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Radu, C.; Radu, C.C.; Bochiș, S.; Arbănași, E.M.; Lucan, A.I.; Murvai, V.R.; Zaha, D.C. Essential Oils and the Oral Microbiome. Encyclopedia. Available online: (accessed on 21 April 2024).
Radu C, Radu CC, Bochiș S, Arbănași EM, Lucan AI, Murvai VR, et al. Essential Oils and the Oral Microbiome. Encyclopedia. Available at: Accessed April 21, 2024.
Radu, Casandra-Maria, Carmen Corina Radu, Sergiu-Alin Bochiș, Emil Marian Arbănași, Alexandra Ioana Lucan, Viorela Romina Murvai, Dana Carmen Zaha. "Essential Oils and the Oral Microbiome" Encyclopedia, (accessed April 21, 2024).
Radu, C., Radu, C.C., Bochiș, S., Arbănași, E.M., Lucan, A.I., Murvai, V.R., & Zaha, D.C. (2023, February 20). Essential Oils and the Oral Microbiome. In Encyclopedia.
Radu, Casandra-Maria, et al. "Essential Oils and the Oral Microbiome." Encyclopedia. Web. 20 February, 2023.
Essential Oils and the Oral Microbiome

The extensive use of antibiotics has resulted in the development of drug-resistant bacteria, leading to a decline in the efficacy of traditional antibiotic treatments. Essential oils (EOs) are phytopharmaceuticals, or plant-derived compounds, that possess beneficial properties such as anti-inflammatory, antibacterial, antimicrobial, antiviral, bacteriostatic, and bactericidal effects.

essential oils therapeutic effect oral microbiome phytopharmaceuticals

1. Introduction

Microbes were discovered in the early 18th century and are prevalent in our environment, affecting every aspect of human life. The oral cavity is home to various microorganisms and habitats that play a crucial role in overall human health. Imbalances in the microbial flora can lead to oral diseases such as dental cavities, periodontitis, gingivitis, oral mucosa diseases, and systemic diseases [1]. Many attempts have been made to develop the ideal antimicrobial agent due to the emergence of antibiotic-resistant bacteria [2]. EOs have been studied for many years as potential antimicrobial agents and are used in various medical fields, including dentistry. In many countries, they are still used as traditional medicine. The earliest known use of EOs is believed to be in Ancient Egypt in 3500 B.C., where they were used in cosmetics, religious ceremonies, and medicinal purposes in various forms such as ointments, inhalations, powders, pills, and maceration extracts [3]. French chemist Rene-Maurice Gattefosse experimented with EOs for wound healing during World War I [4]. India and China also began using herbs as a medicine around the same time as Ancient Egypt, and currently, there is an increasing demand and interest in “natural medicine” due to concerns about synthetic drugs, fertilizers, and pesticides [5]. However, the use of aromatherapy for emotional and mental well-being gained popularity in the 1980s when research on mind–body healing and psychoneuroimmunology increased interest in the potential benefits of aromatherapy. It is commonly believed that certain scents can affect a person’s emotional state [6][7].
Approximately 3000 EOs are known to be used, and their use is increasingly studied now due to the need for alternative therapies for oral microbiome pathologies [8]. According to the World Health Organization, about 80% of the population uses herbal medicine, and its industrialization has highly increased [9]. EOs are effective as antioxidants, mostly because of their activity in food preservation [10], and they are known to possess anti-carcinogenic, antimicrobial, and anti-inflammatory properties due to over 200 constituents [11][12]. EOs are a mixture of volatile constituents produced by aromatic plants, serving as a protective mechanism against microorganisms [13]. Clove oil, also known as Eugenol in dentistry, is an aromatic oil extracted from cloves that have been proven to be very useful in root canal treatments in the past decade. However, many more EOs are now being studied for their therapeutic use, such as Tea tree oil, Thyme oil, Cinnamon oil, Citrus oil, Bergamot oil, Lavender oil, and Peppermint oil. In dentistry, the most common pathologies are bacterial and fungal, with pathogens such as Streptococcus mutans (S. mutans), Streptococcus salivarius (S. salivarius), Streptococcus sanguis (S. sanguis), Streptococcus sobrinus (S. sobrinus), Porphyromonas gingivalis (P. gingivalis), Prevotella intermedia (P. intermedia), Enterococcus faecalis (E. faecalis), Candida albicans (C. albicans), and Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) often modifying the oral microbiome and resisting other known therapies [2][14]. Increased bacterial resistance, the high costs of therapeutic procedures, and the many adverse effects have led to further research on traditional medicines obtained from plant sources [15][16]. Despite the widespread use of commercial drugs as trusted therapies, many people still use natural products for primary healthcare [17].
The oral cavity is a habitat for many microorganisms that form a complex structure, the biofilm, that adheres to teeth and oral epithelium. Oral diseases occur when there is an imbalance between the oral ecosystem and the biofilm; thus, the absence of microorganisms is preferred to maintain oral health [18]. As a result, natural agents have become necessary, making EOs great alternatives to antibiotics and other used therapies, such as photoactivation and lasers [19].

