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HandWiki. Atmospheric-pressure Chemical Ionization. Encyclopedia. Available online: https://encyclopedia.pub/entry/37530 (accessed on 23 September 2026).
HandWiki. Atmospheric-pressure Chemical Ionization. Encyclopedia. Available at: https://encyclopedia.pub/entry/37530. Accessed September 23, 2026.
HandWiki. "Atmospheric-pressure Chemical Ionization" Encyclopedia, https://encyclopedia.pub/entry/37530 (accessed September 23, 2026).
HandWiki. (2022, December 01). Atmospheric-pressure Chemical Ionization. In Encyclopedia. https://encyclopedia.pub/entry/37530
HandWiki. "Atmospheric-pressure Chemical Ionization." Encyclopedia. Web. 01 December, 2022.
Atmospheric-pressure Chemical Ionization
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The content is sourced from: https://handwiki.org/wiki/Chemistry:Atmospheric-pressure_chemical_ionization

Atmospheric pressure chemical ionization (APCI) is an ionization method used in mass spectrometry which utilizes gas-phase ion-molecule reactions at atmospheric pressure (105 Pa), commonly coupled with high-performance liquid chromatography (HPLC). APCI is a soft ionization method similar to chemical ionization where primary ions are produced on a solvent spray. The main usage of APCI is for polar and relatively less polar thermally stable compounds with molecular weight less than 1500 Da. The application of APCI with HPLC has gained a large popularity in trace analysis detection such as steroids, pesticides and also in pharmacology for drug metabolites.

chemical ionization soft ionization liquid chromatography

References

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