Submitted Successfully!
To reward your contribution, here is a gift for you: A free trial for our video production service.
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Version Summary Created by Modification Content Size Created at Operation
1 -- 1389 2022-03-29 10:36:55 |
2 format Meta information modification 1389 2022-03-30 02:52:58 |

Video Upload Options

Do you have a full video?

Confirm

Are you sure to Delete?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Papadopoulos, S.; Alevra, A.; Exadactylos, A.; Mente, E. Melatonin in Sperm Cryopreservation of Farm Animals. Encyclopedia. Available online: https://encyclopedia.pub/entry/21141 (accessed on 15 October 2024).
Papadopoulos S, Alevra A, Exadactylos A, Mente E. Melatonin in Sperm Cryopreservation of Farm Animals. Encyclopedia. Available at: https://encyclopedia.pub/entry/21141. Accessed October 15, 2024.
Papadopoulos, Serafeim, Alexandra Alevra, Athanasios Exadactylos, Eleni Mente. "Melatonin in Sperm Cryopreservation of Farm Animals" Encyclopedia, https://encyclopedia.pub/entry/21141 (accessed October 15, 2024).
Papadopoulos, S., Alevra, A., Exadactylos, A., & Mente, E. (2022, March 29). Melatonin in Sperm Cryopreservation of Farm Animals. In Encyclopedia. https://encyclopedia.pub/entry/21141
Papadopoulos, Serafeim, et al. "Melatonin in Sperm Cryopreservation of Farm Animals." Encyclopedia. Web. 29 March, 2022.
Melatonin in Sperm Cryopreservation of Farm Animals
Edit

Cryopreservation is a technique that offers various advantages, especially in fish, among others, that makes the reproduction of species easier through a constant supply of sperm, synchronization of the gamete availability of both sexes, storage of semen for genetic improvement programs, reduction in the cost by eliminating the need to maintain male broodstock, and conserving the gametes of endangered species. However, freezing and warming procedures for cryopreservation lead to a reduction in the quality and viability of cryopreserved sperm because of oxidative stress.

cryopreservation fish farm animals human semen melatonin antioxidant oxidative stress

1. Introduction

The use of the technology of sperm cryopreservation offers many benefits extensively described in previous reviews for fish [1][2][3], farm animals [4][5][6], and humans [7][8]. In addition, extensive reviews have been published that include detailed protocols for fish species [9][10][11][12].
The development of fish sperm cryopreservation protocols for marine species is not as extensive for freshwater species, and the plethora of research work concerns the latter [2]. The main goal of most work on new species is to maintain stocks to ensure production, to optimize genetic improvement programs, and to properly manage offspring [2][13]; therefore, the development of cryopreservation protocols would help to achieve the above objectives [2]. In addition, cryopreservation of gametes can be used to protect endangered species [14].

2. Cryodamage of Spermatozoa

The cryopreservation of sperm provokes a decrease in its quality and viability, mainly due to the increase in the production of reactive oxygen species (ROS) and the alteration of oxidative metabolism during the process of freezing and warming [15].
Although the sperm of fish, like all biological systems, are provided with protective antioxidants agents [16][17], in the cryopreservation technique, the antioxidant defense of the sperm is almost insufficient due to the reduced amount of these factors after the dilution of sperm [18][19]. As a consequence, during cryopreservation, an imbalance is observed between ROS production and the inherent antioxidant system [20][21], known as oxidative stress. Scientific studies in fish have shown that ROS production during cryopreservation contributes to the occurrence of lesions in sperm [22][23], resulting in lipid peroxidation (LPO) [24][25], DNA fragmentation [18][26], mitochondrial damage and dysfunction [23][27][28][29], protein oxidation [30], and loss or inactivation of enzymes associated with sperm motility [24][31][32]. Due to the aforementioned problems, it has become common practice to enrich the cryopreservation diluents of the sperm of many fish species with enzymatic and non-enzymatic antioxidants [18][33][34][35]; nevertheless, their use is often controversial.

