 2172–2181.
  83. Zhao, Z.Z.; Han, D.F.; Xiao, R.; Wang, T.Q.; Liang, Z.S.; Wu, Z.F.; Han, F.J.; Han, D.X.; Ma, Y.M.; Niu, L. An enzyme-free photoelectrochemical sensor platform for ascorbic acid detection in human urine. Chemosensors 2022, 10, 268.
  84. Sivam, T.; Gowthaman, N.S.K.; Lim, H.N.; Andou, Y.; Arul, P.; Narayanamoorthi, E.; John, S.A. Tunable electrochemical behavior of dicarboxylic acids anchored Co-MOF: Sensitive determination of rutin in pharmaceutical samples. Colloid Surf. A-Physicochem. Eng. Asp. 2021, 622, 126667.
  85. Senocak, A.; Khataee, A.; Demirbas, E.; Doustkhah, E. Ultrasensitive detection of rutin antioxidant through a magnetic micro-mesoporous graphitized carbon wrapped Co nanoarchitecture. Sens. Actuator B-Chem. 2020, 312, 127939.
  86. Senocak, A.; Korkmaz, E.; Khataee, A.; Demirbas, E. A facile and synergetic strategy for electrochemical sensing of rutin antioxidant by Ce-Cr doped Mater. Chem. Phys. 2022, 275, 125298.
  87. Elancheziyan, M.; Ganesan, S.; Theyagarajan, K.; Duraisamy, M.; Thenmozhi, K.; Weng, C.H.; Lin, Y.T.; Ponnusamy, V.K. Novel biomass-derived porous-graphitic carbon coated iron oxide nanocomposite as an efficient electrocatalyst for the sensitive detection of rutin (vitamin P) in food and environmental samples. Environ. Res. 2022, 211, 113012.
  88. Bhaiyya, M.; Pattnaik, P.K.; Goel, S. Simultaneous detection of Vitamin B-12 and Vitamin C from real samples using miniaturized laser-induced graphene based electrochemiluminescence device with closed bipolar electrode. Sens. Actuator A-Phys. 2021, 331, 112831.
  89. Porada, R.; Bas, B. Separation of the overlapped vitamin B1 and B3 voltammetric peaks by means of Continuous Wavelet Transform and differentiation. Monatsh. Chem. 2021, 152, 1107–1117.
  90. Contursi, M.; Coviello, D.; Ciriello, R.; Guerrieri, A.; Palmieri, M.A.; Langerame, F.; Bianco, G.; Salvi, A.M. Surface and electrochemical characterization of a new Layered GC/betaine/Pt electrode and investigation on its performance as a densor for two B complex vitamins, B1 and B6: Preliminary results. Electroanalysis 2021, 33, 483–494.
  91. Wang, H.M.; Zhang, X.L.; Wang, S.J.; Xiao, S.; Ma, H.Y.; Wang, X. Multianalyte electrochemical electrode for the determination of vitamins B2 and B6 in complex biosystem. Microchem. J. 2020, 158, 105233.
  92. Yomthiangthae, P.; Kondo, T.; Chailapakul, O.; Siangproh, W. The effects of the supporting electrolyte on the simultaneous determination of vitamin B-2, vitamin B-6, and vitamin C using a modification-free screen-printed carbon electrode. New J. Chem. 2020, 44, 12603–12612.
  93. Zeybek, B.; Uge, A. Development of carbon-based sensors for electrochemical quantification of vitamins B-2 and B-6 at nanomolar levels. Chem. Pap. 2021, 75, 1323–1339.
  94. Dhanalakshmi, N.; Priya, T.; Karthikeyan, V.; Thinakaran, N. Binary mixture of lanthanide metal doped ZnO nanorod: F-MWCNT nanocomposite for simultaneous and selective determination of vitamins B-2 and B-6. J. Nanosci. Nanotechnol. 2020, 20, 2154–2164.
