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Begum, S.; Patil, P.; , .; Qureshi, K.; Jaremko, M. Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles. Encyclopedia. Available online: (accessed on 25 April 2024).
Begum S, Patil P,  , Qureshi K, Jaremko M. Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles. Encyclopedia. Available at: Accessed April 25, 2024.
Begum, Shabaaz, Pratibha. Patil,  , Kamal Qureshi, Mariusz Jaremko. "Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles" Encyclopedia, (accessed April 25, 2024).
Begum, S., Patil, P., , ., Qureshi, K., & Jaremko, M. (2022, April 19). Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles. In Encyclopedia.
Begum, Shabaaz, et al. "Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles." Encyclopedia. Web. 19 April, 2022.
Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles

Nanoparticles (NPs) are elements derived from a cluster of atoms with one or more dimensions in the nanometer scale in the range of 1–100 nm. The bio nanofabrication of metallic NPs is now an important dynamic area of research, with major significance in applied research. Biogenic synthesis of NPs is more desirable than physical and chemical synthesis due to its eco-friendliness, non-toxicity, lower energy consumption, and multifunctional nature. Plants outperform microorganisms as reducing agents as they contain large secondary biomolecules that accelerate the reduction and stability of the NPs. The produced NPs can then be studied spectroscopically (UV-Visible, XRD, Raman, IR, etc.) and microscopically (SEM, TEM, AFM, etc.). The biological reduction of a metallic ion or its oxide to a nanoparticle is quick, simple, and maybe scaled up at room temperature and pressure. The rise in multi-drug resistant (MDR) microbes due to the immoderate use of antibiotics in non-infected patients is a major cause of morbidity and mortality in humans. The contemporary development of a new class of antibiotics with different mechanisms of action to kill microbes is crucial. Metals and their oxides are extremely toxic to microbes at unprecedentedly low concentrations. In addition, prevailing infections in plants and animals are raising significant concerns across the globe. NPs’ wide range of bioactivity makes them ideal antimicrobial agents in agricultural and medical fields. The present research outlines the synthesis of metallic NPs from botanicals, which enables the metals to be in a stabilized form even after ionization. It also presents a valuable database on the biofunctionalization of synthesized NPs for further drug development.

metallic nanoparticles plant-mediated green synthesis biofunctional antimicrobial activity

1. Synthesis of Nanoparticles (NPs) 

1.1. Perspectives of Nanoparticle Synthesis

The methodology for making ultrafine NPs from ancient times is generally by the breakdown (top-down), and the build-up (bottom-up) approaches, as illustrated in Figure 1.
Pharmaceuticals 15 00455 g001 550
Figure 1. Various approaches for the synthesis of NPs.
The breakdown approach of NP synthesis is usually employed during NPs’ physical and chemical synthesis. The size reduction of bulk material is used as a precursor ultimately to the nanosize by applying physical forces such as grinding, pulverization, etc., in the break down method which is also sometimes called the mechanochemical method [1]. It is challenging to obtain NPs by applying physical forces; usually, microparticles are easily obtained of 3 µm size, which is not significant. The second approach for obtaining NPs is by the build-up process; where major preparation methods for the synthesis of NPs can be achieved in two states of matter, liquid phase and solid phase, without any hazardous chemicals in biogenic synthesis, and remarkable increased use of chemicals in chemical synthesis are used. Biogenic synthesis of NPs falls under the bottom-up approach, where the uses of the biological system or its parts can be seen in the synthesis. To select the best organisms or extracts, one must evaluate their specific properties such as biochemical pathways, phytochemical contents, enzyme activities, cell growth circumstances, and ideal reaction [2].

1.2. Secondary Biomolecules for Capping and Stabilization

Plant extract not only acts as a reductant but also functions as a capping and stabilizing agent, as depicted in Figure 2.
Pharmaceuticals 15 00455 g002 550
Figure 2. Biological reduction of NPs.
Prediction of biomolecules acting as capping and stabilizing agents was realistic when IR spectrum of tea extract [3] showed the involvement of polyphenols, carboxylic acid, polysaccharide, amino acid, and proteins when coordinated with FTIR analysis. Zinc oxide NPs [ZnO NPs] showed peaks in 682–457 cm−1, indicating the presence of a higher percentage of phenolics. The stability studies of silver NPs (Ag NPs) synthesized from Ziziphora tenuior extract at room temperature revealed that bionanofabrication of Ag NPs was due to some metabolite functional groups such as amines, alcohols, ketones, aldehydes, and carboxylic acid. A peak graph of FTIR between the treated and untreated sample showed significant changes and predicted amide group form of proteins possibly be the covering layer of metal NPs [4]. The FTIR peak stretches in the OH, CH, C=C ring, and CH2 wagging of ascorbic acid indicated that Hibiscus cannabis extract comprises ascorbic acid responsible for reducing Ag NPs [5]. The ferric chloride test of coconut shell extract revealed the presence of phenolic compounds; most importantly, benzoquinone yielded the formation of Au NPs. Calotropis gigantea, a large shrub, consists of phytoconstituents such as cardiac glycosides, β-sitosterol, saponins, alkaloids, tannins, trisaccharides, and flavanols FTIR spectra denote the interactions of the biomolecules with Ag NPs [6].

