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Diagonal Earlobe Crease
Diagonal earlobe crease is a wrinkle extending obliquely from the tragus towards the border of the earlobe. It was firstly described by Frank in 1973 in the New England Journal of Medicine in a case series of patients with coronary artery disease. Since then, there have been many reports published regarding its association mainly with atherosclerosis, especially coronary artery disease.
2. Diagonal Earlobe Crease for Diagnosis of Coronary Artery Disease
Generally, most studies defined diagonal earlobe crease as at least a unilateral sign, in two papers bilateral sign was required to be considered as a positive, and another two presented results for both definitions. Two studies showed no more than information of diagonal creasing of earlobe without any other details. In another study, only the word “significant” was added to the positive sign description. One accepted any crease, whereas others provided detailed thresholds of the relation of the crease to the whole length of the earlobe which varied from more than one-third, at least half, at least two-thirds, or 100%. The combination of these approaches leads to the finding that DELC was defined in nine different ways.
The entry is from 10.3390/jcm10132799
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