  95. Buleandra, M.; Popa, D.E.; Popa, A.; Codreanu, N.A.M.; David, I.G. Multi-analyte sensor based on pencil graphite electrode for riboflavin and pyridoxine determination. J. Electrochem. Soc. 2022, 169, 017517.
  96. Pereira, D.F.; Santana, E.R.; Spinelli, A. Electrochemical paper-based analytical devices containing magnetite nanoparticles for the determination of vitamins B-2 and B-6. Microchem. J. 2022, 179, 107588.
  97. Porada, R.L.; Fendrych, K.; Kochana, J.; Bas, B.L. Simple and reliable determination of B group vitamins in various food matrices with the use of the voltammetric sensor based on Ni-zeolite/carbon black nanocomposite. Food Control 2022, 142, 109243.
  98. Martins, E.C.; Santana, E.R.; Spinelli, A. Nitrogen and sulfur co-doped graphene quantum dot-modified electrode for monitoring of multivitamins in energy drinks. Talanta 2023, 252, 123836.
  99. Kaur, A.; Rana, S.; Bharti, A.; Chaudhary, G.R.; Prabhakar, N. Voltammetric detection of vitamin D employing Au-MoS2 hybrid as immunosensing platform. Microchim. Acta 2021, 188, 222.
  100. Kim, W.; Park, J.; Kim, W.; Jo, S.; Kim, M.; Kim, C.; Park, H.; Bang, D.; Lee, W.; Park, J. Bio-inspired Ag nanovilli-based sandwich-type SERS aptasensor for ultrasensitive and selective detection of 25-hydroxy vitamin D3. Biosens. Bioelectron. 2021, 188, 113341.
  101. Kaur, A.; Kapoor, S.; Bharti, A.; Rana, S.; Chaudhary, G.R.; Prabhakar, N. Gold-platinum bimetallic nanoparticles coated 3-(aminopropyl) triethoxysilane (APTES) based electrochemical immunosensor for vitamin D estimation. J. Electroanal. Chem. 2020, 873, 114400.
  102. Anusha, T.; Bhavani, K.S.; Kumar, J.V.S.; Brahman, P.K.; Hassan, R.Y.A. Fabrication of electrochemical immunosensor based on GCN-beta-CD/Au nanocomposite for the monitoring of vitamin D deficiency. Bioelectrochemistry 2022, 143, 107935.
  103. Chauhan, D.; Gupta, P.K.; Solanki, P.R. Amine functionalized noble metal: Metal oxide nanohybrid for efficient electrochemical determination of 25-hydroxy vitamin-D-3 in human serum. J. Electrochem. Soc. 2021, 168, 117508.
  104. Polli, F.; D’Agostino, C.; Zumpano, R.; De Martino, V.; Favero, G.; Colangelo, L.; Minisola, S.; Mazzei, F. electrochemical immunosensor for vitamin D-3 serum samples analysis. Talanta 2023, 251, 123755.
  105. Yin, S.; Hossain, M.N.; Li, Y.X.; Sun, C.J.; Kraatz, H.B. Development of a novel electrochemical aptasensor based on catalytic hairpin assembly and DNA tetrahedron for the detection of 25-hydroxyvitamin D-3. Sens. Actuator B-Chem. 2022, 354, 131217.
  106. Park, J.; Kim, M.; Kim, W.; Jo, S.; Kim, W.; Kim, C.; Park, H.; Lee, W.; Park, J. Ultrasensitive detection of 25-hydroxy vitamin D-3 in real saliva using sandwich-type electrochemical aptasensor. Sens. Actuator B-Chem. 2022, 355, 131239.
  107. Goharrizi, M.; Oskuee, R.K.; Aleyaghoob, G.; Mohajeri, T.; Mohammadinejad, A.; Rezayi, M. A new molecularly imprinted polymer electrochemical sensor based on CuCo2O4/N-doped CNTs/P-doped GO nanocomposite for detection of 25-hydroxyvitamin D-3 in serum samples. Biotechnol. Appl. Biochem. 2022.
