Advantages of Intranasal Administration in Treatment of Depression: Comparison
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As抑郁症作为现代社会的一种精神疾病，发病率越来越高，治愈率低，复发率高。它已成为世界上最致残的疾病。目前，抑郁症的治疗主要以药物治疗为基础，结合心理治疗、物理治疗等辅助治疗方法。抗抑郁药主要外周给药（口服和静脉注射），起效缓慢。抗抑郁活性成分，如神经肽、天然活性成分和一些化学试剂，受到血脑屏障 a mental disease in modern society, depression shows an increasing occurrence, with low cure rate and high recurrence rate. It has become the most disabling disease in the world. At present, the treatment of depression is mainly based on drug therapy combined with psychological therapy, physical therapy, and other adjuvant therapy methods. Antidepressants are primarily administered peripherally (oral and intravenous) and have a slow onset of action. Antidepressant active ingredients, such as neuropeptides, natural active ingredients, and some chemical agents, are limited by factors such as the blood–brain barrier (BBB), first-pass metabolism, and extensive adverse effects caused by systemic administration. The potential anatomical link between the non-invasive nose–brain pathway and the lesion site of depression may provide a more attractive option for the delivery of antidepressant active ingredients. The purpose of this article is to describe the specific link between intranasal administration and depression, the challenges of intranasal administration, as well as studies of intranasal administration of antidepressant active ingredients.（BBB）、首次通过代谢和全身给药引起的广泛不良反应等因素的限制。非侵入性鼻脑通路与抑郁症病变部位之间的潜在解剖学联系可能为抗抑郁活性成分的输送提供更具吸引力的选择。本文的目的是描述鼻内给药与抑郁症之间的特定联系，鼻内给药的挑战，以及鼻内施用抗抑郁活性成分的研究。

  • depression
  • blood–brain barrier
  • brain targeting
  • antidepressant active ingredients
  • intranasal administration
  • challenges of delivery
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