2. Composition

EOs, also known as “volatile oils,” are produced by aromatic plants as secondary metabolites and are characterized by their strong smell [20]. The chemical composition varies and depends on geographical location, botanical origin, genetics, bacterial endophytes, and extraction techniques [21]. They are synthesized from plants, especially from their leaves, fruits, resins, seeds, woods, barks, and berries, and they are known as “essentials” because they trap the essence of the plant, its taste, and its odor [22]. They have attracted the interest of research groups because they can be applied to the development of new solutions used for the improvement of oral hygiene [23]. EOs are complex substances that include hundreds of components [10] but are characterized by two or three significant compounds [24].
The main composition is made of hydrocarbon terpenes and terpenoids [25][26], and other common compounds are alcohols, acids, esters, epoxides, aldehydes, ketones, amines, sulfides, oxides, fatty acids, other sulfur derivates; the most critical ones for their activities are terpineol, thujanol, myrcenol, neral, thujone, camphor, carvone [27][28]. The majority of terpenoids consist of monoterpenes and sesquiterpenes, and the other group is oxygenated derivatives of hydrocarbon terpenes [25]. Due to their potential therapeutic benefits against various illnesses, monoterpenes have been the subject of extensive research [29]. EOs have been proven to be a valuable source of antitumor agents. In addition, their effectiveness in both mechanisms of action and clinical use in cancer treatment has been demonstrated [30]. The bactericide or bacteriostatic effects are due to terpenes and terpenoids, aromatic, and aliphatic constituents [31], and the antimicrobial activity is related to their composition, configuration, amount, and possible interactions [32]. The antimicrobial activities might also be due to their major phenolic or alcohol monoterpenes components [33], but Table 1 explains that in more detail.
Table 1. EOs’ chemical compounds and their bacterial target.

3. Applications

Oral health refers to the health of the teeth, gums, tongue, cheeks, and the entire oro-facial system that provides the human physiological functions. The most common dental diseases are dental cavities, periodontitis, gingivitis, and oral cancer, and EOs seem to have a beneficial role in each one of them, as seen in Table 2. Even though the research area is quite large, further clinical trials must be performed before using these EOs as therapeutic agents [47].
Dental cavities are one of the leading global public health problems; the first step of dental cavities and periodontitis is the accumulation of microbial plaque on dental surfaces. Next, the bacteria produce acids which progress further destruction of the teeth. There are about twenty-five species of Streptococci in the oral cavity, from which S. mutans and S. sobrinus have a direct association with tooth decay [48].
Table 2. Dental diseases and EOs uses.

4. Therapeutic Properties

The applications of EOs depend on the plant source and are very diverse. They are also used in cosmetics and in the food and pharmaceutical industries. In addition, they have immunomodulatory effects by increasing the number of circulating lymphocytes [59]. A certain number of EOs have been reported to be antibacterial, antifungal, and anti-inflammatory agents against oral pathogens, and other therapeutic effects are shown in Figure 1 [60]. Additionally, they can alleviate anxiety, depression, and nausea [61][62][63].
Figure 1. The therapeutic effects of EOs in diverse fields of dentistry.
EOs are found to be most efficient against S. mutans, followed by S. sobrinus, salivarius, sanguis, and Lactobacillus acidophilus (L. acidophilus) [13]. EOs have also been tested against C. albicans, but only a few studies have been conducted on their activity [64][65]. Oregano oil was found to prevent the adhesion and formation of C. albicans biofilm. It also reduced biofilm formation on surfaces previously treated with the oil [60].
The primary antimicrobial mechanisms of EOs are associated with increased cell membrane permeability; this results in the extravasation of ions and cellular contents and cell lysis [66]. EOs damage cells differently by changing the structure and function of the membrane or by interfering with the cell metabolism and causing its death [60]. They can also interfere with protein synthesis or cell division by stimulating the production of reactive oxygen species [66].
Studies have shown that EOs also have antiviral effects on several viruses: Coxsackie, HAdV, HCMV, HIV, HSV (1 and 2), HINI, SARS-CoV, VSV, and YF, but further studies have to comply [59][61][67].

5. Uses of EOs as Products in Dentistry

EOs are recognized as safe, and they stimulated searchers as a natural treatment of dental diseases [60]. However, despite the research progress that has been performed until now, studies regarding EOs’ approaching potential application in dentistry are still not discussed enough [13]. EOs are very useful in dentistry in the following fields: endodontics, periodontics, surgery, and oral prevention [68], and can be found in several dental products, as shown in Figure 2. They are known to be useful as oral hygiene adjuncts, anxiolytics, wound dressing, dental implants, and preservatives.
Figure 2. EOs found in dental products.

