Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Ver. Summary Created by Modification Content Size Created at Operation
1 + 3032 word(s) 3032 2021-09-21 05:03:39 |
2 The format is correct + 84 word(s) 3116 2021-09-22 03:57:32 |

Video Upload Options

Do you have a full video?


Are you sure to Delete?
If you have any further questions, please contact Encyclopedia Editorial Office.
Mariani, F. Antimicrobial Mediterranean Wild Edible Plants. Encyclopedia. Available online: (accessed on 30 November 2023).
Mariani F. Antimicrobial Mediterranean Wild Edible Plants. Encyclopedia. Available at: Accessed November 30, 2023.
Mariani, Francesca. "Antimicrobial Mediterranean Wild Edible Plants" Encyclopedia, (accessed November 30, 2023).
Mariani, F.(2021, September 21). Antimicrobial Mediterranean Wild Edible Plants. In Encyclopedia.
Mariani, Francesca. "Antimicrobial Mediterranean Wild Edible Plants." Encyclopedia. Web. 21 September, 2021.
Antimicrobial Mediterranean Wild Edible Plants

Mediterranean wild edible plants (MWEPs) and their antimicrobial properties have been known from ancient times, and nowadays, a growing number of people have rediscovered them as natural remedies for common infections. One of the problems concerning their use is the heterogeneity of the protocols used to extract and analyze the properties of their active principles; such heterogeneity still marks the overall set of scientific studies on MWEPs, not to mention the enormous heterogeneity that characterizes the properties of plants at the outset. We reviewed the current literature on medicinal value of Mediterranean native edible plants trying to emphasize both the weaknesses and the opportunities of these plants. The majority of the reviewed MWEPs can inhibit both Gram-negative and Gram-positive bacteria, and fungi.

wild edible plants antimicrobial effect Mediterranean plant Gram+ bacteria Gram− bacteria extraction protocols bioactive compounds essential oils

1. Introduction

Bacterial resistance to antimicrobial drugs is an emerging threat [1]. Pathogenic and opportunistic bacteria in nosocomial-acquired infections more and more often cause complications in a postoperative period. This is even more worrying given the induction of immune suppression in modern medicine, the misuse of antibiotics in the latest fifty years, and the unbalance of healthy nutrients in the Western diet.
On the other hand, many people rediscover herbal medicine, which blurs the line between food and medicines—a line that, in many cultures, was never fixed and definitive.
In India, for example, the practice of modern medicine co-exists with indigenous traditional medicine, such as Ayurveda, Unani, and Siddha, which are extensively used by wide sections of the population [2]. Recently, Ayurveda’s immunity boosting measures were even recommended by the Indian government against SARS-CoV-2 infection. The principle behind such measures is that enhancing the body’s natural defense system (immunity) plays an important role in maintaining optimum health.
Additionally, Chinese herbal medicine (CHM) has a long history in the treatment of a variety of human diseases. Accumulating evidence shows that the clinical effects of CHM, too, are related to the up- or down-regulation of immune responses [3].

2. Antimicrobial Properties of Mediterranean Wild Edible Plants

We report those few studies showing no antimicrobial effects at all (8), in which Raphanus raphanistrum did not meet our threshold criteria for being classified as antimicrobial (see Materials and Methods). In addition, Eremurus spectabilis extracts [4] did not pass the threshold of values established for classification of antimicrobial activity.
There was only one study exclusively using an IC50 assay in which eight MWEPs showed a very high antibacterial capacity, measured as less than 20 ppm [5].
There was only one in which the authors isolated the unique active compound cnicin, [6]—that is, in Centaurea raphanina, which was the only isolated compound displaying antifungal activity.
There were only two studies analyzing Allium roseum proteic extract [7][8], both of which did not display any antibacterial activity.
There was only one study undertaken with olive oils extracted from ripe and unripe fruit by mechanical pressing [9]; however, such oils did not show any antibacterial activity according to our criteria.

