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Tang, X.;  Xu, Q.;  Yang, S.;  Huang, X.;  Wang, L.;  Huang, F.;  Luo, J.;  Zhou, X.;  Wu, A.;  Mei, Q.; et al. Inflammation and Platelets. Encyclopedia. Available online: https://encyclopedia.pub/entry/40216 (accessed on 16 November 2024).
Tang X,  Xu Q,  Yang S,  Huang X,  Wang L,  Huang F, et al. Inflammation and Platelets. Encyclopedia. Available at: https://encyclopedia.pub/entry/40216. Accessed November 16, 2024.
Tang, Xiaoqin, Qian Xu, Shuo Yang, Xinwu Huang, Long Wang, Feihong Huang, Jiesi Luo, Xiaogang Zhou, Anguo Wu, Qibing Mei, et al. "Inflammation and Platelets" Encyclopedia, https://encyclopedia.pub/entry/40216 (accessed November 16, 2024).
Tang, X.,  Xu, Q.,  Yang, S.,  Huang, X.,  Wang, L.,  Huang, F.,  Luo, J.,  Zhou, X.,  Wu, A.,  Mei, Q.,  Zhao, C., & Wu, J. (2023, January 16). Inflammation and Platelets. In Encyclopedia. https://encyclopedia.pub/entry/40216
Tang, Xiaoqin, et al. "Inflammation and Platelets." Encyclopedia. Web. 16 January, 2023.
Inflammation and Platelets
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This entry is adapted from the peer-reviewed paper 10.3390/ijms24021010

Platelets are the second most abundant blood component after red blood cells and can participate in a variety of physiological and pathological functions. Beyond its traditional role in hemostasis and thrombosis, it also plays an indispensable role in inflammatory diseases.

toll-like receptors inflammation thrombopoiesis

1. Introduction

Platelets are small (2–4 μm) and are the end products of membrane protrusions from MKs that extend into the sinusoidal vessels, where they are sheered off by blood flow [1]. Remarkably, megakaryocytes (MKs) migrate from the HSC (hematopoietic stem cell) osteoblastic niche to the vascular niche, which is spatially and temporally regulated by transcription factors, signaling and adhesion molecules, and cytokines and chemokines in the process of progressive differentiation [2]. Various aspects, such as differentiation maturity, determine the formation of platelets. Generally, megakaryocytes tailor their cytoplasm and membrane systems for platelet biogenesis. Before a megakaryocyte has the capacity to release platelets, it enlarges considerably and fills with high concentrations of ribosomes and a complete demarcation membrane system (DMS) [3][4][5]. In adults, platelet generation can be divided into two stages that entail the differentiation of HSCs into mature megakaryocytes (MKs; termed megakaryocytes) and the release of platelets from MKs (termed thrombopoiesis or platelet biogenesis) (Figure 1) [6][7]. Although human adults contain nearly one trillion platelets in circulation that are turned over every 8–10 days, it is worth noting that the reduction in platelet count and the dysfunction of platelets will lead to a variety of diseases. Thus, the relevant mechanisms driving platelet formation and platelet function are appreciated. At present, platelets have been recognized as integral players in the inflammatory response and an important mediator in the activation of innate immunity [8][9][10][11][12]. At the same time, studies have shown that platelets express a variety of receptors, some of which are involved in platelet activation, platelet–leucocyte reciprocal activation, immunopathology, and platelet-dependent antimicrobial activity, including the TLR family [13][14]. Toll-like receptors (TLRs) can regulate inflammation and activate the innate immune signaling pathways. Meanwhile, TLRs exist in hematopoietic stem cells and megakaryocytes, which can promote platelet generation and function (see below).
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Figure 1. Schematic of platelet production. Inflammatory factors play an important role in the formation of platelets by bone marrow hematopoietic stem cells under physiological and inflammatory conditions. Acute inflammation can drive efficient cell cycle activation and maturation of SL-MKPs to rapidly replenish platelet pools. HSC: hematopoietic stem cell; CLP: common lymphoid progenitor; GMP: granulocyte-macrophage progenitor; CMP: common myeloid progenitor; MEP: megakaryocyte-erythroid progenitor; Mk-P: megakaryocyte progenitor; Sl-Mkp: stem-like megakaryocyte progenitors; TPO: thrombopoietin; MK: megakaryocyte; IL: interleukin.
TLRs are one of the most important receptors in the activation of innate immunity and have a certain regulatory effect on the regulation of inflammation, and there is an inseparable connection between the two [15]. TLR activation triggers signaling cascades with a common downstream signaling pathway to induce the production of pro-inflammatory cytokines and type I interferons: the former triggers the synthesis of the inflammatory mediators that cause fever, pain and other inflammation, and the latter mediates antiviral responses [16][17]. In addition, studies have found that TLR’s activation of the immune response is a temporary coordinated output that can transition from releasing pro-inflammatory attack mediators to initiating the inflammatory mediators required for decomposition and tissue repair [18]. However, the abnormal activation of TLR signals can lead to autoimmune, sepsis and chronic inflammatory diseases [19][20][21]. In conclusion, TLRs are an important therapeutic or regulatory target in the inflammatory response. On one hand, the high expression of TLR on CD34+ cells suggests that the expression of TLR on HSCs is an early sensory mechanism for HSCs to directly detect infection and immediately generate immune effector cells [22]. On the other hand, the expression of TLRs is also regulated during HSC differentiation, which has also been reported previously [23][24]. It has been proven that the inflammatory factors IL-3, IL-6, IL-9 and IL-11 indirectly affect TPO-induced MK production, while IL-3 and TPO synergistically promote MK differentiation [25][26][27]. Surprisingly, as early as 1987, an increase in MK progenitor cell formation was observed in mice treated with an inflammatory agent [28]. At the same time, TLR activation produces IL-6 and tumor necrosis factor-α (TNF-α). These two cytokines have a certain effect on platelet production. A series of studies have been conducted on its mechanism [29].
These results indicate that inflammatory factors can promote platelet production and that TLR is an important receptor for regulating inflammation. Meanwhile, platelets also express TLRs, and activating this receptor can regulate the function of platelets. In addition, TLR2 and TLR4 are the main receptors associated with platelet production/function and inflammation in the TLR family [30]. Moreover, some drugs acting on the TLR2 and TLR4 signaling pathways have been developed to treat diseases in order to improve the probability of cure and quality of life [31].

