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Zinicovscaia, I.; , .; Rogatkin, D.; Yushin, N.; Grozdov, D.; Vergel, K. Effect of Nanosilver on Humans. Encyclopedia. Available online: https://encyclopedia.pub/entry/22161 (accessed on 05 December 2025).
Zinicovscaia I,  , Rogatkin D, Yushin N, Grozdov D, Vergel K. Effect of Nanosilver on Humans. Encyclopedia. Available at: https://encyclopedia.pub/entry/22161. Accessed December 05, 2025.
Zinicovscaia, Inga, , Dmitry Rogatkin, Nikita Yushin, Dmitrii Grozdov, Konstantin Vergel. "Effect of Nanosilver on Humans" Encyclopedia, https://encyclopedia.pub/entry/22161 (accessed December 05, 2025).
Zinicovscaia, I., , ., Rogatkin, D., Yushin, N., Grozdov, D., & Vergel, K. (2022, April 22). Effect of Nanosilver on Humans. In Encyclopedia. https://encyclopedia.pub/entry/22161
Zinicovscaia, Inga, et al. "Effect of Nanosilver on Humans." Encyclopedia. Web. 22 April, 2022.
Effect of Nanosilver on Humans
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This entry is adapted from the peer-reviewed paper 10.3390/app12073476

Among produced metal nanoparticles, silver nanoparticles are widely used in everyday life products, cosmetics, and medicine. It has already been established that, in nanoscale form, many even inert materials become toxic. 

nanoparticles silver toxicity occupational brain

1. Introduction

Nanoparticles are found in numerous spheres of life. Their application in medicine, food and cosmetic industries, and everyday life is expanding [1]. Due to their unique electrical, optical, chemical, and antimicrobial properties, silver nanoparticles (AgNPs) are the most common type of NPs used in consumer products [2]. At the same time, according to publications in toxicology, a wealth of information has already been accumulated confirming that contact with NPs entails serious negative consequences for cells, tissues, and organs, such as the development of oxidative stress, the accumulation of DNA disorders, the induction of apoptosis and inflammation, and the disturbance of the structure and functions of tissues and organs [3][4][5].
Almost every person in the modern world is constantly in contact with NPs, through products or objects containing nanoparticles, or through air, water, and soil. The environment begins to suffer greatly from pollution by various nano-sized substances as a result of emissions from enterprises and vehicle exhaust, sewage discharges, and waste. Due to the widespread use of NPs, including AgNPs, in various industries, employees in the workplace face an increased risk of health problems owing to prolonged (chronic) contact with small doses of NPs that enter the body from the air in contaminated work areas, as well as with water and/or food. Occupational pathology has already accumulated bodies of evidence on the development of diseases caused by NPs in industrial workers, which cannot be explained by other reasons [6][7]. In women of reproductive age employed in industrial fields, contact with NPs is associated with risks for their unborn children due to the ability of NPs to penetrate the placental barrier, which leads to the transfer of NPs from mother to child [8][9].

