Allosteric Antagonism of the Pregnane X Receptor
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  • Release Date: 2022-10-13
  • PXR
  • pregnane X receptor
  • allosteric site
  • CAR
  • colon cancer
  • nuclear receptor
Video Introduction

This video is adapted from 10.3390/cells11192974

The pregnane X receptor (PXR, NR1I2) is a nuclear receptor superfamily member. Nuclear receptors are mostly activated by exogenous and endogenous compounds. Interestingly, the classified nuclear receptors conserve the DNA binding domain (DBD), but not its ligand-binding domain (LBD). PXR belongs to the NR1I subfamily together with the vitamin D receptor (VDR, NR1I1) and the constitutive androstane receptor (CAR, NR1I3).
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Kamaraj, R.; Drastik, M.;  Maixnerova, J.; Pavek, P. Allosteric Antagonism of the Pregnane X Receptor. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/437 (accessed on 24 June 2024).
Kamaraj R, Drastik M,  Maixnerova J, Pavek P. Allosteric Antagonism of the Pregnane X Receptor. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/437. Accessed June 24, 2024.
Kamaraj, Rajamanikkam, Martin Drastik, Jana Maixnerova, Petr Pavek. "Allosteric Antagonism of the Pregnane X Receptor" Encyclopedia, https://encyclopedia.pub/video/video_detail/437 (accessed June 24, 2024).
Kamaraj, R., Drastik, M.,  Maixnerova, J., & Pavek, P. (2022, October 13). Allosteric Antagonism of the Pregnane X Receptor. In Encyclopedia. https://encyclopedia.pub/video/video_detail/437
Kamaraj, Rajamanikkam, et al. "Allosteric Antagonism of the Pregnane X Receptor." Encyclopedia. Web. 13 October, 2022.
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