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HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Screening
Screening, in medicine, is a strategy used to look for as-yet-unrecognised conditions or risk markers. This testing can be applied to individuals or to a whole population. The people tested may not exhibit any signs or symptoms of a disease, or they might exhibit only one or two symptoms, which by themselves do not indicate a definitive diagnosis. Screening interventions are designed to identify conditions which could at some future point turn into disease, thus enabling earlier intervention and management in the hope to reduce mortality and suffering from a disease. Although screening may lead to an earlier diagnosis, not all screening tests have been shown to benefit the person being screened; overdiagnosis, misdiagnosis, and creating a false sense of security are some potential adverse effects of screening. Additionally, some screening tests can be inappropriately overused. For these reasons, a test used in a screening program, especially for a disease with low incidence, must have good sensitivity in addition to acceptable specificity. Several types of screening exist: universal screening involves screening of all individuals in a certain category (for example, all children of a certain age). Case finding involves screening a smaller group of people based on the presence of risk factors (for example, because a family member has been diagnosed with a hereditary disease). Screening interventions are not designed to be diagnostic, and often have significant rates of both false positive and false negative results. Frequently updated recommendations for screening are provided by the independent panel of experts, the United States Preventive Services Task Force.
  • 1.6K
  • 14 Oct 2022
Topic Review
Telugu Script
Telugu script (Telugu: తెలుగు లిపి, romanized: Telugu lipi), an abugida from the Brahmic family of scripts, is used to write the Telugu language, a Dravidian language spoken in the India n states of Andhra Pradesh and Telangana as well as several other neighbouring states. The Telugu script is also widely used for writing Sanskrit texts and to some extent the Gondi language. It gained prominence during the Eastern Chalukyas also known as Vengi Chalukya era. It shares extensive similarities with the Kannada script, as it has evolved from Kadamba and Bhattiprolu scripts of the Brahmi family. In 2008, Telugu language was given the status of Classical Languages of India, this status owes to its rich history and heritage.
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  • 14 Oct 2022
Topic Review
Information Technology Specialist (Military)
Information Technology Specialist or Information Systems Operator-Analyst is a Military Occupational Specialty (MOS) in the United States Army. Information Technology Specialists have the responsibility of maintaining, processing and troubleshooting military computer systems and operations.
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  • 14 Oct 2022
Topic Review
Tanpopo (Mission)
The Tanpopo mission is an orbital astrobiology experiment investigating the potential interplanetary transfer of life, organic compounds, and possible terrestrial particles in the low Earth orbit. The purpose is to assess the panspermia hypothesis and the possibility of natural interplanetary transport of microbial life as well as prebiotic organic compounds. The collection and exposure phase took place from May 2015 through February 2018 utilizing the Exposed Facility located on the exterior of Kibo, the Japanese Experimental Module of the International Space Station. The mission, designed and performed by Japan, used ultra-low density silica gel (aerogel) to collect cosmic dust by, which is being analyzed for amino acid-related compounds and microorganisms following their return to Earth. The last samples were retrieved in February 2018 and analyses are ongoing. The principal investigator is Akihiko Yamagishi, who heads a team of researchers from 26 universities and institutions in Japan, including JAXA.
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  • 14 Oct 2022
Topic Review
German University of Administrative Sciences, Speyer
The German University of Administrative Sciences Speyer (German: Deutsche Universität für Verwaltungswissenschaften Speyer; sometimes referred to as Speyer University), is a national graduate school for administrative sciences and public management located in Speyer, Rhineland-Palatinate, Germany . Founded in 1947 by the French occupational authorities as a grande école, today it is operated under the joint responsibility of both the Federal Republic (Bund) and all 16 German states (Länder). It runs four Master's programs, grants doctoral degrees and habilitations, offers a postgraduate certificate program, and administers programs of executive education. The school is a major training ground for German and international senior government officials. Noted alumni and faculty include former President of Germany Roman Herzog, current Minister of Justice Christine Lambrecht, former President of the Bundesbank Helmut Schlesinger, former Prosecutor General of Germany Alexander von Stahl, and CEO of BASF Jürgen Strube. The school was founded in 1947 as the State Academy of Administrative Sciences Speyer (Staatliche Akademie für Verwaltungswissenschaften Speyer). In 1950 it was renamed the School of Administrative Sciences Speyer (Hochschule für Verwaltungswissenschaften Speyer) and after reunification became the German School of Administrative Sciences Speyer (Deutsche Hochschule für Verwaltungswissenschaften Speyer).
