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| Version | Summary | Created by | Modification | Content Size | Created at | Operation |
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| 1 | Fumio Fukai | + 3580 word(s) | 3580 | 2021-04-08 06:06:05 | | | |
| 2 | Nora Tang | -1 word(s) | 3579 | 2021-04-13 11:10:45 | | | | |
| 3 | Vicky Zhou | -2946 word(s) | 633 | 2022-04-13 11:57:38 | | |
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Fukai, F.; Fujita, M.; Sasada, M.; Iyoda, T.; Osada, S. Biofunctional Peptide FNIII14: Therapeutic Potential. Encyclopedia. Available online: https://encyclopedia.pub/entry/8528 (accessed on 15 November 2026).
Fukai F, Fujita M, Sasada M, Iyoda T, Osada S. Biofunctional Peptide FNIII14: Therapeutic Potential. Encyclopedia. Available at: https://encyclopedia.pub/entry/8528. Accessed November 15, 2026.
Fukai, Fumio, Motomichi Fujita, Manabu Sasada, Takuya Iyoda, Satoshi Osada. "Biofunctional Peptide FNIII14: Therapeutic Potential" Encyclopedia, https://encyclopedia.pub/entry/8528 (accessed November 15, 2026).
Fukai, F., Fujita, M., Sasada, M., Iyoda, T., & Osada, S. (2021, April 08). Biofunctional Peptide FNIII14: Therapeutic Potential. In Encyclopedia. https://encyclopedia.pub/entry/8528
Fukai, Fumio, et al. "Biofunctional Peptide FNIII14: Therapeutic Potential." Encyclopedia. Web. 08 April, 2021.
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Biofunctional Peptide FNIII14: Therapeutic Potential
This is a peer-reviewed entry published in Encyclopedia Journal, full entry can be found at
https://doi.org/10.3390/encyclopedia1020029
Biofunctional peptide FNIII14, which is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule, is capable of inhibiting cell adhesion to the extracellular matrix (ECM). This functional site is usually buried within the molecular structure of FN, but can be exposed by conformational changes and proteolytic cleavage. Peptide FNIII14 can induce a conformational change in β1-integrin from the active to the inactive form, causing functional inactivation. Based on this anti-adhesive activity, peptide FNIII14 exhibits therapeutic potential for several diseases such as metabolic diseases, organ fibrosis, and malignant tumors. Peptide FNIII14 blocks integrin-mediated signaling by a mechanism entirely distinct from that of conventional antagonisitic peptides, including Arg-Gly-Asp peptides that competitively inhibit the ECM binding of integrin.
extracellular matrix
fibronectin
FNIII14
integrin inactivation
cell adhesion
anti-fibrotic activ-ity
anti-cancer activity
References
- de Castro Brás, L.E.; Frangogiannis, N.G. Extracellular Matrix-Derived Peptides in Tissue Remodeling and Fibrosis. Matrix Biol. 2020, 91–92, 176–187.
- Miller, L.M.; Pritchard, J.M.; Macdonald, S.J.F.; Jamieson, C.; Watson, A.J.B. Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins. J. Med. Chem. 2017, 60, 3241–3251.
- Davis, G.E.; Bayless, K.J.; Davis, M.J.; Meininger, G.A. Regulation of Tissue Injury Responses by the Exposure of Matricryptic Sites within Extracellular Matrix Molecules. Am. J. Pathol. 2000, 156, 1489–1498.
- Ricard-Blum, S.; Salza, R. Matricryptins and Matrikines: Biologically Active Fragments of the Extracellular Matrix. Exp. Dermatol. 2014, 23, 457–463.
- Pankov, R.; Yamada, K.M. Fibronectin at a Glance. J. Cell Sci. 2002, 115, 3861–3863.
- Johansson, S.; Svineng, G.; Wennerberg, K.; Armulik, A.; Lohikangas, L. Fibronectin-Integrin Interactions. Front. Biosci. J. Virtual Libr. 1997, 2, d126–d146.
- Nieberler, M.; Reuning, U.; Reichart, F.; Notni, J.; Wester, H.-J.; Schwaiger, M.; Weinmüller, M.; Räder, A.; Steiger, K.; Kessler, H. Exploring the Role of RGD-Recognizing Integrins in Cancer. Cancers 2017, 9, 116.
- Fujita, M.; Sasada, M.; Iyoda, T.; Fukai, F. Involvement of Integrin-Activating Peptides Derived from Tenascin-C in Cancer Aggression and New Anticancer Strategy Using the Fibronectin-Derived Integrin-Inactivating Peptide. Molecules 2020, 25, 3239.
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