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Topic Review
Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is a devastating disease predominately found in premature infants that is associated with significant morbidity and mortality. Despite decades of research, medical management with broad spectrum antibiotics and bowel rest has remained relatively unchanged, with no significant improvement in patient outcomes. The etiology of NEC is multi-factorial; however, gastrointestinal dysbiosis plays a prominent role in a neonate’s vulnerability to and development of NEC. Probiotics have recently emerged as a new avenue for NEC therapy. However, current delivery methods are associated with potential limitations, including the need for at least daily administration in order to obtain any improvement in outcomes. We present a novel formulation of enterally delivered probiotics that addresses the current limitations. A single enteral dose of Lactobacillus reuteri delivered in a biofilm formulation increases probiotic survival in acidic gastric conditions, increases probiotic adherence to gastrointestinal epithelial cells, and reduces the incidence, severity, and neurocognitive sequelae of NEC in experimental models.
  • 586
  • 25 Mar 2021
Topic Review
Nutrition and COVID-19
SARS-CoV-2, the cause of the COVID-19 disease, is posing unprecedent challenges. In the literature, increasing evidence highlights how malnutrition negatively affects the immune system functionality, impairing protection from infections.
  • 586
  • 29 Apr 2021
Topic Review
Nordic Diet and Inflammation
Low-grade inflammation (LGI) has been suggested to be involved in the development of chronic diseases. Healthy dietary patterns, such as the Mediterranean diet (MD), may decrease the markers of LGI. Healthy Nordic diet (HND) has many similarities with MD, but its effects on LGI are less well known. Both of these dietary patterns emphasize the abundant use of fruits and vegetables (and berries in HND), whole grain products, fish, and vegetable oil (canola oil in HND and olive oil in MD), but restrict the use of saturated fat and red and processed meat. 
  • 586
  • 12 Oct 2021
Topic Review
Proanthocyanidins and Anthocyanins in Nicotine-Induced NSCLC Treatment
In traditional medicine, different parts of plants, including fruits, have been used for their anti-inflammatory and anti-oxidative properties. Plant-based foods, such as fruits, seeds and vegetables, are used for therapeutic purposes due to the presence of flavonoid compounds. Proanthocyanidins (PCs) and anthocyanins (ACNs) are the major distributed flavonoid pigments in plants, which have therapeutic potential against certain chronic diseases. PCs and ACNs derived from plant-based foods and/or medicinal plants at different nontoxic concentrations have shown anti-non-small cell lung cancer (NSCLC) activity in vitro/in vivo models through inhibiting proliferation, invasion/migration, metastasis and angiogenesis and by activating apoptosis/autophagy-related mechanisms.
  • 586
  • 02 Aug 2022
Topic Review
Biological Activities of the Olive Tree's Polyphenolic Components
The main polyphenolic components present in the fruit and in the wax that covers the olive leaves are represented by hydroxytyrosol, luteolin, oleuropein, verbascoside, gallic acid, vanillic acid, caffeic acid, and the aldehyde derivative oleocanthal. Among all of them, the main and most studied representative is hydroxytyrosol (HT), (2-(3,4-dihydroxyphenyl) ethanol, 3,4-dihydroxyphenethyl alcohol, DOPET, C8H10O3, and presents a molecular mass of 154.16. It is a natural compound, whose structure corresponds to a type of polyphenol, widely distributed throughout the plant kingdom, being especially abundant in the Oleaceae family. It can be found in high concentrations in extra olive oil, fruits and leaves of Olea europaea, and in other products such as fruits, vegetables, and tea. HT in oil is found in free form, as an acetate, or as part of more complex compounds such as oleuropein (a secoiridoide glycoside esterified with a phenylpropanoid alcohol, the major phenolic component of green olive pulp), the flavonoid luteolin (a 5,7-dihidroxi-4-cromenona with hydroxytyrosol), and verbascoside (a phenylethanoid with hydroxytyrosol and a phenylpropanoid sugar ester with caffeic acid).
