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Topic Review
Lactase Persistence
In humans, the ability to digest milk lactose is conferred by a β-galactosidase enzyme called lactase-phlorizin hydrolase (LPH). The LPH enzyme is encoded by the lactase (LCT) gene, located on the chromosome 2q21. Exclusively expressed in the small intestine, in the apical part of microvilli within the brush border membrane of enterocytes, the LPH enzyme reaches the highest levels of activity during the nursing period. After the weaning phase, however, in the majority of humans, the activity of LPH declines rapidly because of a decrease in the levels of the enzyme, and this trait is known as lactase non-persistence (LNP). As a consequence of LNP, the majority of humans are unable to digest lactose during adulthood, and some suffer clinical complications when they consume it. It has been estimated that approximately two-thirds of humans are LNP worldwide. In the remaining third, however, there are individuals with the ability to digest milk and other lactose-rich dairy products during adulthood. This trait is known as lactase persistence (LP), and is particularly common in descendants from populations that have traditionally practiced cattle domestication.
  • 2.0K
  • 09 Sep 2020
Topic Review
Biological Medicinal Products
Definitions of biological medicinal products (BMPs) vary depending on the source. BMPs are manufactured using complex biological/biotechnological processes involving living cell lines, tissues and organisms such as microorganisms, plants, humans and even animals.
  • 2.0K
  • 25 Dec 2020
Topic Review
BiOCl and g-C3N4
Many organic pollutants are discharged into the environment, which results in the frequent detection of organic pollutants in surface water and underground water. Some of the organic pollutants can stay for a long time in the environment due to their recalcitrance. Advanced oxidation processes (AOPs) can effectively treat the recalcitrant organic compounds in water. Photocatalysis as one of the AOPs has attracted a lot of interest. BiOCl and g-C3N4 are nice photocatalysts. However, their catalytic activity should be further improved for industrial utilization. The construction of heterojunction between the two different components is deemed as an efficient strategy for developing a highly efficient photocatalyst. As a typical type-II heterojunction, g-C3N4/BiOCl heterojunctions showed better photocatalytic performance. To date, the g-C3N4/BiOCl composites were mainly studied in the field of water purification. The photoactivity of the pristine catalysts was greatly enhanced by the combination of the two materials. However, three kinds of proposed mechanisms were used to explain the improvement of the g-C3N4/BiOCl heterojunctions. But few researchers tried to explain why there were three different scenarios employed to explain the charge transfer. According to the articles reviewed, no direct evidence could indicate whether the band structures of the heterojunctions based on BiOCl and g-C3N4 were changed. Therefore, many more studies are needed to reveal the truth. Having a clearer understanding of the mechanism is beneficial for researchers to construct more efficient photocatalysts. This article is trying to start a new direction of research to inspire more researchers to prepare highly effective photocatalysts.
  • 2.0K
  • 15 Sep 2021
Topic Review
Soil Remediation Strategy
Although soil is a valuable and non-renewable ecological system, it has always been subject to widespread degradation due to anthropic activities. The most severe risks are point source and diffuse soil pollution. The remediation of contaminated soils and sites is, therefore, a significant step in the protection of the environment and living organisms, and must be included in the broader multidisciplinary scenario of strategic green transition.
  • 2.0K
  • 15 Feb 2022
Topic Review
Germ Cell Development
Mechanistic understanding of germ cell formation at a genome-scale level can aid in developing novel therapeutic strategies for infertility. Germ cell formation is a complex process that is regulated by various mechanisms, including epigenetic regulation, germ cell-specific gene transcription, and meiosis.
  • 2.0K
  • 11 Mar 2021
Topic Review
Complement System Activation and Functions
The complement system is an essential component of innate immunity. Acting as a first line of defence, the complement system recognises and aids in the elimination of pathogens. Complement proteins also play key roles in homeostasis and they support the inductive of the adaptive immune response.
  • 2.0K
  • 23 Mar 2021
Topic Review
Single-Chromosome Sequencing
Sequencing of DNA from single isolated chromosomes (ChromSeq) is an elegant approach to determine the chromosome content and assign genome assemblies to chromosomes, thus bridging the gap between cytogenetics and genomics. 