2.1. Results of Syntheses

2.1.1. The Antimicrobial Effects Reported for the Most Studied Species

Three species were analyzed in four studies: Allium roseum, Centaurea raphanina, and Sonchus oleraceus.
For Allium roseum, out of four studies, only one was undertaken with alcoholic and aqueous extracts [10], while the remaining three used protein extracts [11][7][8]. Interestingly, only the alcohol extracts (containing polyphenols) displayed a significant antimicrobial effect vs. many Gram-positive and Gram-negative bacteria, while the three protein extracts MIC were above the threshold we set up in this review.
For Centaurea raphanina, four studies compared the plant grown in situ, or wild, with the ex situ, or cultivated [12], through a further analysis of the soil enrichment effects on the plant antimicrobial properties [13][6][14]. The wild C. raphanina displayed the highest capacity to inhibit bacterial growth.
Sonchus oleraceus, with two studies on human pathogenic bacteria [15][16] and another two on pathogenic fungi [17][13], displayed relevant antimicrobial properties in all four independent studies.
Foeniculum vulgare was analyzed in three studies and displayed antibacterial IC50 values of less than 20 ppm [5] vs. Staphylococcus mutans, while it did not show relevant antimicrobial activities vs. other bacteria of fungi [18][19]. It is interesting that the only study showing antimicrobial properties was undertaken with plants collected from the mountains of the Nablus region and Kabul mountain (north Galilee), while the plants in the remaining studies were collected in the Sidi Bennour region (central Morocco, altitude 185 m above sea level) [18] and in sixteen locations in Tunisia [19], of which only two were at an altitude > 590 m above sea level.

2.1.2. The Overall Picture of MWEPs Antimicrobial Effects on Gram-Positive Bacteria, Gram-Negative Bacteria, Fungi

In Figure 1 we report the number of studies on Gram-negative (n = 27 species), Gram-positive (n = 18 species) bacteria and Fungi (n = 25 species) treated with MWEPs extracts.
1. How many Gram-negative bacteria are sensitive to MWEPs extracts?
Figure 1a shows all of the Gram-negative species and whether or not the MWEPs were efficacious. Overall, we found that 19 species out of 27 Gram-negative bacteria were sensitive to inhibition by the MWEPs extracts, and they represented 70% of the species analyzed in the thirty-eight studies of this review.
Figure 1. Number of studies (ordinate axis) of antimicrobial properties of MWEPs on Gram-negative (27 species), Gram-positive (18 species) bacteria and fungi (25 species). In different colors, we grouped the studies displaying an antibacterial effect (in white) and those in which no antibacterial (W/O, short for without) effect (in grey) could be included according to our thresholds. (a). Gram-positive bacteria; (b). Gram-negative bacteria; (c). fungi.
For the main Gram-negative bacteria of this group, which is composed of E. coli, P. aeruginosa, S. typhimurium, and K. pneumoniae, the studies with MIC ≤ 0.5 mg/mL were slightly fewer than those that were over this threshold. It is important to note, though, that these bacteria displayed a high incidence of nosocomial-associated antibiotic bacterial resistant (ABR) strains; as a matter of fact, P. aeruginosa and K. pneumoniae were included in the ESKAPE group (an acronym representing six nosocomial pathogens that exhibit multidrug resistance and virulence: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) [20].
In this scenario the availability of several MWEPs species able to inhibit and eventually kill these dangerous bacterial species might represent a strategic reservoir of natural products for therapeutic interventions and disinfecting procedures. The reviewed studies did not show antimicrobial assays undertaken with clinically isolated and documented ABR strains. Nevertheless, the MWEPs’ property to inhibit the wild-type strains of nosocomial bacteria might contribute by lowering their replication and the growth of ABR strains. It goes without saying that studies undertaken with MWEPs on documented ABR nosocomial bacterial species are necessary.
It is also worth noting the very limited number of studies, i.e., one or four articles at most, on the Gram-negative species not sensitive to the MWEPs extracts. Nonetheless, this is a suggestion that future research be undertaken on these species, four of which are nosocomial-associated bacteria such as E. cloacae, M. morganii, S. marcescens, and P. mirabilis.
2. How many Gram-positive bacteria are sensitive to MWEPs extracts?
Overall, we found that 15 species, out of 18 of Gram-positive bacteria, were sensitive to the MWEPs extracts, representing 83% of the species analyzed in this review.
In Figure 1b, all of the Gram-positive species are shown and whether or not the MWEPs were efficacious. For the main bacteria of this group, which is composed of S. aureus Methicillin Sensible (MSSA), B. cereus, E. faecalis, L. monocytogenes, B. subtilis, and S. epidermidis, the studies with MIC ≤ 0.5 mg/mL were slightly more in number than those over this threshold. This is in accordance with the higher sensitivity of Gram-positive bacteria to antimicrobial drugs, but the use of natural products might also help to lower the antibiotic doses in human treatments.
The three species not inhibited by MWEPs extracts were analyzed only in one study each: they are environmental bacteria, such as B. brevis and S. lutea, or opportunistic bacterial infection in immune compromised hosts, such as M. kristinae. Again, the studies concerning these bacteria are very few.
3. How many fungi are susceptible to MWEPs extracts?
For fungal species, 88% were sensitive according to 38 studies.
In Figure 1c, all the fungi species are shown and whether or not the MWEPs were efficacious. It is quite clear that MWEPs were fairly efficient in inhibiting fungal growth, given that the number of studies demonstrating antimicrobial activity was higher than those proving the absence of such effect.

