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Wang, Z.; Han, D.; Wang, H.; Zheng, M.; Xu, Y.; Zhang, H. Organic Semiconducting Nanoparticles for Biosensor. Encyclopedia. Available online: https://encyclopedia.pub/entry/44807 (accessed on 27 August 2024).
Wang Z, Han D, Wang H, Zheng M, Xu Y, Zhang H. Organic Semiconducting Nanoparticles for Biosensor. Encyclopedia. Available at: https://encyclopedia.pub/entry/44807. Accessed August 27, 2024.
Wang, Zheng, Dongyang Han, Hongzhen Wang, Meng Zheng, Yanyi Xu, Haichang Zhang. "Organic Semiconducting Nanoparticles for Biosensor" Encyclopedia, https://encyclopedia.pub/entry/44807 (accessed August 27, 2024).
Wang, Z., Han, D., Wang, H., Zheng, M., Xu, Y., & Zhang, H. (2023, May 25). Organic Semiconducting Nanoparticles for Biosensor. In Encyclopedia. https://encyclopedia.pub/entry/44807
Wang, Zheng, et al. "Organic Semiconducting Nanoparticles for Biosensor." Encyclopedia. Web. 25 May, 2023.
Organic Semiconducting Nanoparticles for Biosensor
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This entry is adapted from the peer-reviewed paper 10.3390/bios13040494

Highly bio-compatible organic semiconductors are widely used as biosensors, but their long-term stability can be compromised due to photo-degradation and structural instability. To address this issue, scientists have developed organic semiconductor nanoparticles (OSNs) by incorporating organic semiconductors into a stable framework or self-assembled structure. OSNs have shown excellent performance and can be used as high-resolution biosensors in modern medical and biological research. They have been used for a wide range of applications, such as detecting small biological molecules, nucleic acids, and enzyme levels, as well as vascular imaging, tumor localization, and more. In particular, OSNs can simulate fine particulate matters (PM2.5, indicating particulate matter with an aerodynamic diameter less than or equal to 2.5 μm) and can be used to study the biodistribution, clearance pathways, and health effects of such particles.

biosensors organic semiconducting nanoparticles in vivo tracking in vitro tracking

1. Introduction

In recent years, biosensor technology has experienced significant development due to advances in biomedicine and computational science [1][2][3][4]. Biosensors have found widespread use in medicine and biology, from detecting disease biomarkers [5][6] and tracking drug release [7], to ion imaging [8][9][10] and fluorescence imaging in living animals [11][12][13]. These applications have greatly improved the imaging resolution and can assist physicians in making more accurate disease diagnoses. In order to achieve tracking detection in organisms, scientists have developed biosensors with different fluorescence properties [14][15]. These biosensors have the ability to track and monitor specific targets within the body, enabling real-time and precise detection.
Organic semiconductor materials can be excited by various forms of energy, such as light or electricity, which leads to an excited state from the ground state S0 to the first excited state S1, S2, or Sn. However, the excited state is unstable and will return to the ground state via radiation transition and/or non-radiation transition [16]. Herein, radiation transition is typically divided into fluorescence and phosphorescence [17]. Due to their π-conjugated structure, organic semiconductor materials possess semiconductor properties.
Recently, scientists have successfully developed a number of specific recognition fluorescent probes using different strategies, for example, through binding different identifying groups or changing the molecular structure by reaction with the target [18][19]. The organic semiconductor with high biocompatibility is widely used in biosensors [20][21], such as AIE (aggregation-induced emission) based probes. The small size of the organic semiconductor probes makes it easy to penetrate cells [22]. In addition, the outstanding diffusion properties of organic semiconductor probes help improve the resolution of imaging [23]. However, there are still some problems that restrict the development of organic semiconductor probes. On the one hand, organic semiconductor probes usually have poor photostability [24][25]. On the other hand, their toxic effects and metabolism in organisms remain a challenge for organic semiconductor probes application. To solve these problems, researchers have constructed OSNs (organic semiconductor nanoparticles) by attaching or wrapping organic semiconductors in inorganic matrices [26], Metal-organic frameworks (MOFs) [27][28][29], polymers [30], etc. Due to their excellent properties, OSNs are widely used in biosensors (Figure 1).
/media/item_content/202305/646eee5820f09biosensors-13-00494-g001.png
Figure 1. The application of OSNs in biosensors.
OSNs are widely used as biosensors for high-resolution tracking in vitro and in vivo [31][32]. Compared to inorganic fluorescent materials, OSNs can be designed with various photosensitive properties and high biocompatibility through different design strategies [33][34]. However, to construct high-performance OSNs for bioimaging, the materials must not only exhibit intense fluorescence, but they must also be designed in a comprehensive manner. For instance, the attachment and wrapping between OSNs and nanoparticles should be stable to prevent detachment [35][36]. Additionally, toxicity is a crucial factor in bioimaging, as some reacting OSNs may be non-toxic before reacting with the target, but they could become toxic when combined with it [37]. Furthermore, the sensitivity and effectiveness of OSN sensors still require further improvements for practical applications.