3. Antioxidant Supplementation of Semen Extenders: The Case of Melatonin

Considering that the increased production of ROS during the cryopreservation process is partly responsible for the poor quality of sperm after thawing, various antioxidants have been proposed and tested for the cryopreservation of sperm of various terrestrial animals and fish [36]. Recent published studies focus on the protective role of various antioxidants, especially melatonin, in maintaining male fertility in both productive animals [37][38] and fish species [39], thus demonstrating the increased interest in this hormone.
Melatonin, the principal hormone secreted by the pineal gland, has been suggested as a free radical scavenger and antioxidant [40]. Mainly due to the fact of its amphiphilic nature that allows it to pass through all morphophysiological barriers of the cell; it is one of the most effective antioxidants protecting cells from oxidative stress caused by reactive species [41]. In addition, its lipophilic nature allows it to easily cross cell membranes and act directly in various organs including those of the reproductive system [42][43]. Of particular interest is the fact that melatonin’s metabolites, which are formed when the hormone functions as a scavenger, are likewise equally as good or better than the parent molecule in neutralizing toxic oxygen-based and nitrogen-based reactants [44].
The cytoprotective action of melatonin and its metabolites is due to the fact of its direct and indirect antioxidant properties [45]. The direct properties include the scavenging of both ROS and RNS (reactive nitrogen species) [46], while the indirect effects cover the stimulation of antioxidative enzymes and inhibition of pro-oxidative enzymes [47], probably through epigenetic mechanisms [48]. This molecule with its strong detoxifying effect at the mitochondrial level, could be an appropriate candidate for improving the quality of animal sperm during cryopreservation [49][50]. It has been observed that this substance could protect sperm from oxidative damage [51], maintain its viability [42][52], and reduce morphological abnormalities [53][54] and DNA fragmentation [55]. Improvement in sperm quality due to the high levels of endogenous melatonin has been found in humans [56], while in vitro treatment with this hormone can improve human sperm motility [56] and several quality parameters of ram [57] and pig [58] sperm. Finally, melatonin has been used as an additive antioxidant in the cryopreservation of sperm [59][60] helping to increase its quality after thawing [61].

4. Melatonin Supplementation in Farm Animals and Human Freezing Medium

The majority of recent studies evaluating the effect of melatonin on the cryopreservation of sperm focus on cattle compared to those on sheep, pigs, or goats [38].
In summary, the effect of melatonin on sperm is shown in Table 1 and the pathway of action in Figure 1.
Figure 1. Illustration of the positive effects of melatonin (MEL) on spermatozoa. MT1: melatonin type 1 receptor; MT2: melatonin type 2 receptor; ROS: reactive oxygen species; RNS: reactive nitrogen species; LOP: lipid peroxidation; SOD: superoxide dismutase; CAT: catalase; GPX: glutathione peroxidase; HSP90: heat shock protein 90; AST: aspartate amino transferase; ALT: alanine aminotransferase; AKP: alkaline phosphatase; MDA: malondialdehyde; MPTP: mitochondrial permeability transition pore.
Table 1. Effects of melatonin on sperm.
Pathway of Action Εffects on Spermatozoa References
Reduction in excessive production of free radicals. Positive effects on the function and morphometry parameters of sperm in humans and various farm animals. [62][63][64]
Upregulation of the expression of heat shock protein (HSP) 90. Resistance to stress factors in frozen–thawed sperm. [62]
Upregulation of antioxidant enzymes, e.g., superoxide dismutase, glutathione peroxidase, and catalase. Elimination of ROS levels causing preservation of membrane fluidity and motility. [62][65][66]
Regulation of mitochondrial permeability transition pores (MPTPs) as a result of binding to the MT1 receptor and the activation of the PI3K/AKT/GSK 3β pathway. Improvement in the quality and fertilizing capacity of frozen–thawed ram sperm. [67]
Reduction of LPO production leads to (a) stabilization of membrane integrity and (b) prevention of leakage of intracellular enzymes, e.g., aspartate transaminase (AST), alanine transaminase (ALT), and phosphatase. Decreased malondialdehyde (MDA) concentrations and oxidative stress. [68][69]
Enhancement of the functions of antioxidant enzymes. Protection against oxidative modifications of DNA. DNA becomes more resistant to fragmentation, reducing the rate of sperm degradation and enhancing its viability and functions. [42][59][70][71]
Action as an anti-apoptotic molecule.
(a)
Reduction of mitochondrial CYT C release and inhibition of the activation of CAS-9 and CAS-3 proteins.
[72]
(b)
Reduction of pro-apoptotic BAX mRNA transcripts and increase in anti-apoptotic BCL-2 mRNA transcripts in bull and buck sperm.
[73][74]
Several studies have shown that the cryoprotective effects of melatonin depend on its concentration [59][75]. In the international literature, many different concentrations have been defined as being optimal for the cryoprotection of sperm. Among others, some studies have shown that 1 and 2 mM are the optimal concentrations, while another study found that the best concentration was 0.25 mg/mL in various species [76]. In humans, a better range of sperm viability and motility were observed at a 3 mM melatonin concentration, and intracellular ROS levels were reduced [51]. The vitality of thawed human sperm was found to be improved after the supplementation of 0.1 mM melatonin, while it was adversely affected by other concentrations (i.e., 0.001 and 1 mM) [62]. Karimfar et al. [75] reported that the best protection for human sperm against cryopreservation damage was observed at a 0.01 mM melatonin concentration.
Studies have shown that parameters, such as membrane integrity, motility and velocity, capacitation, antioxidant protein quantity, and developmental competence of fresh and frozen sperm improved after administration of moderate melatonin concentrations [62][77][78][79]. The addition of melatonin to cryopreservation solutions of bovine sperm [71], sheep [80][81], goats [82][83], rams [70], buffalo [84], and pigs [85][86] increased the number of live sperm with normal quality after thawing, including the normal length and movement of the tail, and reduced morphological defects of the sperm. In addition, in farmed animals, the frozen sperm with membrane integrity showed greater motility [60][86].
The scientific work on the role of melatonin in the mitigation of oxidative damage, mostly concerns humans and fewer farm animals. Significant progress has been made in understanding the action of melatonin against oxidative damage caused by cryopreservation [38]. In studies of farm animals, the available data focus on the positive effects of melatonin on sperm quality indicators but without clearly identifying the mechanisms by which it acts. It would therefore be crucial to further investigate these mechanisms in both fresh and frozen sperm, especially in sheep, goats, and pigs [38].