2. Structural Analysis of NPs

The synergistic synthesized metallic NPs are characterized by assessment of their shape, size, morphology, and surface area, using various characterization tools such as Ultraviolet-visible spectrophotometry (UV-Vis), X-ray diffraction (XRD), Energy dispersive X-ray analysis (EDAX), Particle size distribution (PDS), Zeta potential (ZP), Photoluminescence (PL), Dynamic light scattering (DLS), Raman spectroscopy (R), Infrared spectroscopy (IR), Cyclic voltammetry (CV), Nanoparticle tracking analysis (NTA), Fourier transform-infrared spectroscopy (FTIR), Thermal gravimetric analysis (TGA), Selected area electron diffraction (SAED), Atomic field microscopy (AFM), Scanning electron microscope (SEM), field emission scanning electron microscopy (FESEM), Transmission electron microscopy (TEM), High-resolution transmission electron microscopy (HRTEM).
Characterization of a particular biomaterial depends on the complexity of the matrix, the analyte concentration, and the physio-chemical composition [7].
The UV-visible spectroscopy is primarily used as a characterization technique soon after synthesizing NPs of size from 2–100 nm in the range wavelength of 300–800 nm. The brownish color change of grapefruit extract from yellow due to the formation of silver ion complex was confirmed when a broad surface plasmon resonance band was observed around 450–470 nm [8]. Magnesium oxide NPs (MgO NPs) cubic structures formed in the presence of reductant Emblica officinalis [9]. The peak intensity profile was characteristic of NPs calculated with Scherer’s formula. The crystalline size determined for the mean particle size of the MgO NPs was around 27 nm which was well matched with SEM images. Every element in its unblended form will have unique atomic structures with a set of peaks EDAX can identify. A spectrum of Ag NPs observed at ~3 Kev confirmed the presence of silver as a major constituent element [10]. The elemental composition of Ag NPs synthesized from the plant extract of Boerhaavia diffusa was resolute by SEM equipped with an EDAX detector showing a strong signal in the silver region [11]. The stability of Ag NPs was evaluated by a zeta potentiometer. It was noted that synthesized NPs were stable in a wide range of pH from 6–12. An increase in the pH increased ZP. At pH 12, Ag NPs were found to be more stable. Raman spectroscopy of Ag NPs was carried out to gain the information of bio components initially for the biosynthesis [12] such as the polyphenol interactions with S+ ions during nanoparticle formation. Diluted samples of Ag NPs subjected to NTA reveal minimum and maximum 28 and 22 nm with a standard deviation of ±8 nm, and the results correlated with TEM findings were consistent [13][14]. Studies of possible biomolecules responsible for capping and stabilization of NPs were carried out by FT-IR and GC-MS analysis. Cocos nucifera coir extract confirmed the presence of biomolecules containing hydrocarbon such as nonacosane and heptacosames, which were predicted in the stabilization of Ag NPs by GC-Ms analysis [15]. The thermal gravimetric analysis allowed the research of the thermal stability of palladium NPs (Pd NPs) and showed that the phytoconstituents are responsible for reducing Pd+2 to Pdo [16]. AFM characterized at ambient temperature exemplified the results of particles of 41 nm [17]. SEM images of carbon stretches provide a morphologically excellent view of NPs. Only TEM can reveal the exact shape and size of physical, chemical, or bio reduced NPs. TEM pictures of Ag NPs showed that most particles were spherical and measured between 5 and 20 nm [18].

3. Biofunctionalization of NPs

3.1. Gold NPs (Au NPs)

As the years have passed, gold has become a scarce commodity. Gold, a soft yellow metal with the highest ductility and malleability of any metal, is highly prized for various reasons; however, its physical qualities are critical to modern society’s functioning. In the treatment of rheumatic diseases and discoid lupus erythematosus, restorative dentistry, and other inflammatory skin conditions such as pemphigus urticaria and psoriasis, gold and its compounds were utilized [19]. Due to their small size, gold NPs (Au NPs) have a much higher surface area and dispersion. In terms of textural qualities, gold has the highest specific surface of any metal.
Plant-based Au NPs are biocompatible and have unique chemical and optical properties, making them useful for photo-thermal treatment, bio-sensing, antioxidants, anti-microbials, and drug delivery [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Plant-Au NPs with surface modifications have been used in biomedical research and treatment [35][36][37][38][39]. Plant-Au NPs can interact with bacteria’s biomolecules, altering their structure and causing them to die. Plant-Au NPs, for example, were synthesized using flower extract of Musa acuminate Colla as a stabilizer and reducing agent [24] and displayed anticancer activity in addition to antibacterial activity against beta-lactamase-producing bacteria. Endocytosis allowed the plant-Au NPs to penetrate the cells after accumulating on the cell surface. On the surface of the Au NPs, free radicals were produced. Electron spin resonance spectroscopy revealed the formation of free radicals on the surface of Au NPs. When Au NPs were cultured with bacteria, the generation of free radicals indicated the ability of the Au NPs to disrupt cell membranes and make cells permeable, eventually leading to cell death. Plant antioxidants play a critical role in their biological competence, including interfering in cancer formation (including instigation, development, advancement, invasion, and metastasis) [25]. Plant extract-based Au NPs use free radicals and ROS in live cells in an antioxidant application [26]. When evaluated with 2, 2-diphenyl-1-picrylhydrazyl, the Thymus vulgaris aqueous extract was used to produce Au NPs [27], which exhibits antioxidant activity. The therapeutic impact on diabetic and obese rats using Au NPs derived from Smilax glabra was examined [28], and Smilax glabra rhizome extract capped Au NPs were generated. Histopathological investigations demonstrated the antidiabetic and antiobesity properties of plant based-Au NPs which reinstated the nuclei, inner membrane, and cytoplasm. Furthermore, Vetex negundo extract-stabilized Au NPs [37] and Au NPs capped using leaves extract of Camellia sinensis [31] were employed to cure severe myeloid leukemia in animal samples throughout pro-apoptotic evaluation of human gastric cancer cells, respectively.
A low-cost approach of gold NPs (Au NPs) at room temperature using aqueous seed extract of Abelmoschus esculentus yielded spherical particles, a narrow size range of 45–75 nm with a high antifungal effect against Puccinia graminis and Candida albicans [2]. As the demand for synthesis for NPs increased, various parts of the plants were utilized. Ananas comosus blended fruit extracts served as an excellent reductant for synthesizing Au NPs, having better antimicrobial activity than standard antibiotics used [39]. Microwave-mediated synthesis of Au NPs with coconut water is an incredible example of rapid NP synthesis, with an optimum time of 17 s. Furthermore, cytotoxicity was tested on two human cancer cell lines, HeLa (human cervical cancer) and MCF-7 (human breast cancer), and found to be nontoxic [40]. Leaf extract of Ficus benghalensis used as a capping agent in synthesis yielding spherical shape of Au NPs; the TEM analysis showed the formation of well-dispersed Au NPs of size 17–50 nm [41]. Au NPs from Ficus religiosa extract showed excellent stability and uniform capping due to the presence of polyphenols, amines and carboxylates and were nontoxic to the HEK293 cell lines at 80 µM concentration [42]. Nanotriangles and nanohexagons Au NPs of ~10 nm obtained from Gnidia glauca flower extract exhibit chemocatalytic activity in reducing 4-nitrophenol to 4-aminophenol by NaBH4 in the aqueous phase. In vitro antibacterial properties of polyshaped Au NPs synthesized from Senna siamea showed significant antibacterial activity against Pseudomonas aeruginosa (P. aeruginosa) [43].