2. In Vitro Tracking

2.1. Biological Small Molecules Tracking

Biological small molecules in the body can reveal health conditions, and their detection and tracing are of great importance for biomedical research. Glutathione (GSH), the essential endogenous antioxidant, is the most abundant intracellular nonprotein thiol in mammalian and eukaryotic cells [38][39]. The disturbances in GSH content are generally considered to be associated with various human diseases, such as psoriasis, human immunodeficiency virus (HIV), liver damage, and diabetes [40][41][42]. Given its importance in medicine, achieving highly sensitive detection of GSH, as well as tracking of GSH in living cells, is urgent. Moreover, the tracking of GSH in organisms is favorable for biological investigations and early disease diagnoses [43].

2.2. Enzyme Concentration Measurement

Enzymes are widely present in the body and act as biocatalysts. The International Union of Biochemistry and Molecular Biology (IUBMB) classifies enzymes into seven categories, including oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, and translocases [44]. They all play decisive roles in the activity of the organism. If the activity of enzymes is weakened due to certain defects caused by various factors, it can lead to abnormal reactions, disorders of substance metabolism, and even development of clinical diseases. As a consequence, tracking the concentration and activity of enzymes is of major importance.

2.3. Nucleic Acid Concentration Measurement

Nucleic acid concludes deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). It is a biological macromolecular compound polymerized by many nucleotides and is one of the most basic substances of life [45][46][47]. DNA is the main basis for storing, replicating, and transmitting genetic information. Meanwhile, RNA plays an important role in protein synthesis. Thus, facile and reliable methods for the detection of DNA are of vital importance to the medical field, such as medical diagnosis, mutational analysis, gene therapy, biological studies, and specific genomic techniques [48][49].

3. In Vivo Tracking

Different from the biosensors used for in vitro imaging, the influencing factors for in vivo tracking are more complex. Factors, such as water solubility, diffusion resistance, blood circulation, pH, and temperature, all need to be systematically considered during probe design. Moreover, the probes may be non-toxic to the target but toxic to other cells or organs. Therefore, before applying probe technology for in vivo tracking, in vitro experiments should first be performed to ensure its biosafety. Additionally, the probe should have different metabolism speeds corresponding to different tracking periods. In addition, stability and biocompatibility both are decisive factors for OSNs probes in in vivo tracking [50]. Reasonable molecular designing can improve the stability and biocompatibility of OSNs, such as designing a stable molecular skeleton, reducing halogen atom content, and so on [51][52][53][54]. Moreover, changes in molecular polarity due to changes in molecular structure may change the toxicity of the system.

3.1. Tumor Localization

Today, cancer is a major public health problem and the major cause of death globally [55][56]. At present, the main diagnostic methods of cancer include ultrasound imaging (US) [57], single photon emission computed tomography (SPECT) [58][59][60], positron emission tomography (PET) [61][62][63], electronic computed tomography (CT) [64], magnetic resonance imaging (MRI) [65][66][67], and optical imaging [68][69][70]. Among them, radiological imaging has not only unavoidable radiological risks but also certain deficiencies in specificity, sensitivity, resolution, etc. [71][72][73][74]. As a non-invasive technique, fluorescence imaging has the advantages of low risk of harm to humans, high sensitivity, and short response time, thus receiving increasing attention from researchers.

3.2. Blood Vessel Imaging

In the biomedical field, fluorescence imaging, as a highly sensitive non-invasive imaging technique, poses less risk of harm to the human body and has a shorter response time. It has great potential in organ tracking, especially for deep-tissue diagnosis [75]. X-ray radiography is a common method for gastrointestinal disease diagnosis [76][77][78]. Before the X-ray radiography, the patient needs to take the contrast agent orally, such as in the form of a barium meal. The barium meal will be excreted out of the body by defecation [79][80][81][82][83]. In short-period medical examinations, metabolism is crucial for the contrast medium.

