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Topic Review
Gastro-Esophageal Junction Precancerosis
A diagnosis of Barrett’s esophagus (BE) requires the macroscopic visualization of gastric-appearing mucosa in the esophagus and the identification of intestinal metaplasia on histologic examination. Histologic diagnosis of BE dysplasia can be challenging due to sampling error, pathologists’ experience, interobserver variation, and difficulty in histologic interpretation: all these problems complicate patient management.
  • 357
  • 15 Dec 2023
Topic Review Peer Reviewed
Towards a Social Model of Prematurity: Understanding the Social Impact of Prematurity and the Role of Inclusive Parenting Practices in Neonatal Intensive Care Units
Prematurity, defined as a birth before 37 weeks of gestation, affects approximately 15 million infants worldwide yearly. Beyond the Neonatal Intensive Care Unit and the possibility of long-term developmental challenges affecting children’s quality of life, prematurity influences family dynamics, including parental mental health, financial stability, employment, and daily life. On a broader scale, research highlights the significant socioeconomic consequences of preterm birth that influence public healthcare policies, healthcare systems, and long-term costs. Addressing these challenges requires a multidisciplinary approach, beginning in the NICUs, with parental inclusion as a key component. The shift toward parental inclusion in the NICU may represent a fundamental transition from a medical to a social model of prematurity. The concept of a social model of prematurity parallels the social model of disability, from disability studies, focusing on premature babies, strengthening their abilities and nurturing early caregiver—infant relationships. It highlights how societal structures, such as accessibility and support systems, shape developmental outcomes and inclusion of premature infants, rather than framing prematurity solely in terms of survival and treatment.
  • 305
  • 16 Sep 2025
Topic Review
Emerging Therapeutic Platforms: A Scientific and Regulatory Overview
The landscape of modern medicine is undergoing a paradigm shift, driven by a convergence of innovations in biotechnology, computational science, and molecular biology. This paper provides a comprehensive overview of several emerging therapeutic platforms poised to redefine the treatment of complex diseases, including cancer, infectious diseases, and substance use disorders. We examine the scientific foundations, mechanisms of action, and clinical potential of next-generation cell therapies (CAR-NK), oncolytic virotherapy, theranostics, proximity-based therapeutics (PROTACs), and AI-driven drug discovery. Furthermore, this analysis identifies the key regulatory bodies and frameworks, such as those established by the FDA, EMA, and TGA, that govern the development and deployment of these advanced modalities. The central theme is the transition towards highly targeted, often personalized or "living" drugs, and the corresponding evolution required in regulatory science to ensure their safety and efficacy.
  • 209
  • 21 Jul 2025
Topic Review
The Ultimate Tool for Organizing Your Personal Library
we’ll explore what makes All My Books such a valuable tool, its key features, benefits, and why it’s a must-have for anyone serious about their reading habit.
  • 170
  • 09 Sep 2025
Topic Review
Preventive Health Care Neglect: Motives and Underlying Mechanisms
Understanding why individuals do not engage in recommended preventive or routine health behaviors is essential for designing effective interventions and improving public‐health programs. Drawing on behavioral‐psychology, decision‐science, and social‐ecological frameworks, this review synthesizes major findings on motives for health‐neglect. Key theoretical frameworks (the Health Belief Model, Theory of Planned Behavior, COM‑B) provide structure, while empirical evidence is drawn from screening uptake, blood‐testing adherence, dental‐care utilization, and broader preventive behaviors. Intervention evidence is reviewed, showing that multi‐component, theory‑based interventions are typically more effective than single‐focus approaches. The principal conclusion is that motive‐structures for not caring for health are multi‐faceted and interactive: cognitive, motivational, affective, and structural factors combine; hence effective intervention must address multiple levels simultaneously. Limitations in the literature (heterogeneity, intention‑behavior gap, equity issues) and interdisciplinary collaboration, as well as future research directions are discussed.
  • 5
  • 09 Dec 2025
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