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Immortalized Hepatic Stellate Cells | Interview with Dr. Ralf Weiskirchen
- Subjects: Cell Biology; Gastroenterology & Hepatology
- |
- Contributor:
- Ralf Weiskirchen
Playlist
- liver disease
- fibrosis
- biomarker
- cytokines
- chemokines
- translational medicine
Chapter
00:36
1. Before we begin, could you briefly introduce your academic background and your role as Guest Editor of Livers?
02:42
2. What motivated your research into immortalized hepatic stellate cells (HSCs), leading to the development and characterization of the GRX cell line?
04:44
3. The GRX cell line is a key model for studying liver fibrosis. How does it overcome limitations of primary HSCs or other immortalized lines (e.g., LX-2)?
07:02
4. In your previous study (Genetic and Molecular Characterization of GRX), what were the most surprising or clinically relevant findings about this cell line?
09:37
5. Hepatic stellate cells play a dual role in fibrosis and regeneration. How has the GRX line advanced our understanding of these opposing functions?
11:51
6. CRISPR and other genetic tools now allow precise modification of immortalized lines. How do you envision engineered GRX derivatives shaping future liver research?
14:56
7. Immortalized lines sometimes drift genetically over time. How do you ensure the stability and reproducibility of GRX in different labs?
18:00
8. What advice would you give to young researchers selecting between primary cells, immortalized lines (like GRX), or organoids for liver disease studies?
Video Introduction
Video interview with Dr. Ralf Weiskirchen, Liver Disease Expert at the Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, and Associate Editor of Livers, on his groundbreaking research and career.
Full Transcript
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If you have any further questions, please contact Encyclopedia Editorial Office.
Weiskirchen, R. Immortalized Hepatic Stellate Cells | Interview with Dr. Ralf Weiskirchen. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/1659 (accessed on 05 December 2025).
Weiskirchen R. Immortalized Hepatic Stellate Cells | Interview with Dr. Ralf Weiskirchen. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/1659. Accessed December 05, 2025.
Weiskirchen, Ralf. "Immortalized Hepatic Stellate Cells | Interview with Dr. Ralf Weiskirchen" Encyclopedia, https://encyclopedia.pub/video/video_detail/1659 (accessed December 05, 2025).
Weiskirchen, R. (2025, July 23). Immortalized Hepatic Stellate Cells | Interview with Dr. Ralf Weiskirchen. In Encyclopedia. https://encyclopedia.pub/video/video_detail/1659
Weiskirchen, Ralf. "Immortalized Hepatic Stellate Cells | Interview with Dr. Ralf Weiskirchen." Encyclopedia. Web. 23 July, 2025.
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