1. General Introduction
1.1. Age and Sex
Age ranged from 18 to 87 years, with a mean age of 57.2, all in patients older than 30 years, except 2 cases affecting a male of 18 years and a male of 20 years.
The present research has highlighted a predominance of SP among males (39 males, 25 females; M/F ratio: 1.6:1).
1.2. Clinical Features
The palate was the most common involved site, with 48 (75%) cases, of these specifically, 37 (58%) were on the hard palate, 6 (9.5%) on the hard and soft palate junction, 4 (6%) on the soft palate and 1 (1.5%) on unspecified palatal localization.
Other sites included buccal mucosa (6; 9.5%), upper lip mucosa (3; 5%), mandibular retromolar area (2; 3%), floor of the mouth (2; 3%), tongue (2; 3%), and left faucial pillar (1; 1.5%).
SP usually presents as an asymptomatic, a slow growing, and a papillary exophytic lesion. In most cases an erythematous area within an otherwise normal mucosa is present (Figure 1A). Most frequent differential diagnoses is papilloma, on the basis of the keratotic appearance with papillary surface. Other clinical diagnostic hypotheses include palatal fistulas, pyogenic granuloma, soft tissues neoplasms and other benign and malignant minor salivary gland tumors.
Figure 1. (A) Sialoadenoma papilliferum on the hard palate of a 48-year-old female patient; (B) Surgical excision under local anesthesia; (C) Surgical specimen.
In the cases analyzed in the present research, tumor size ranged from very small (0.3 cm) to large lesions up to 4 cm, with a mean size of 0.79 cm.
Larger cases up to 7 cm can occur in the parotid and again up to now with four cases described including Abram’s case 
1.3. Histological Features
Histological description of cases evaluated in the present analysis were very similar, the histopathologic pattern of SP being rather characteristic.
The tumor seems to originate from the superficial portion of salivary glands excretory ducts. Papillary processes develop, eventually forming convoluted cleft and spaces. Each papillary projection is lined by consisting of two or three layers of cells, supported by a core of fibrovascular connective tissue. The most superficial portions of the lesion have a squamous epithelial lining; deeper areas show mainly cuboidal to columnar cells, often oncocytic in appearance (Figure 2). As growth progresses, the overlying mucous membrane becomes papillary or verrucous, much like a squamous papilloma.
Figure 2. Example of histological features of SP (case different from that presented in Figure 1): exophytic papillary structure covered by stratified squamous epithelium and glandular structures below the mucosa (H&E—50×).
Various research has attempted to identify the cell of origin of SP based on light microscopy, immunohistochemistry (IHC), and electron microscopy (EM) 
. These methods have yielded variable results with most investigators suggesting excretory duct or excretory duct reserve cell origin 
. Other authors hypothesized an origin from intercalated duct cells 
or myoepithelial cells 
Fowler and Damm documented that basal cell on the ductal structures were immunoreactive for p63 and p40, a myoepithelial immunophenotype 
. Variable reactivity in the basal cell layer with smooth muscle actin (SMA) was also identified. In all cases reported in their paper, the luminal cells within the ductal structures were immunoreactive to epithelial membrane antigen (EMA). These results indicate two cell types comprising the convoluted ductal structures of SP: a basal layer of myoepithelial cells (p40+, p63+, and SMA+) and a luminal layer of ductal epithelial cells (EMA+) (Figure 3
Figure 3. (A,B) Focal immunohistochemical positivity for p63 and smooth muscle actin (SMA). Immunoreactivity for p63 in basal cells of ductal structures suggesting a myoepithelial immunophenotype. Positivity of ductal structures is also evident; (C,D) positive immunohistochemical expression for cytokeratins 7 and 14 (CK7 and CK14) in ductal luminal cells, possibly confirming the epithelial origin (100× and 200×).
A recent immunohistochemical analysis reported by Atarbashi-Moghadam et al. shows positivity for cytokeratins 13, 14, 7, 8, and 19, and it is negative for vimentin and smooth muscle actin. This immunoprofile is similar to excretory ducts of the salivary gland 
Conservative excision seems to be the treatment of choice (Figure 1
B,C). Because of the rarity of SP, no clinical protocols have been proposed with regard to the possible duration of follow-up. According to van der Wal and van der Waal, follow-up should be scheduled at regular intervals 
SP is a benign neoplasm with limited growth and limited potential for local aggressiveness, recurrence rate is low, with only 2 cases out of 64 described within 3 years after surgical excision 
1.6. Possible Malignant Transformation
It is uncertain eventual malignant transformation of SP or on the existence of a malignant variant of the tumor. According to this research four cases with uncertain malignancy have been reported.
Solomon et al., presented a case of a possibly malignant SP 
, even though the diagnosis has been challenged by other authors (Ellis, G.L. and Auclair, P.L., 1991).
Ide et al., described an SP with potentially malignant features, such as rapid and destructive growth, radiographic resorption of the underlying bone, and atypical histological features 
Santos et al. also reported a case of SP on the tongue with apparently malignant clinical aspects, which led to the clinical diagnosis of squamous cell carcinoma 
Shimoda et al. reported the first case of SP with a definite malignant component 
However, Fowler and Damm mentioned that there was insufficient evidence to support this diagnosis and to consider that as a malignancy from preexisting SP 
In short, whether SP has a malignant potential therefore remains unanswered.
2. Intraoral Sialadenoma Papilliferum
Salivary gland tumors are a morphologically and clinically diverse group of neoplasms that affect predominantly major salivary glands but also are not uncommon in the minor salivary glands.
The global annual incidence, when all salivary glands tumors are considered, is approximately 1 case per 100,000 per year 
Pleomorphic adenoma and mucoepidermoid carcinoma are the two most common benign and malignant minor salivary gland tumors, while SP represents only a small percentage of cases (1.1–1.6%) 
A usual difficulty in the management of minor salivary gland tumors is the very heterogeneous clinical and radiographic features, as well as the rather wide range of histopathological subtypes.
The exophytic growth pattern of SP is similar to most intraoral salivary gland tumors, which present as submucosal nodular swellings, with or without superficial ulceration. Such a clinic pattern is shared with other lesions, including among others squamous papilloma, verrucous hyperplasia, and exophytic ductal papilloma.
Squamous papilloma and verrucous hyperplasia show only squamous epithelial proliferation and thus can be easily differentiated from SP. Exophytic ductal papilloma displays exophytic papillary ductal epithelial proliferation, but it lacks a ductal proliferation underneath the epithelium. Instead, SP shows as unique histopathologic features an exophytic proliferation of papillary stratified squamous epithelium and a contiguously endophytic salivary ductal proliferation underneath 
SP frequently presents as an erythematous lesion, with ulceration or erosion that may suggest a malignant lesion, such as verrucous carcinoma or even sarcomas 
From the epidemiological point of view, age and gender are not very helpful in the differential diagnosis, as most salivary gland tumors have no gender predilection and the mean age found in the present research for SP is similar to that reported for other salivary gland tumors (45 years, with a range of 11–74) 
SP appears to have a limited growth potential, with an average size at diagnosis of 0.79 cm, facilitating a conservative surgical treatment. There are insufficient data to support the malignant potential of SP, although four cases of supposed malignant transformation were reported.
Research is currently focused to determine the cells of origin of SP, but despite immunohistochemical studies, such question remain unanswered.
In conclusion SP, though rare, should be taken into consideration in the differential diagnosis of intraoral swellings, particularly those located on the palate, and more studies are necessary to better understand its biology.