  • 2.0K
  • 17 Mar 2021
Topic Review
Green Wireless Sensor Networks
The issue of energy balancing in Wireless Sensor Networks is a pivotal one, crucial in their deployment. This problem can be subdivided in three areas: (i) energy conservation techniques, usually implying minimizing the cost of communication at the nodes since it is known that the radio is the biggest consumer of the available energy; (ii) energy-harvesting techniques, converting energy from not full-time available environmental sources and usually storing it; and (iii) energy transfer techniques, sharing energy resources from one node (either specialized or not) to another one.
  • 2.0K
  • 01 Jul 2021
Topic Review
New Human Resource Management Practices on Innovation Performance
The conventional set of human resource management practices as an important source should create a flexible and innovative view to maintain the significant effects in unique organizational strategies that distinguish committed employees, wherever continuous innovation is essential for gaining organizational sustainability. The competitive and unpredictable situation requires new human resource practices (NHRM) to deal with problems in the organizations to enhance their climate, contribute and heighten innovation performance. This shifts the entire scenario to technological processes such as E-recruitment selection, training, reward systems, employee involvement in decision-making, and teamwork linked strongly with organizational performance and HR outcomes. Evolutionary research is required on HRM practices because different researchers have indicated that the studies are scarce, as such research examines the relationship between NHRM and innovation performance. 
  • 2.0K
  • 24 Mar 2022
Topic Review
Biometal
Biometals are metals normally present, in small but important and measurable amounts, in biology, biochemistry, and medicine. The metals copper, zinc, iron, and manganese are examples of metals that are essential for the normal functioning of most plants and the bodies of most animals, such as the human body. A few (calcium, potassium, sodium) are present in relatively larger amounts, whereas most others are trace metals, present in smaller but important amounts (the image shows the percentages for humans). Approximately 2/3 of the existing periodic table is composed of metals with varying properties, accounting for the diverse ways in which metals (usually in ionic form) have been utilized in nature and medicine.
  • 2.0K
  • 10 Oct 2022
Topic Review
Gadget (Computer Science)
In computational complexity theory, a gadget is a subset of a problem instance that simulates the behavior of one of the fundamental units of a different computational problem. Gadgets are typically used to construct reductions from one computational problem to another, as part of proofs of NP-completeness or other types of computational hardness. The component design technique is a method for constructing reductions by using gadgets. (Szabó 2009) traces the use of gadgets to a 1954 paper in graph theory by W. T. Tutte, in which Tutte provided gadgets for reducing the problem of finding a subgraph with given degree constraints to a perfect matching problem. However, the "gadget" terminology has a later origin, and does not appear in Tutte's paper.
  • 2.0K
  • 18 Oct 2022
Topic Review
Therapeutic Community
Therapeutic community is a participative, group-based approach to long-term mental illness, personality disorders and drug addiction. The approach was usually residential, with the clients and therapists living together, but increasingly residential units have been superseded by day units. It is based on milieu therapy principles, and includes group psychotherapy as well as practical activities. Therapeutic communities have gained some reputation for success in rehabilitation and patient satisfaction in Britain and abroad. In Britain, 'democratic analytic' therapeutic communities have tended to specialise in the treatment of moderate to severe personality disorders and complex emotional and interpersonal problems. The evolution of therapeutic communities in the United States has followed a different path with hierarchically arranged communities (or concept houses) specialising in the treatment of drug and alcohol dependence.
  • 2.0K
  • 02 Dec 2022
Topic Review
Telomere Structure and Homeostasis
Telomere dynamics play a crucial role in the maintenance of chromosome integrity; changes in telomere length may thus contribute to the development of various diseases including cancer. Understanding the role of telomeric DNA in carcinogenesis and detecting the presence of cell-free telomeric DNA (cf-telDNA) in body fluids offer a potential biomarker for novel cancer screening and diagnostic strategies. Telomeres are protected by specialized nucleoprotein capping structures consisting of DNA and shelterin protein complexes.