3.2. Silver NPs (Ag NPs)

In the current situation, numerous publications have been published on the laboratory-scale synthesis of Ag NPs from plants, which have emerged as antibacterial agents due to their unique physical and chemical properties. “Nobel silver NPs” are working to push the boundaries of science and technology, notably in the medical field [44]. Ag NPs have attracted intensive research in the biomedical, food industry, drug delivery, agriculture, water treatment, textile industries, antimicrobial agent, and anticancer drugs.
Anti-angiogenic properties of Ag NPs in the rat aortic ring model were evaluated. Results showed that Ag NPs at 200 µg/mL led to a 50% reduction in the length and number of vessel-like structures [45]. Artocarpus heterophyllus assisted Ag NPs reduction, showing excellent antibacterial activity against Staphylococcus aureus (S. aureus) with an inhibition zone of 15 mm diameter compared to the other bacterial strains used [46]. Antibacterial activity of phytosynthesized Ag NPs from Boerhaavia diffusa L. extract were tested against fish bacterial pathogens Aeromonas hydrophila, Flavobacterium branchiophilum, and Pseudomonas fluorescens; and they demonstrated high antibacterial activity towards Flavobacterium branchiophilum when compared to other two fish bacterial pathogens [11]. FTIR research revealed that protein fractions acted as reducing and stabilizing agents during the production of Ag NPs using latex from Calotropis gigantea L. [6]. In situ green synthesis of Ag NPs was done using Coriandrum sativum L. seed extract, then exposed to synergistic tests. The results showed that the potency of conventional antibiotics could be increased in the presence of Ag NPs. Green Ag NPs reduced using Cocos nucifera coir extract were effective anti-larvicidal agents against C. quinquefasciatus and Anopheles stephensi [15]. Ag NPs serve as an excellent substitute besides synthetic and chemical insecticides synthesized from Euphorbia hirta L. extract, and administration of it to the crop pest cotton bollworm Helicoverpa armigera impacted its biological parameters such as less consumption of food index due to a decrease in the level of digestive enzymes. Systematic evaluation of antibacterial properties of Ag NPs synthesized from extracts of Hibiscus cannabis [47], Moringa oleifera L. [48], Prosporis fracta [49], Pterocarpus santalinus [50], and Vitis vinifera against common human pathogens such as Klebsiella pneumoniae (K. pneumoniae), Escherichia coli (E. coli), Enterococcus faecalis, Enterobacter cloacae (E. cloacae), Proteus vulgaris, S. aureus, S. saprophyticus, Bacillus subtilis, and P. aeruginosa gave a brief insight on eradicating the conventional antibiotics and exploring more therapeutic applications of Ag NPs as nanoantibiotics against MDR bacteria [51]. Extensive study of bioactivity of Ag NPs against breast cancer cell lines MCF 7 interestingly displayed a decrease in the cell viability. Direct sunlight assisted Ag NPs within five minutes, providing better fungicidal activity against Candida albicans, Candida glabrata, and Aspergillus niger. Ag NPs’ biological activity from Illicium verum Hook. [18], was not reported.

3.3. Platinum Group of Metals

Platinum is a silvery-white metal costlier than gold, known for its malleability, durability and ductility. The first research on Pt NPs using leaf extract described the use of an aqueous leaf solution of Diospyros kaki as a bio-reducing agent in the green extracellular synthesis of Pt NPs from an aqueous H2PtCl6.6H2O solution [52]. With a reaction temperature of 95 °C, platinum ions’ conversion to NPs greater than 90% was accomplished. The mechanism of action was unknown at the time, but the FTIR research indicated that Pt NPs are surrounded by metabolites such as terpenoids, which have functional groups of amines, alcohols, ketones, aldehydes, and carboxylic acids. A single-step technique was proposed for synthesizing Pt NPs using an invasive weed, Lantana camara, and a moderate reducing agent, ascorbic acid [53]. The procedure entails mixing adequate amounts of platinum (VI) solution, Lantana leaf extract, and ascorbic acid, then heating the mixture to 95 °C for 8 min. Ascorbic acid and leaf extract combined with decreasing chloroplatinic acid to platinum NPs, with leaf extract also serving as a stabilizing agent for the NPs. The resultant NPs are 35 nm in diameter and crystallize in face-centered cubic symmetry. Palladium is a sister metal of platinum and belongs to the platinum group metals (PGM). It has a white luster finish and is light. However, it is less ductile than platinum.
Palladium NPs (Pd NPs), which are important due to their catalytic characteristics and affinity for hydrogen, have been phyto-sensitized using Solanum trilobatum under contemporary pH and room temperature which exhibited antibacterial and cytotoxic effects [54]. Pd NPs have also been used as a homogeneous or heterogeneous catalysts in various scientific fields, including hydrogen storage, chemo-optical transducers, and chemical modifiers in ETV-ICP-MS, hydrogen sensor, automotive catalytic converter, plasmonic waveguides, and optical limiting devices. For the production of Pd NPs using diverse concentrations and temperatures, an eco-friendly and cost-effective green technique using water-soluble leaf extract of Sapium sebiferum as a reducing and capping agent was developed. The optimized Pd NPs synthesized using 10 mL leaf extract showed strong bacterial inhibition against P. aeruginosa (11 ± 0.6 mm), Bacillus subtilis (19 ± 0.6 mm), and S. aureus (29 ± 0.8 mm) [55]. Uniform-sized palladium NPs were synthesized using Curcuma longa tuber extract with an average size ranging between 10–15 nm [56]. Liquid flower extracts of Moringa oleifera flower extracts with 1 mM palladium acetate solution yielded 10–50 nm size bio Pd NPs [57]. GC-MS analysis showed that Bis-phthalate was mostly the reducing agent. Pd NPs caused significant cytotoxicity to A549 cells and did not induce toxicity in normal healthy peripheral lymphocytes.