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  • 14 Oct 2022
Topic Review
Landrush Period
A landrush period is the time during which domain names are available for registration, usually to a closed group (usually through a premium price), to entities that do not own a trademark in the name they wish to register, for example generic terms like loan or car, and thus would not qualify for registration during the sunrise period. Orders may or may not be treated on a first-come-first-served basis. This period follows the sunrise period just after the launch of a new top-level domain or second-level domain during which, for example, owners of trademarks may register a domain name containing the owned mark, but a landrush period precedes a period of general availability, when any qualifying entity can register any name on a first come first-served basis.
  • 1.3K
  • 14 Oct 2022
Topic Review
Parallel Virtual File System
The Parallel Virtual File System (PVFS) is an open-source parallel file system. A parallel file system is a type of distributed file system that distributes file data across multiple servers and provides for concurrent access by multiple tasks of a parallel application. PVFS was designed for use in large scale cluster computing. PVFS focuses on high performance access to large data sets. It consists of a server process and a client library, both of which are written entirely of user-level code. A Linux kernel module and pvfs-client process allow the file system to be mounted and used with standard utilities. The client library provides for high performance access via the message passing interface (MPI). PVFS is being jointly developed between The Parallel Architecture Research Laboratory at Clemson University and the Mathematics and Computer Science Division at Argonne National Laboratory, and the Ohio Supercomputer Center. PVFS development has been funded by NASA Goddard Space Flight Center, The DOE Office of Science Advanced Scientific Computing Research program, NSF PACI and HECURA programs, and other government and private agencies. PVFS is now known as OrangeFS in its newest development branch.
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  • 14 Oct 2022
Topic Review
Kadambari
Kādambari is a romantic novel in Sanskrit. It was substantially composed by Bāṇabhaṭṭa in the first half of the 7th century CE, who did not survive to see it through completion. The novel was completed by Banabhatta's son Bhushanabhatta, according to the plan laid out by his late father. It is conventionally divided into Purvabhaga (earlier part) written by Banabhatta, and Uttarabhaga (latter part) by Bhushanabhatta. (An alternate tradition gives the son's name as Pulindabhatta.) The standard editions of the original Sanskrit text are by Peterson and Kane. There are translations into English by Kale, Layne and Ridding; and an abridgement into Gujarati by Bhalan (edited by Keshavlal Dhruv). This novel has an extremely intricate plot which is difficult to summarize concisely. Its central thread is that of a romantic attachment (and eventual union) between the hero Chandrapeeda and the heroine Kadambari. However, there are several competing subplots; indeed, the heroine does not make her appearance until past the midpoint. Many of the characters appear in multiple incarnations, some as humans and some as demigods or animals. The narration proceeds in a succession of nested frames; a large part of it is a retelling by a parrot of a story which was told to it by a sage. The latter story also contains several instances of one character relating a sub-story to another character. The plot has probably been adapted from the story of King Sumanas from Gunadhya's Brihatkatha (a conjectural collection of stories in the extinct Paishachi language). This story also appears in Somadeva's Kathasaritsagara (which is believed to be a Sanskrit precis of Gunadhya's work). This work can be plausibly claimed to be one of the first novels in the world; making due allowance for the ambiguities of such a classification. In fact, two modern Indian languages (Kannada and Marathi) use 'kadambari' as a generic term for a romance or a novel. Apart from the Kadambari, Banabhatta is also the author of Harshacharita, a biography of his patron king Harshavardhana. It is this circumstance which allows one to date the author with a reasonable degree of certainty.