  • 2.0K
  • 20 Apr 2023
Topic Review
Gas Turbine Power Generation Systems
This paper reviews the modeling techniques and control strategies applied to gas turbine power generation plants. Recent modeling philosophies are discussed and the state-of-the-art feasible strategies for control are shown. Research conducted in the field of modeling, simulation, and control of gas turbine power plants has led to notable advancements in gas turbines’ operation and energy efficiency. Tracking recent achievements and trends that have been made is essential for further development and future research. A comprehensive survey is presented here that covers the outdated attempts toward the up-to-date techniques with emphasis on different issues and turbines’ characteristics. Critical review of the various published methodologies is very useful in showing the importance of this research area in practical and technical terms. The different modeling approaches are classified and each category is individually investigated by reviewing a considerable number of research articles. Then, the main features of each category or approach is reported. The modern multi-variable control strategies that have been published for gas turbines are also reviewed. Moreover, future trends are proposed as recommendations for planned research.
  • 2.0K
  • 28 Jul 2020
Topic Review Peer Reviewed
Edu-Escape Rooms
Escape Rooms are cooperative games in which players must find clues, solve puzzles, and perform a variety of tasks within a limited time. The goal is usually to escape or leave a room, place, or environment. When the Escape Rooms have a pedagogical purpose, they are usually called Edu-Escape Rooms and can be related to gamification and Game-Based Learning. The potential for student engagement and motivation is one of the main advantages of Edu-Escape Rooms.
  • 2.0K
  • 13 Apr 2022
Topic Review
Reconfigurable Intelligent Surfaces for 5G and beyond technologies
With possible new use cases and demanding requirements of future 5th generation (5G) and beyond cellular networks, the future of mobile communications sounds promising. However, the propagation medium has been considered a randomly acting agent between the transmitter and the receiver. With the advent of the digital age of wireless communications, the received signal quality is degrading due to the uncontrollable interactions of the transmitted radio waves with the surrounding artifacts. 
  • 2.0K
  • 23 Dec 2021
Topic Review
Interpersonal Effects of Guilt
Research on the effects of guilt on interpersonal relationships has shown that guilt, as a moral emotion, frequently motivates prosocial behavior in dyadic social situations.  
  • 2.0K
  • 08 Apr 2022
Topic Review
Flavanols and Methylxanthines in Cocoa
Despite the health benefits associated with the ingestion of the bioactive compounds in cocoa, the high concentrations of polyphenols and methylxanthines in the raw cocoa beans negatively influence the taste, confer the astringency and bitterness, and affect the stability and digestibility of the cocoa products. It is, therefore, necessary to process cocoa beans to develop the characteristic color, taste, and flavor, and reduce the astringency and bitterness, which are desirable in cocoa products. 
  • 2.0K
  • 08 Feb 2023
Topic Review
Multilingualism in and out of Films and Stereotypes
Films serve to (re-)create a ‘world’ within the mind of the audience. Additionally, they introduce or reinforce stereotypes portrayed as a reality of the modern world through multiplexity and the strategic use of foreign languages, dialects, and non-native language use, among others. Various concepts of stereotypes can be explored in fiction feature films, especially as film characters are often based on different kinds of stereotypes. Audiovisual texts tend to operate as cultural constructs that reflect and convey certain ideologies within an industry that holds the power to marginalize or belittle voices. Multilingual films highlight the contrasts among and within cultures; hence, they can further exacerbate the marginalization and stereotyping of different cultures and nations, ultimately having damaging effects on society’s perception of different stereotypes, such as race and gender groups, which is shown with the examples from a multilingual film. 
  • 2.0K
  • 07 Aug 2023
Topic Review
Snail Shell Waste in Food Industries
Effective waste management has become an urgent societal challenge. Food waste is made up of items meant for human consumption that are lost, polluted, disposed of, or deteriorated; the reutilization of shells from mollusk waste is a severe problem in terms of environmental protection and the development of the circular economy. The properties of waste shells are presented and discussed, including their biological–natural origin and high calcium carbonate content. This could add social and innovation focus on shell waste management, getting a non-toxic, eco-sustainable, low-cost, biodegradable supplement to invest in. Furthermore, it has the potential to support the circular economy approach by creating a closed system that minimizes the use of natural resources and environmental contamination. 
  • 2.0K
  • 19 Mar 2024
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