3.4. Metallic Oxide NPs

Different types of metal oxides synthesized using the plant parts are useful for bioactivity. The bio-reduction of other metal oxides NPs and their bioactivity is listed in Table 1.
Table 1. Bio-reduction of other metal oxides NPs and their bioactivity.
Sr. No. Botanical Names of Plants Part Used Size Range (nm)
Characterization Tools Bio-Functionalization Ref.
Zinc oxide NPs
1. Trianthema
Extract 25–90 UV–Vis, XRD,
  • Cytotoxic
  • Cytotoxic
  • Antibacterial
  • Antifungal
  • Antioxidant
2. Matricaria chamomilla
L., Lycopersicon
esculentum M., Olea
Extract 40.5–124 UV–Vis, XRD,
  • Antibacterial
3. Punica granatum Extract 32.98–81.84 UV–Vis, XRD,
  • Cytotoxic
  • Antibacterial
4. Rheum turketanicum Extract 17–20 UV–Vis, XRD,
  • Cytotoxic
5. Tecoma castanifolia Extract 70–75 UV–Vis, XRD,
  • Antibacterial
  • Antioxidant
  • Anticancer
6. Silybum marianum Extract 31.2 UV–Vis, XRD,
  • Antifungal
  • Antibacterial
  • Cytotoxic
7. Anchusa italic Flower ~8–~14 UV-Vis, EDX XRD, FT-IR, FESEM, TEM
  • Antibacterial
  • Cytotoxic
8. Aloe vera Leaves 8–20 UV-Vis, EDX, XRD, FT-IR, GC-MS, SEM TEM
  • Antibacterial
  • Cytotoxic
9. Rosa canina Fruit 50–400 XRD, EDX, DLS, FT-IR, SEM
  • Antibacterial
  • Antioxidant
  • Cytotoxic
10. Boswellia ovalifoliata Bark 20 UV-Vis, DLS, ZP, FTIR, SEM, TEM
  • Antimicrobial
Magnesium oxide NPs
1. Emblica officinalis Fruit 27 UV-Vis, XRD, EDX, FT-IR, SEM
  • Antibacterial
2. Clitoria ternatea Whole plant 50–400 nm UV-Vis, XRD, PL, FTIR, EDS, FESEM
  • Antioxidant
Copper oxide NPs
1. Ocimum tenuiflorum Extract 20–30 nm UV–Vis, XRD,
  • Antibacterial
2. Moringa oleifera Extract 35–95 nm UV–Vis, XRD,
  • Antifungal
3. Eichhornia crassipes Leaves 28 ± 4 UV-Vis, XRD, FT-IR, FESEM
  • Antifungal
4. Gloriosa superba Leaves 5–10 UV-Vis, PXRD, SEM TEM
  • Antibacterial
Titanium dioxide NPs
1. Artocarpus heterophyllus Extract 15–20 nm UV–Vis, XRD,
  • Anticancer
  • Cytotoxic
  • Antibacterial
2. Citrus sinensis Fruit peel 20–50 nm UV–Vis, XRD,
  • Anticancer
  • Cytotoxic
  • Antibacterial
3. Musa alinsanaya Fruit peel 31.5 nm UV–Vis, XRD,
  • Larvicidal
  • antibacterial
4. Psidium guajava Leaves 32.58 XRD, EDX, FT-IR, FESEM
  • Antibacterial
  • Antioxidant
5. Vitex negundo Leaves 93.33 UV-Vis, XRD, EDX, FTIR, SEM
  • Antibacterial
Samarium NPs
1. Medicago sativa leaves 10 UV-Vis
  • Antitumor
Neodymium NPs
1. Medicago sativa Leaves 10 UV-Vis, RS, PSD, DLS, EDAX, XRD, FT-IR, SEM
  • NR
Note: NR = Not reported.

4. Applications of Phytofabricated NPs

4.1. In Agriculture

Antimicrobials based on NPs have an impact because of their extensive physiochemical properties in terms of size, shape, surface area, surface energy, crystallinity, charge, aggregation, agglomeration, and chemical composition.
In previous investigations, the microbicidal activities of several inorganic NPs such as TiO2, Ag, CuO, MgO, S, and ZnO were examined separately or in combination with biopolymer [80][81][82]. As a result, it is important to create the new green synthesis-based NPs capable of managing fungal phytopathogens through biofunctionalized antimicrobial NPs to protect plants in a cost-effective, environmentally friendly, and long-term manner.

4.2. Applications of Phytofabricated NPs as Nanoantibiotics

Over past decades, resistance to antibiotics has become increasingly widespread and resulted in noteworthy deaths of humans. The emergence and re-emergence of pathogens have become a major public health concern worldwide, and the rapid emergence of antibiotic-resistant Gram-positive and Gram-negative pathogenic germs is a major public health concern [83][84][85][86][87]. The long list of drug-resistant bacteria includes macrolide-resistant Streptococcus pyogenes, sulfonamide, penicillin, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus, penicillin-resistant Streptococcus pneumoniae, multi-drug resistant Mycobacterium tuberculosis (MDR-M. tuberculosis), penicillin-resistant Neisseria gonorrhoeae (PRNG), E. coli, E. cloacae, K. pneumoniae, Salmonella enterica, Shigella flexneri, Acinetobacter baumannii, Vibrio cholerae, P. aeruginosa, and beta-lactamase-expressing Haemophilus influenzae.