3.3. Particles Tracking

Air pollution is an important health concern globally. According to data published by the World Health Organization (WHO), upwards of four million people die early each year due to outdoor air pollution, and the main cause of this is particulate matter pollution [84][85]. Therefore, exploring the deposition of particulate matter in the body and developing imaging techniques for it is a crucial area of cutting-edge scientific research. With the rapid development of nanotechnology, an increasing number of studies are applying biosensors and nanotechnology for tracing particulate matter and in vivo imaging. OSNs, consisting of fluorescently stained polystyrene nanoparticles, are now widely used to model atmospheric particulate matter. In one study, this OSN was successfully used to observe the dynamic deposition of particles in the lungs of mice in real-time using a two-photon microscope [86]. 

4. Conclusions

Organic semiconductor nanoparticles (OSNs) offer several advantages for biosensing applications, including strong fluorescence emission, adjustable emission wavelength, and high biocompatibility, among others. Furthermore, by employing different design strategies, scholars can develop a wide range of functional probes to meet various biosensing requirements. The development of OSNs has the potential to advance the fields of biology and medical science in several ways. Firstly, OSNs can serve as a platform for researchers to monitor the circulation of ions or biological molecules in organisms, thus deepening our understanding of their underlying mechanisms. Secondly, OSNs can be utilized for in vivo tracking to enable faster and more accurate disease diagnosis. Overall, the development of OSNs has the potential to significantly enhance medical science.