5.1. Oral Hygiene Adjuncts

EOs have been used since the 19th century in dentistry as a mouthwash for the prevention of dental diseases. Bacterial counts in saliva dropped 10–20% after rinsing and remained efficient for 7 to 12 h [69]. A randomized clinical trial found that the daily use of an EO-based mouthwash can significantly reduce plaque, gingivitis, and periodontitis more than 0.05% cetyl pyridinium chloride-containing mouth rinse [70]. A short daily application of EO mouthwash rinses is not harmful and has no irritation potential [71], but some clinical trials showed that they possess different degrees of cytotoxicity [72]. EOs seem to have a plaque-inhibitory effect, so the soft tissues would gain supplementary protection against bacterial attack [73]. Even if chlorhexidine (CHX) tends to be the first choice for plaque control and the management of gingivitis and periodontitis, the most reliable alternative is EOs; CHX provides tooth discoloration, the desquamation of oral mucosa, taste disturbances, and supragingival calculus deposition so that EOs could be preferred [74][75]. EOs in mouthwashes kill viruses by disrupting the phospholipid bilayer, altering the viral envelope, and spiking proteins to prevent the virus from attaching to host cells. The main side effects of using EO mouthwashes are a burning sensation and temporary enanthema [67]. Lavender oil also has solid antiseptic properties against Staphylococcus aureus (S. aureus) and Enterococcus coli (E. coli) [39]. However, for Candida albicans (C. albicans), more studies need to be conducted [8][76]. It is used in mouth, throat, and upper respiratory tract infections by showing substantial antibacterial effects. Thyme oil showed antiviral properties against the Herpes simplex virus and had bacteriostatic and antimicrobial effects [35][38]. Citrus fruits such as sweet orange, bitter orange, lemon, lime, grapefruit, bergamot, yuzu, and kumquat are found to be effective as medicinal agents in mouthwashes, too; they have the following properties: anti-tumor, antibacterial, antifungal, larvicidal, antioxidant, anti-carcinogenic, and anti-inflammatory effects, but the data based on oral pathology are not shown yet [77][78]. Other studies concluded that even if the natural-based mouth rinses have plaque-inhibitory potential, the gold standard remains CHX-based mouthwashes [75][79][80].

5.2. Anxiolytics

Aromatherapy, a form of complementary therapy, is widely used in many countries and involves using EOs through inhalation, skin absorption, or ingestion for preventive and active medical care. In recent years, it has alleviated insomnia, depression, anxiety, and cognitive disorders. In addition, accumulating evidence over the past decade has demonstrated that EOs have measurable pharmacological effects without the adverse effects commonly associated with psychotropic drugs [81]. The emotional stress that often appears in dental patients can also be altered by using EOs [40][82]. Using aromatherapy of Lavender oil in the waiting area or Citrus oil to reduce salivary cortisol and pulse rate has also been helpful in stress management. A study shows that using a candle warmer diluted with Lavender oil in dental offices before procedures increased sedation, decreased stress and anxiety, and improved overall mood [83]; it was found to be useful in third molar extractions and orthognathic surgeries because of its anxiolytic properties [21][76][84][85]. A study by Sioh Kim et al. showed that Lavender oil also reduces injection pain [86].