  1. Jamkhande, P.G.; Ghule, N.W.; Bamer, A.H.; Kalaskar, M.G. Metal nanoparticles synthesis: An overview on methods of preparation, advantages and disadvantages, and applications. J. Drug Deliv. Sci. Technol. 2019, 53, 101174.
  2. Jayaseelan, C.; Ramkumar, R.; Rahuman, A.A.; Perumal, P. Green synthesis of gold nanoparticles using seed aqueous extract of Abelmoschus esculentus and its antifungal activity. Ind. Crops Prod. 2013, 45, 423–429.
  3. Jeevanandam, J.; Kiew, S.F.; Boakye-Ansah, S.; Lau, S.Y.; Barhoum, A.; Danquah, M.K.; Rodrigues, J. Green approaches for the synthesis of metal and metal oxide nanoparticles using microbial and plant extracts. Nanoscale 2022, 14, 2534–2571.
  4. Sushma, N.J.; Prathyusha, D.; Swathi, G.; Madhavi, T.; Raju, B.D.P.; Mallikarjuna, K.; Kim, H.-S. Facile approach to synthesize magnesium oxide nanoparticles by using Clitoria ternatea—characterization and in vitro antioxidant studies. Appl. Nanosci. 2015, 6, 437–444.
  5. Jyoti, K.; Pattnaik, P.; Singh, T. Green Synthesis of Silver Nanoparticles Using Sustainable Resources and their Use as Antibacterial Agents: A Review. Curr. Mater. Sci. Former. Recent Pat. Mater. Sci. 2021, 14, 40–52.
  6. Mathew, S.; Victorio, C.P.; Sidhi, J.; Thanzeela, B.H.B. Biosynthesis of silver nanoparticle using flowers of Calotropis gigantea (L.) WT Aiton and activity against pathogenic bacteria. Arab. J. Chem. 2020, 13, 9139–9144.
  7. Kalimuthu, K.; Cha, B.S.; Kim, S.; Park, K.S. Eco-friendly synthesis and biomedical applications of gold nanoparticles: A review. Microchem. J. 2019, 152, 104296.
  8. Jadoun, S.; Arif, R.; Jangid, N.K.; Meena, R.K. Green synthesis of nanoparticles using plant extracts: A review. Environ. Chem. Lett. 2020, 19, 355–374.
  9. Suresh, J.; Yuvakkumar, R.; Sundrarajan, M.; Hong, S.I. Green synthesis of magnesium oxide nanoparticles. In Advanced Materials Research; Trans Tech Publications Ltd: Bäch, Switzerland, 2014; Volume 952, pp. 141–144.
  10. Karaiskos, I.; Giamarellou, H. Multidrug-resistant and extensively drug-resistant Gram-negative pathogens: Current and emerging therapeutic approaches. Expert Opin. Pharmacother. 2014, 15, 1351–1370.
  11. Komal, R.; Arya, V. Biosynthesis and characterization of silver nanoparticles from aqueous leaf extracts of Carica papaya and its antibacterial activity. Int. J. Nanomater. Biostruct. 2013, 3, 17–20.
  12. Kumara, P.P.N.V.; Pammib, S.V.N.; Kollu, P.; Satyanarayana, K.V.V.; Shameema, U. Green synthesis and characterization of silver nanoparticles using Boerhaavia diffusa plant extract and their anti-bacterial activity. Ind. Crop. Prod. 2014, 52, 562–566.
  13. Lade, B.D.; Shanware, A.S. Phytonanofabrication: Methodology and factors affecting biosynthesis of nanoparticles. In Smart Nanosystems for Biomedicine, Optoelectronics and Catalysis; IntechOpen: London, UK, 2020.
  14. Farhadi, S.; Ajerloo, B.; Mohammadi, A. Low-cost and eco-friendly phyto-synthesis of Silver nanoparticles by using grapes fruit extract and study of antibacterial and catalytic effects. Int. J. Nano Dimens. 2017, 8, 49–60.
  15. Roopan, S.M.; Madhumitha, G.; Rahuman, A.A.; Kamaraj, C.; Bharathi, A.; Surendra, T.V. Low-cost and eco-friendly phyto-synthesis of silver nanoparticles using Cocos nucifera coir extract and its larvicidal activity. Ind. Crop. Prod. 2013, 43, 631–635.
  16. Fahmy, S.A.; Preis, E.; Bakowsky, U.; Azzazy, H.M.E.-S. Palladium Nanoparticles Fabricated by Green Chemistry: Promising Chemotherapeutic, Antioxidant and Antimicrobial Agents. Materials 2020, 13, 3661.
  17. Devi, G.D.; Murugan, K.; Selvam, C.P. Green synthesis of silver nanoparticles using Euphorbia hirta (Euphorbiaceae) leaf extract against crop pest of cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae). J. Biopestic. 2014, 7, 54.
  18. Luna, C.; Chávez, V.; Barriga-Castro, E.D.; Núñez, N.O.; Mendoza-Reséndez, R. Biosynthesis of silver fine particles and particles decorated with nanoparticles using the extract of Illicium verum (star anise) seeds. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2015, 141, 43–50.
  19. Qiao, J.; Qi, L. Recent progress in plant-gold nanoparticles fabrication methods and bio-applications. Talanta 2020, 223, 121396.
  20. Zhang, Y.; Zhang, C.; Xu, C.; Wang, X.; Liu, C.; Waterhouse, G.; Wang, Y.; Yin, H. Ultrasmall Au nanoclusters for biomedical and biosensing applications: A mini-review. Talanta 2019, 200, 432–442.
  21. Xiao, T.; Huang, J.; Wang, D.; Meng, T.; Yang, X. Au and Au-Based nanomaterials: Synthesis and recent progress in electrochemical sensor applications. Talanta 2019, 206, 120210.
  22. Shahriari, M.; Hemmati, S.; Zangeneh, A.; Zangeneh, M.M. Biosynthesis of gold nanoparticles using Allium noeanum Reut. ex Regel leaves aqueous extract; characterization and analysis of their cytotoxicity, antioxidant, and antibacterial properties. Appl. Organomet. Chem. 2019, 33, e5189.
  23. Gharehyakheh, S.; Ahmeda, A.; Haddadi, A.; Jamshidi, M.; Nowrozi, M.; Zangeneh, M.M.; Zangeneh, A. Effect of gold nanoparticles synthesized using the aqueous extract of Satureja hortensis leaf on enhancing the shelf life and removing Escherichia coli O157:H7 and Listeria monocytogenes in minced camel’s meat: The role of nanotechnology in the food industry. Appl. Organomet. Chem. 2020, 34, e5492.
