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Lim, E. Nutraceuticals. Encyclopedia. Available online: https://encyclopedia.pub/entry/9750 (accessed on 02 May 2024).
Lim E. Nutraceuticals. Encyclopedia. Available at: https://encyclopedia.pub/entry/9750. Accessed May 02, 2024.
Lim, Erin. "Nutraceuticals" Encyclopedia, https://encyclopedia.pub/entry/9750 (accessed May 02, 2024).
Lim, E. (2021, May 18). Nutraceuticals. In Encyclopedia. https://encyclopedia.pub/entry/9750
Lim, Erin. "Nutraceuticals." Encyclopedia. Web. 18 May, 2021.
Nutraceuticals
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This entry is adapted from the peer-reviewed paper 10.3390/molecules26092540

Nutraceuticals are essential food constituents that provide nutritional benefits as well as medicinal effects. The benefits of these foods are due to the presence of active compounds such as carotenoids, collagen hydrolysate, and dietary fibers.

functional foods anti-cancer anti-inflammation antioxidant activity anti-lipid activity nutraceuticals safety and toxicity

1. Introduction

Nutraceuticals are known as bioactive substances that are present in common food or botanical-based sources that can be delivered in the form of dietary supplements or functional food, supplying beneficial effects in addition to the nutritional essential components [1]. Nutraceuticals comprise a wide range of bioactive derivatives accumulated in edible sources including antioxidants, phytochemicals, fatty acids, amino acids, and probiotics. With either established previously or potential effects, nutraceuticals are well-known for their role of being involved in disease treatment and prevention, anti-aging properties, and malignancy prevention. Consuming probiotics is encouraged due to its significant role in the treatment and prevention of gastroenterological diseases [2]. Garlic, for example, has been suggested as a complementary therapy for high blood pressure and cholesterol [3].

With the presence of side effects induced by some pharmaceutical drugs and the emergence of antimicrobial resistance, nutraceutical compounds have gained attention as an alternative therapeutic and preventive approach alongside the advantages of being more affordable and available. Several studies have significantly shown the beneficial effects of nutraceutical ingredients on immune system functions. Such functions include enhancing the infection response mechanism, boosting immunomodulatory activity, and contributing to reducing the impacts of autoimmune disorders and hypersensitivity. Nutraceuticals have also been shown to exert lipid-lowering, anti-inflammatory, anti-cancer and antioxidant activity [4][5][6][7].

The acknowledgment of the science of nutraceuticals has been growing, with increased interest in finding novel therapeutic options by utilizing new technologies and scientific methods. Although many nutraceuticals have been reported for their effective properties in the immune system, there is a necessity of conducting more high-level, clearly evidenced clinical trials for further investigation regarding the long-term effects and public safety.

2. Types of Nutraceuticals Based on Source, Nature and Application

Nutraceuticals have been classified based on their application into traditional, non-traditional, fortified, recombinant, phytochemical, herbal, functional foods, dietary supplements, probiotics and prebiotics [8][9]. Nutraceuticals with their different classes have a variety of applications and uses depending on their nature. Table 1 summarizes the classes of nutraceuticals with their beneficial effects to health.

Table 1. Summary of types of nutraceuticals and their potential effects on health.

Class/Type of Nutraceutical Examples Active Ingredient Advantages References
Traditional approaches        
Functional foods Tomatoes Lycopene Anticancer activities, e.g., lung and prostate, reduce blood pressure [10]
Salmon Omega 3 Lower cardiovascular, diabetes disease risk [11]
Soy Saponins Antioxidant, detoxification of enzymes, stimulate immune response, hormonal metabolism [12]
Fermented milk and milk products L. acidophilus, Bifidobacterium spp. Prevent gastrointestinal infections, lower the level of cholesterol [13]
Marine algae Fucoidans Antioxidant, anticancer, anticoagulant activity [14]
Broccoli Sulforaphane, glucosinolates Decrease risk of several cancers, antioxidant [15][16]
Carrots β-carotene Reduce cancer risk, improve immune system [15][17]
Aloe Aloins Wound healing, antiulcer, anti-inflammatory, immunostimulant, antimicrobial activity, hematopoietic stimulation [18][19]
Turmeric Curcumin Anti-inflammatory, anticarcinogenic [18][20]
Dietary supplements Folic acid   Prevent defect in neural tubes, Red blood cells formation [18][21]
Vitamin A   Antioxidant, growth, treat some skin diseases [22]
Calcium   Bone, muscles, teeth nerve health, prevent osteoporosis [23][24]
Iron   Carry oxygen, produce energy [22]
Vitamin D   Bone and teeth health, help in calcium absorption, musculoskeletal health [25]
Probiotics Lactobacillus acidophilus, Bifidobacterium spp., Streptococci, Enterococci   Gut health, replace diarrhea-causing bacteria, anticancer [22][26][27]
Prebiotics Fructo-oligosaccharides   Enhance probiotics growth, bifidobacteria growth enhancement [28]
Inulin   Enhance immune system, minerals absorption, protect bones [29][26][30]
Non-conventional approach        
Fortified Orange juice with calcium Calcium, ascorbic acid Glycemic control enhancement, sensitivity to insulin [31]
Anthocyanin-fortified bread Anthocyanin Reduce digestion rate [32]
Recombinant Gold kiwifruit Ascorbic acid, carotenoids Immune system enhancement [8][33]