2.2. The Comparison of MIC Values

Most studies analyzed both E. coli (Gram-negative) and S. aureus (Gram-positive); therefore, we could compare all the MIC values reported for these two main species (Figure 2).
It is well known that Gram-negative bacteria are more resistant to antibiotic treatments and that they embody 67% of the ESKAPE group of ABR bacterial species [20]. It is then important to note that the majority of MWEPs extracts displayed MIC values (Figure 2a) below the very stringent threshold adopted in our selection (see Materials and Methods).
Instead, S. aureus showed MIC values distributed at the turn of the threshold value (as shown in Figure 2b).
Figure 2. MIC values (in mg/mL) reported in the thirty-eight studies for MWEPs extracts vs. the two main and most studied pathogenic bacteria: (a) the Gram-negative E. coli and (b) the Gram-positive S. aureus.
Only three studies analyzed the antimicrobial properties of the plants against clinically isolated strains [8][21][22]. It is worth noting that, in all the comparisons between collection species and the clinically isolated strains, the MIC values were not always higher for the latter (16 vs. 256 μg/mL for the most effective plants, such as Chenopodium album), but in some cases were significantly lower, even lower than conventional antibiotics (as for Silene conoidea, 0.01 vs. 0.1 mg/mL ampicillin).
Finally, there were only six studies using essential oils (EO), among which the EO distilled from C. coronarium [23] was the only one where MIC values were given in EO dilutions (v/v). Overall, the EOs were shown to be highly efficient in inhibiting bacterial and fungal growth [24][25][26][27], displaying in some cases, as compared with routinely employed antibiotics, a similar (vs. streptomycin) or even higher efficiency (vs. ampicillin) vs. Gram-negative bacteria [28]. The only exception was EO of F. vulgare, which did not show any antibacterial activity [19].