2. Inflammation and Platelets

Inflammation, as the second line of defense in innate immunity, is the body’s defense mechanism against pathogens, allergens/irritants, damaged cells, or any foreign invaders, manifested as redness, swelling, heat, pain, or dysfunction [32][33][34]. It is also an important part of innate immunity. At present, studies have shown that the body activates different pathways in response to the relevant stimuli and generally releases a large number of inflammatory factors, primarily γ-interferon, interleukin (IL), nitric oxide (NO) and TNF-α. It is beneficial to the body to remove harmful signals and initiate the response of the tissue healing process. Generally, it can be divided into two types, chronic and acute, depending on the characteristics of the response and stimulation. Among them, acute inflammation is primarily a form of regulation to restore homeostasis after damage to the body tissue, the symptoms of which are fever, redness, swelling and pain. The body response mainly involves mast cells releasing histamine and prostaglandins to dilate their blood vessels, and granulocytes migrate quickly to neutralize and remove harmful substances [35]. However, if acute inflammation fails to restore homeostasis, acute inflammation will gradually evolve into chronic inflammation and even cause more diseases. In chronic inflammation, macrophages and T lymphocytes mainly produce cytokines and enzymes that lead to tissue destruction, manifested as tissue fibrosis. As vascular first responders, platelets are key elements in the early phases of the inflammatory response (Figure 2). Platelets in the human body are not a uniform population, and platelet content varies with their size. Smaller platelets carry more inflammatory transcripts than larger platelets in a healthy population [36]. During the period of infection, antiviral protein in the blood platelet increases because the megakaryocyte cells start the reaction in the process of infection as a response to pathogens, directly activating platelets and releasing extracellular vesicles. In addition, platelets can directly sense pathogens and endogenous danger signals and promote the formation of antimicrobial and procoagulant neutrophil extracellular traps (NETs) through the expression of TLRs [37]. Remarkably, at the same time, platelets help leukocytes infiltrate tissues and exert their immune functions; they limit host tissue collateral damage by repairing vascular breaches caused by leukocyte trafficking and activation [37]. This suggests that platelets are an important mediator between innate immunity and inflammation [38]. In addition, the pathogenesis of inflammatory disease models has been demonstrated to rely on platelet-neutrophil complex formation [39]. First, they activate macrophages and monocytes and are critical in the recruitment and activation of neutrophils and they collaborate with neutrophils to initiate intravascular thrombosis, contributing to pathogen recognition, trapping, and disposal, thereby protecting the integrity of the host [39]. However, intravascular thrombosis caused by the interaction of platelets and white blood cells is called immune thrombosis, and this thrombotic reaction lasts too long in the body and may lead to disseminated intravascular coagulation (DIC), followed by multiple organ failure and even death. Second, platelets can migrate, aggregate, and adhere to bacteria in the body, contributing to the recruitment and stimulation of neutrophils and thus playing a direct antibacterial role [40][41]. This makes platelets attractive therapeutic targets for diseases ranging from chronic to acute inflammation or autoimmune diseases to bacterial, viral, and parasitic infections [42][43]. However, it is worth noting that, whilst platelets are the link between inflammation and host defense, the overreaction of platelets can also lead to disease. This is sufficient to show the multiplicity of platelets in inflammation.