  1. Gao, L.; Xu, T.; Huang, G.; Jiang, S.; Gu, Y.; Chen, F. Oral Microbiomes: More and More Importance in Oral Cavity and Whole Body. Protein Cell 2018, 9, 488–500.
  2. Kuang, X.; Chen, V.; Xu, X. Novel Approaches to the Control of Oral Microbial Biofilms. BioMed Res. Int. 2018, 2018, 6498932.
  3. Bungau, S.G.; Popa, V.-C. Between Religion and Science: Some Aspects: Concerning Illness and Healing in Antiquity. Transylv. Rev. 2015, 24, 3–18.
  4. Robins, J.L. The Science and Art of Aromatherapy. J. Holist. Nurs. Off. J. Am. Holist. Nurses’ Assoc. 1999, 17, 5–17.
  5. Hoffmann, K.H. Essential Oils. Z. Fur Naturforsch. Sect. C J. Biosci. 2020, 75, 177.
  6. Fung, T.K.H.; Lau, B.W.M.; Ngai, S.P.C.; Tsang, H.W.H. Therapeutic Effect and Mechanisms of Essential Oils in Mood Disorders: Interaction between the Nervous and Respiratory Systems. Int. J. Mol. Sci. 2021, 22, 4844.
  7. Zhang, Y.; Long, Y.; Yu, S.; Li, D.; Yang, M.; Guan, Y.; Zhang, D.; Wan, J.; Liu, S.; Shi, A.; et al. Natural Volatile Oils Derived from Herbal Medicines: A Promising Therapy Way for Treating Depressive Disorder. Pharmacol. Res. 2021, 164, 105376.
  8. Thosar, N.; Basak, S.; Bahadure, R.N.; Rajurkar, M. Antimicrobial Efficacy of Five Essential Oils against Oral Pathogens: An in Vitro Study. Eur. J. Dent. 2013, 7, S071–S077.
  9. Leherbauer, I.; Stappen, I. Selected Essential Oils and Their Mechanisms for Therapeutic Use against Public Health Disorders. An Overview. Z. Naturforsch. C. 2020, 75, 205–223.
  10. Ramsey, J.T.; Shropshire, B.C.; Nagy, T.R.; Chambers, K.D.; Li, Y.; Korach, K.S. Essential Oils and Health. Yale J. Biol. Med. 2020, 93, 291–305.
  11. Kouidhi, B.; Al Qurashi, Y.M.A.; Chaieb, K. Drug Resistance of Bacterial Dental Biofilm and the Potential Use of Natural Compounds as Alternative for Prevention and Treatment. Microb. Pathog. 2015, 80, 39–49.
  12. Freires, I.A.; Denny, C.; Benso, B.; De Alencar, S.M.; Rosalen, P.L. Antibacterial Activity of Essential Oils and Their Isolated Constituents against Cariogenic Bacteria: A Systematic Review. Molecules 2015, 20, 7329–7358.
  13. Toscano-Garibay, J.D.; Arriaga-Alba, M.; Sánchez-Navarrete, J.; Mendoza-García, M.; Flores-Estrada, J.J.; Moreno-Eutimio, M.A.; Espinosa-Aguirre, J.J.; González-Ávila, M.; Ruiz-Pérez, N.J. Antimutagenic and Antioxidant Activity of the Essential Oils of Citrus Sinensis and Citrus Latifolia. Sci. Rep. 2017, 7, 11479.
  14. Rahman, M.M.; Alam Tumpa, M.A.; Zehravi, M.; Sarker, M.T.; Yamin, M.; Islam, M.R.; Harun-Or-Rashid, M.; Ahmed, M.; Ramproshad, S.; Mondal, B.; et al. An Overview of Antimicrobial Stewardship Optimization: The Use of Antibiotics in Humans and Animals to Prevent Resistance. Antibiotics 2022, 11, 667.
  15. Salehi, B.; Valussi, M.; Flaviana Bezerra Morais-Braga, M.; Nalyda Pereira Carneiro, J.; Linkoln Alves Borges Leal, A.; Douglas Melo Coutinho, H.; Vitalini, S.; Kręgiel, D.; Antolak, H.; Sharifi-Rad, M.; et al. Tagetes Spp. Essential Oils and Other Extracts: Chemical Characterization and Biological Activity. Molecules 2018, 23, 2847.
  16. Bersan, S.M.F.; Galvão, L.C.C.; Goes, V.F.F.; Sartoratto, A.; Figueira, G.M.; Rehder, V.L.G.; Alencar, S.M.; Duarte, R.M.T.; Rosalen, P.L.; Duarte, M.C.T. Action of Essential Oils from Brazilian Native and Exotic Medicinal Species on Oral Biofilms. BMC Complement. Altern. Med. 2014, 14, 451.
  17. Mocanu, R.C.; Martu, M.-A.; Luchian, I.; Sufaru, I.G.; Maftei, G.A.; Ioanid, N.; Martu, S.; Tatarciuc, M. Microbiologic Profiles of Patients with Dental Prosthetic Treatment and Periodontitis before and after Photoactivation Therapy-Randomized Clinical Trial. Microorganisms 2021, 9, 713.