2.3. Antioxidant vs. Antimicrobial Properties: Direct or Inverse Association?

Even if most studies underpin the role of the antioxidant and reducing power of a MWEP by conferring it with effective antimicrobial capacity, there are still contradictory results to be evaluated. Overall, we cannot draw a conclusion yet.
For example, Sonchus species, with the highest reducing power, are the very same species displaying the highest antimicrobial properties [15]. C. raphanina cultivated plants have less polyphenol content than the wild plants, which correlates with their lower antimicrobial capacity [12].
In Allium roseum the authors found a direct association between antimicrobial properties and total phenolic compounds (TPCs) in the extracts made with different parts of the plant (either leaves, flowers, or bulbs) [29]. For Silene spp., the order of descending antimicrobial properties was compared with the respective order for metal chelating potential [21]. While it is true that the most antimicrobial species (S. conoidea) are also the most powerful in chelating metals, we must acknowledge that the descending order for both features in the six Silene species does not allow a direct association between them to be established. In another example [23], P. hydropiper proved to have a high level of antioxidant properties but weak antimicrobial properties: according to our threshold, none of the extracts were able to inhibit bacterial growth. In another study of MWEPs, the total antioxidant and free radical-scavenging activities of plant species showed a linear correlation with the total phenolics. For example, M. polymorpha was found to be the most active, and high antioxidant activity was observed for G. laevigata. Nonetheless, the antibacterial activity of methanolic extracts of all the plant species was lower than that of the positive control (streptomycin) against the tested bacterial species [30].
On the other hand, in a study on C. macrocarpa, it is interesting to note strong correlation values (0.7–0.9 and >0.9) between reducing power, total flavan-3-ols (TF3O), total phenolic compounds (TPC), and inhibiting properties vs. some Gram-positive bacteria tested (E. faecalis, L. monocytogenes, MRSA, and MSSA), even if the MIC values were over the threshold we set. Conversely, for DPPH scavenging activity, the strong correlation values were associated with total phenolic acids (TPA), total flavonols (TF), and inhibiting properties vs. E. faecalis and MRSA only [31].
Finally, the authors of another study wondered whether the results they had obtained could lead to the conclusion that there is no correlation between antibacterial activity against S. mutans and free radical scavenging [5]. However, an in-depth analysis revealed that the extracts of plants that exhibited an EC50 (amount of antioxidant necessary to decrease the initial DPPH absorbance by 50%) ≤ 100 ppm showed some degree of enrichment (4 orders of magnitude) in antibacterial activity.
From the analysis of the studies’ results, it is also evident that geographical location of plant collections (such as altitude in the case of F. vulgare) and extraction procedures also have substantial effects on the activity of the extracts [9].

2.4. MWEPs Useful Properties

2.4.1. Antimicrobial Efficacy

1. Gram-negative bacteria are sensitive to MWEPs extracts.
A total of 70% of the assayed Gram-negative species were inhibited by MWEPs extracts. For E. coli, most inhibiting MIC values were significantly below our stringent threshold. This effective antimicrobial property might suggest their possible use in co-administration with antibiotics as a means to fight Gram-negative bacterial infections.
Some of the Gram-negative bacteria not inhibited by MWEPs are opportunistic and responsible for urinary tract infections in immunocompromised hosts or in the event of catheter insertions, and the search for inhibiting natural products derived from MWEPs is definitely worthwhile.
2. Gram-positive bacteria are sensitive to MWEPs extracts.
A total of 83% of the assayed Gram-positive species were inhibited by MWEPs extracts. For S. aureus, the inhibiting MIC values were distributed at the turn of the threshold value, most of them being below the threshold.
3. Fungi are sensitive to MWEPs extracts.
Regarding fungi, 88% of the species analyzed in the thirty-eight studies were sensitive to MWEPs extracts. Approximately 300 fungal species on Earth are known to cause illnesses, such as Candida spp. and dermatophytes. In the food industry, bacteria and fungi cause problems during product processing and storage [32]. MWEPs could be a new safe and effective antimicrobial agent that could be applied in many fields.