  24. Valsalam, S.; Agastian, P.; Esmail, G.A.; Ghilan, A.-K.M.; Al-Dhabi, N.A.; Arasu, M.V. Biosynthesis of silver and gold nanoparticles using Musa acuminata colla flower and its pharmaceutical activity against bacteria and anticancer efficacy. J. Photochem. Photobiol. B Biol. 2019, 201, 111670.
  25. Zhaleh, M.; Zangeneh, A.; Goorani, S.; Seydi, N.; Zangeneh, M.M.; Tahvilian, R.; Pirabbasi, E. In vitro and in vivo evalution of cytotocicity, antioxidant, antibacterial, antifungal, and cutaneous wound healing properies of gold nanoparticles produced via a green chemistry synthesis using Gundelia tournefortii L. as acapping and reducing agent. Appl. Organomet. Chem. 2019, 33, e5015.
  26. Jeyarani, S.; Vinita, N.M.; Puja, P.; Senthamilselvi, S.; Devan, U.; Velangani, A.J.; Biruntha, M.; Pugazhendhi, A.; Kumar, P. Biomimetic gold nanoparticles for its cytotoxicity and biocompatibility evidenced by fluorescence-based assays in cancer (MDA-MB-231) and non-cancerous (HEK-293) cells. J. Photochem. Photobiol. B Biol. 2020, 202, 111715.
  27. Hemmati, S.; Joshani, Z.; Zangeneh, A.; Zangeneh, M.M. Green synthesis and chemical characterization of Thymus vulgaris leaf aqueous extract conjugated gold nanoparticles for the treatment of acute myeloid leukemia in comparison to doxorubicin in a leukemic mouse model. Appl. Organomet. Chem. 2019, 34, e5267.
  28. Ansari, S.; Bari, A.; Ullah, R.; Mathanmohun, M.; Veeraraghavan, V.P.; Sun, Z. Gold nanoparticles synthesized with Smilax glabra rhizome modulates the anti-obesity parameters in high-fat diet and streptozotocin induced obese diabetes rat model. J. Photochem. Photobiol. B Biol. 2019, 201, 111643.
  29. Ismail, E.H.; Saqer, A.M.A.; Assirey, E.; Naqvi, A.; Okasha, R.M. Successful Green Synthesis of Gold Nanoparticles using a Corchorus olitorius Extract and Their Antiproliferative Effect in Cancer Cells. Int. J. Mol. Sci. 2018, 19, 2612.
  30. Filip, G.A.; Moldovan, B.; Baldea, I.; Olteanu, D.; Suharoschi, R.; Decea, N.; Cismaru, C.M.; Gal, E.; Cenariu, M.; Clichici, S.; et al. UV-light mediated green synthesis of silver and gold nanoparticles using Cornelian cherry fruit extract and their comparative effects in experimental inflammation. J. Photochem. Photobiol. B Biol. 2018, 191, 26–37.
  31. Ahmeda, A.; Zangeneh, A.; Zangeneh, M.M. Green synthesis and chemical characterization of gold nanoparticle synthesized using Camellia sinensis leaf aqueous extract for the treatment of acute myeloid leukemia in comparison to daunorubicin in a leukemic mouse model. Appl. Organomet. Chem. 2020, 34, e5290.
  32. Liu, R.; Pei, Q.; Shou, T.; Zhang, W.; Hu, J.; Li, W. Apoptotic effect of green synthesized gold nanoparticles from Curcuma wenyujin extract against human renal cell carcinoma A498 cells. Int. J. Nanomed. 2019, 14, 4091–4103.
  33. Liu, Y.; Kim, S.; Kim, Y.J.; Perumalsamy, H.; Lee, S.; Hwang, E.; Yi, T.H. Green synthesis of gold nanoparticles using Euphrasia officinalis leaf extract to inhibit lipopolysaccharide-induced inflammation through NF-kappa B and JAK/STAT pathways in RAW 264.7 macrophages. Int. J. Nanomed. 2019, 14, 2945–2959.
  34. Park, S.Y.; Yi, E.H.; Kim, Y.; Park, G. Anti-neuroinflammatory effects of Ephedra sinica Stapf extract-capped gold nanoparticles in microglia. Int. J. Nanomed. 2019, 14, 2861–2877.
  35. Zhang, T.; Dang, M.; Zhang, W.; Lin, X. Gold nanoparticles synthesized from Euphorbia fischeriana root by green route method alleviates the isoprenaline hydrochloride induced myocardial infarction in rats. J. Photochem. Photobiol. B Biol. 2019, 202, 111705.
  36. Ahmeda, A.; Zangeneh, M.M. Novel green synthesis of Boswellia serrata leaf aqueous extract conjugated gold nanoparticles with excellent anti-acute myeloid leukemia property in comparison to mitoxantrone in a leukemic mice model: Introducing a new chemotherapeutic drug. Appl. Organomet. Chem. 2019, 34, e5344.
  37. Yun, Z.; Chinnathambi, A.; Alharbi, S.A.; Jin, Z. Biosynthesis of gold nanoparticles using Vetex negundo and evaluation of pro-apoptotic effect on human gastric cancer cell lines. J. Photochem. Photobiol. B Biol. 2019, 203, 111749.
  38. Siddiqi, K.S.; Husen, A. Recent advances in plant-mediated engineered gold nanoparticles and their application in biological system. J. Trace Elements Med. Biol. 2017, 40, 10–23.
  39. Acharya, D.; Mohanta, B.; Pandey, P. Green synthesis of Silver and Silver-gold core-shell nanoparticles using Pineapple leaf extract (Ananas comosus) and study of their antibacterial properties. Int. J. Nano Dimens. 2021, 12, 203–210.
  40. Babu, P.J.; Das, R.K.; Kumar, A.; Bora, U. Microwave-Mediated Synthesis of Gold Nanoparticles Using Coconut Water. Int. J. Green Nanotechnol. 2011, 3, 13–21.
  41. Francis, G.; Thombre, R.; Parekh, F.; Leksminarayan, P. Bioinspired synthesis of gold nanoparticles using Ficus benghalensis (Indian Banyan) leaf extract. Chem. Sci. Trans. 2014, 3, 470–474.
  42. Wani, K.; Choudhari, A.; Chikate, R.; Kaul-Ghanekar, R. Synthesis and characterization of gold nanoparticles using Ficus religiosa extract. Carbon Sci. Technol. 2013, 5, 203–210.