3. Classification of Nutraceuticals Based on Modes of Action

3.1. Anti-Cancer Activity

The use of nutraceuticals as chemo-preventative agents has been studied, and promising results were obtained as per their ability to prevent and treat cancer. Nutraceuticals of different origins have been shown to exhibit anti-cancer activity. Table 2 summarizes anti-cancer modes of action.

Table 2. Selected anti-cancer modes of action classified based on cancer type and nutraceutical.

Type of Cancer Mode of Action Nutraceutical References
Prostate cancer Antiproliferation, cell cycle inhibition, angiogenesis inhibition and promotion of apoptosis Vitamin D [34]
Antioxidation, antiproliferation, and promotion of apoptosis Catechins in green tea [35][36]
Colon cancer Tumor marker suppression, promotion of apoptosis, metastasis inhibition, and antiproliferation Polyphenols [37][38]
Antioxidant, antiproliferation, promotion of apoptosis, inflammatory protein inhibition Terpenoids [39][40]
  Autophagy induction and promotion of apoptosis Alkaloids [41][42][43]
  Induction of DNA hypomethylation, promotion of apoptosis, and antiproliferation Micronutrients [44][45]
Breast cancer Antiproliferation, angiogenesis inhibition, and promotion of apoptosis Allicin in garlic [46][47][48]
Antiproliferation and promotion of apoptosis Curcumin [49]
Cell cycle inhibition, promotion of apoptosis, and inhibition of metastasis Vitamin D [50][51]
Oral cancer Prevent tumor initiation Strawberry [44]
Antioxidation Rosemary [45]
Antiproliferation, promotion of apoptosis, and angiogenesis inhibition Geraniol [52]

3.2. Anti-Inflammatory Activity

Nutraceuticals exert anti-inflammatory activities which help in the prevention and treatment of chronic inflammation-associated diseases [53]. Another benefit of nutraceuticals as anti-inflammatory agents is that they can be used as a complementary alternative to anti-inflammatory therapeutic drugs, which leads to a reduction in drug dosage, and therefore reducing side effects [54]. Chronic inflammation is the major cause of chronic diseases such as cardiovascular diseases, pulmonary diseases, diabetes, and cancer [53]. Table 3 summarizes anti-inflammatory modes of action.

Table 3. Selected anti-inflammatory modes of action classified based on nutraceutical and benefits.

Mode of Action Nutraceutical Benefits Reference
Reduce nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), production of nitric oxide (NO), interleukin-1β (IL-1β), nuclear factor kappa B (NF-κB) Resveratrol Neuroprotective [55]
Inhibit the activation of NF-κB and limits the inflammatory response, such as ICAM-1, MCP-1, Cox-2, TNF-α, IL-1β, and IL-6 Baicalin Improvement of trinitrobenzene sulphonic acid (TNBS) induced colitis [56]
Reduce the expression of TNF-α, COX-2, 5-LOX, and IL-6 and increase IL-10 levels Flavocoxid Protects from sepsis [57]
Reduces the expression of TNFα, IL-1β and reduces myeloperoxidase (MPO) activity Curcumin Improve dextran sulfate sodium (DSS)-induced colitis [58]
Decreases the expression of iNOS and COX-2 6-Gingerol Protects from carbon tetrachloride (CCl4)-induced liver fibrosis [59]
Inhibits the expression of TLR4 and NF-κB and suppress iNOS, COX-2, TNF-α, IL-6, and IL-1β Apigenin Protects against blood-brain barrier disruption [60]
Reduced the expression of TNF-α, IL-1β, and IL-6 and increases IL-10 expression.
Decreases TLR-2 and TLR-4 expression
Inhibits phosphorylation of I-κB, p65, p38, ERK, and JNK		 Piperine Reduces inflammatory injury in Staphylococcus aureus endometritis. [61]
Suppresses the activity of renal MPO Naringin Decreases neutrophil infiltration in the kidneys. [62]
Reduces NF-kappa B p65 subunit activation which decreases inflammatory cells and reduces cytokine secretion Eucalyptol Potential agent in the treatment of cigarette smoke-induced acute lung inflammation. [63]
Suppresses NF-kB and p38 and reduces the level of TNF-α and IL-1β levels