2.4.2. MWEPs vs. Antibiotic-Resistant Species

We report some examples of the advantages of the widening use of MWEPs extracts, also co-administered with conventional antibiotics to decrease the typically required drug amount and to contribute to slowing down the increase in antibiotic resistance [33].
For example, Bacillus cereus is an opportunistic bacterium that became a serious cause of nosocomial infections [34]. Nine studies reported in this review provide experimental data of MWEPs effective against this bacterium that could become pathogenic in immunocompromised hosts [16][35][24][13][12][36][7][8][21].
Additionally, regarding Enterococcus faecalis, which is responsible for urinary tract infections and under surveillance for resistance to aminoglycosides, six studies reported MWEPs extracts were effective in inhibiting its growth [28][29][8][27][21][22].
Another pathogen belonging to the ESKAPE group of ABR bacteria is Klebsiella pneumoniae, in which two studies reported effective inhibitory activity of MWEPs extracts [37][25].
Altogether, the studies here reviewed provide natural tools for inhibiting the growth of five out six ESKAPE pathogens, and the only one missing is an Enterobacter, for which we could include only one study.

2.4.3. Antioxidant vs. Antimicrobial Properties

In the thirty-eight studies reported, there is still some controversy concerning the type of association between the antioxidant power of MWPs and their corresponding antimicrobial power, which is an issue deserving further investigation. Instead, what is clearer so far is the adjuvant role of natural antioxidant compounds in maintaining the good performance of the immune system [38][39]. This might suggest that even if the MWEPs antioxidant properties are not always the ones solely responsible for the killing of microbes, they certainly improve the capacity of the immune system to orchestrate the microbicide response of the infected host.

2.4.4. Implications of the Results for Practice, Policy, and Future Research

MWEPs are being more and more rediscovered by consumers, both in Mediterranean and Northern European countries [34]. Their use in the daily diet might provide important micronutrients and healthy active components. We should start, then, to face the overwhelming heterogeneity that characterizes the way in which MWEPs are studied, in order to more systematically and consistently document their precious properties.
If it does not sound conceited, we would like to propose a list of steps to be shared and hopefully discussed inside the scientific community in order to reduce the great heterogeneity of the studies on MWEPs (as is also very often indicated in the EU Pharmacopoeia).
We should all put our best efforts forward to perform the very same tests to describe the antimicrobial properties of plant extracts. This means that at least the disk diffusion test and the MIC/MBC test should be included in our future studies, in order to allow comparison with similar studies.
Concerning the protocols for extraction, in order to allow comparison with similar studies, we should include at least alcoholic, hydro-alcoholic, and aqueous extracts from the very same part of the plant analyzed.
For aromatic plants, we should include the analysis of essential oils, which are highly effective in inhibiting bacteria and fungi.
Finally, concerning the pathogens analyzed, we should include at least the more characterized Gram-positive (S. aureus, MRSA) and Gram-negative (E. coli, P. aeruginosa) bacteria, which are

highly effective in inhibiting bacteria and fungi.

Finally, for what concerns the pathogens analysed, we should include at least the more characterized Gram-positive (S. aureus, MRSA) and Gram-negative (E. coli, P. aeruginosa) bacteria, which are responsible for the major number of infections in humans, in particular for community-associated infections.

3. Conclusions

We found that, out of seventy-four MWEPs species, fifty-one (69%) belong to eight out of the twenty-five botanical families analysed in this review (see table S1). In particular, Asteraceae, Apiaceae, Brassicaceae, Caryophyllaceae and Lamiaceae contain more than eight of the species most studied, and most of them display antimicrobial properties.

It is true that we still know very little about MWEPs, and it is necessary to standardize the protocols to further study these plants.

It is advisable to avoid the extinction of MWEPs cultivation; however, the agronomic practices must be as closer as possible to the in situ growth, to preserve the active principles.

The study of their effect on viruses must be increased.

On the other hand, MWEPs can inhibit both Gram-negative and Gram-positive bacteria, and fungi. Importantly, the effective MIC on Gram-negative is significantly below the stringent threshold we employed, and some extracts do inhibit clinical isolates.