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  • 14 Oct 2022
Topic Review
Benzodiazepine Use Disorder
Benzodiazepine use disorder (BUD), also called misuse or abuse, is the use of benzodiazepines without a prescription, often for recreational purposes, which poses risks of dependence, withdrawal and other long-term effects. Benzodiazepines are one of the more common prescription drugs used recreationally. When used recreationally benzodiazepines are usually administered orally but sometimes they are taken intranasally or intravenously. Recreational use produces effects similar to alcohol intoxication. In tests in pentobarbital trained rhesus monkeys benzodiazepines produced effects similar to barbiturates. In a 1991 study, triazolam had the highest self-administration rate in cocaine trained baboons, among the five benzodiazepines examined: alprazolam, bromazepam, chlordiazepoxide, lorazepam, triazolam. A 1985 study found that triazolam and temazepam maintained higher rates of self-injection in both human and animal subjects compared to a variety of other benzodiazepines (others examined: diazepam, lorazepam, oxazepam, flurazepam, alprazolam, chlordiazepoxide, clonazepam, nitrazepam, flunitrazepam, bromazepam, and clorazepate). A 1991 study indicated that diazepam, in particular, had a greater abuse liability among people who were drug abusers than did many of the other benzodiazepines. Some of the available data also suggested that lorazepam and alprazolam are more diazepam-like in having relatively high abuse liability, while oxazepam, halazepam, and possibly chlordiazepoxide, are relatively low in this regard. A 1991–1993 British study found that the hypnotics flurazepam and temazepam were more toxic than average benzodiazepines in overdose. A 1995 study found that temazepam is more rapidly absorbed and oxazepam is more slowly absorbed than most other benzodiazepines. Benzodiazepines have been abused both orally and intravenously. Different benzodiazepines have different abuse potential; the more rapid the increase in the plasma level following ingestion, the greater the intoxicating effect and the more open to abuse the drug becomes. The speed of onset of action of a particular benzodiazepine correlates well with the 'popularity' of that drug for abuse. The two most common reasons for preference were that a benzodiazepine was 'strong' and that it gave a good 'high'. According to Dr. Chris Ford, former clinical director of Substance Misuse Management in General Practice, among drugs of abuse, benzodiazepines are often seen as the 'bad guys' by drug and alcohol workers. Illicit users of benzodiazepines have been found to take higher methadone doses, as well as showing more HIV/HCV risk-taking behavior, greater poly-drug use, higher levels of psychopathology and social dysfunction. However, there is only limited research into the adverse effects of benzodiazepines in drug misusers and further research is needed to demonstrate whether this is the result of cause or effect.
  • 2.3K
  • 18 Oct 2022
Topic Review
Attachment Therapy
Attachment therapy (also called "the Evergreen model," "holding time," "rage-reduction," "compression therapy," "rebirthing," "corrective attachment therapy," and Coercive Restraint Therapy) is a pseudoscientific child mental health intervention intended to treat attachment disorders. It is found primarily in the United States, and much of it is centered in about a dozen clinics in Evergreen, Colorado, where Foster Cline, one of the founders, established his clinic in the 1970s. The practice has resulted in adverse outcomes for children, including at least six documented child fatalities. Since the 1990s there have been a number of prosecutions for deaths or serious maltreatment of children at the hands of "attachment therapists" or parents following their instructions. Two of the most well-known cases are those of Candace Newmaker in 2000 and the Gravelles in 2003. Following the associated publicity, some advocates of attachment therapy began to alter views and practices to be less potentially dangerous to children. This change may have been hastened by the publication of a Task Force Report on the subject in January 2006, commissioned by the American Professional Society on the Abuse of Children (APSAC) which was largely critical of attachment therapy. In April 2007, ATTACh, an organization originally set up by attachment therapists, formally adopted a White Paper stating its unequivocal opposition to the use of coercive practices in therapy and parenting, promoting instead newer techniques of attunement, sensitivity and regulation. Attachment therapy is primarily based on Robert Zaslow's rage-reduction therapy from the 1960s and '70s and on psychoanalytic theories about suppressed rage, catharsis, regression, breaking down of resistance and defence mechanisms. Zaslow, Tinbergen, Martha Welch and other early proponents used it as a treatment for autism, based on the now discredited belief that autism was the result of failures in the attachment relationship with the mother. This form of treatment differs significantly from evidence-based attachment-based therapies, talking psychotherapies such as attachment-based psychotherapy and relational psychoanalysis.
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  • 14 Oct 2022
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