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Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous cellular signal transduction pathways that regulate all aspects of life (such as development of eye) and are frequently altered in disease. Once activated through phosphorylation, these MAPKs in turn phosphorylate and activate transcription factors present either in the cytoplasm or in the nucleus, leading to the expression of target genes and, as a consequence, they elicit various biological responses.
Gene Name | Protein Name | Alternative Protein Names | Pathway Involved | MAPK Level | Other Gene/Protein Names |
---|---|---|---|---|---|
MAPK1 | ERK2 | p42-MAPK | MEK/ERK | MAPK | MAPK2, p38, p40, p41, ERT1, NS13 |
MAPK3 | ERK1 | p44-MAPK | MEK/ERK | MAPK | ERT2, PRKM3 |
MAPK4 | ERK4 | p63-MAPK | atypical MAPK | MAPK | PRKM4 |
MAPK6 | ERK3 | p97-MAPK | atypical MAPK | MAPK | PRKM6, HsT17250 |
MAPK7 | ERK5 | ERK5 | MAPK | PRKM7, BMK1 | |
MAPK8 | JNK1 | SAPK1 | JNK | MAPK | PRKM8 |
MAPK9 | JNK2 | p54aSAPK | JNK | MAPK | PRKM9 |
MAPK10 | JNK3 | p54bSAPK | JNK | MAPK | PRKM10, SAPK1b, p493F12 |
MAPK11 | p38 beta | SAPK2, SAPK2B | p38 | MAPK | PRKM11 |
MAPK12 | p38 gamma | ERK6, SAPK-3 | p38 | MAPK | PRKM12 |
MAPK13 | p38 delta | SAPK4 | p38 | MAPK | PRKM13 |
MAPK14 | p38 alpha | SAPK2A, Mxi2 | p38 | MAPK | PRKM14, PRKM15, CSBP, EXIP |
MAPK15 | ERK7/8 | atypical MAPK | MAPK | ||
MAP2K1 | MEK1 | MKK1, MAPKK1 | MEK/ERK | MAP2K | CFC3 |
MAP2K2 | MEK2 | MKK2, MAPKK2 | MEK/ERK | MAP2K | CFC4 |
MAP2K3 | MEK3 | MKK3, MAPKK3 | p38 | MAP2K | SAPKK2 |
MAP2K4 | MEK4 | MKK4, MAPKK4 | JNK | MAP2K | SAPKK1, JNKK1, JNKK |
MAP2K5 | MEK5 | MAPKK5 | ERK5 | MAP2K | |
MAP2K6 | MEK6 | MKK6, MAPKK6 | p38 | MAP2K | SAPKK3 |
MAP2K7 | MEK7 | MKK7, MAPKK7 | JNK | MAP2K | SAPKK4, JNKK2 |
RAF1 | c-Raf | Raf-1 | MEK/ERK | MAP3K | |
BRAF | B-Raf | BRAF-1, RAFB1 | MEK/ERK | MAP3K | NS7 |
MAP3K1 | MEKK1 | JNK | MAP3K | ||
MAP3K2 | MEKK2 | MEKK2B | ERK5 | MAP3K | |
MAP3K3 | MEKK3 | MAPKKK3 | ERK5 | MAP3K | |
MAP3K4 | MEKK4 | MAPKKK4 | MAP3K | MTK1, PRO0412 | |
MAP3K5 | ASK1 | MEKK5, MAPKKK5 | JNK and p38 | MAP3K | |
MAP3K6 | ASK2 | MEKK6, MAPKKK6 | MAP3K | ||
MAP3K7 | TAK1 | MEKK7, TGF1a | JNK and p38 | MAP3K | CSCF, FMD2 |
MAP3K8 | MEKK8 | Tpl-2, c-COT | MAP3K | COT, EST, ESTF, AURA2 | |
MAP3K9 | MLK1 | MEKK9 | MAP3K | PRKE1 | |
MAP3K10 | MLK2 | MEKK10 | MAP3K | MST | |
MAP3K11 | MLK3 | MEKK11 | JNK and p38 | MAP3K | PTK1, SPRK |
MAP3K12 | ZPK | MEKK12 | MAP3K | DLK, MUK, HP09298 | |
MAP3K13 | LZK | MEKK13 | JNK | MAP3K | MLK |
MAP3K14 | MAP3K | FTDCR1B, HS, HSNIK, NIK | |||
MAP3K15 | ASK3 | MAP3K | bA723P2.3 | ||
TAOK1 | PSK2 | MAP3K16, TAO1 | JNK | MAP3K | DDIB, KFC-B, MARKK, hKFC-B |
TAOK2 | PSK | MAP3K17, TAO2 | MAP3K | Tao2beta, PSK1-BETA | |
TAOK3 | MAP3K18 | p38 | MAP3K | DPK, JIK, hKFC-A | |
MAP3K19 | MAP3K | RCK, YSK4 | |||
MAP3K20 | MLK7 | mlklak, pk | MAP3K | AZK, MLT, MRK, ZAK, SFMMP | |
MAP3K21 | MLK4 | dJ862P8.3 | MAP3K |