Their common antioxidant and metal chelating properties, despite some controversy, exert a positive effect on human and domestic animals’ immune system, further helping them to face infections.

Despite the problems listed, MWEPs constitute a very important source of antimicrobial compounds to be explored.


  1. O’Neill, J. Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. The Review on Antimicrobial Resistance, 2016. Wellcome Trust and HM Government. Available online: (accessed on 14 April 2021).
  2. Shankar, D.; Patwardhan, B. AYUSH for New India: Vision and strategy. J. Ayurveda Integr. Med. 2017, 8, 137–139.
  3. Li, J.; Li, J.; Zhang, F. The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells. J. Ethnopharmacol. 2015, 171, 184–195.
  4. Panagouleas, C.; Skaltsa, H.; Lazari, D.; Skaltsounis, A.-L.; Sokovic, M. Antifungal Activity of Secondary Metabolites of Centaurea raphanina ssp. mixta, Growing Wild in Greece. Pharm. Biol. 2003, 41, 266–270.
  5. Rayan, M.; Abu-Farich, B.; Basha, W.; Rayan, A.; Abu-Lafi, S. Correlation between Antibacterial Activity and Free-Radical Scavenging: In-Vitro Evaluation of Polar/Non-Polar Extracts from 25 Plants. Processes 2020, 8, 117.
  6. Najjaa, H.; Neffati, M.; Ammar, E.; Fattouch, S. Antimicrobial properties of Allium roseum L.: A wild edible species in Southern Tunisia. Acta Hortic. 2010, 853, 323–328.
  7. Najjaa, H.; Ammar, E.; Neffati, M. Antimicrobial activities of protenic extracts of Allium roseum L., a wild edible species in North Africa. J. Food Agric. Environ. 2009, 7, 150–154.
  8. Hussain, A.; Qarshi, I.A.; Liaqat, R.; Akhtar, S.; Aziz, I.; Ullah, I.; Shinwari, Z.K. Antimicrobial potential of leaf and fruit extracts and oil of wild and cultivated edible olive. Pak. J. Bot. 2014, 46, 1463–1468.
  9. Gatto, M.A.; Ippolito, A.; Linsalata, V.; Cascarano, N.A.; Nigro, F.; Vanadia, S.; Di Venere, D. Activity of extracts from wild edible herbs against postharvest fungal diseases of fruit and vegetables. Postharvest Biol. Technol. 2011, 61, 72–82.
  10. Najjaa, H.; Zouari, S.; Ammar, E.; Neffati, M. Phytochemical screening and antibacterial properties of Allium roseum L., A WILD EDIBLE SPECIES IN NORTH AFRICA. J. Food Biochem. 2011, 35, 699–714.
  11. Petropoulos, S.A.; Fernandes, Â.; Dias, M.I.; Pereira, C.; Calhelha, R.; Di Gioia, F.; Tzortzakis, N.; Ivanov, M.; Sokovic, M.; Barros, L.; et al. Wild and Cultivated Centaurea raphanina subsp. mixta: A Valuable Source of Bioactive Compounds. Antioxidants 2020, 9, 314.
  12. Petropoulos, S.A.; Fernandes, Â.; Dias, M.I.; Pereira, C.; Calhelha, R.C.; Ivanov, M.; Sokovic, M.D.; Ferreira, I.C.; Barros, L. The Effect of Nitrogen Fertigation and Harvesting Time on Plant Growth and Chemical Composition of Centaurea raphanina subsp. mixta (DC.) Runemark. Molecules 2020, 25, 3175.
  13. Petropoulos, S.; Fernandes, Â.; Dias, M.; Pereira, C.; Calhelha, R.; Ivanov, M.; Sokovic, M.; Ferreira, I.; Barros, L. Effects of Growing Substrate and Nitrogen Fertilization on the Chemical Composition and Bioactive Properties of Centaurea raphanina ssp. mixta (DC.) Runemark. Agronomy 2021, 11, 576.