  43. Reddy, G.R.; Morais, A.B.; Gandhi, N.N. Green Synthesis, Characterization and in vitro Antibacterial Studies of Gold Nanoparticles by Using Senna siamea Plant Seed Aqueous Extract at Ambient Conditions. Asian J. Chem. 2013, 25, 8541–8544.
  44. Amini, S.M. Preparation of antimicrobial metallic nanoparticles with bioactive compounds. Mater. Sci. Eng. C 2019, 103, 109809.
  45. Baharara, J.; Namvar, F.; Ramezani, T.; Hosseini, N.; Mohamad, R. Green Synthesis of Silver Nanoparticles using Achillea biebersteinii Flower Extract and Its Anti-Angiogenic Properties in the Rat Aortic Ring Model. Molecules 2014, 19, 4624–4634.
  46. Jagtap, U.B.; Bapat, V.A. Green synthesis of silver nanoparticles using Artocarpus heterophyllus Lam. seed extract and its antibacterial activity. Ind. Crop. Prod. 2013, 46, 132–137.
  47. Bindhu, M.; Umadevi, M. Synthesis of monodispersed silver nanoparticles using Hibiscus cannabius leaf extract and its antimicrobial activity. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2013, 101, 184–190.
  48. Das, S.; Parida, U.K.; Bindhani, B.K. Green biosynthesis of silver nanoparticles using Moringa oleifera L. leaf. Int. J. Nanotechnol. Appl. 2013, 3, 51–62.
  49. Salari, S.; Bahabadi, S.E.; Samzadeh-Kermani, A.; Yosefzaei, F. In-vitro Evaluation of Antioxidant and Antibacterial Potential of Green Synthesized Silver Nanoparticles Using Prosopis farcta Fruit Extract. Iran. J. Pharm. Res. IJPR 2019, 18, 430–455.
  50. Gopinath, K.; Gowri, S.; Arumugam, A. Phytosynthesis of silver nanoparticles using Pterocarpus santalinus leaf extract and their antibacterial properties. J. Nanostruct. Chem. 2013, 3, 68.
  51. Gnanajobitha, G.; Paulkumar, K.; Vanaja, M.; RajeshKumar, S.; Malarkodi, C.; Annadurai, G.; Kannan, C. Fruit-mediated synthesis of silver nanoparticles using Vitis vinifera and evaluation of their antimicrobial efficacy. J. Nanostruct. Chem. 2013, 3, 67.
  52. Attar, A.; Yapaoz, M.A. Biosynthesis of palladium nanoparticles using Diospyros kaki leaf extract and determination of antibacterial efficacy. Prep. Biochem. Biotechnol. 2018, 48, 629–634.
  53. Mavukkandy, M.O.; Chakraborty, S.; Abbasi, T.; Abbasi, S.A. A Clean-Green Synthesis of Platinum Nanoparticles Utilizing a Pernicious Weed Lantana (Lantana Camara). Am. J. Eng. Appl. Sci. 2016, 9, 84–90.
  54. Narendhran, S.; Manikandan, M.; & Shakila, P. Antibacterial, antioxidant properties of Solanum trilobatum and sodium hydroxide-mediated magnesium oxide nanoparticles: A green chemistry approach. Bull. Mater. Sci. 2019, 42, 1–8.
  55. Tahir, K.; Nazir, S.; Li, B.; Ahmad, A.; Nasir, T.; Khan, A.U.; Shah, S.A.A.; Khan, Z.U.H.; Yasin, G.; Hameed, M.U. Sapium sebiferum leaf extract mediated synthesis of palladium nanoparticles and in vitro investigation of their bacterial and photocatalytic activities. J. Photochem. Photobiol. B Biol. 2016, 164, 164–173.
  56. Sathishkumar, M.; Sneha, K.; Yun, Y.S. Palladium nanocrystal synthesis using Curcuma longa tuber extract. Int. J. Mater. Sci. 2009, 4, 11–17.
  57. Surendra, T.; Roopan, S.M.; Arasu, M.V.; Al-Dhabi, N.A.; Rayalu, G.M. RSM optimized Moringa oleifera peel extract for green synthesis of M. oleifera capped palladium nanoparticles with antibacterial and hemolytic property. J. Photochem. Photobiol. B Biol. 2016, 162, 550–557.
  58. Khan, Z.U.H.; Sadiq, H.M.; Shah, N.S.; Khan, A.U.; Muhammad, N.; Hassan, S.U.; Tahir, K.; Safi, S.Z.; Khan, F.U.; Imran, M.; et al. Greener synthesis of zinc oxide nanoparticles using Trianthema portulacastrum extract and evaluation of its photocatalytic and biological applications. J. Photochem. Photobiol. B Biol. 2019, 192, 147–157.
  59. Ogunyemi, S.O.; Abdallah, Y.; Zhang, M.; Fouad, H.; Hong, X.; Ibrahim, E.; Masum, M.I.; Hossain, A.; Mo, J.; Li, B. Green synthesis of zinc oxide nanoparticles using different plant extracts and their antibacterial activity against Xanthomonas oryzae pv. oryzae. Artif. Cells Nanomed. Biotechnol. 2019, 47, 341–352.
  60. Sukri, S.N.A.M.; Shameli, K.; Wong, M.M.-T.; Teow, S.-Y.; Chew, J.; Ismail, N.A. Cytotoxicity and antibacterial activities of plant-mediated synthesized zinc oxide (ZnO) nanoparticles using Punica granatum (pomegranate) fruit peels extract. J. Mol. Struct. 2019, 1189, 57–65.
  61. Nemati, S.; Hosseini, H.A.; Hashemzadeh, A.; Mohajeri, M.; Sabouri, Z.; Darroudi, M.; Oskuee, R.K. Cytotoxicity and photocatalytic applications of biosynthesized ZnO nanoparticles by Rheum turketanicum rhizome extract. Mater. Res. Express 2019, 6, 125016.
  62. Sharmila, G.; Thirumarimurugan, M.; Muthukumaran, C. Green synthesis of ZnO nanoparticles using Tecoma castanifolia leaf extract: Characterization and evaluation of its antioxidant, bactericidal and anticancer activities. Microchem. J. 2018, 145, 578–587.
  63. Hameed, S.; Khalil, A.T.; Ali, M.; Numan, M.; Khamlich, S.; Shinwari, Z.K.; Maaza, M. Greener synthesis of ZnO and Ag–ZnO nanoparticles using Silybum marianum for diverse biomedical applications. Nanomedicine 2019, 14, 655–673.
  64. Azizi, S.; Mohamad, R.; Bahadoran, A.; Bayat, S.; Rahim, R.A.; Ariff, A.; Saad, W.Z. Effect of annealing temperature on antimicrobial and structural properties of bio-synthesized zinc oxide nanoparticles using flower extract of Anchusa italica. J. Photochem. Photobiol. B Biol. 2016, 161, 441–449.
