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HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Adaptive Design
In an adaptive design of a clinical trial, the parameters and conduct of the trial for a candidate drug or vaccine may be changed based on an interim analysis. Adaptive design typically involves advanced statistics to interpret a clinical trial endpoint. This is in contrast to traditional randomized clinical trials (RCTs) that are static in their protocol and do not modify any parameters until the trial is completed. The adaptation process generally continues throughout the trial, as prescribed in the trial protocol. Adaptions may include modifications to: dosage, sample size, drug undergoing trial, patient selection criteria and/or "cocktail" mix. The PANDA (A Practical Adaptive & Novel Designs and Analysis toolkit) provides comprehensive summary of different adaptive designs. In some cases, trials have become an ongoing process that regularly adds and drops therapies and patient groups as more information is gained. Importantly, the trial protocol is set before the trial begins which pre-specifies the adaptation schedule and processes.
  • 1.2K
  • 09 Oct 2022
Topic Review
Domain Hack
A domain hack is a domain name that suggests a word, phrase, or name when concatenating two or more adjacent levels of that domain. For example, "bir.ds" and "examp.le", using the fictitious country-code domains .ds and .le, suggest the words birds and example respectively. In this context, the word hack denotes a clever trick (as in programming), not an exploit or break-in (as in security). Domain hacks offer the ability to produce short domain names. This makes them potentially valuable as redirectors, pastebins, base domains from which to delegate subdomains and URL shortening services.
  • 2.3K
  • 30 Sep 2022
Topic Review
Extreme Points of Earth
This is a list of extreme points of Earth, the geographical locations that are farther north or south than, higher or lower in elevation than, or farthest inland or out to sea from, any other locations on the landmasses, continents or countries. For other lists of extreme points on Earth, including places that hold temperature and weather records, see Extremes on Earth, Lists of extreme points, and List of weather records.
  • 24.1K
  • 30 Sep 2022
Topic Review
Emirate of Ras Al Khaimah
Ras Al Khaimah (RAK) (Arabic: رَأْس ٱلْخَيْمَة; IPA: [raʔs lˈxajma]), also spelled as Ras al Khaimah or Ras al-Khaimah, is one of the seven emirates that make up the United Arab Emirates (UAE). The city of Ras Al Khaimah, sometimes simply abbreviated to RAK City, is the capital of the emirate and home to most of the emirate's residents. It is linked to the medieval trading port of Julfar.[lower-alpha 1] Its name in English means "top of the tent". The emirate borders Oman's exclave of Musandam, and occupies part of the same peninsula. It covers an area of 2,486 km2 (960 sq mi) and has 64 km (40 mi) of beach coastline. As of 2015, the emirate had a population of about 345,000, of which about 31% were Emirati citizens. RAK city has two main areas - the Old Town and Nakheel - on either side of a creek that is home to mangroves and is framed by the North-Western Hajar Mountains. The emirate also consists of several villages and new gated residential developments, such as Al Hamra Village and Mina Al Arab. The emirate is served by Ras Al Khaimah International Airport. Its geography consists of a northern part (where Ras Al Khaimah City and most towns are situated) and a large southerly inland exclave (near the Dubai exclave of Hatta), and a few small islands in the Persian Gulf. Ras Al Khaimah has the most fertile soil in the country, due to a larger share of rainfall and underground water streams from the Hajar.
  • 5.7K
  • 10 Oct 2022
Topic Review
Informing Science
Informing science is a transdiscipline that was established to promote the study of informing processes across a diverse set of academic disciplines, including management information systems, education, business, instructional technology, computer science, communications, psychology, philosophy, library science, information science and many others. Its principal unit of analysis is the informing system, a collection of informers, clients, and channels that has been designed or has evolved to serve a particular informing need. The organization created to advance the informing science transdiscipline is the Informing Science Institute (ISI), whose founder, Eli Cohen, proposed the need for the field in his article "Reconceptualizing Information Systems as a Field of the Transdiscipline Informing Science: From Ugly Duckling to Swan" (Cohen, 1999). The ISI presently hosts an annual conference (Informing Science & Information Technology Education (InSITE)), publishes thirteen academic journals, and—through its Informing Science Press—has published dozens of books. Both its journals and books are open access at no cost online, as well as being available for purchase in print form.