  14. Xia, D.-Z.; Yu, X.-F.; Zhu, Z.-Y.; Zou, Z.-D. Antioxidant and antibacterial activity of six edible wild plants (Sonchus spp.) in China. Nat. Prod. Res. 2011, 25, 1893–1901.
  15. Petropoulos, S.A.; Fernandes, Â.; Tzortzakis, N.; Sokovic, M.; Ciric, A.; Barros, L.; Ferreira, I.C. Bioactive compounds content and antimicrobial activities of wild edible Asteraceae species of the Mediterranean flora under commercial cultivation conditions. Food Res. Int. 2019, 119, 859–868.
  16. Iyda, J.H.; Fernandes, Â.; Ferreira, F.D.; Alves, M.J.; Pires, T.C.S.P.; Barros, L.; Amaral, J.S.; Ferreira, I.C.F.R. Chemical composition and bioactive properties of the wild edible plant Raphanus raphanistrum L. Food Res. Int. 2019, 121, 714–722.
  17. Aboukhalaf, A.; El Amraoui, B.; Tabatou, M.; Da Rocha, J.M.F.; Belahsen, R. Screening of the antimicrobial activity of some extracts of edible wild plants in Morocco. Funct. Foods Health Dis. 2020, 10, 265.
  18. Khammassi, M.; Loupassaki, S.; Tazarki, H.; Mezni, F.; Slama, A.; Tlili, N.; Zaouali, Y.; Mighri, H.; Jamoussi, B.; Khaldi, A. Variation in essential oil composition and biological activities of Foeniculum vulgare Mill. populations growing widely in Tunisia. J. Food Biochem. 2018, 42, e12532.
  19. Mulani, M.S.; Kamble, E.; Kumkar, S.N.; Tawre, M.S.; Pardesi, K.R. Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review. Front. Microbiol. 2019, 10, 539.
  20. Zengin, G.; Mahomoodally, M.F.; Aktumsek, A.; Ceylan, R.; Uysal, S.; Mocan, A.; Yilmaz, M.A.; Picot-Allain, C.M.N.; Ćirić, A.; Glamočlija, J.; et al. Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties. Food Biosci. 2018, 23, 75–82.
  21. Akgunlu, S.; Sekeroglu, N.; Koca-Caliskan, U.; Ozkutlu, F.; Ozcelik, B.; Kulak, M.; Gezici, S. Research on selected wild edible vegetables: Mineral content and antimicrobial potentials. Ann. Phytomed. Int. J. 2016, 5, 50–57.
  22. Ivashchenko, I.V. Chemical composition of essential oil and antimicrobial properties of Chrysantemum coronarium (Asteraceae). Biosyst. Divers. 2017, 25, 119–123.
  23. Ušjak, L.; Petrović, S.; Drobac, M.; Sokovic, M.; Stanojković, T.; Ciric, A.; Niketić, M. Edible wild plant Heracleum pyrenaicum subsp. orsinii as a potential new source of bioactive essential oils. J. Food Sci. Technol. 2017, 54, 2193–2202.
  24. Anzabi, Y.; Aghdam, V.B.; Makoui, M.H.; Anvarian, M.; Mousavinia, M.N. Evaluation of antibacterial properties of edible oils and extracts of a native plant, Ziziphora clinopodioides (mountains’ Kakoty), on bacteria isolated from urinary tract infections. Life Sci. J. 2013, 10 (Suppl. 4), 121–127.
  25. Shehadeh, M.; Jaradat, N.; Al-Masri, M.; Zaid, A.N.; Hussein, F.; Khasati, A.; Suaifan, G.; Darwish, R. Rapid, cost-effective and organic solvent-free production of biologically active essential oil from Mediterranean wild Origanum syriacum. Saudi Pharm. J. 2019, 27, 612–618.