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Figure 2. Inflammation and platelet interaction. Platelets are at the junction between inflammation and host defense. Platelets carry not only inflammatory transcripts but also antiviral proteins. Platelets activate/recruit a variety of cells for host defense in inflammation, meanwhile, and inflammation can promote platelet production through multiple channels. Red arrows indicate the enhanced physiological effects. Red “×” indicate the role of sterilization. Sl-Mkp: Stem-like megakaryocyte progenitors; TPO: Thrombopoietin; MK: megakaryocyte; MkP: Megakaryocyte progenitor.
In addition to some host-protecting reactions of platelets during inflammation, there are also studies showing that inflammation also plays a certain role in regulating platelet production. Thrombopoietin (TPO) is the most important regulator of megakaryocyte differentiation and platelet production [44]. In addition, studies have found that many inflammatory factors, such as IL-3, IL-6, IL-9, IL-11, IL-1α and IL-1β, can promote the role of TPO in promoting platelet production, while IL-3 and TPO can synergistically promote MK differentiation [25][26][27][45][46][47]. These results suggest that in the inflammatory state, inflammatory factors may be involved in mediating megakaryocyte differentiation and promoting platelet generation by regulating TPO synthesis [48][49]. In addition, IL-6 contributes to driving thrombocytosis in systemic inflammation during the acute inflammatory response [47][50]. For megakaryocyte progenitors, studies have also shown that inflammatory signals activate posttranscriptional protein synthesis, maturation and cell cycle induction in quiescence but initiate stem-like megakaryocyte progenitors (sl-MKPs) to improve megakaryocyte formation to replenish the platelet pool during acute inflammation, while sl-MKPs remain in the activated but quiescent state in the homeostatic state [51]. In addition, as early as 1987, after treating mice with inflammatory preparations, it was observed that the formation of MK progenitor cells increased [28]. The further link between inflammation and megakaryopoiesis can be the ROS (reactive oxygen species). When the body is endangered, innate immunity is activated, in which macrophages and neutrophils are activated and release ROS. At this time, HSCs will develop a bias toward the megakaryocyte lineage [52]. In addition, studies have also shown that in acute inflammation, IL-1α leads to the rapid, TPO-independent production of platelets, primarily through IL-1α signaling, decreased plasma membrane stability, dysregulated tubulin expression and proplatelet formation, which eventually trigger megakaryocytes to rupture and release large numbers of platelets in a short period of time [53]. According to research, megakaryocytes, the major source of platelets, express TLR, tumor necrosis factor receptors (TNFR1 and 2), IL-1β and IL-6 receptors, and the activation of the above receptors can lead to inflammatory factors, chemokine release and the activation of the NF-κB channels, which link inflammation with platelet formation [54][55][56][57]. TLRs are a crucial family in the inflammatory response and innate immunity. Once activated, the downstream pathway releases inflammatory factors and regulates the process of platelet generation; meanwhile, TLRs are also expressed on platelet surfaces. Therefore, it is very important to understand the relationship between TLRs and platelets and inflammation, which has certain prospects for the study of thrombocytopenia or the treatment of inflammatory diseases.

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Subjects: Physiology
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Xiaoqin Tang
,
Qian Xu
,
Shuo Yang
,
Xinwu Huang
,
Long Wang
,
Feihong Huang
,
Jiesi Luo
,
Xiaogang Zhou
,
Anguo Wu
,
Qibing Mei
,
Chunling Zhao
,
Jianming Wu
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Update Date: 17 Jan 2023
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