References

  1. Gong, S.; Qin, A.; Zhang, Y.; Li, M.; Chen, X.; Liang, Y.; Xu, X.; Wang, Z.; Wang, S. A New Ratiometric AIE Fluorescent Probe for Detecting Cysteine in Food Samples and Imaging in the Biological System. Food Chem. 2023, 400, 134108.
  2. Bao, B.; Ma, M.; Zai, H.; Zhang, L.; Fu, N.; Huang, W.; Wang, L. Conjugated Polymer Nanoparticles for Label-Free and Bioconjugate-Recognized DNA Sensing in Serum. Adv. Sci. 2015, 2, 1400009.
  3. Lin, H.; Bai, H.; Yang, Z.; Shen, Q.; Li, M.; Huang, Y.; Lv, F.; Wang, S. Conjugated Polymers for Biomedical Applications. Chem. Commun. 2022, 58, 7232–7244.
  4. Li, J.; Jiang, R.; Wang, Q.; Li, X.; Hu, X.; Yuan, Y.; Lu, X.; Wang, W.; Huang, W.; Fan, Q. Semiconducting Polymer Nanotheranostics for NIR-II/Photoacoustic Imaging-Guided Photothermal Initiated Nitric Oxide/Photothermal Therapy. Biomaterials 2019, 217, 119304.
  5. Gao, H.; Kam, C.; Chou, T.Y.; Wu, M.-Y.; Zhao, X.; Chen, S. A Simple yet Effective AIE-Based Fluorescent Nano-Thermometer for Temperature Mapping in Living Cells Using Fluorescence Lifetime Imaging Microscopy. Nanoscale Horiz. 2020, 5, 488–494.
  6. Zhou, L.; Zhang, X.; Dong, Y.; Pan, Y.; Li, J.; Zang, Y.; Li, X. A Tandemly Activated Fluorescence Probe for Detecting Senescent Cells with Improved Selectivity by Targeting a Biomarker Combination. ACS Sens. 2022, 7, 1958–1966.
  7. Wang, R.; Zhou, L.; Wang, W.; Li, X.; Zhang, F. In Vivo Gastrointestinal Drug-Release Monitoring through Second near-Infrared Window Fluorescent Bioimaging with Orally Delivered Microcarriers. Nat. Commun. 2017, 8, 14702.
  8. Xu, J.; Xiong, J.; Qin, Y.; Li, Z.; Pan, C.; Huo, Y.; Zhang, H. A Novel Quinolinyl-Tetraphenylethene-Based Fluorescence “Turn-on” Sensor for Zn2+ with a Large Stokes Shift and Its Applications for Portable Test Strips and Biological Imaging. Mater. Chem. Front. 2020, 4, 3338–3348.
  9. Enbanathan, S.; Iyer, S.K. A Novel Phenanthridine and Terpyridine Based D-π-A Fluorescent Probe for the Ratiometric Detection of Cd2+ in Environmental Water Samples and Living Cells. Ecotoxicol. Environ. Saf. 2022, 247, 114272.
  10. Jiang, N.; Gong, X.; Zhong, T.; Zheng, Y.; Wang, G. A Highly Selective and Sensitive “Turn-on” Fluorescent Probe for Rapid Recognition and Detection of Cu2+ in Aqueous Solution and in Living Cells. J. Mol. Struct. 2020, 1219, 128573.
  11. Li, Q.; Ding, Q.; Li, Y.; Zeng, X.; Liu, Y.; Lu, S.; Zhou, H.; Wang, X.; Wu, J.; Meng, X.; et al. Novel Small-Molecule Fluorophores for in Vivo NIR-IIa and NIR-IIb Imaging. Chem. Commun. 2020, 56, 3289–3292.
  12. Fortibui, M.M.; Jang, M.; Lee, S.; Ryoo, I.-J.; Ahn, J.S.; Ko, S.-K.; Kim, J. Near-Infrared Fluorescence Probe for Specific Detection of Acetylcholinesterase and Imaging in Live Cells and Zebrafish. ACS Appl. Bio Mater. 2022, 5, 2232–2239.
  13. Bhaskar, S.; Srinivasan, V.; Ramamurthy, S.S. Nd2O3-Ag Nanostructures for Plasmonic Biosensing, Antimicrobial, and Anticancer Applications. ACS Appl. Nano Mater. 2023, 6, 1129–1145.
  14. Chen, H.; Cheng, Z.; Zhou, X.; Wang, R.; Yu, F. Emergence of Surface-Enhanced Raman Scattering Probes in Near-Infrared Windows for Biosensing and Bioimaging. Anal. Chem. 2022, 94, 143–164.
  15. Li, Y.; Cai, Z.; Liu, S.; Zhang, H.; Wong, S.T.H.; Lam, J.W.Y.; Kwok, R.T.K.; Qian, J.; Tang, B.Z. Design of AIEgens for Near-Infrared IIb Imaging through Structural Modulation at Molecular and Morphological Levels. Nat. Commun. 2020, 11, 1255.
  16. Albani, J.R. Principles and Applications of Fluorescence Spectroscopy, 1st ed.; Wiley: Hoboken, NJ, USA, 2007; ISBN 978-1-4051-3891-8.
