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1 Zimei Wu + 3180 word(s) 3180 2021-08-10 03:36:46 |
2 corrected the format Dean Liu -8 word(s) 3172 2021-08-13 10:31:51 | |
3 Remove the content except Introduction and Description. Dean Liu -2741 word(s) 431 2022-04-13 11:28:29 |

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Wu, Z. Nanotechnology-Enabled COVID-19 mRNA Vaccines. Encyclopedia. Available online: https://encyclopedia.pub/entry/12977 (accessed on 17 September 2026).
Wu Z. Nanotechnology-Enabled COVID-19 mRNA Vaccines. Encyclopedia. Available at: https://encyclopedia.pub/entry/12977. Accessed September 17, 2026.
Wu, Zimei. "Nanotechnology-Enabled COVID-19 mRNA Vaccines" Encyclopedia, https://encyclopedia.pub/entry/12977 (accessed September 17, 2026).
Wu, Z. (2021, August 10). Nanotechnology-Enabled COVID-19 mRNA Vaccines. In Encyclopedia. https://encyclopedia.pub/entry/12977
Wu, Zimei. "Nanotechnology-Enabled COVID-19 mRNA Vaccines." Encyclopedia. Web. 10 August, 2021.
Peer Reviewed
Nanotechnology-Enabled COVID-19 mRNA Vaccines
This is a peer-reviewed entry published in Encyclopedia Journal, full entry can be found at 10.3390/encyclopedia1030059

COVID-19 mRNA vaccines contain synthetic mRNA sequences encoded for the Spike proteins expressed on the surface of SARS-CoV-2, and utilize the host cells to produce specific antigens that stimulate both humoral and cellular immunities. Lipid nanoparticles are essential to facilitate the intracellular delivery of the mRNA to its action site, the ribosome, to fully exert its effect.

mRNA vaccine lipid nanoparticles intracellular delivery endosome escape

References

  1. Zhou, P.; Yang, X.; Wang, X.G.; Hu, B.; Zhang, L.; Zhang, W.; Si, H.R.; Zhu, Y.; Li, B.; Huang, C.L.; et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020, 579, 270–273.
  2. Lamb, Y.N. BNT162b2 mRNA COVID-19 vaccine: First approval. Drugs 2021, 81, 495–501.
  3. Food and Drug Administration. FDA Briefing Document: Moderna COVID-19 Vaccine. Available online: https://www.fda.gov/media/144434/download (accessed on 3 May 2021).
  4. European Medicines Agency. Comirnaty: EPAR-Product Information. Available online: https://www.ema.europa.eu/en/documents/product-information/comirnaty-epar-product-information_en.pdf (accessed on 3 May 2021).
  5. Wu, Z.; Li, T. Nanoparticle-mediated cytoplasmic delivery of messenger RNA vaccines: Challenges and future perspectives. Pharm. Res. 2021, 38, 473–478.
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Subjects: Infectious Diseases
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Zimei Wu
View Times: 3.9K
Reprint: Encyclopedia of COVID-19
Entry Collection: COVID-19
Online Date: 10 Aug 2021
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