Unmanned Aerial Vehicles (UAVs) demand technologies so they can not only fly autonomously, but also communicate with base stations, flight controllers, computers, devices, or even other UAVs. Still, UAVs usually operate within unlicensed spectrum bands, competing against the increasing number of mobile devices and other wireless networks. Combining UAVs with Cognitive Radio (CR) may increase their general communication performance, thus allowing them to execute missions where the conventional UAVs face limitations. CR provides a smart wireless communication which, instead of using a transmission frequency defined in the hardware, uses software transmission. CR smartly uses free transmission channels and/or chooses them according to application’s requirements. Moreover, CR is considered a key enabler for deploying technologies that require high connectivity, such as Smart Cities, 5G, Internet of Things (IoT), and the Internet of Flying Things (IoFT).