Is there any reason, to believe a modern natural philosophy makes sense? The history of natural philosophy is marked by the search for principles that determine all beings independently whether they are abiotic matter or living organisms. Empirical data on the key features of life contradict even the possibility to find such principles because life in contrast to abiotic matter offers some main characteristics that are completely absent on abiotic planets. This means, if a modern natural philosophy should have any benefit it must be divided into a natural philosophy of physics or cosmology and a natural philosophy of life. If it is possible to give an updated definition of life, empirically based, non-reductive, non-mechanistic and without metaphysical assumptions, this would be an appropriate basis for a global consensus how future of humans may be generated in symbiosis with global biosphere. If we think on billions invested in health and drug research a new natural philosophy of life could orientate future of research on health and new drugs and avoid misinvestments.