References

  1. Cabrita, E.; Sarasquete, C.; Martínez-Páramo, S.; Robles, V.; Beirão, J.; Pérez-Cerezales, S.; Herráez, M.P. Cryopreservation of Fish Sperm: Applications and Perspectives. J. Appl. Ichthyol. 2010, 26, 623–635.
  2. Martinez-Paramo, S.; Horváth, A.; Labbe, C.; Zhang, T.; Robles, V.; Herraez, P.; Suquet, M.; Adams, S.; Viveiros, A.; Tiersch, T.R.; et al. Cryobanking of Aquatic Species. Aquaculture 2017, 472, 156–177.
  3. Magnotti, C.; Cerqueira, V.; Lee-Estevez, M.; Farias, J.G.; Valdebenito, I.; Figueroa, E. Cryopreservation and Vitrification of Fish Semen: A Review with Special Emphasis on Marine Species. Rev. Aquac. 2018, 10, 15–25.
  4. Lv, C.; Wu, G.; Hong, Q.; Quan, G. Spermatozoa Cryopreservation: State of Art and Future in Small Ruminants. Biopreserv. Biobank. 2019, 17, 171–182.
  5. Salinas, M.B.; Chuammitri, P.; Sringarm, K.; Boonyayatra, S.; Sathanawongs, A. Current Perspectives on Ruminant Sperm Freezability: Harnessing Molecular Changes Related to Semen Quality through Omics Technologies. Veter. Integr. Sci. 2021, 19, 487–511.
  6. Yánez-Ortiz, I.; Catalán, J.; Rodríguez-Gil, J.E.; Miró, J.; Yeste, M. Advances in Sperm Cryopreservation in Farm Animals: Cattle, Horse, Pig and Sheep. Anim. Reprod. Sci. 2021, 106904, in press.
  7. Di Santo, M.; Tarozzi, N.; Nadalini, M.; Borini, A. Human Sperm Cryopreservation: Update on Techniques, Effect on DNA Integrity, and Implications for ART. Adv. Urol. 2012, 2012, 854837.
  8. Tao, Y.; Sanger, E.; Saewu, A.; Leveille, M.-C. Human Sperm Vitrification: The State of the Art. Reprod. Biol. Endocrinol. 2020, 18, 17.
  9. Kopeika, E.; Kopeika, J.; Zhang, T. Cryopreservation of Fish Sperm. In Cryopreservation and Freeze-Drying Protocols; Day, J.G., Stacey, G.N., Eds.; Humana Press: Totowa, NJ, USA, 2007; Volume 368, pp. 203–217. ISBN 978-1-58829-377-0.
  10. Cabrita, E.; Robles, V.; Herraez, P. Methods in Reproductive Aquaculture: Marine and Freshwater Species, 1st ed.; CRC Press: Boca Raton, FL, USA, 2008; ISBN 978-0-8493-8053-2.
  11. Tiersch, T.R.; Yang, H.; Jenkins, J.A.; Dong, Q. Sperm Cryopreservation in Fish and Shellfish. Soc. Reprod. Fertil. Suppl. 2007, 65, 493–508.
  12. Tiersch, T.R. Introduction to the Second Edition. In Cryopreservation in Aquatic Species, 2nd ed.; Tiersch, T.R., Green, C.C., Eds.; World Aquaculture Society: Baton Rouge, LA, USA, 2011; pp. 1–17.
  13. Exadactylos, A.; Arvanitoyannis, I. Aquaculture Biotechnology for enhanced fish production for human consumption. In Microbial biotechnology in Agriculture and Aquaculture; Ray, R.C., Ed.; Science Publishers Inc.: Enfield, NH, USA, 2006; Volume II.
  14. Zhou, G.-B.; Zhu, S.-E.; Hou, Y.-P.; Jin, F.; Yang, Q.-E.; Yang, Z.-Q.; Quan, G.-B.; Tan, H.-M. Vitrification of Mouse Embryos at Various Stages by Open-Pulled Straw (OPS) Method. Anim. Biotechnol. 2005, 16, 153–163.
  15. Marques, L.S.; Fossati, A.A.N.; Rodrigues, R.B.; da Rosa, H.T.; Izaguirry, A.P.; Ramalho, J.B.; Moreira, J.C.F.; Santos, F.W.; Zhang, T.; Streit, D.P. Slow Freezing versus Vitrification for the Cryopreservation of Zebrafish (Danio rerio) Ovarian Tissue. Sci. Rep. 2019, 9, 15353.