2. General Toxicity of AgNPs for Cells, Tissues, and Organs

According to numerous publications, the main mechanism of the cellular and molecular toxicity of AgNPs is oxidative stress [10][11]. Thus, 20 nm spherical AgNPs reduced mRNA levels of sodium dismutase 1 and glutathione reductase in male Wistar rats [9]. In the presence of AgNPs, the formation of reactive oxygen species [10], the level of gene expression and the content of antioxidant proteins decrease, and DNA damage [11] increases. The prolonged exposure of adult rats to citrate-stabilized silver NPs at a low dose of 0.2 mg/kg resulted in a decrease in the level of expression of structural proteins, in particular, myelin in myelin sheath cells. AgNPs were also found to increase the body weight and body temperature of animals [12]. The level of developmental regulators (for example, neuronal) also decreases; however, the levels of expression of apoptosis regulators increase; therefore, ultimately, the cell often undergoes apoptosis. At the tissue level, inflammation, swelling, and, as an extreme outcome, necrosis, can develop [13]. In zebrafish, AgNPs caused a decrease in brain and muscle acetylcholinesterase activity, as well as in liver and gill catalase activity. Contact with AgNPs also led to morphological changes such as the fusion of secondary lamellae, curvature, dilated marginal channel, and epithelial lifting [14]. The administration of male CD-1 mice with AgNPs of 10 nm size, compared with NPs with a size of 40 and 100 nm, resulted in overt hepatobiliary toxicity [15].
Some reports indicate that AgNPs are genotoxic and mutagenic, and the degree of their impact directly depends on the dose of NPs and inversely depends on their size [16][17][18]. After exposure of BEAS-2B cells to AgNPs of different primary particle sizes (10, 40, and 75 nm), a cytotoxic effect was observed only at a particle size of 10 nm [19]. The same finding was reported in [20]. Coating agents used to stabilize NPs in a solution can also affect general toxicity, including genotoxicity. For example, AgNPs coated with citrate had more noticeable toxic effects on L5718Y cells than those coated with polyvinylpyrrolidone [21]. The study by Recordati et al. [15] showed that the coating of NPs had no relevant impact on animals. Citrate-coated silver nanopowder was toxic to human skin HaCaT keratinocyte cells, whereas polyvinylpyrrolidone-coated silver nanoprism or nanoparticle powder did not exhibit any toxic effect [22]. In a study by Gliga et al. [19], the coating-dependent difference in the cytotoxicity of AgNPs was not detected. El Badawy and al. [23] demonstrated a direct correlation between the toxicity of AgNPs and their surface charge. Thus, negatively charged citrate-coated AgNPs were less toxic to microorganisms than positively charged branched polyethyleneimine-coated AgNPs. The low toxicity of citrate-coated AgNPs was observed in comparison with polyvinylpyrrolidone- and gum arabic-coated AgNPs [24].
It should be noted that the results of evaluating the mutagenicity of AgNPs may also depend on the chosen object of study; for example, Prokhorova et al. [25] did not find chromosomal abnormalities in plant cells after exposure to AgNPs. Studying the effect of AgNPs on freshwater invertebrates with different life strategies—namely, Hydra vulgaris, Daphnia carinata, and Paratya australiensis—the authors described Daphnia carinata as the most sensitive species, followed by Paratya australiensis and Hydra vulgaris [26]. Toxic effects of AgNPs on different organisms in the study by Ivask et al. [20] varied by about two orders of magnitude, with the lowest observed for crustaceans and algae and the highest for mammalian cells.
The results of studies of the effects of NPs on the reproductive function and development of animal organisms are also ambiguous and often contradictory. The bulk of studies demonstrated that AgNPs could cause defects in the neurological, cardiovascular, reproductive, and immune systems of the embryos and fetus; however, in some studies, no adverse effect on the development of AgNPs was found, even at high doses [27]. The development of oxidative stress, the occurrence of morphological defects, slowing heart rate, the appearance of pericardial edema, delayed hatching from eggs, and increased mortality were observed in studies on zebrafish embryos exposed to AgNPs [28][29][30]. Morphological changes in the ovary and testis were observed in rat offspring exposed to AgNPs [31]. Developmental exposure to AgNPs results in long-term gut dysbiosis, body fat increase, and neurobehavioral alterations in mouse offspring [32]. At the same time, it should be mentioned that silver ions (Ag+) provoke similar toxic effects at concentrations hundreds of times lower than those applied for AgNPs [29][30]. It was suggested by some authors that the compounds used for NP coating significantly affected the level of AgNP toxicity. Thus, after contact with polyvinylpyrrolidone-coated AgNPs, zebrafish larva did not differ in morphology and behavior from control ones; however, when citrate was used as a coating agent, some disturbances were detected [33]. In a study by González et al. [34], in which the level of AgNPs in solution was close to their environmental concentrations in water (0.03–3 ppm), no negative changes in the survival, hatching, or morphology of Danio rerio were found. According to a number of studies, after a single oral administration, reproductive dysfunctions in males and females (inhibition of spermatogenesis, histopathological disorders in ovaries, etc.) were observed in rodents exposed to AgNPs. It is noteworthy that the smaller the dose and size of AgNPs were, the less pronounced were the effects [35]. Undoubtedly, the dose–response principle also works in nanotoxicology.