  26. Kayiran, S.D.; Ozkan, E.E.; Kara, E.M.; Yilmaz, M.A.; Zengin, G.; Boga, M. Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn. J. Food Biochem. 2019, 43, e12928.
  27. Mhamdi, B.; Abbassi, F.; Abdelly, C. Chemical composition, antioxidant and antimicrobial activities of the edible medicinal Ononis natrix growing wild in Tunisia. Nat. Prod. Res. 2015, 29, 1157–1160.
  28. Najjaa, H.; Zerria, K.; Fattouch, S.; Ammar, E.; Neffati, M. Antioxidant and Antimicrobial Activities of Allium roseum L. “Lazoul,” A Wild Edible Endemic Species in North Africa. Int. J. Food Prop. 2011, 14, 371–380.
  29. Khan, H.; Jan, S.A.; Javed, M.; Shaheen, R.; Khan, Z.; Ahmad, A.; Safi, S.Z.; Imran, M. Nutritional Composition, Antioxidant and Antimicrobial Activities of Selected Wild Edible Plants. J. Food Biochem. 2015, 40, 61–70.
  30. Souilem, F.; Dias, M.I.; Barros, L.; Calhelha, R.C.; Alves, M.J.; Harzallah-Skhiri, F.; Ferreira, I.C. Phenolic Profile and Bioactive Properties of Carissa macrocarpa (Eckl.) A.DC: An In Vitro Comparative Study between Leaves, Stems, and Flowers. Molecules 2019, 24, 1696.
  31. Nayaka, N.; Sasadara, M.; Sanjaya, D.; Yuda, P.; Dewi, N.; Cahyaningsih, E.; Hartati, R. Piper betle (L.): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications. Molecules 2021, 26, 2321.
  32. Anand, U.; Nandy, S.; Mundhra, A.; Das, N.; Pandey, D.K.; Dey, A. A review on antimicrobial botanicals, phytochemicals and natural resistance modifying agents from Apocynaceae family: Possible therapeutic approaches against multidrug resistance in pathogenic microorganisms. Drug Resist. Updates 2020, 51, 100695.
  33. Heinrich, M.; Prieto, J. Diet and healthy ageing 2100: Will we globalise local knowledge systems? Ageing Res. Rev. 2008, 7, 249–274.
  34. Adedapo, A.; Jimoh, F.; Afolayan, A. Comparison of the nutritive value and biological activities of the acetone, methanol and water extracts of the leaves of Bidens pilosa and Chenopodium album. Acta Pol. Pharm. 2011, 68, 83–92.
  35. Coruh, I.; Gormez, A.A.; Ercisli, S.; Bilen, S. Total phenolics, mineral elements, antioxidant and antibacterial activities of some edible wild plants in Turkey. Asian J. Chem. 2007, 19, 5755–5762.
  36. Karaman, K.; Polat, B.; Ozturk, I.; Sagdic, O.; Ozdemir, C. Volatile Compounds and Bioactivity of Eremurus spectabilis (Ciris), a Turkish Wild Edible Vegetable. J. Med. Food 2011, 14, 1238–1243.
  37. Silveira, D.; Prieto-Garcia, J.M.; Boylan, F.; Estrada, O.; Fonseca-Bazzo, Y.M.; Jamal, C.M.; Magalhães, P.O.; Pereira, E.O.; Tomczyk, M.; Heinrich, M. COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy? Front. Pharmacol. 2020, 11, 581840.
  38. Peterfalvi, A.; Miko, E.; Nagy, T.; Reger, B.; Simon, D.; Miseta, A.; Czéh, B.; Szereday, L. Much More Than a Pleasant Scent: A Review on Essential Oils Supporting the Immune System. Molecules 2019, 24, 4530.
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to :
View Times: 445
Revisions: 2 times (View History)
Update Date: 24 Nov 2021