  16. Silva, S.; Soares, A.; Batista, A.; Almeida, F.; Nunes, J.; Peixoto, C.; Guerra, M. In Vitro and In Vivo Evaluation of Ram Sperm Frozen in Tris Egg-Yolk and Supplemented with Superoxide Dismutase and Reduced Glutathione: In Vitro and In Vivo Effect of the Addition of SOD and GSH. Reprod. Domest. Anim. 2011, 46, 874–881.
  17. Birben, E.; Sahiner, U.M.; Sackesen, C.; Erzurum, S.; Kalayci, O. Oxidative Stress and Antioxidant Defense. World Allergy Organ. J. 2012, 5, 9–19.
  18. Cabrita, E.; Ma, S.; Diogo, P.; Martínez-Paramo, S.; Sarasquete, C.; Dinis, M.T. The Influence of Certain Aminoacids and Vitamins on Post-Thaw Fish Sperm Motility, Viability and DNA Fragmentation. Anim. Reprod. Sci. 2011, 125, 189–195.
  19. Martinez-Paramo, S.; Diogo, P.; Dinis, M.T.; Herraez, M.P.; Sarasquete, C.; Cabrita, E. Incorporation of Ascorbic Acid and α-Tocopherol to the Extender Media to Enhance Antioxidant System of Cryopreserved Sea Bass Sperm. Theriogenology 2012, 77, 1129–1136.
  20. Halliwell, B. Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life. Plant Physiol. 2006, 141, 312–322.
  21. Shaliutina-Kolesova, A.; Xian, M.; Nian, R. Antioxidant Defense System in Protein Fractions of Common Carp (Cyprinus carpio) Seminal Plasma. Czech J. Anim. Sci. 2019, 64, 265–271.
  22. Balamurugan, B.; Ghosh, S.; Lone, S.; Prasad, J.; Das, G.; Katiyar, R.; Mustapha, A.R.; Kumar, A.; Verma, M. Partial Deoxygenation of Extender Improves Sperm Quality, Reduces Lipid Peroxidation and Reactive Oxygen Species during Cryopreservation of Buffalo (Bubalus bubalis) Semen. Anim. Reprod. Sci. 2018, 189, 60–68.
  23. Figueroa, E.; Lee-Estevez, M.; Valdebenito, I.; Watanabe, I.-S.; Oliveira, R.P.S.; Romero, J.; Castillo, R.L.; Farías, J.G. Effects of Cryopreservation on Mitochondrial Function and Sperm Quality in Fish. Aquaculture 2019, 511, 634190.
  24. Klaiwattana, P.; Srisook, K.; Srisook, E.; Vuthiphandchai, V.; Neumvonk, J. Effect of cryopreservation on lipid composition and antioxidant enzyme activity of seabass (Lates calcarifer) sperm. Iran. J. Fish. Sci. 2016, 15, 157–169.
  25. Riesco, M.F.; Oliveira, C.; Soares, F.; Gavaia, P.J.; Dinis, M.T.; Cabrita, E. Solea senegalensis Sperm Cryopreservation: New Insights on Sperm Quality. PLoS ONE 2017, 12, e0186542.
  26. Öğretmen, F.; İnanan, B.E.; Kutluyer, F.; Kayim, M. Effect of Semen Extender Supplementation with Cysteine on Postthaw Sperm Quality, DNA Damage, and Fertilizing Ability in the Common Carp (Cyprinus carpio). Theriogenology 2015, 83, 1548–1552.
  27. He, S.; Woods III, L.C. Effects of Dimethyl Sulfoxide and Glycine on Cryopreservation Induced Damage of Plasma Membranes and Mitochondria to Striped Bass (Morone saxatilis) Sperm. Cryobiology 2004, 48, 254–262.
  28. Cabrita, E.; Robles, V.; Cuñado, S.; Wallace, J.C.; Sarasquete, C.; Herráez, M.P. Evaluation of Gilthead Sea Bream, Sparus aurata, Sperm Quality after Cryopreservation in 5 mL Macrotubes. Cryobiology 2005, 50, 273–284.
  29. Figueroa, E.; Valdebenito, I.; Merino, O.; Ubilla, A.; Risopatrón, J.; Farias, J.G. Cryopreservation of Atlantic Salmon Salmo salar Sperm: Effects on Sperm Physiology. J. Fish. Biol. 2016, 89, 1537–1550.
