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Li, V. EIF2B5 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/5322 (accessed on 19 April 2024).
Li V. EIF2B5 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/5322. Accessed April 19, 2024.
Li, Vivi. "EIF2B5 Gene" Encyclopedia, https://encyclopedia.pub/entry/5322 (accessed April 19, 2024).
Li, V. (2020, December 24). EIF2B5 Gene. In Encyclopedia. https://encyclopedia.pub/entry/5322
Li, Vivi. "EIF2B5 Gene." Encyclopedia. Web. 24 December, 2020.
EIF2B5 Gene
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/eif2b5

Eukaryotic translation initiation factor 2B subunit epsilon

genes

1. Normal Function

The EIF2B5 gene provides instructions for making one of five parts of a protein called eIF2B, specifically the epsilon subunit of this protein. The eIF2B protein helps regulate overall protein production (synthesis) in the cell by interacting with another protein, eIF2. The eIF2 protein is called an initiation factor because it is involved in starting (initiating) protein synthesis.

Under some conditions, eIF2B increases protein synthesis by helping to recycle molecules called GTP, which carry energy to the initiation factor. Under other conditions, it slows protein synthesis by binding tightly to the initiation factor, which converts the eIF2B protein into an inactive form and prevents recycling of GTP.

Proper regulation of protein synthesis is vital for ensuring that the correct levels of protein are available for the cell to cope with changing conditions. For example, cells must synthesize protein much faster if they are multiplying than if they are in a resting state.

2. Health Conditions Related to Genetic Changes

2.1 Leukoencephalopathy with Vanishing White Matter

Mutations in the EIF2B5 gene have been identified in about 65 percent of people with leukoencephalopathy with vanishing white matter, including those with a severe, early-onset form that is seen among the Cree and Chippewayan populations of Quebec and Manitoba (Cree leukoencephalopathy) and some affected females with a variant of the disorder in which the neurological features are accompanied by ovarian failure (ovarioleukodystrophy). These mutations cause partial loss of eIF2B function. Impairment of eIF2B function makes it more difficult for the body's cells to regulate protein synthesis and deal with changing conditions and stress. Researchers believe that cells in the white matter (nerve fibers covered by a fatty substance called myelin that insulates and protects nerves) may be particularly affected by an abnormal response to stress, resulting in the signs and symptoms of leukoencephalopathy with vanishing white matter.

3. Other Names for This Gene

  • CACH

  • CLE

  • EI2BE_HUMAN

  • EIF-2B

  • eIF-2B GDP-GTP exchange factor

  • EIF2Bepsilon

  • eukaryotic translation initiation factor 2B, subunit 5 (epsilon, 82kD)

  • eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa

  • LVWM

References

  1. Dietrich J, Lacagnina M, Gass D, Richfield E, Mayer-Pröschel M, Noble M,Torres C, Pröschel C. EIF2B5 mutations compromise GFAP+ astrocyte generation invanishing white matter leukodystrophy. Nat Med. 2005 Mar;11(3):277-83.
  2. Eurekah Bioscience: Mechanism of Translation Initiation in Eukaryotes
  3. Fogli A, Boespflug-Tanguy O. The large spectrum of eIF2B-related diseases.Biochem Soc Trans. 2006 Feb;34(Pt 1):22-9. Review.
  4. Fogli A, Schiffmann R, Hugendubler L, Combes P, Bertini E, Rodriguez D,Kimball SR, Boespflug-Tanguy O. Decreased guanine nucleotide exchange factoractivity in eIF2B-mutated patients. Eur J Hum Genet. 2004 Jul;12(7):561-6.
  5. Li W, Wang X, Van Der Knaap MS, Proud CG. Mutations linked toleukoencephalopathy with vanishing white matter impair the function of theeukaryotic initiation factor 2B complex in diverse ways. Mol Cell Biol. 2004Apr;24(8):3295-306.
  6. Molecular Biology of the Cell (fourth edition, 2002): The Phosphorylation of an Initiation Factor Globally Regulates Protein Synthesis
  7. Pavitt GD. eIF2B, a mediator of general and gene-specific translationalcontrol. Biochem Soc Trans. 2005 Dec;33(Pt 6):1487-92. Review.
  8. Pronk JC, van Kollenburg B, Scheper GC, van der Knaap MS. Vanishing whitematter disease: a review with focus on its genetics. Ment Retard Dev Disabil Res Rev. 2006;12(2):123-8. Review.
  9. Scali O, Di Perri C, Federico A. The spectrum of mutations for the diagnosisof vanishing white matter disease. Neurol Sci. 2006 Sep;27(4):271-7. Review.
  10. Scheper GC, Proud CG, van der Knaap MS. Defective translation initiationcauses vanishing of cerebral white matter. Trends Mol Med. 2006 Apr;12(4):159-66.
  11. van der Voorn JP, van Kollenburg B, Bertrand G, Van Haren K, Scheper GC,Powers JM, van der Knaap MS. The unfolded protein response in vanishing whitematter disease. J Neuropathol Exp Neurol. 2005 Sep;64(9):770-5.
  12. van Kollenburg B, van Dijk J, Garbern J, Thomas AA, Scheper GC, Powers JM, vander Knaap MS. Glia-specific activation of all pathways of the unfolded proteinresponse in vanishing white matter disease. J Neuropathol Exp Neurol. 2006Jul;65(7):707-15.
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Subjects: Genetics & Heredity
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Vivi Li
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Entry Collection: MedlinePlus
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Update Date: 24 Dec 2020
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