Iron Metabolism in Pancreatic Beta-Cell Function and Dysfunction
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  • Release Date: 2021-12-14
  • Iron metabolism
  • beta-cell function
  • reactive oxygen species
  • diabetes
Video Introduction

This video is adapted from 10.3390/cells10112841

Iron is an essential element involved in a variety of physiological functions. In the pancreatic beta-cells, being part of Fe-S cluster proteins, it is necessary for the correct insulin synthesis and processing. In the mitochondria, as a component of the respiratory chain, it allows the production of ATP and reactive oxygen species (ROS) that trigger beta-cell depolarization and potentiate the calcium-dependent insulin release. Iron cellular content must be finely tuned to ensure the normal supply but also to prevent overloading. Indeed, due to the high reactivity with oxygen and the formation of free radicals, iron excess may cause oxidative damage of cells that are extremely vulnerable to this condition because the normal elevated ROS production and the paucity in antioxidant enzyme activities. Defects in iron-storing or -chaperoning proteins have been detected in diabetic conditions; therefore, the control of iron metabolism in beta-cells deserves further investigation as a promising target  for the development of new disease treatments.

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Castagna, M.; Galli, A.; Algerta, M.; Dule, N.; Marciani, P.; Perego, C. Iron Metabolism in Pancreatic Beta-Cell Function and Dysfunction. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/137 (accessed on 19 April 2024).
Castagna M, Galli A, Algerta M, Dule N, Marciani P, Perego C. Iron Metabolism in Pancreatic Beta-Cell Function and Dysfunction. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/137. Accessed April 19, 2024.
Castagna, Michela, Alessandra Galli, Marku Algerta, Nevia Dule, Paola Marciani, Carla Perego. "Iron Metabolism in Pancreatic Beta-Cell Function and Dysfunction" Encyclopedia, https://encyclopedia.pub/video/video_detail/137 (accessed April 19, 2024).
Castagna, M., Galli, A., Algerta, M., Dule, N., Marciani, P., & Perego, C. (2021, December 14). Iron Metabolism in Pancreatic Beta-Cell Function and Dysfunction. In Encyclopedia. https://encyclopedia.pub/video/video_detail/137
Castagna, Michela, et al. "Iron Metabolism in Pancreatic Beta-Cell Function and Dysfunction." Encyclopedia. Web. 14 December, 2021.