3. Effect of AgNPs on the Brain and Behavior

AgNPs along with other metal NPs are able to cross not just the placental barrier but the blood–brain barrier as well [8][9]. Tang et al. [36] proposed two mechanisms of AgNP penetration across the blood–brain barrier, i.e., the transcytosis of endothelial cells of the brain–blood capillary and the reduction in the close connection between endothelial cells, or dissolution of endothelial cell membranes. The main mechanisms of nanoparticles for crossing the blood–brain barrier according to the literature are summarized in Figure 1.
Figure 1. Possible mechanisms of AgNPs for crossing the blood–brain barrier [37][38][39].
Therefore, upon contact with NPs, there is a risk of biochemical, histological, and functional disorders in the brain, including cognitive dysfunctions. Studies of the effect of NPs on brain functions have received much attention in recent years. After a single dose injection of AgNPs, the parameters of oxidative stress and the antioxidant potential of the brain on gene expression and the level of protein (superoxide dismutase and glutathione reductase) activity were altered [40]. The shape of astrocytes was disturbed, cerebral capillaries were deformed, and edema was developed in adjacent areas [10][13][41]. In addition, the permeability of the blood–brain barrier increased in direct proportion to the dose of AgNPs received by animals [10].
After seven daily injections, impairments of working memory were noted in rats: The animals meaningfully more often made mistakes by repeatedly looking into the arm of the maze they had just examined; however, referential memory and the long-term understanding of the structure of space were not disturbed [41]. After three weeks of injections, the social behavior of the mice differed significantly from the normal behavior in the study by Greish et al. [42] The mice administrated with AgNPs preferred to stay in an empty chamber rather than to familiarize themselves with new animals. In experimental animals, motor coordination and balance were impaired, but the swimming speed in the Morris test was preserved, which revealed the absence of spatial memory formation in individuals treated with AgNPs. The emotional state, the level of anxiety, and the ability to conditioned-reflex learning, in which fear is the motivation, were considered in the study by Antsiferova et al. [43]. After long-term (1–6 months) oral contact with small doses of AgNPs (50 µg) through drinking water, the authors recorded and interpreted the test results as two attempts of the brain to adapt to the effects of AgNPs. Thus, after 2 months of contact, anxiety and fear increased, and after 4 months, they decreased with a simultaneous increase in exploratory behavior. After continued contact with AgNPs (up to 6 months), the impairment of long-term memory and conditioned-reflex learning was observed. The fading effect was noted in the research by González et al. [34]. Although several days after exposure to AgNPs, zebrafish larvae were hyperactive at changes in illumination, no fluctuations in their activity were detected after 5 days.
The influence of prenatal contact with AgNPs on the brain and behavior is described in a limited number of studies. After regular injections of AgNPs to future mothers during pregnancy, the spatial memory of their offspring was impaired, while conditioned-reflex learning and the emotional state of young rats did not differ from the offspring of the control group [44]. The experimental offspring demonstrated signs of depressive-like behavior, i.e., passivity and lack of interest in food [45]. After zebrafish embryos were exposed to AgNP solution, their avoidance motor response to the touch was disrupted; the membrane potentials of their motoneurons were decreased, and the expression of many genes connected with neurogenesis was low [46].
In studies of the effect of AgNP coating material (BSA, polyethylene glycol, and citrate) on cognition, spatial memory, and neurotransmitter levels in the rat hippocampus, only rats administrated with citrate-coated NPs maintained long-term spatial memory. For other NPs and Ag+, the induction of peripheral inflammation, which was reflected by alterations in the level of serum inflammatory mediators, was observed [47]. Wu et al. [48] showed a significant reduction in GAP-43 mRNA and protein expression in the hippocampus of offspring exposed to uncoated AgNPs, suggesting cognitive impairments in rats.
However, in some studies on adult animals, after subchronic contact with AgNPs, no behavioral disturbances were noticed. In the study by Liu et al. [49], no significant differences between experimental and control mice in the formation of spatial and working memory were found, and secondary neurogenesis in the hippocampus was not impaired. In the research by Dabrowska-Bouta et al. [12], pathological changes in the structure of myelin sheaths and a decrease in the level of three myelin-specific proteins were detected in the brain of experimental rats treated with AgNPs or Ag+. However, neither motion nor exploratory behavior or memory was impaired in animals treated with silver nanoparticles present in the two forms. After an intranasal introduction of AgNPs, experimental mice coped with the recognition of a new object in the same way as the control ones; however, their spatial memory was presumably impaired, while the ability for spatial learning itself did not decrease [50]. After AgNPs were injected into lactating mice, their grown offspring, which contacted with AgNPs through milk, did not differ from control animals in terms of their emotional state, social interactions, and locomotion [51].