Ortho-eugenol

 Treatment of pain and inflammation. [64]

3.3. Antioxidant Activity

The main sources of antioxidants are food, vitamins, and supplements. Foods such as fruits and vegetables are considered a great source of antioxidants due to their high levels of vitamins and phytochemicals [65]. Beetroot contains betalain and phenolic compounds which cause an increase in the resistance of low-density lipoproteins (LDLs) to oxidation [66], protect the liver from damage [67], and decrease blood pressure [68]. Dried fruits are a good source of antioxidants and have health benefits to humans. They can reduce glucose levels in the blood in addition to reducing risk factors associated with heart disease [69].

3.4. Anti-Lipid Activity

The application of nutraceuticals as hypolipidemic agents has shown great potential in lowering total cholesterol (TC) and low-density lipoprotein (LDL) concentrations. Lipid-lowering nutraceuticals can be classified into three groups based on their mechanism of action. Such mechanisms include the inhibition of cholesterol absorption, inhibition of cholesterol synthesis, and excretion of LDL [70]. Plant sterol foods or supplements have displayed effectiveness in lowering lipid profiles. It has been established that plant sterols modify lipid profiles by decreasing the intestinal absorption of cholesterol [71]. It has been found that the intake of plant sterols demonstrated an effect on lipid profiles by lowering the concentrations of triglycerides and LDL in individuals at risk or suffering from type-2 diabetes mellitus [72]. Red yeast rice (RYR) exhibited potent effects on lowering lipid profiles in patients suffering from cardiovascular disease and dyslipidemia [73][74][75]. The consumption of dietary fibers is considered an effective approach in modulating lipid profiles. Dietary fibers are divided into soluble and insoluble fibers. Soluble fibers are more beneficial because they are fermented by the microbiota of the large intestine [76].

In summary, many nutraceuticals and functional foods have been proven for their ability in regulating lipid profiles. Owing to their mechanism of action, nutraceuticals can either inhibit cholesterol synthesis, inhibit cholesterol absorption, or enhance cholesterol excretion. 

4. Nutraceuticals' Safety on Consumers

The majority of nutraceuticals on the market are safe for human consumption and only in some instances may cause harm because some nutraceuticals have toxic effects on human health. Studies have shown that some widely consumed nutraceuticals possess many health benefits with very minimal toxicity when used in correct controllable amounts. Nutraceuticals such as anthocyanins, polyphenols, and catechins are widely used and are safe for human consumption on controlled use. There have been very few studies that have indicated how these substances are harmful to human health.

Nevertheless, studies on nutraceuticals have shown that benefits of use outweigh the risk, and they are widely approved for human use within the correct amounts and dosages [70]. However, misuse and overuse of these products may pose health risks to humans. The safety of these nutraceuticals on consumers basically depends on the type, time, and the quantity used. Use of some nutraceuticals, especially when one is under medication, can result in interactions between the drug and the nutraceutical compounds causing very harmful effects on the body [77]. Thus, for safe usage, they should be used only when prescribed by qualified personnel at the right quantity, the correct quality, and timing.