  17. Feng, G.; Zhang, G.-Q.; Ding, D. Design of Superior Phototheranostic Agents Guided by Jablonski Diagrams. Chem. Soc. Rev. 2020, 49, 8179–8234.
  18. Han, W.; Du, Y.; Song, M.; Sun, K.; Xu, B.; Yan, F.; Tian, W. Fluorescent Nanorods Based on 9,10-Distyrylanthracene (DSA) Derivatives for Efficient and Long-Term Bioimaging. J. Mater. Chem. B 2020, 8, 9544–9554.
  19. Liu, S.; Zhu, Y.; Wu, P.; Xiong, H. Highly Sensitive D–A–D-Type Near-Infrared Fluorescent Probe for Nitric Oxide Real-Time Imaging in Inflammatory Bowel Disease. Anal. Chem. 2021, 93, 4975–4983.
  20. Deng, S.; Li, L.; Zhang, J.; Wang, Y.; Huang, Z.; Chen, H. Semiconducting Polymer Dots for Point-of-Care Biosensing and In Vivo Bioimaging: A Concise Review. Biosensors 2023, 13, 137.
  21. Xiong, Y.; Shepherd, S.; Tibbs, J.; Bacon, A.; Liu, W.; Akin, L.D.; Ayupova, T.; Bhaskar, S.; Cunningham, B.T. Photonic Crystal Enhanced Fluorescence: A Review on Design Strategies and Applications. Micromachines 2023, 14, 668.
  22. Zhao, Z.; Bi, X.; Mao, W.; Xu, X. A Novel HPQ-Based Turn-on Fluorescent Probe for Detection of Fluoride Ions in Living Cells. Tetrahedron Lett. 2017, 58, 4129–4132.
  23. Li, K.; Lyu, Y.; Huang, Y.; Xu, S.; Liu, H.-W.; Chen, L.; Ren, T.-B.; Xiong, M.; Huan, S.; Yuan, L.; et al. A de Novo Strategy to Develop NIR Precipitating Fluorochrome for Long-Term in Situ Cell Membrane Bioimaging. Proc. Natl. Acad. Sci. USA 2021, 118, e2018033118.
  24. Li, B.; Chen, T.; Wang, Z.; Guo, Z.; Peña, J.; Zeng, L.; Xing, J. A Novel Cross-Linked Nanoparticle with Aggregation-Induced Emission Properties for Cancer Cell Imaging. J. Mater. Chem. B 2020, 8, 2431–2437.
  25. Yu, C.Y.Y.; Zhang, W.; Kwok, R.T.K.; Leung, C.W.T.; Lam, J.W.Y.; Tang, B.Z. A Photostable AIEgen for Nucleolus and Mitochondria Imaging with Organelle-Specific Emission. J. Mater. Chem. B 2016, 4, 2614–2619.
  26. Feng, G.; Liu, B. Aggregation-Induced Emission (AIE) Dots: Emerging Theranostic Nanolights. Acc. Chem. Res. 2018, 51, 1404–1414.
  27. Wang, Y.; Wu, W.; Liu, J.; Manghnani, P.N.; Hu, F.; Ma, D.; Teh, C.; Wang, B.; Liu, B. Cancer-Cell-Activated Photodynamic Therapy Assisted by Cu(II)-Based Metal–Organic Framework. ACS Nano 2019, 13, 6879–6890.
  28. Hu, F.; Mao, D.; Kenry; Wang, Y.; Wu, W.; Zhao, D.; Kong, D.; Liu, B. Metal–Organic Framework as a Simple and General Inert Nanocarrier for Photosensitizers to Implement Activatable Photodynamic Therapy. Adv. Funct. Mater. 2018, 28, 1707519.
  29. Cai, X.; Mao, D.; Wang, C.; Kong, D.; Cheng, X.; Liu, B. Multifunctional Liposome: A Bright AIEgen-Lipid Conjugate with Strong Photosensitization. Angew. Chem. Int. Ed. 2018, 57, 16396–16400.
  30. Wu, W.; Mao, D.; Xu, S.; Kenry; Hu, F.; Li, X.; Kong, D.; Liu, B. Polymerization-Enhanced Photosensitization. Chem 2018, 4, 1937–1951.
  31. Liang, B.; Hu, X.; Ding, Y.; Liu, M. Tumor-derived Exosomes in the PD-1/PD-L1 Axis: Significant Regulators as Well as Promising Clinical Targets. J. Cell. Physiol. 2021, 236, 4138–4151.
  32. Xu, S.; Duan, Y.; Liu, B. Precise Molecular Design for High-Performance Luminogens with Aggregation-Induced Emission. Adv. Mater. 2020, 32, 1903530.
  33. Kuno, M.; Fromm, D.P.; Hamann, H.F.; Gallagher, A.; Nesbitt, D.J. Nonexponential “Blinking” Kinetics of Single CdSe Quantum Dots: A Universal Power Law Behavior. J. Chem. Phys. 2000, 112, 3117–3120.
  34. Smith, W.E.; Brownell, J.; White, C.C.; Afsharinejad, Z.; Tsai, J.; Hu, X.; Polyak, S.J.; Gao, X.; Kavanagh, T.J.; Eaton, D.L. In Vitro Toxicity Assessment of Amphiphillic Polymer-Coated CdSe/ZnS Quantum Dots in Two Human Liver Cell Models. ACS Nano 2012, 6, 9475–9484.