  30. Purdy, P.H.; Barbosa, E.A.; Praamsma, C.J.; Schisler, G.J. Modification of Trout Sperm Membranes Associated with Activation and Cryopreservation. Implications for Fertilizing Potential. Cryobiology 2016, 73, 73–79.
  31. Dietrich, M.A.; Arnold, G.J.; Fröhlich, T.; Otte, K.A.; Dietrich, G.J.; Ciereszko, A. Proteomic Analysis of Extracellular Medium of Cryopreserved Carp (Cyprinus carpio L.) Semen. Comp. Biochem. Physiol. Part D Genom. Proteom. 2015, 15, 49–57.
  32. Nynca, J.; Arnold, G.J.; Fröhlich, T.; Ciereszko, A. Cryopreservation-Induced Alterations in Protein Composition of Rainbow Trout Semen. Proteomics 2015, 15, 2643–2654.
  33. Lahnsteiner, F.; Mansour, N.; Kunz, F.A. The Effect of Antioxidants on the Quality of Cryopreserved Semen in Two Salmonid Fish, the Brook Trout (Salvelinus fontinalis) and the Rainbow Trout (Oncorhynchus mykiss). Theriogenology 2011, 76, 882–890.
  34. Figueroa, E.; Farias, J.G.; Lee-Estevez, M.; Valdebenito, I.; Risopatrón, J.; Magnotti, C.; Romero, J.; Watanabe, I.; Oliveira, R.P.S. Sperm Cryopreservation with Supplementation of α-Tocopherol and Ascorbic Acid in Freezing Media Increase Sperm Function and Fertility Rate in Atlantic Salmon (Salmo salar). Aquaculture 2018, 493, 1–8.
  35. Li, P.; Xi, M.; Du, H.; Qiao, X.; Liu, Z.; Wei, Q. Antioxidant Supplementation, Effect on Post-Thaw Spermatozoan Function in Three Sturgeon Species. Reprod. Domest. Anim. 2018, 53, 287–295.
  36. Sandoval-Vargas, L.; Silva Jiménez, M.; Risopatrón González, J.; Villalobos, E.F.; Cabrita, E.; Valdebenito Isler, I. Oxidative Stress and Use of Antioxidants in Fish Semen Cryopreservation. Rev. Aquac. 2021, 13, 365–387.
  37. Sun, T.-C.; Li, H.-Y.; Li, X.-Y.; Yu, K.; Deng, S.-L.; Tian, L. Protective Effects of Melatonin on Male Fertility Preservation and Reproductive System. Cryobiology 2020, 95, 1–8.
  38. Ofosu, J.; Qazi, I.H.; Fang, Y.; Zhou, G. Use of Melatonin in Sperm Cryopreservation of Farm Animals: A Brief Review. Anim. Reprod. Sci. 2021, 233, 106850.
  39. Félix, F.; Oliveira, C.C.V.; Cabrita, E. Antioxidants in Fish Sperm and the Potential Role of Melatonin. Antioxidants 2020, 10, 36.
  40. Meng, X.; Li, Y.; Li, S.; Zhou, Y.; Gan, R.-Y.; Xu, D.-P.; Li, H.-B. Dietary Sources and Bioactivities of Melatonin. Nutrients 2017, 9, 367.
  41. Hardeland, R.; Cardinali, D.P.; Srinivasan, V.; Spence, D.W.; Brown, G.M.; Pandi-Perumal, S.R. Melatonin—A Pleiotropic, Orchestrating Regulator Molecule. Prog. Neurobiol. 2011, 93, 350–384.
  42. Reiter, R.J.; Tan, D.-X.; Manchester, L.C.; Paredes, S.D.; Mayo, J.C.; Sainz, R.M. Melatonin and Reproduction Revisited. Biol. Reprod. 2009, 81, 445–456.
  43. Maitra, S.K.; Hasan, K.N. The Role of Melatonin as a Hormone and an Antioxidant in the Control of Fish Reproduction. Front. Endocrinol. 2016, 7, 38.
  44. Galano, A.; Tan, D.X.; Reiter, R.J. On the Free Radical Scavenging Activities of Melatonin’s Metabolites, AFMK and AMK. J. Pineal Res. 2013, 54, 245–257.
  45. Reiter, R.J.; Rosales-Corral, S.; Tan, D.X.; Jou, M.J.; Galano, A.; Xu, B. Melatonin as a Mitochondria-Targeted Antioxidant: One of Evolution’s Best Ideas. Cell. Mol. Life Sci. 2017, 74, 3863–3881.