  108. Anusha, T.; Bhavani, K.S.; Kumar, J.V.S.; Bonanni, A.; Brahman, P.K. Fabrication of handmade paper sensor based on silver-cobalt doped copolymer-ionic liquid composite for monitoring of vitamin D-3 level in real samples. Microchem. J. 2021, 161, 105789.
  109. Wadhwa, S.; John, A.T.; Nagabooshanam, S.; Mathur, A.; Narang, J. Graphene quantum dot-gold hybrid nanoparticles integrated aptasensor for ultra-sensitive detection of vitamin D-3 towards point-of-care application. Appl. Surf. Sci. 2020, 521, 146427.
  110. Anusha, T.; Bhavani, K.S.; Kumar, J.V.S.; Brahman, P.K. Designing and fabrication of electrochemical nanosensor employing fullerene-C-60 and bimetallic nanoparticles composite film for the detection of vitamin D-3 in blood samples. Diamond Relat. Mater. 2020, 104, 107761.
  111. Bora, H.; Mandal, D.; Chandra, A. High-performance, nitrogen-doped, carbon-nanotube-based electrochemical sensor for vitamin D3 detection. ACS Appl. Bio Mater. 2022, 5, 1721–1730.
  112. Jashari, G.; Kastrati, G.; Korecka, L.; Metelka, R.; Sys, M.; Ashrafi, A.M. Electrochemical behaviour of tocopherols: Possibilities of their simultaneous voltammetric detection. Appl. Sci. 2021, 11, 8095.
  113. Rostami-Javanroudi, S.; Babakhanian, A. New electrochemical sensor for direct quantification of vitamin K in human blood serum. Microchem. J. 2021, 163, 105716.
  114. Kastrati, G.; Jashari, G.; Sys, M.; Svecova, B.; Arbneshi, T.; Metelka, R.; Bilkova, Z.; Korecka, L. Simultaneous determination of vitamin E and vitamin K in food supplements using adsorptive stripping square-wave voltammetry at glassy carbon electrode. Appl. Sci. 2020, 10, 4759.
  115. Thangphatthanarungruang, J.; Yakoh, A.; Laocharoensuk, R.; Chotsuwan, C.; Chailapakul, O.; Siangproh, W. High-efficient of graphene nanocomposite: Application to rapidly simultaneous identification and quantitation of fat-soluble vitamins in different matric samples. J. Electroanal. Chem. 2020, 873, 114361.
  116. Avan, A.A.; Filik, H. Simultaneous determination of fat-soluble vitamins by using modified glassy carbon electrode. Russ. J. Electrochem. 2021, 57, 858–871.
  117. Darabi, R.; Shabani-Nooshabadi, M.; Khoobi, A. A potential strategy for simultaneous determination of deferoxamine and vitamin C using MCR-ALS with nanostructured electrochemical sensor in serum and urine of thalassemia and diabetic patients. J. Electrochem. Soc. 2021, 168, 046514.
  118. Kumar, M.; Wang, M.; Swamy, B.E.K.; Praveen, M.; Zhao, W. Poly (alanine)/NaOH/ MoS2/MWCNTs modified carbon paste electrode for simultaneous detection of dopamine, ascorbic acid, serotonin and guanine. Colloid Surf. B-Biointerfaces 2020, 196, 111299.
  119. Arroquia, A.; Acosta, I.; Armada, M.P.G. Self-assembled gold decorated polydopamine nanospheres as electrochemical sensor for simultaneous determination of ascorbic acid, dopamine, uric acid and tryptophan. Mater. Sci. Eng. C-Mater. Biol. Appl. 2020, 109, 110602.
  120. Atta, N.F.; Galal, A.; El-Gohary, A.R. Crown ether modified poly(hydroquinone)/carbon nanotubes based electrochemical sensor for simultaneous determination of levodopa, uric acid, tyrosine and ascorbic acid in biological fluids. J. Electroanal. Chem. 2020, 863, 114032.