  18. Mutlu-Ingok, A.; Devecioglu, D.; Dikmetas, D.N.; Karbancioglu-Guler, F.; Capanoglu, E. Antibacterial, Antifungal, Antimycotoxigenic, and Antioxidant Activities of Essential Oils: An Updated Review. Molecules 2020, 25, 4711.
  19. Dobler, D.; Runkel, F.; Schmidts, T.; Osso, D.; Kanani, N.; Bersan, S.M.F.; Galvão, L.C.C.; Goes, V.F.F.; Sartoratto, A.; Figueira, G.M.; et al. Essential Oils: Extraction Techniques, Pharmaceutical And Therapeutic Potential—A Review. BMC Complement. Altern. Med. 2018, 15, 10–18.
  20. Lemes, R.S.; Alves, C.C.F.; Estevam, E.B.B.; Santiago, M.B.; Martins, C.H.G.; Dos Santos, T.C.L.; Crotti, A.E.M.; Miranda, M.L.D. Chemical Composition and Antibacterial Activity of Essential Oils from Citrus Aurantifolia Leaves and Fruit Peel against Oral Pathogenic Bacteria. An. Acad. Bras. Cienc. 2018, 90, 1285–1292.
  21. De Oliveira, J.R.; Camargo, S.E.A.; De Oliveira, L.D. Rosmarinus Officinalis L. (Rosemary) as Therapeutic and Prophylactic Agent. J. Biomed. Sci. 2019, 26, 5.
  22. Donato, R.; Sacco, C.; Pini, G.; Bilia, A.R. Antifungal Activity of Different Essential Oils against Malassezia Pathogenic Species. J. Ethnopharmacol. 2020, 249, 112376.
  23. Nazzaro, F.; Fratianni, F.; Coppola, R.; De Feo, V. Essential Oils and Antifungal Activity. Pharmaceuticals 2017, 10, 86.
  24. Carrouel, F.; Gonçalves, L.S.; Conte, M.P.; Campus, G.; Fisher, J.; Fraticelli, L.; Gadea-Deschamps, E.; Ottolenghi, L.; Bourgeois, D. Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2. J. Dent. Res. 2021, 100, 124–132.
  25. Elyemni, M.; Louaste, B.; Nechad, I.; Elkamli, T.; Bouia, A.; Taleb, M.; Chaouch, M.; Eloutassi, N. Extraction of Essential Oils of Rosmarinus Officinalis L. by Two Different Methods: Hydrodistillation and Microwave Assisted Hydrodistillation. Sci. World J. 2019, 2019, 3659432.
  26. Machado, T.Q.; da Fonseca, A.C.C.; Duarte, A.B.S.; Robbs, B.K.; de Sousa, D.P. A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update. Biomed Res. Int. 2022, 2022, 6317201.
  27. Farrar, A.J.; Farrar, F.C. Clinical Aromatherapy. Nurs. Clin. N. Am. 2020, 55, 489–504.
  28. Jampilek, J.; Kralova, K. Anticancer Applications of Essential Oils Formulated into Lipid-Based Delivery Nanosystems. Pharmaceutics 2022, 14, 2681.
  29. Karadağlıoğlu, Ö.İ.; Ulusoy, N.; Başer, K.H.C.; Hanoğlu, A.; Şık, İ. Antibacterial Activities of Herbal Toothpastes Combined with Essential Oils against Streptococcus Mutans. Pathogens 2019, 8, 20.
  30. Quintas, V.; Prada-López, I.; Carreira, M.J.; Suárez-Quintanilla, D.; Balsa-Castro, C.; Tomás, I. In Situ Antibacterial Activity of Essential Oils with and without Alcohol on Oral Biofilm: A Randomized Clinical Trial. Front. Microbiol. 2017, 8, 2162.
  31. Zomorodian, K.; Ghadiri, P.; Saharkhiz, M.J.; Moein, M.R.; Mehriar, P.; Bahrani, F.; Golzar, T.; Pakshir, K.; Fani, M.M. Antimicrobial Activity of Seven Essential Oils from Iranian Aromatic Plants against Common Causes of Oral Infections. Jundishapur J. Microbiol. 2015, 8, e17766.
  32. Jafri, H.; Ahmad, I. Thymus Vulgaris Essential Oil and Thymol Inhibit Biofilms and Interact Synergistically with Antifungal Drugs against Drug Resistant Strains of Candida Albicans and Candida Tropicalis. J. Mycol. Med. 2020, 30, 100911.
  33. Abdelli, W.; Bahri, F.; Romane, A.; Höferl, M.; Wanner, J.; Schmidt, E.; Jirovetz, L. Chemical Composition and Anti-Inflammatory Activity of Algerian Thymus Vulgaris Essential Oil. Nat. Prod. Commun. 2017, 12, 611–614.