  • 586
  • 14 Apr 2022
Topic Review
Nutraceuticals in Viral Infection
Nutraceuticals, including vitamin D, vitamin A, zinc, lactoferrin, polyphenols coenzyme Q, magnesium, and selenium, are implicated in the modulation of the complex molecular pathways involved in the immune response against viral pathogens. A common element of the activity of nutraceuticals is their ability to enhance the innate immune response against pathogens by acting on the major cellular subsets and inducing the release of pro-inflammatory cytokines and antimicrobial peptides. In some cases, this action is accompanied by a direct antimicrobial effect, as evidenced in the specific case of lactoferrin. Furthermore, nutraceuticals act through complex molecular mechanisms to minimize the damage caused by the activation of the immune system against pathogens, reducing the oxidative damage, influencing the antigen presentation, enhancing the differentiation and proliferation of regulatory T cells, driving the differentiation of lymphocyte subsets, and modulating the production of pro-inflammatory cytokines.
  • 585
  • 10 Aug 2021
Topic Review
Effect of Curcumin Consumption on Inflammation/Oxidative Stress
Advanced chronic kidney disease (CKD) stages lead to exacerbated inflammation and oxidative stress. Patients with CKD in stage 5 need renal hemodialysis (HD) to remove toxins and waste products. However, this renal replacement therapy (RRT) is inefficient in controlling inflammation. Regular curcumin consumption has been shown to reduce inflammation and oxidative stress in subjects with chronic pathologies, suggesting that the daily intake of curcumin may alleviate these conditions in HD patients.
  • 584
  • 26 Jun 2023
Topic Review
Bioaccessibility of Cereal Polyphenols
Cereal bioactive compounds, especially polyphenols, are known to possess a wide range of disease preventive properties that are attributed to their antioxidant and anti-inflammatory activity. However, due to their low plasma concentrations after oral intake, there is controversy regarding their therapeutic benefits in vivo. Within the gastrointestinal tract, some cereal polyphenols are absorbed in the small intestine, with the majority accumulating and metabolised by the colonic microbiota.
  • 583
  • 10 Sep 2021
Topic Review
Diet in Ulcerative Colitis
Epidemiological and experimental studies have suggested that diet is one of the environmental factors that contributes to the onset and pathophysiology of ulcerative colitis.
  • 583
  • 22 Sep 2021
Topic Review
Vitamins and Cancer
There is a large body of evidence suggesting a strong correlation between vitamin intake as well as vitamin blood concentrations with the occurrence of certain types of cancer. The direction of association between the concentration of a given vitamin and cancer risk is tumor specific.
  • 583
  • 19 Nov 2021
Topic Review
Nutraceuticals for Improving Sleep Quality
Functional beverages can be a valuable component of the human diet with the ability to not only provide essential hydration but to deliver important bioactive compounds that can contribute to chronic disease treatment and prevention. One area of the functional beverage market that has seen an increase in demand in recent years are beverages that promote relaxation and sleep. Sleep is an essential biological process, with optimal sleep being defined as one of adequate duration, quality and timing. It is regulated by a number of neurotransmitters which are, in turn, regulated by dietary intake of essential bioactive compounds. 
  • 583
  • 14 Oct 2022
Topic Review
Copper/Zinc Ratio in Childhood and Adolescence
Both copper (Cu) and zinc (Zn) are crucial micronutrients for human growth and development. Children and adolescents with acute and chronic conditions are at greater risk of developing elevated Cu/Zn ratios, related to altered nutritional, infectious, and inflammatory status.
  • 583
  • 18 Jan 2023
Topic Review
Omega 3 and Preterm Birth
Preterm birth (PTB) is a major cause of neonatal death and long-term consequences for the newborn.  There is not enough available evidence that supports the conclusion that omega 3 supplementation during pregnancy reduces the risk of PTB and ePTB.
  • 582
  • 01 Jun 2021
Topic Review
Very Low-Calorie Diets and Diabetes
Very low-calorie diets (VLCD) are hypocaloric dietary regimens of approximately 400–800 kcal/day that result in 20–30% reductions in body weight, sometimes in just 12–16 weeks. A body of evidence demonstrates that adherence to VLCD in adults with type 2 diabetes (T2D) can result in marked improvements to glycemic control and even full T2D remission, challenging the convention that T2D is a lifelong disease. Although these data are promising, the majority of VLCD studies have focused on weight loss and not T2D remission as a primary endpoint.