  46. Tan, D.-X.; Chen, L.D.; Poeggeler, B.; Manchester, L.C.; Reiter, R. Melatonin: A Potent Endogenous Hydroxyl Radical Scavenger. Endocr. J. 1993, 1, 57–60.
  47. Reiter, R.J.; Tan, D.; Sainz, R.M.; Mayo, J.C.; Lopez-Burillo, S. Melatonin: Reducing the Toxicity and Increasing the Efficacy of Drugs. J. Pharm. Pharmacol. 2010, 54, 1299–1321.
  48. Korkmaz, A.; Rosales-Corral, S.; Reiter, R.J. Gene Regulation by Melatonin Linked to Epigenetic Phenomena. Gene 2012, 503, 1–11.
  49. Da Silva, C.M.B.; Macías-García, B.; Miró-Morán, A.; González-Fernández, L.; Morillo-Rodriguez, A.; Ortega-Ferrusola, C.; Gallardo-Bolaños, J.M.; Stilwell, G.; Tapia, J.A.; Peña, F.J. Melatonin Reduces Lipid Peroxidation and Apoptotic-like Changes in Stallion Spermatozoa: Melatonin Reduces Lipid Peroxidation. J. Pineal Res. 2011, 51, 172–179.
  50. Chen, X.-J.; Zhang, Y.; Jia, G.-X.; Meng, Q.-G.; Bunch, T.-D.; Liu, G.-S.; Zhu, S.-E.; Xhou, G.-B. Effect of Melatonin Supplementation on Cryopreserved Sperm Quality in Mouse. Cryo Lett. 2016, 37, 115–122.
  51. Najafi, A.; Adutwum, E.; Yari, A.; Salehi, E.; Mikaeili, S.; Dashtestani, F.; Abolhassani, F.; Rashki, L.; Shiasi, S.; Asadi, E. Melatonin Affects Membrane Integrity, Intracellular Reactive Oxygen Species, Caspase3 Activity and AKT Phosphorylation in Frozen Thawed Human Sperm. Cell Tissue Res. 2018, 372, 149–159.
  52. Reiter, R.; Rosales-Corral, S.; Manchester, L.; Tan, D.-X. Peripheral Reproductive Organ Health and Melatonin: Ready for Prime Time. Int. J. Mol. Sci. 2013, 14, 7231–7272.
  53. Aripin, S.A.; Jintasataporn, O.; Yoonpundh, R. Effects of Melatonin in Clarias macrocephalus Male Broodstock First Puberty. In Proceedings of the International Conference of Aquaculture Indonesia (ICAI), Bandung, Indonesia, 1 January 2014.
  54. Aripin, S.-A.; Jintasatap, O.; Yoonpundh, R. Effects of Exogenous Melatonin and Zinc Amino Acid on Male Clarias macrocephalus Broodstock. Asian J. Sci. Res. 2018, 11, 515–521.
  55. Sarabia, L.; Maurer, I.; Bustos-Obregón, E. Melatonin Prevents Damage Elicited by the Organophosphorous Pesticide Diazinon on Mouse Sperm DNA. Ecotoxicol. Environ. Saf. 2009, 72, 663–668.
  56. Ortiz, A.; Espino, J.; Bejarano, I.; Lozano, G.M.; Monllor, F.; García, J.F.; Pariente, J.A.; Rodríguez, A.B. High Endogenous Melatonin Concentrations Enhance Sperm Quality and Short-Term in Vitro Exposure to Melatonin Improves Aspects of Sperm Motility: Melatonin Improves Sperm Quality. J. Pineal Res. 2010, 50, 132–139.
  57. Casao, A.; Vega, S.; Palacín, I.; Pérez-Pe, R.; Laviña, A.; Quintín, F.; Sevilla, E.; Abecia, J.; Cebrián-Pérez, J.; Forcada, F.; et al. Effects of Melatonin Implants During Non-Breeding Season on Sperm Motility and Reproductive Parameters in Rasa aragonesa Rams: Melatonin on Ram Sperm Motility and Reproductive Parameters. Reprod. Domest. Anim. 2008, 45, 425–432.
  58. Jang, H.; Kim, Y.; Kim, B.; Park, I.; Cheong, H.; Kim, J.; Park, C.; Kong, H.; Lee, H.; Yang, B. Ameliorative Effects of Melatonin against Hydrogen Peroxide-Induced Oxidative Stress on Boar Sperm Characteristics and Subsequent In Vitro Embryo Development: Effect of Melatonin against Oxidative Stress in Pig Germ Cell. Reprod. Domest. Anim. 2010, 45, 943–950.