  121. Buledi, J.A.; Ameen, S.; Khand, N.H.; Solangi, A.R.; Taqvi, I.H.; Agheem, M.H.; Wajdan, Z. CuO nanostructures based electrochemical sensor for simultaneous determination of hydroquinone and ascorbic acid. Electroanalysis 2020, 32, 1600–1607.
  122. Swamy, B.K.; Shiprath, K.; Rakesh, G.; Ratnam, K.V.; Manjunatha, H.; Janardan, S.; Naidu, K.C.B.; Ramesh, S.; Suresh, K.; Ratnamala, A. Simultaneous detection of dopamine, tyrosine and ascorbic acid using NiO/graphene modified graphite electrode. Biointerface Res. Appl. Chem. 2020, 10, 5599–5609.
  123. Muhammad, H.Y.; Faizullah, A.T. Double injection-single detector flow injection spectrophotometric method for simultaneous determination of ascorbic acid and paracetamol in pharmaceutical formulations. J. Iran. Chem. Soc. 2020, 17, 111–118.
  124. Veerapandi, G.; Meenakshi, S.; Anitta, S.; Arul, C.; Ashokkumar, P.; Sekar, C. Precise and quick detection of ascorbic acid and eugenol in fruits, pharmaceuticals and medicinal herbs using hydroxyapatite-titanium dioxide nanocomposite-based electrode. Food Chem. 2022, 382, 132251.
  125. Rees, M.; Wright, A.G.; Holdcroft, S.; Bertoncello, P. Voltammetry at hexamethyl-P-terphenyl poly(benzimidazolium) (HMT-PMBI)-coated glassy carbon electrodes: Charge transport properties and detection of uric and ascorbic acid. Sensors 2020, 20, 443.
  126. Luo, X.L.; Chen, L.M.; Yang, J.Y.; Li, S.T.; Li, M.T.; Mo, Q.; Li, Y.B.; Li, X.C. Electrochemically simultaneous detection of ascorbic acid, sulfite and oxalic acid on Pt-Pd nanoparticles/chitosan/nitrogen doped graphene modified glassy carbon electrode: A method for drug quality control. Microchem. J. 2021, 169, 106623.
  127. Abo-bakr, A.M.; Abd-Elsabour, M.; Abou-Krisha, M.M. An efficient novel electrochemical sensor for simultaneous determination of vitamin C and aspirin based on a PMR/Zn-Al LDH/GCE. Electroanalysis 2021, 33, 2476–2489.
  128. Ghanbari, H.; Chamjangali, M.A.; Faraji, M. Simultaneous electrochemical determination of ascorbic acid, dopamine, and uric acid in a variety of food, pharmaceutical, and biologic samples using a modified glassy carbon electrode with sunset yellow. Anal. Bioanal. Chem. Res. 2022, 9, 411–429.
  129. Wang, M.Y.; Ceto, X.; del Valle, M. A novel electronic tongue using electropolymerized molecularly imprinted polymers for the simultaneous determination of active pharmaceutical ingredients. Biosens. Bioelectron. 2022, 198, 113807.
  130. Tesfaye, G.; Negash, N.; Tessema, M. Sensitive and selective determination of vitamin B2 in non-alcoholic beverage and milk samples at poly (glutamic acid)/zinc oxide nanoparticles modified carbon paste electrode. BMC Chem. 2022, 16, 69.
  131. Amalraj, A.J.J.; Wang, S.F. An effective morphology controlled hydrothermal synthesis of Bi2WO6 and its application in riboflavin electrochemical sensor. Colloid Surf. A-Physicochem. Eng. Asp. 2022, 648, 129183.
  132. Karastogianni, S.; Girousi, S. Square wave voltammetric (SWV) determination of cyanocobalamin (vitamin B12) in pharmaceuticals and supplements on a carbon paste electrode (CPE) modified by a manganese(II) polymeric film. Anal. Lett. 2022, 55, 399–410.
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to : , , ,
View Times: 132
Revisions: 2 times (View History)
Update Date: 19 Jun 2023