  • 582
  • 21 Jun 2021
Topic Review
Health Effects of Selected Supplement
Dietary supplements are products containing nutrients sold in various medicinal forms, and their widespread use may stem from the conviction that a preparation that looks like a drug must have therapeutic properties. The aim of this scoping review is to present what is known about the effects of using selected dietary supplements in the context of chronic diseases, as well as the risks associated with their use. The literature shows that the taking of vitamin and mineral supplements by healthy people neither lowers their risk of cardiovascular diseases nor prevents the development of malignancies. Many scientific societies recognize that omega-3 fatty acids lower blood triglycerides, but whether taking them prevents heart disease is less clear-cut. Taking weight loss supplements is not an effective method of fighting obesity. Often, some supplements are increasingly sold illegally, which is then also associated with the higher risk that they may be adulterated with banned substances, thus making them even more dangerous and potentially life-threatening. Supplements are necessary in cases of nutrient deficiency; however, even though prescription is not required, their use should be recommended and monitored by a physician. 
  • 582
  • 10 Sep 2021
Topic Review
Osteopontin Levels in Human Milk
Breast milk is a unique source of nutrients that is physiologically tailored to meet the changing needs of the infant during the first six or more months of life. In addition to providing optimal energy and nutrition, breast milk optimally manages the transition of the neonate to extrauterine life through a combination of bioactive proteins, lipids, oligosaccharides, and immunomodulatory components.
  • 582
  • 01 Dec 2021
Topic Review
Diet in COPD
Chronic obstructive pulmonary disease is one of the leading causes of morbidity and mortality worldwide and a growing healthcare problem. Several dietary options can be considered in terms of COPD prevention and/or progression. Although definitive data are lacking, the available scientific evidence indicates that some foods and nutrients, especially those nutraceuticals endowed with antioxidant and anti-inflammatory properties and when consumed in combinations in the form of balanced dietary patterns, are associated with better pulmonary function, less lung function decline, and reduced risk of COPD.
  • 579
  • 22 Sep 2021
Topic Review
Nutrition on Adiponectin
Adiponectin is one of the most important adipokines. It is a bioactive peptide composed of 244 amino acids constituting approximately 0.01% of plasma proteins.
  • 578
  • 24 May 2021
Topic Review
Osteoarthritis in The Elderly
Lower-extremity osteoarthritis (OA) is a prevalent musculoskeletal disease in elder population. The main symptom of OA is pain which leads to muscle weakness and physical disability. Recently, most studies indicated that muscle weakness, function limitation, and severity of disease are closely associated with ageing-related muscle attenuations. Therefore, elder individuals with OA have potential sarcopenia risks. Under multifactor risks of OA, it is important to identify effectiveness and efficiency of multidisciplinary management for such elder population to achieve healthy status. Previous studies have indicated that protein supplementation (PS) enhances exercise efficacy by additionally increasing muscle mass and strength for elder individuals with high sarcopenia and frailty risks who were undergoing exercise training (ET). However, it remains unclear whether PS in combination with ET augments benefits in lean mass, strength, and physical function of older adults with lower-extremity OA. In addition, few systematic reviews and meta-analysis studies regarding the effects of PS plus ET have emphasized on elder people with OA. Therefore, this study aimed to investigate whether PS plus ET exert beneficial effects on functional outcomes in older individuals with lower-extremity OA by using the methods of systematic reviews and meta-analysis.
  • 576
  • 28 Aug 2020
Topic Review
Osteonecrosis of the Jaw
Osteonecrosis of the jaw (ONJ) is a severe clinical condition characterized mostly but not exclusively by an area of exposed bone in the mandible and/or maxilla that typically does not heal over a period of 6-8 weeks. The diagnosis is first of all clinical, but an imaging feedback such as Magnetic Resonance is essential to confirm the clinical suspect. In the last decade, the medical-related Osteonecrosis of the jaw (MRONJ) has been widely discussed. Almost all papers concerning this topic conclude that bisphosphonates (BPs) can induce this severe clinical condition, particularly in cancer patients. Nevertheless, the exact mechanism by which amino-BPs would be responsible for ONJ is still debatable. Recent findings suggest a possible alternative explanation for BPs role in this pattern. In the present work we discuss how a condition of osteomalacia and low vitamin D levels might be determinant factors.
  • 576
  • 03 Mar 2021
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