4. AgNPs Effect on the Brain and Behavior

To study the effect of AgNPs on the brain and behavior, experiments were performed on mice exposed to AgNPs in adulthood [52]. The animals received a solution of AgNPs (size 25 nm; polyvinylpyrrolidone as coating agent) at a concentration of 25 μg/mL for 2 or 4 months, while control individuals drank pure water. When consuming compound animal feedstuff, one mouse drank an average of 5.38 mL of liquid per day; consequently, the daily dose of AgNPs per mouse was 4.5 and 5 mg/kg of body weight for males and females, respectively. At the end of the experiment, the learning ability and spatial memory of the animals were assessed in the Morris water maze (MWM) [53]. In this standard behavioral test, an underwater platform on which the animal can climb to come out of the water is placed in a round white pool filled with water colored and turbid with milk powder. The task of the animal is to find this platform and memorize its location relative to the out-of-labyrinth landmarks [53] in order to use its spatial memory next time to find the platform quicker. The methodology for conducting tests is described in detail in [52].
To establish a correlation between possible cognitive impairments in the brain of animals exposed to NPs and the level of AgNPs accumulated in the brain, the silver content in the brain, as well as in other tissues and organs, was determined after the animals’ slaughter using NAA [54]. NAA, due to the possibility of determining a wide number of elements in biological samples, allows assessing the content of silver and iron in organs and blood samples, estimating the passage of nanoparticles through the blood–brain barrier, and quantifying its accumulation in the neuronal tissues of the brain. The technique is described in detail in [52][54].
According to the NAA results, the relative mass of silver in the brain of experimental animals was 319 ± 155 ng after 2 months of nanoparticle intake and 870 ± 200 ng after 4 months, which is significantly higher, almost an order of magnitude, than the silver content in the control group [52]. Notwithstanding the accumulation of silver in the brain, within groups of individuals with a preference for different behavioral strategies in the MWM (for details, see [55]), adult experimental animals learned to find the platform just as successfully as control ones. In experiments in which the period of AgNP intake passed after the initial testing, which made it possible to identify groups of individuals with a preference for different behavioral strategies in the test [52], all mice retained learned information about the test for 2 and 4 months. Thus, it was concluded that in adult animals, the long-term oral consumption of AgNPs did not impair the ability to form spatial memory, as well as the ability to store and apply information learned before exposure to AgNPs.
Following this series of experiments, a study was carried out that simulated the effect of AgNPs on children born by women employed in the production industry or who were in close contact with AgNPs during pregnancy and lactation at home [56]. During the entire period of pregnancy and lactation (2 months in total), female mice were given to drink a solution of AgNPs (size 25 nm; polyvinylpyrrolidone as coating agent) with a concentration of 25 μg/mL. Thus, their offspring were exposed to AgNPs during prenatal development and early postnatal development. When the pups reached the age of 2 months, their learning ability and spatial memory were assessed in the MWM, while the silver content in their brain and the mother’s brain was determined by NAA. It was found that within groups of individuals with a preference for different behavioral strategies in the MWM, experimental mice did not learn to find the platform, while control individuals coped with the task successfully. Silver accumulated in the brain of both mothers and pups was at a level comparable to that in adult mice after 2 months of silver NP intake (373 ± 75 ng and 385 ± 57 ng, respectively), which exceeded the silver content in the control group approximately 20 times [57]. This experiment clearly demonstrated that, firstly, AgNPs easily overcame various biological barriers (blood–brain, placental) and migrated from the mother’s body to the offspring’s body; secondly, the study revealed that the fragile body of a developing child, including its brain, in general, was more sensitive to the toxic effect of AgNPs than the body of an adult, even an elderly one.

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Subjects: Developmental Biology
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Inga Zinicovscaia ,
, Dmitry Rogatkin , Nikita Yushin , Dmitrii Grozdov , Konstantin Vergel
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Update Date: 26 Apr 2022
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