The Problem of Drug Resistance in Cancer Chemotherapy: Comparison
Please note this is a comparison between Version 1 by Karol Bukowski and Version 3 by Rita Xu.

Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the past decades, chemotherapy still remains the main method for cancer treatment. Multidrug resistance (MDR) is responsible for over 90% of deaths in cancer patients receiving traditional chemotherapeutics or novel targeted drugs. The mechanisms of MDR include elevated metabolism of xenobiotics, enhanced efflux of drugs, growth factors, increased DNA repair capacity, and genetic factors (gene mutations, amplifications, and epigenetic alterations). Rapidly increasing numbers of biomedical studies are focused on designing chemotherapeutics that are able to evade or reverse MDR.

  • cancer
  • multidrug resistance
  • chemotherapeutics
  • inhibitors
  • P-glycoprotein
  • drugmetabolism
  • growth factors
  • DNA repair
  • epigenetic alterations
  • microRNA
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