  59. Succu, S.; Berlinguer, F.; Pasciu, V.; Satta, V.; Leoni, G.G.; Naitana, S. Melatonin Protects Ram Spermatozoa from Cryopreservation Injuries in a Dose-Dependent Manner. J. Pineal Res. 2011, 50, 310–318.
  60. Ashrafi, I.; Kohram, H.; Ardabili, F.F. Antioxidative Effects of Melatonin on Kinetics, Microscopic and Oxidative Parameters of Cryopreserved Bull Spermatozoa. Anim. Reprod. Sci. 2013, 139, 25–30.
  61. Domínguez-Rebolledo, Á.E.; Fernández-Santos, M.R.; Bisbal, A.; Ros-Santaella, J.L.; Ramón, M.; Carmona, M.; Martínez-Pastor, F.; Garde, J.J. Improving the Effect of Incubation and Oxidative Stress on Thawed Spermatozoa from Red Deer by Using Different Antioxidant Treatments. Reprod. Fertil. Dev. 2010, 22, 856–870.
  62. Deng, S.-L.; Sun, T.-C.; Yu, K.; Wang, Z.-P.; Zhang, B.-L.; Zhang, Y.; Wang, X.-X.; Lian, Z.-X.; Liu, Y.-X. Melatonin Reduces Oxidative Damage and Upregulates Heat Shock Protein 90 Expression in Cryopreserved Human Semen. Free Radic. Biol. Med. 2017, 113, 347–354.
  63. Zhu, Z.; Li, R.; Lv, Y.; Zeng, W. Melatonin Protects Rabbit Spermatozoa from Cryo-Damage via Decreasing Oxidative Stress. Cryobiology 2019, 88, 1–8.
  64. Mehaisen, G.M.K.; Partyka, A.; Ligocka, Z.; Niżański, W. Cryoprotective Effect of Melatonin Supplementation on Post-Thawed Rooster Sperm Quality. Anim. Reprod. Sci. 2020, 212, 106238.
  65. García, J.J.; Reiter, R.J.; Guerrero, J.M.; Escames, G.; Yu, B.P.; Oh, C.S.; Muñoz-Hoyos, A. Melatonin Prevents Changes in Microsomal Membrane Fluidity during Induced Lipid Peroxidation. FEBS Lett. 1997, 408, 297–300.
  66. Reiter, R.J.; Tan, D.; Osuna, C.; Gitto, E. Actions of Melatonin in the Reduction of Oxidative Stress: A Review. J. Biomed. Sci. 2000, 7, 444–458.
  67. Fang, Y.; Zhao, C.; Xiang, H.; Jia, G.; Zhong, R. Melatonin Improves Cryopreservation of Ram Sperm by Inhibiting Mitochondrial Permeability Transition Pore Opening. Reprod. Domest. Anim. 2020, 55, 1240–1249.
  68. Perumal, P.; Chang, S.; Baruah, K.K.; Srivastava, N. Administration of Slow Release Exogenous Melatonin Modulates Oxidative Stress Profiles and In Vitro Fertilizing Ability of the Cryopreserved Mithun (Bos frontalis) Spermatozoa. Theriogenology 2018, 120, 79–90.
  69. ChaithraShree, A.R.; Ingole, S.D.; Dighe, V.D.; Nagvekar, A.S.; Bharucha, S.V.; Dagli, N.R.; Kekan, P.M.; Kharde, S.D. Effect of Melatonin on Bovine Sperm Characteristics and Ultrastructure Changes Following Cryopreservation. Vet. Med. Sci. 2020, 6, 177–186.
  70. Pool, K.R.; Rickard, J.P.; Tumeth, E.; de Graaf, S.P. Treatment of Rams with Melatonin Implants in the Non-Breeding Season Improves Post-Thaw Sperm Progressive Motility and DNA Integrity. Anim. Reprod. Sci. 2020, 221, 106579.
  71. El-Raey, M.; Badr, M.R.; Rawash, Z.M.; Darwish, G.M. Evidences for the Role of Melatonin as a Protective Additive During Buffalo Semen Freezing. Am. J. Anim Vet. Sci 2014, 9, 252–262.
  72. El-Raey, M.; Badr, M.R.; Assi, M.M.; Rawash, Z.M. Effect of melatonin on buffalo bull sperm freezability, ultrastructure changes and fertilizing potentials. Assiut Vet. Med. J. 2015, 61, 201–208.