  35. Huang, H.; Zhang, X.; Hu, X.; Shao, Z.; Zhu, J.; Dai, L.; Man, Z.; Yuan, L.; Chen, H.; Zhou, C.; et al. A Functional Biphasic Biomaterial Homing Mesenchymal Stem Cells for in Vivo Cartilage Regeneration. Biomaterials 2014, 35, 9608–9619.
  36. Singh, P.; Srivastava, S.; Singh, S.K. Nanosilica: Recent Progress in Synthesis, Functionalization, Biocompatibility, and Biomedical Applications. ACS Biomater. Sci. Eng. 2019, 5, 4882–4898.
  37. Yong, K.-T.; Law, W.-C.; Hu, R.; Ye, L.; Liu, L.; Swihart, M.T.; Prasad, P.N. Nanotoxicity Assessment of Quantum Dots: From Cellular to Primate Studies. Chem. Soc. Rev. 2013, 42, 1236–1250.
  38. Hopkins, F.G.; Morgan, E.J. Some relations between ascorbic acid and glutathione. Biochem. J. 1936, 30, 1446–1462.
  39. Balendiran, G.K.; Dabur, R.; Fraser, D. The Role of Glutathione in Cancer. Cell Biochem. Funct. 2004, 22, 343–352.
  40. Mulay, S.V.; Kim, Y.; Choi, M.; Lee, D.Y.; Choi, J.; Lee, Y.; Jon, S.; Churchill, D.G.; Estrela, J.M.; Ortega, A.; et al. Enhanced Doubly Activated Dual Emission Fluorescent Probes for Selective Imaging of Glutathione or Cysteine in Living Systems. Anal. Chem. 2018, 90, 2648–2654.
  41. Valko, M.; Rhodes, C.J.; Moncol, J.; Izakovic, M.; Mazur, M. Free Radicals, Metals and Antioxidants in Oxidative Stress-Induced Cancer. Chem.-Biol. Interact. 2006, 160, 1–40.
  42. Mulay, S.V.; Kim, Y.; Choi, M.; Lee, D.Y.; Choi, J.; Lee, Y.; Jon, S.; Churchill, D.G.; Estrela, J.M.; Ortega, A.; et al. Glutathione in Cancer Biology and Therapy. Crit. Rev. Clin. Lab. Sci. 2006, 43, 143–181.
  43. Forman, H.J.; Zhang, H.; Rinna, A. Glutathione: Overview of Its Protective Roles, Measurement, and Biosynthesis. Mol. Asp. Med. 2009, 30, 1–12.
  44. McDonald, A.G.; Tipton, K.F. Enzyme Nomenclature and Classification: The State of the Art. FEBS J. 2022, febs.16274.
  45. Todorov, T.I.; Morris, M.D. Comparison of RNA, Single-Stranded DNA and Double-Stranded DNA Behavior during Capillary Electrophoresis in Semidilute Polymer Solutions. Electrophoresis 2002, 23, 1033–1044.
  46. Dahm, R. Discovering DNA: Friedrich Miescher and the Early Years of Nucleic Acid Research. Hum. Genet. 2008, 122, 565–581.
  47. Gregory, S.G.; Barlow, K.F.; McLay, K.E.; Kaul, R.; Swarbreck, D.; Dunham, A.; Scott, C.E.; Howe, K.L.; Woodfine, K.; Spencer, C.C.A.; et al. The DNA Sequence and Biological Annotation of Human Chromosome 1. Nature 2006, 441, 315–321.
  48. Zhang, C.-Y.; Yeh, H.-C.; Kuroki, M.T.; Wang, T.-H. Single-Quantum-Dot-Based DNA Nanosensor. Nat. Mater. 2005, 4, 826–831.
  49. He, S.; Song, B.; Li, D.; Zhu, C.; Qi, W.; Wen, Y.; Wang, L.; Song, S.; Fang, H.; Fan, C. A Graphene Nanoprobe for Rapid, Sensitive, and Multicolor Fluorescent DNA Analysis. Adv. Funct. Mater. 2010, 20, 453–459.
  50. MacFarlane, L.R.; Shaikh, H.; Garcia-Hernandez, J.D.; Vespa, M.; Fukui, T.; Manners, I. Functional Nanoparticles through π-Conjugated Polymer Self-Assembly. Nat. Rev. Mater. 2020, 6, 7–26.
  51. Jiang, Y.; Zhao, X.; Huang, J.; Li, J.; Upputuri, P.K.; Sun, H.; Han, X.; Pramanik, M.; Miao, Y.; Duan, H.; et al. Transformable Hybrid Semiconducting Polymer Nanozyme for Second Near-Infrared Photothermal Ferrotherapy. Nat. Commun. 2020, 11, 1857.
  52. Zhen, X.; Xie, C.; Pu, K. Temperature-Correlated Afterglow of a Semiconducting Polymer Nanococktail for Imaging-Guided Photothermal Therapy. Angew. Chem. Int. Ed. 2018, 57, 3938–3942.
  53. Pu, K.; Shuhendler, A.J.; Jokerst, J.V.; Mei, J.; Gambhir, S.S.; Bao, Z.; Rao, J. Semiconducting Polymer Nanoparticles as Photoacoustic Molecular Imaging Probes in Living Mice. Nat. Nanotechnol. 2014, 9, 233–239.