  • 1.7K
  • 30 Sep 2022
Topic Review
Individualist Anarchism in France
Individualist anarchism in France has developed a line of thought that starts from the pioneering activism and writings of Pierre-Joseph Proudhon and Anselme Bellegarrigue in the mid-19th century. In the early 20th century, it produced publications such as L'En-Dehors, L'Anarchie and around its principles it found writers and activists such as Émile Armand, Han Ryner, Henri Zisly, Albert Libertad and Zo d'Axa. In the post-war years, there appeared the publication L'Unique and activist writers such as Charles-Auguste Bontemps. In contemporary times, it has found a new expression in the writings of the prolific philosopher Michel Onfray. Individualist anarchism is a group of several traditions of thought within the anarchist movement that emphasize the individual and his or her will over external determinants such as groups, society, traditions and ideological systems. French individualist anarchism was characterized by an eclectic set of currents of thought and practices which included anti-militarism, freelove, freethought, illegalism and naturism. While most American individualist anarchists advocates mutualism, a libertarian socialist from of market socialism, or a free-market socialist form of classical economics, European individualist anarchists are pluralists who advocate anarchism without adjectives and synthesis anarchism, ranging from anarcho-communist to mutualist economic types.
  • 4.6K
  • 11 Oct 2022
Topic Review
Allard J2 (Original)
The Allard J2 is a sports roadster that was made by Allard. The J2 was mainly intended for the American market. Since 1981, replicas of the later J2X have been manufactured by a succession of companies in Canada, whilst a continuation of the original models is also now being produced in the UK.
  • 1.2K
  • 30 Sep 2022
Topic Review
List of ASTM International Standards (E)
This is a list of ASTM International standards for "Materials for Specific Applications".
  • 11.2K
  • 30 Sep 2022
Topic Review
Sine
In mathematics, the sine is a trigonometric function of an angle. The sine of an acute angle is defined in the context of a right triangle: for the specified angle, it is the ratio of the length of the side that is opposite that angle, to the length of the longest side of the triangle (the hypotenuse). For an angle [math]\displaystyle{ x }[/math], the sine function is denoted simply as [math]\displaystyle{ \sin x }[/math]. More generally, the definition of sine (and other trigonometric functions) can be extended to any real value in terms of the length of a certain line segment in a unit circle. More modern definitions express the sine as an infinite series, or as the solution of certain differential equations, allowing their extension to arbitrary positive and negative values and even to complex numbers. The sine function is commonly used to model periodic phenomena such as sound and light waves, the position and velocity of harmonic oscillators, sunlight intensity and day length, and average temperature variations throughout the year. The function sine can be traced to the jyā and koṭi-jyā functions used in Gupta period Indian astronomy (Aryabhatiya, Surya Siddhanta), via translation from Sanskrit to Arabic, and then from Arabic to Latin. The word "sine" (Latin "sinus") comes from a Latin mistranslation by Robert of Chester of the Arabic jiba, which is a transliteration of the Sanskrit word for half the chord, jya-ardha.
  • 6.0K
  • 11 Oct 2022
Topic Review
HMS Whiting (1812)
HMS Whiting, built in 1811 by Thomas Kemp as a Baltimore pilot schooner, was launched as Arrow. On 8 May 1812 a British navy vessel seized her under Orders in Council, for trading with the French. The Royal Navy re-fitted her and then took her into service under the name HMS Whiting. In 1816, after four years service, Whiting was sent to patrol the Irish Sea for smugglers. She grounded on the Doom Bar. When the tide rose, she was flooded and deemed impossible to refloat.
  • 1.2K
  • 30 Sep 2022
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