1000/1000
Hot
Most Recent
Keratin 16
The KRT16 gene provides instructions for making a protein called keratin 16 or K16. Keratins are a group of tough, fibrous proteins that form the structural framework of certain cells, particularly cells that make up the skin, hair, and nails. Keratin 16 is produced in the nails, the skin on the palms of the hands and soles of the feet, and the oral mucosa that lines the inside of the mouth.
Keratin 16 partners with a similar protein, keratin 6a, to form molecules called keratin intermediate filaments. These filaments assemble into dense networks that provide strength and resilience to the skin, nails, and other tissues. Networks of keratin intermediate filaments protect these tissues from being damaged by friction and other everyday physical stresses. Keratin 16 is also among several keratins involved in wound healing.
At least 19 mutations in the KRT16 gene have been identified in people with pachyonychia congenita, a rare condition that primarily affects the nails and skin. In most cases, this condition becomes apparent within the first few months of life. Most of the KRT16 gene mutations associated with pachyonychia congenita change single protein building blocks (amino acids) in keratin 16. A few mutations delete a small number of amino acids from the protein.
The KRT16 gene mutations responsible for pachyonychia congenita change the structure of keratin 16, preventing it from interacting effectively with keratin 6a and interfering with the assembly of the keratin intermediate filament network. Without this network, skin cells become fragile and are easily damaged, making the skin less resistant to friction and minor trauma. Even normal activities such as walking can cause skin cells to break down, resulting in the formation of severe, painful blisters and calluses. Additionally, fragile skin cells may abnormally produce more keratin in response to damage, which makes the skin problems worse. Defective keratin 16 also disrupts the growth and function of other tissues, such as the hair follicles and nails, which explains why the signs and symptoms of pachyonychia congenita can also affect these other parts of the body.
CK16
cytokeratin 16
cytokeratin-16
K16
K1C16_HUMAN
K1CP
keratin 16 (focal non-epidermolytic palmoplantar keratoderma)
keratin 16, type I
keratin, type I cytoskeletal 16
keratin-16
KRT16A
NEPPK