  65. Ali, K.; Dwivedi, S.; Azam, A.; Saquib, Q.; Al-Said, M.S.; Al-Khedhairy, A.; Musarrat, J. Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates. J. Colloid Interface Sci. 2016, 472, 145–156.
  66. Jafarirad, S.; Mehrabi, M.; Divband, B.; Kosari-Nasab, M. Biofabrication of zinc oxide nanoparticles using fruit extract of Rosa canina and their toxic potential against bacteria: A mechanistic approach. Mater. Sci. Eng. C 2016, 59, 296–302.
  67. Supraja, N.; Prasad, T.N.V.K.V.; Krishna, T.G.; David, E. Synthesis, characterization, and evaluation of the antimicrobial efficacy of Boswellia ovalifoliolata stem bark-extract-mediated zinc oxide nanoparticles. Appl. Nanosci. 2015, 6, 581–590.
  68. Ramanujam, K.; Sundrarajan, M. Antibacterial effects of biosynthesized MgO nanoparticles using ethanolic fruit extract of Emblica officinalis. J. Photochem. Photobiol. B Biol. 2014, 141, 296–300.
  69. Altikatoglu, M.; Attar, A.; Erci, F.; Cristache, C.M.; Isildak, I. Green synthesis of copper oxide nanoparticles using Ocimum basilicum extract and their antibacterial activity. Fresenius Environ. Bull. 2017, 25, 7832–7837.
  70. Pagar, K.; Ghotekar, S.; Pagar, T.; Nikam, A.; Pansambal, S.; Oza, R.; Sanap, D.; Dabhane, H. Antifungal activity of biosynthesized CuO nanoparticles using leaves extract of Moringa oleifera and their structural characterizations. Asian J. Nanosci. Mater. 2020, 3, 15–23.
  71. Vanathi, P.; Rajiv, P.; Sivaraj, R. Synthesis and characterization of Eichhornia-mediated copper oxide nanoparticles and assessing their antifungal activity against plant pathogens. Bull. Mater. Sci. 2016, 39, 1165–1170.
  72. Naika, H.R.; Lingaraju, K.; Manjunath, K.; Kumar, D.; Nagaraju, G.; Suresh, D.; Nagabhushana, H. Green synthesis of CuO nanoparticles using Gloriosa superba L. extract and their antibacterial activity. J. Taibah Univ. Sci. 2015, 9, 7–12.
  73. Ullah, A.M.; Tamanna, A.N.; Hossain, A.; Akter, M.; Kabir, M.F.; Tareq, A.R.; Kibria, A.F.; Kurasaki, M.; Rahman, M.M.; Khan, M.N. In vitro cytotoxicity and antibiotic application of green route surface modified ferromagnetic TiO2 nanoparticles. RSC Adv. 2019, 23, 13254–13262.
  74. Rueda, D.; Arias, V.; Zhang, Y.; Cabot, A.; Agudelo, A.C.; Cadavid, D. Low-cost tangerine peel waste mediated production of Titanium Dioxide Nanocrystals: Synthesis and characterization. Environ. Nanotechnol. Monit. Manag. 2020, 13, 100285.
  75. Kirthi, A.V.; Jayaseelan, C.; Rahuman, A. Biosynthesis and characterization of different nanoparticles and its larvicidal activity against human disease vectors. Mar. Biomater. 2013, 25, 273–288.
  76. Santhoshkumar, T.; Rahuman, A.A.; Jayaseelan, C.; Rajakumar, G.; Marimuthu, S.; Kirthi, A.V.; Velayutham, K.; Thomas, J.; Venkatesan, J.; Kim, S.-K. Green synthesis of titanium dioxide nanoparticles using Psidium guajava extract and its antibacterial and antioxidant properties. Asian Pac. J. Trop. Med. 2014, 7, 968–976.
  77. Ambika, S.; Sundrarajan, M. BF4 ionic liquid-mediated synthesis of TiO2 nanoparticles using Vitex negundo Linn extract and its antibacterial activity. J. Mol. Liquids 2016, 221, 986–992.
  78. Hu, R.; Beguiristain, T.; De Junet, A.; Leyval, C. Bioavailability and transfer of elevated Sm concentration to alfalfa in spiked soils. Environ. Sci. Pollut. Res. 2020, 27, 44333–44341.
  79. Rezaee, A. Accumulation and Toxicity of Lanthanum and Neodymium in Horticultural Plants. Ph.D. Thesis, University of Guelph, Guelph, ON, Canada, 2018.
  80. Küünal, S.; Rauwel, P.; Rauwel, E. Plant extract mediated synthesis of nanoparticles. In Emerging Applications of Nanoparticles and Architecture Nanostructures; Elsevier: Amsterdam, The Netherlands, 2018; Volume 12, pp. 411–446.
  81. Parham, S.; Wicaksono, D.H.B.; Bagherbaigi, S.; Lee, S.L.; Nur, H. Antimicrobial Treatment of Different Metal Oxide Nanoparticles: A Critical Review. J. Chin. Chem. Soc. 2016, 63, 385–393.
  82. Qamar, S.U.R.; Ahmad, J.N. Nanoparticles: Mechanism of biosynthesis using plant extracts, bacteria, fungi, and their applications. J. Mol. Liq. 2021, 334, 116040.
  83. Saka, R.; Chella, N. Nanotechnology for delivery of natural therapeutic substances: A review. Environ. Chem. Lett. 2020, 19, 1097–1106.
  84. Sharma, V.; Kaushik, S.; Pandit, P.; Dhull, D.; Yadav, J.P.; Kaushik, S. Green synthesis of silver nanoparticles from medicinal plants and evaluation of their antiviral potential against chikungunya virus. Appl. Microbiol. Biotechnol. 2018, 103, 881–891.
  85. Singh, A.; Gautam, P.K.; Verma, A.; Singh, V.; Shivapriya, P.M.; Shivalkar, S.; Sahoo, A.K.; Samanta, S.K. Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review. Biotechnol. Rep. 2020, 25, e00427.
  86. Singh, P.; Kim, Y.-J.; Zhang, D.; Yang, D.-C. Biological Synthesis of Nanoparticles from Plants and Microorganisms. Trends Biotechnol. 2016, 34, 588–599.
  87. Sunny, N.E.; Kaviya, A.; Kumar, S.V. Mechanistic approach on the synthesis of metallic nanoparticles from microbes. In Agri-Waste and Microbes for Production of Sustainable Nanomaterials; Elsevier: Amsterdam, The Netherlands, 2022; pp. 577–602.
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