  54. Zeng, W.; Wu, L.; Sun, Y.; Wang, Y.; Wang, J.; Ye, D. Ratiometric Imaging of MMP-2 Activity Facilitates Tumor Detection Using Activatable Near-Infrared Fluorescent Semiconducting Polymer Nanoparticles. Small 2021, 17, 2101924.
  55. Zhou, Z.; Song, J.; Nie, L.; Chen, X. Reactive Oxygen Species Generating Systems Meeting Challenges of Photodynamic Cancer Therapy. Chem. Soc. Rev. 2016, 45, 6597–6626.
  56. Ge, J.; Lan, M.; Zhou, B.; Liu, W.; Guo, L.; Wang, H.; Jia, Q.; Niu, G.; Huang, X.; Zhou, H.; et al. A Graphene Quantum Dot Photodynamic Therapy Agent with High Singlet Oxygen Generation. Nat. Commun. 2014, 5, 4596.
  57. Lin, S.; Liu, C.; Han, X.; Zhong, H.; Cheng, C. Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy. Int. J. Mol. Sci. 2021, 22, 1728.
  58. Shivran, N.; Tyagi, M.; Mula, S.; Gupta, P.; Saha, B.; Patro, B.S.; Chattopadhyay, S. Syntheses and Photodynamic Activity of Some Glucose-Conjugated BODIPY Dyes. Eur. J. Med. Chem. 2016, 122, 352–365.
  59. Shen, Y.; Shuhendler, A.J.; Ye, D.; Xu, J.-J.; Chen, H.-Y. Two-Photon Excitation Nanoparticles for Photodynamic Therapy. Chem. Soc. Rev. 2016, 45, 6725–6741.
  60. Roy, I.; Ohulchanskyy, T.Y.; Pudavar, H.E.; Bergey, E.J.; Oseroff, A.R.; Morgan, J.; Dougherty, T.J.; Prasad, P.N. Ceramic-Based Nanoparticles Entrapping Water-Insoluble Photosensitizing Anticancer Drugs: A Novel Drug−Carrier System for Photodynamic Therapy. J. Am. Chem. Soc. 2003, 125, 7860–7865.
  61. Citrin, D.; Lee, A.K.; Scott, T.; Sproull, M.; Ménard, C.; Tofilon, P.J.; Camphausen, K. In Vivo Tumor Imaging in Mice with near-Infrared Labeled Endostatin. Mol. Cancer Ther. 2004, 3, 481–488.
  62. Wang, D.; Su, H.; Kwok, R.T.K.; Hu, X.; Zou, H.; Luo, Q.; Lee, M.M.S.; Xu, W.; Lam, J.W.Y.; Tang, B.Z. Rational Design of a Water-Soluble NIR AIEgen, and Its Application in Ultrafast Wash-Free Cellular Imaging and Photodynamic Cancer Cell Ablation. Chem. Sci. 2018, 9, 3685–3693.
  63. Kamkaew, A.; Lim, S.H.; Lee, H.B.; Kiew, L.V.; Chung, L.Y.; Burgess, K. BODIPY Dyes in Photodynamic Therapy. Chem. Soc. Rev. 2013, 42, 77–88.
  64. Nolting, D.D.; Gore, J.C.; Pham, W. Near-Infrared Dyes: Probe Development and Applications in Optical Molecular Imaging. Curr. Org. Synth. 2011, 8, 521–534.
  65. Guo, Z.; Park, S.; Yoon, J.; Shin, I. Recent Progress in the Development of Near-Infrared Fluorescent Probes for Bioimaging Applications. Chem. Soc. Rev. 2014, 43, 16–29.
  66. Yuan, L.; Lin, W.; Zheng, K.; He, L.; Huang, W. Far-Red to near Infrared Analyte-Responsive Fluorescent Probes Based on Organic Fluorophore Platforms for Fluorescence Imaging. Chem. Soc. Rev. 2013, 42, 622–661.
  67. Patel, N.; Pera, P.; Joshi, P.; Dukh, M.; Tabaczynski, W.A.; Siters, K.E.; Kryman, M.; Cheruku, R.R.; Durrani, F.; Missert, J.R.; et al. Highly Effective Dual-Function Near-Infrared (NIR) Photosensitizer for Fluorescence Imaging and Photodynamic Therapy (PDT) of Cancer. J. Med. Chem. 2016, 59, 9774–9787.
  68. Zhang, X.; Zhang, X.; Yang, B.; Liu, M.; Liu, W.; Chen, Y.; Wei, Y. Fabrication of Aggregation Induced Emission Dye-Based Fluorescent Organic Nanoparticles via Emulsion Polymerization and Their Cell Imaging Applications. Polym. Chem. 2014, 5, 399–404.
  69. Zheng, Y.; Lu, H.; Jiang, Z.; Guan, Y.; Zou, J.; Wang, X.; Cheng, R.; Gao, H. Low-Power White Light Triggered AIE Polymer Nanoparticles with High ROS Quantum Yield for Mitochondria-Targeted and Image-Guided Photodynamic Therapy. J. Mater. Chem. B 2017, 5, 6277–6281.
