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Asthma is a common chronic respiratory inflammatory disease. It is characterized by airway hyperresponsiveness, allergen-specific IgE secretion, mucus hypersecretion, and airway inflammation. In recent years, the incidence of asthma has increased due to increases in indoor dust, pollen, toxic particles, environmental pollutants, and other allergens. It has been reported that many traditional Chinese herbs are effective in reducing asthma symptoms in both humans and animals. Eupatilin, a pharmacologically active flavone extracted from Artemisia argyi, has a variety of pharmacological activities, including anti-inflammatory, anticancer, antioxidant, antiallergic, cardioprotective, and neuroprotective activities. In the present study, eupatilin was found to attenuate OVA-induced asthma by modulating NF-κB, MAPK and Nrf2 signaling pathways for the first time. Eupatilin may be a promising therapeutic agent for the treatment of asthma.