Mecanismes of Carragenine to Induce Animal Models
Mecanismes of Carragenine to Induce Animal Models
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Carrageenan, a polysaccharide derived from red seaweeds, is commonly used to induce inflammation in animal models for studying inflammatory diseases. Its pro-inflammatory effects involve several key mechanisms:

  1. Activation of the Immune System: Carrageenan stimulates local immune cells, particularly macrophages, leading to an increased release of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6.

  2. Disruption of Epithelial Barrier: It causes damage to the intestinal epithelial barrier, increasing intestinal permeability and facilitating the entry of pathogens and toxins, which exacerbates inflammation.

  3. Production of Inflammatory Mediators: Carrageenan enhances the production of inflammatory mediators like prostaglandins and leukotrienes, contributing to inflammation and pain.

  4. Modulation of Signaling Pathways: It affects important signaling pathways, including NF-κB and MAPK, which are crucial in regulating the inflammatory response.

These mechanisms make carrageenan a valuable tool for studying inflammatory processes and evaluating the efficacy of anti-inflammatory treatments in animal models.

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26 Dec 2024
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Carrageenaninflammationcytokinesmechanisms
Wahnou, H. Mecanismes of Carragenine to Induce Animal Models. Encyclopedia. Available online: https://encyclopedia.pub/image/1501 (accessed on 20 January 2025).
Wahnou H. Mecanismes of Carragenine to Induce Animal Models. Encyclopedia. https://encyclopedia.pub/image/1501. Published Aug 22, 2024. Accessed 20 January, 2025.
Wahnou, Hicham. Mecanismes of Carragenine to Induce Animal Models. 2024. Encyclopedia. https://encyclopedia.pub/image/1501.
Wahnou, H. (2024). Mecanismes of Carragenine to Induce Animal Models. Encyclopedia. https://encyclopedia.pub/image/1501
Wahnou, Hicham. "Mecanismes of Carragenine to Induce Animal Models." Encyclopedia, 2024, https://encyclopedia.pub/image/1501. Accessed 20 January, 2025.
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