  73. Feng, T.-Y.; Li, Q.; Ren, F.; Xi, H.-M.; Lv, D.-L.; Li, Y.; Hu, J.-H. Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway. Oxid. Med. Cell. Longev. 2020, 2020, 5954635.
  74. Chaudhary, S.C.; Aeksiri, N.; Wanangkarn, A.; Liao, Y.-J.; Inyawilert, W. Effects of Melatonin on Cryopreserved Semen Parameters and Apoptosis of Thai Swamp Buffalo Bull (Bubalus bubalis) in Different Thawing Conditions. Adv. Anim. Vet. Sci. 2020, 9, 238–245.
  75. Karimfar, M.; Niazvand, F.; Haghani, K.; Ghafourian, S.; Shirazi, R.; Bakhtiyari, S. The Protective Effects of Melatonin against Cryopreservation-Induced Oxidative Stress in Human Sperm. Int. J. Immunopathol Pharm. 2015, 28, 69–76.
  76. Appiah, M.O.; He, B.; Lu, W.; Wang, J. Antioxidative Effect of Melatonin on Cryopreserved Chicken Semen. Cryobiology 2019, 89, 90–95.
  77. Tamura, H.; Jozaki, M.; Tanabe, M.; Shirafuta, Y.; Mihara, Y.; Shinagawa, M.; Tamura, I.; Maekawa, R.; Sato, S.; Taketani, T.; et al. Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging. Int. J. Mol. Sci. 2020, 21, 1135.
  78. Pool, K.R.; Rickard, J.P.; Pini, T.; de Graaf, S.P. Exogenous Melatonin Advances the Ram Breeding Season and Increases Testicular Function. Sci. Rep. 2020, 10, 9711.
  79. Pool, K.R.; Rickard, J.P.; de Graaf, S.P. Melatonin Improves the Motility and DNA Integrity of Frozen-Thawed Ram Spermatozoa Likely via Suppression of Mitochondrial Superoxide Production. Domest. Anim. Endocrinol. 2021, 74, 106516.
  80. Ashrafi, I.; Kohram, H.; Naijian, H.; Bahreini, M.; Poorhamdollah, M. Protective effect of melatonin on sperm motility parameters on liquid storage of ram semen at 5 °C. Afr. J. Biotechnol. 2011, 10, 6670–6674.
  81. Rateb, S.A.; Khalifa, M.A.; El-Hamid, I.S.A.; Shedeed, H.A. Enhancing Liquid-Chilled Storage and Cryopreservation Capacities of Ram Spermatozoa by Supplementing the Diluent with Different Additives. Asian-Australasan J. Anim. Sci. 2020, 33, 1068–1076.
  82. Medrano, A.; Contreras, C.F.B.; Herrera, F.M.; Alcantar-Rodriguez, A.M. Melatonin as an Antioxidant Preserving Sperm from Domestic Animals. Asian Pac. J. Reprod. 2017, 6, 241.
  83. El-Battawy, K. Preservation of goat semen at 5 °C with emphasis on its freezability and the impact of melatonin. Int. J. Vet. Sci. Res. 2019, 5, 35–38.
  84. Inyawilert, W.; Rungruangsak, J.; Liao, Y.; Tang, P.; Paungsukpaibool, V. Melatonin Supplementation Improved Cryopreserved Thai Swamp Buffalo Semen. Reprod. Domest. Anim. 2021, 56, 83–88.
  85. Maldjian, A.; Pizzi, F.; Gliozzi, T.; Cerolini, S.; Penny, P.; Noble, R. Changes in Sperm Quality and Lipid Composition during Cryopreservation of Boar Semen. Theriogenology 2005, 63, 411–421.
  86. Martín-Hidalgo, D.; Barón, F.J.; Bragado, M.J.; Carmona, P.; Robina, A.; García-Marín, L.J.; Gil, M.C. The Effect of Melatonin on the Quality of Extended Boar Semen after Long-Term Storage at 17 °C. Theriogenology 2011, 75, 1550–1560.
More
Information
Subjects: Fisheries
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : , , ,
View Times: 529
Revisions: 2 times (View History)
Update Date: 30 Mar 2022
1000/1000
ScholarVision Creations