  34. Marchese, A.; Barbieri, R.; Coppo, E.; Orhan, I.E.; Daglia, M.; Nabavi, S.F.; Izadi, M.; Abdollahi, M.; Nabavi, S.M.; Ajami, M. Antimicrobial Activity of Eugenol and Essential Oils Containing Eugenol: A Mechanistic Viewpoint. Crit. Rev. Microbiol. 2017, 43, 668–689.
  35. Alexa, V.T.; Szuhanek, C.; Cozma, A.; Galuscan, A.; Borcan, F.; Obistioiu, D.; Dehelean, C.A.; Jumanca, D. Natural Preparations Based on Orange, Bergamot and Clove Essential Oils and Their Chemical Compounds as Antimicrobial Agents. Molecules 2020, 25, 5502.
  36. Bogdan, M.A.; Bungau, S.; Tit, D.M.; Zaha, D.C.; Nechifor, A.C.; Behl, T.; Chambre, D.; Lupitu, A.I.; Copolovici, L.; Copolovici, D.M. Chemical Profile, Antioxidant Capacity, and Antimicrobial Activity of Essential Oils Extracted from Three Different Varieties (Moldoveanca 4, Vis Magic 10, and Alba 7) of Lavandula Angustifolia. Molecules 2021, 26, 4381.
  37. Arslan, I.; Aydinoglu, S.; Karan, N.B. Can Lavender Oil Inhalation Help to Overcome Dental Anxiety and Pain in Children? A Randomized Clinical Trial. Eur. J. Pediatr. 2020, 179, 985–992.
  38. Liu, Z.; Mei, L.; Wang, Q.; Shao, Y.; Tao, Y. Optimization of Subcritical Fluid Extraction of Seed Oil from Nitraria Tangutorum Using Response Surface Methodology. LWT—Food Sci. Technol. 2014, 56, 168–174.
  39. Yanakiev, S. Effects of Cinnamon (Cinnamomum Spp.) in Dentistry: A Review. Molecules 2020, 25, 4184.
  40. Choonharuangdej, S.; Srithavaj, T.; Thummawanit, S. Fungicidal and Inhibitory Efficacy of Cinnamon and Lemongrass Essential Oils on Candida Albicans Biofilm Established on Acrylic Resin: An in Vitro Study. J. Prosthet. Dent. 2021, 125, 707.e1–707.e6.
  41. Dagli, N.; Dagli, R.; Mahmoud, R.S.; Baroudi, K. Essential Oils, Their Therapeutic Properties, and Implication in Dentistry: A Review. J. Int. Soc. Prev. Community Dent. 2015, 5, 335–340.
  42. Chaudhari, L.K.D.; Jawale, B.A.; Sharma, S.; Sharma, H.; Kumar, H.S.C.M.; Kulkarni, P.A. Antimicrobial Activity of Commercially Available Essential Oils against Streptococcus Mutans. J. Contemp. Dent. Pract. 2012, 13, 71–74.
  43. Białoń, M.; Krzyśko-Łupicka, T.; Koszałkowska, M.; Wieczorek, P.P. The Influence of Chemical Composition of Commercial Lemon Essential Oils on the Growth of Candida Strains. Mycopathologia 2014, 177, 29–39.
  44. Dosoky, N.S.; Setzer, W.N. Biological Activities and Safety of Citrus Spp. Essential Oils. Int. J. Mol. Sci. 2018, 19, 1966.
  45. Shetty, S.B.; Mahin-Syed-Ismail, P.; Varghese, S.; Thomas-George, B.; Kandathil-Thajuraj, P.; Baby, D.; Haleem, S.; Sreedhar, S.; Devang-Divakar, D. Antimicrobial Effects of Citrus Sinensis Peel Extracts against Dental Caries Bacteria: An in Vitro Study. J. Clin. Exp. Dent. 2016, 8, e71–e77.
  46. Takahashi, N.; Nyvad, B. The Role of Bacteria in the Caries Process: Ecological Perspectives. J. Dent. Res. 2011, 90, 294–303.
  47. Kouidhi, B.; Zmantar, T.; Bakhrouf, A. Anticariogenic and Cytotoxic Activity of Clove Essential Oil (Eugenia Caryophyllata) against a Large Number of Oral Pathogens. Ann. Microbiol. 2010, 60, 599–604.
  48. Moghadam, P.; Dadelahi, S.; Hajizadeh, Y.S.; Matin, M.G.; Amini, M.; Hajazimian, S. Chemical Composition and Antibacterial Activities of Sumac Fruit (Rhus Coriaria) Essential Oil on Dental Caries Pathogens. Open Microbiol. J. 2020, 14, 142–146.
  49. Scannapieco, F.A.; Gershovich, E. The Prevention of Periodontal Disease—An Overview. Periodontol. 2000 2020, 84, 9–13.
  50. Dadpe, M.V.; Trambakrao Dahake, P.; Pathan, J.M.; Kale, Y.J.; Dahake, P.T.; Kendre, S.B. Evaluation of Lavender Oil as a Topical Analgesic Agent before Dental Anaesthesia through Pain Rating Scales-An in Vivo Study. Artic. IOSR J. Dent. Med. Sci. 2020, 19, 6–13.