  70. Yuan, Y.; Zhang, C.-J.; Kwok, R.T.K.; Xu, S.; Zhang, R.; Wu, J.; Tang, B.Z.; Liu, B. Light-Up Probe for Targeted and Activatable Photodynamic Therapy with Real-Time In Situ Reporting of Sensitizer Activation and Therapeutic Responses. Adv. Funct. Mater. 2015, 25, 6586–6595.
  71. Wang, H.; Liu, G.; Dong, S.; Xiong, J.; Du, Z.; Cheng, X. A PH-Responsive AIE Nanoprobe as a Drug Delivery System for Bioimaging and Cancer Therapy. J. Mater. Chem. B 2015, 3, 7401–7407.
  72. Wang, Z.; Yong, T.-Y.; Wan, J.; Li, Z.-H.; Zhao, H.; Zhao, Y.; Gan, L.; Yang, X.-L.; Xu, H.-B.; Zhang, C. Temperature-Sensitive Fluorescent Organic Nanoparticles with Aggregation-Induced Emission for Long-Term Cellular Tracing. ACS Appl. Mater. Interfaces 2015, 7, 3420–3425.
  73. Minchinton, A.I.; Tannock, I.F. Drug Penetration in Solid Tumours. Nat. Rev. Cancer 2006, 6, 583–592.
  74. Fox, R.G.; Lytle, N.K.; Jaquish, D.V.; Park, F.D.; Ito, T.; Bajaj, J.; Koechlein, C.S.; Zimdahl, B.; Yano, M.; Kopp, J.L.; et al. Image-Based Detection and Targeting of Therapy Resistance in Pancreatic Adenocarcinoma. Nature 2016, 534, 407–411.
  75. Jiang, Y.; Pu, K. Multimodal Biophotonics of Semiconducting Polymer Nanoparticles. Acc. Chem. Res. 2018, 51, 1840–1849.
  76. Urade, M.; Shinbo, T. Barium Appendicitis 1 Month After a Barium Meal. Int. Surg. 2013, 97, 296–298.
  77. Kurer, M.A.; Chintapatla, S. Intestinal Obstruction Due to Inspissated Barium. N. Engl. J. Med. 2007, 356, 1656.
  78. Cumberland, D.C. Optimum Viscosity of Barium Suspension for Use in the Double Contrast Barium Meal. Gastrointest. Radiol. 1977, 2, 169–174.
  79. Stringer, D.A.; Hassall, E.; Ferguson, A.C.; Cairns, R.; Nadel, H.; Sargent, M. Hypersensitivity Reaction to Single Contrast Barium Meal Studies in Children. Pediatr. Radiol. 1993, 23, 587–588.
  80. Nijhawan, S.; Kumpawat, S.; Mallikarjun, P.; Bansal, R.; Singla, D.; Ashdhir, P.; Mathur, A.; Rai, R.R. Barium Meal Follow through with Pneumocolon: Screening Test for Chronic Bowel Pain. World J. Gastroenterol. 2008, 14, 6694.
  81. Tada, S.; Iida, M.; Fuchigami, T.; Matsui, T.; Iwashita, A.; Yao, T.; Fujishima, M. Barium Meal Study for Amyloidosis of the Small Intestine: Measurements on Radiograph. Gastrointest. Radiol. 1990, 15, 320–324.
  82. Tai, C.-J.; Wang, W.; Huang, Y.-M. Barium Meal Peritonitis, Fatal Outcome in Unsuspected Small Bowel Perforation. Indian J. Surg. 2021, 83, 1589–1590.
  83. Elman, R.; MacLeod, J.W. Studies on the Neutralization of Gastric Acidity: Ewald Test Meal and X-Ray (Barium Meal) Studies in Patients with Duodenal Ulcer, Gastro-Jejunostomy and Gastric Resection. Am. J. Dig. Dis. Nutr. 1935, 2, 21–26.
  84. Zhang, Y.; West, J.J.; Mathur, R.; Xing, J.; Hogrefe, C.; Roselle, S.J.; Bash, J.O.; Pleim, J.E.; Gan, C.-M.; Wong, D.C. Long-term trends in the ambient PM2.5- and O3-related mortality burdens in the United States under emission reductions from 1990 to 2010. Atmos. Chem. Phys. 2018, 18, 15003–15016.
  85. Li, X.; Jin, L.; Kan, H. Air pollution: A global problem needs local fixes. Nature 2019, 570, 437–439.
  86. Li, D.; Li, Y.; Li, G.; Zhang, Y.; Li, J.; Chen, H. Fluorescent Reconstitution on Deposition of PM2.5 in Lung and Extrapulmonary Organs. Proc. Natl. Acad. Sci. USA 2019, 116, 2488–2493.
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Subjects: Chemistry, Organic
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Zheng Wang
,
Dongyang Han
,
Hongzhen Wang
,
Meng Zheng
,
Yanyi Xu
,
Haichang Zhang
View Times: 311
Revisions: 2 times (View History)
Update Date: 25 May 2023
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