  51. Tiberiu Alexa, V.; Galuscan, A.; Popescu, I.; Tirziu, E.; Obistioiu, D.; Floare, A.D.; Perdiou, A.; Jumanca, D. Synergistic/Antagonistic Potential of Natural Preparations Based on Essential Oils Against Streptococcus Mutans from the Oral Cavity. Molecules 2019, 24, 4043.
  52. Zhang, N.; Yao, L. Anxiolytic Effect of Essential Oils and Their Constituents: A Review. J. Agric. Food Chem. 2019, 67, 13790–13808.
  53. Carvalho, A.A.; Andrade, L.N.; De Sousa, É.B.V.; De Sousa, D.P. Antitumor Phenylpropanoids Found in Essential Oils. Biomed. Res. Int. 2015, 21, 392674.
  54. Bhalla, Y.; Gupta, V.K.; Jaitak, V. Anticancer Activity of Essential Oils: A Review. J. Sci. Food Agric. 2013, 93, 3643–3653.
  55. Andrade, M.A.; Braga, M.A.; Cesar, P.H.S.; Trento, M.V.C.; Espósito, M.A.; Silva, L.F.; Marcussi, S. Anticancer Properties of Essential Oils: An Overview. Curr. Cancer Drug Targets 2018, 18, 957–966.
  56. Haro-González, J.N.; Castillo-Herrera, G.A.; Martínez-Velázquez, M.; Espinosa-Andrews, H. Clove Essential Oil (Syzygium Aromaticum L. Myrtaceae): Extraction, Chemical Composition, Food Applications, and Essential Bioactivity for Human Health. Molecules 2021, 26, 6387.
  57. Sandner, G.; Heckmann, M.; Weghuber, J. Immunomodulatory Activities of Selected Essential Oils. Biomolecules 2020, 10, 1139.
  58. Shamseddine, L.; Chidiac, J.J. Composition’s Effect of Origanum Syriacum Essential Oils in the Antimicrobial Activities for the Treatment of Denture Stomatitis. Odontology 2021, 109, 327–335.
  59. Dagli, N. Unexplored Potential of Essential Oils in Reducing SARS-CoV-2 Viral Load in Dental Clinics. J. Int. Soc. Prev. Community Dent. 2021, 11, 357.
  60. Karan, N.B. Influence of Lavender Oil Inhalation on Vital Signs and Anxiety: A Randomized Clinical Trial. Physiol. Behav. 2019, 211, 112676.
  61. Soares, G.A.B.E.; Bhattacharya, T.; Chakrabarti, T.; Tagde, P.; Cavalu, S. Exploring Pharmacological Mechanisms of Essential Oils on the Central Nervous System. Plants 2021, 11, 21.
  62. Souza, C.M.C.; Junior, S.A.P.; Moraes, T.D.S.; Damasceno, J.L.; Mendes, S.A.; Dias, H.J.; Stefani, R.; Tavares, D.C.; Martins, C.H.G.; Crotti, A.E.M.; et al. Antifungal Activity of Plant-Derived Essential Oils on Candida Tropicalis Planktonic and Biofilms Cells. Med. Mycol. 2016, 54, 515–523.
  63. Rodrigues, C.F.; Rodrigues, M.E.; Henriques, M.C.R. Promising Alternative Therapeutics for Oral Candidiasis. Curr. Med. Chem. 2019, 26, 2515–2528.
  64. Ferreira, E.D.S.; Rosalen, P.L.; Benso, B.; de Cássia Orlandi Sardi, J.; Denny, C.; Alves de Sousa, S.; Queiroga Sarmento Guerra, F.; de Oliveira Lima, E.; Almeida Freires, I.; Dias de Castro, R. The Use of Essential Oils and Their Isolated Compounds for the Treatment of Oral Candidiasis: A Literature Review. Evid. Based Complement. Altern. Med. 2021, 2021, 1059274.
  65. Chen, M.-H.; Chang, P.-C. The Effectiveness of Mouthwash against SARS-CoV-2 Infection: A Review of Scientific and Clinical Evidence. J. Formos. Med. Assoc. 2022, 121, 879–885.
  66. Lakhdar, L.; Hmamouchi, M.; Rida, S.; Ennibi, O. Antibacterial Activity of Essential Oils against Periodontal Pathogens: A Qualitative Systematic Review. Odontostomatol. Trop. 2012, 35, 38–46.
  67. Van Leeuwen, M.P.C.; Slot, D.E.; Van der Weijden, G.A. Essential Oils Compared to Chlorhexidine With Respect to Plaque and Parameters of Gingival Inflammation: A Systematic Review. J. Periodontol. 2011, 82, 174–194.
  68. Sharma, N.C.; Araujo, M.W.B.; Wu, M.M.; Qaqish, J.; Charles, C.H. Superiority of an Essential Oil Mouthrinse When Compared with a 0.05% Cetylpyridinium Chloride Containing Mouthrinse: A Six-Month Study. Int. Dent. J. 2010, 60, 175–180.
  69. Saliasi, I.; Llodra, J.C.; Bravo, M.; Tramini, P.; Dussart, C.; Viennot, S.; Carrouel, F. Effect of a Toothpaste/Mouthwash Containing Carica Papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial. Int. J. Environ. Res. Public Health 2018, 15, 2660.
  70. Filipović, G.; Stevanović, M.D.; Stojanović-Radić, Z.; Obradović, R.; Randjelović, P.J.; Radulović, N.S. Choosing the Right Essential Oil for a Mouthwash: Chemical, Antimicrobial and Cytotoxic Studies. Chem. Biodivers. 2020, 17, e2000748.
  71. Dagli, N.; Dagli, R. Possible Use of Essential Oils in Dentistry. J. Int. Oral Health JIOH 2014, 6, i–ii.
  72. Van der Weijden, F.A.; Van der Sluijs, E.; Ciancio, S.G.; Slot, D.E. Can Chemical Mouthwash Agents Achieve Plaque/Gingivitis Control? Dent. Clin. North Am. 2015, 59, 799–829.
  73. Singh, A.; Daing, A.; Dixit, J. The Effect of Herbal, Essential Oil and Chlorhexidine Mouthrinse on de Novo Plaque Formation. Int. J. Dent. Hyg. 2013, 11, 48–52.
  74. Kajjari, S.; Joshi, R.S.; Hugar, S.M.; Gokhale, N.; Meharwade, P.; Uppin, C. The Effects of Lavender Essential Oil and Its Clinical Implications in Dentistry: A Review. Int. J. Clin. Pediatr. Dent. 2022, 15, 385–388.
  75. Dosoky, N.S.; Setzer, W.N. Chemical Composition and Biological Activities of Essential Oils of Curcuma Species. Nutrients 2018, 10, 1196.
  76. Geraci, A.; Di Stefano, V.; Di Martino, E.; Schillaci, D.; Schicchi, R. Essential Oil Components of Orange Peels and Antimicrobial Activity. Nat. Prod. Res. 2017, 31, 653–659.
  77. Marica, A.; Fritea, L.; Banica, F.; Sinescu, C.; Iovan, C.; Hulka, I.; Rusu, G.; Cavalu, S. Carbon Nanotubes for Improved Performances of Endodontic Sealer. Materials 2021, 14, 4284.
  78. Raj, R.; Haideri, S.; Yadav, B.K.; Chandra, J.; Malik, R.; Raj, A. The Effect of Mouthwashes on Fluoride Dentifrices in Preventing Dental Abrasion or Erosion. J. Med. Life 2021, 14, 361–366.
  79. Lizarraga-Valderrama, L.R. Effects of Essential Oils on Central Nervous System: Focus on Mental Health. Phytother. Res. 2021, 35, 657–679.
  80. Lowring, L.M. Using Therapeutic Essential Oils to Support the Management of Anxiety. J. Am. Assoc. Nurse Pract. 2019, 31, 558–561.
  81. Zabirunnisa, M.; Gadagi, J.S.; Gadde, P.; Myla, N.; Koneru, J.; Thatimatla, C. Dental Patient Anxiety: Possible Deal with Lavender Fragrance. J. Res. Pharm. Pract. 2014, 3, 100–103.
  82. Aćimović, M. Essential Oils: Inhalation Aromatherapy-A Comprehensive Review. Technol. Eng. Manag. J. Agron. Technol. Eng. Manag. 2021, 4, 547–557.
  83. Bozkurt, P.; Vural, Ç. Effect of Lavender Oil Inhalation on Reducing Presurgical Anxiety in Orthognathic Surgery Patients. J. Oral Maxillofac. Surg. Off. J. Am. Assoc. Oral Maxillofac. Surg. 2019, 77, e1–e2466.
  84. Kim, S.; Kim, H.-J.; Yeo, J.-S.; Hong, S.-J.; Lee, J.-M.; Jeon, Y. The Effect of Lavender Oil on Stress, Bispectral Index Values, and Needle Insertion Pain in Volunteers. J. Altern. Complement. Med. 2011, 17, 823–826.
  85. Budzyńska, A.; Sadowska, B.; Wieckowska-Szakiel, M.; Rózalska, B. In vitro efficacy analysis of absorbent dressing modified with essential oils, against Staphylococcus aureus and Candida albicans. Med. Dosw. Mikrobiol. 2013, 65, 77–86.
  86. Gheorghita, D.; Grosu, E.; Robu, A.; Ditu, L.M.; Deleanu, I.M.; Gradisteanu Pircalabioru, G.; Raiciu, A.-D.; Bita, A.-I.; Antoniac, A.; Antoniac, V.I. Essential Oils as Antimicrobial Active Substances in Wound Dressings. Materials 2022, 15, 6923.
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