5. Summary

Nutraceuticals embody a novel and exhilarating research field for the discovery of innovative health products with tremendous potentials of health benefits including safety, efficacy, and economy. Globally, researchers have realized the fact that proper nutrition and dietary supplements can prevent and cure chronic diseases. This research area has major attractions both for academia and pharmaceutical/food industries. A few pharma-industries including Ranbaxy and Abbot have taken the initiative of synthesizing a range of nutraceutical products for different age consumers. The preventive role of these products is uncovered by researchers to a great extent; therefore, further extensive research both from academia as well as the pharmaceutical sector is necessary regarding their safety and efficacy. Furthermore, use of advanced and high-throughput technologies can help us understand the underlying mechanisms of action and develop this exciting area of research to new horizons for the betterment of humanity, both in terms of economic benefits as well as health outcomes.

References

  1. Nasri, H.; Baradaran, A.; Shirzad, H.; Rafieian-Kopaei, M. New Concepts in Nutraceuticals as Alternative for Pharmaceuticals. Int. J. Prev. Med. 2014, 5, 1487–1499.
  2. Caramia, G.; Silvi, S. Probiotics: From the Ancient Wisdom to the Actual Therapeutical and Nutraceutical Perspective. In Probiotic Bacteria and Enteric Infections: Cytoprotection by Probiotic Bacteria; Malago, J.J., Koninkx, J.F.J.G., Marinsek-Logar, R., Eds.; Springer: Dordrecht, The Netherlands, 2011; pp. 3–37.
  3. Ried, K. Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review. J. Nutr. 2016, 146, 389S–396S.
  4. Affuso, F.; Ruvolo, A.; Micillo, F.; Saccà, L.; Fazio, S. Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. Nutr. Metab. Cardiovasc. Dis. 2010, 20, 656–661.
  5. Chen, G.-L.; Chen, S.-G.; Chen, F.; Xie, Y.-Q.; Han, M.-D.; Luo, C.-X.; Zhao, Y.-Y.; Gaob, Y.-Q. Nutraceutical potential and antioxidant benefits of selected fruit seeds subjected to an in vitro digestion. J. Funct. Foods 2016, 20, 317–331.
  6. Pitchaiah, G.; Akula, A.; Chandi, V. Anticancer Potential of Nutraceutical Formulations in MNU-induced Mammary Cancer in Sprague Dawley Rats. Pharmacogn. Mag. 2017, 13, 46–50.
  7. Singla, V.; Pratap Mouli, V.; Garg, S.K.; Rai, T.; Choudhury, B.N.; Verma, P.; Deb, R.; Tiwari, V.; Rohatgi, S.; Dhingra, R.; et al. Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis—A randomized, placebo-controlled, pilot study. J. Crohn’s Colitis 2014, 8, 208–214.
  8. Ruchi, S. Role of nutraceuticals in health care: A review. Int. J. Green Pharm. 2017, 11.
  9. Singh, J.; Sinha, S. Classification, regulatory acts and applications of nutraceuticals for health. Int. J. Pharm. Bio Sci. 2012, 2, 177–187.
  10. Bhowmik, D.; Kumar, K.P.S.; Paswan, S.; Srivastava, S. Tomato-A Natural Medicine and Its Health Benefits. J. Pharmacogn. Phytochem. 2012, 1, 33–43.
  11. Smith, L.K.; Guentzel, L.J. Mercury concentrations and omega-3 fatty acids in fish and shrimp: Preferential consumption for maximum health benefits. Mar. Pollut. Bull. 2010, 60, 1615–1618.
  12. Singh, B.; Singh, J.P.; Kaur, A. Saponins in pulses and their health promoting activities: A review. Food Chem. 2017, 233, 540–549.
  13. Shiby, V.K.; Mishra, H.N. Fermented Milks and Milk Products as Functional Foods—A Review. Crit. Rev. Food Sci. Nutr. 2013, 53, 482–496.
  14. Vo, T.-S.; Kim, S.-K. Fucoidans as a natural bioactive ingredient for functional foods. J. Funct. Foods 2013, 5, 16–27.
  15. Lobo, V.; Patil, A.; Phatak, A.; Chandra, N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn. Rev. 2010, 4, 118–126.
  16. Latté, K.P.; Appel, K.-E.; Lampen, A. Health benefits and possible risks of broccoli—An overview. Food Chem. Toxicol. 2011, 49, 3287–3309.
  17. Irw Jaswir, I.; Noviendri, D.; Hasrini, R.F.; Octavianti, F. Carotenoids: Sources, medicinal properties and their application in food and nutraceutical industry. JMPR 2011, 5, 7119–7131.
  18. Chauhan, B.; Kumar, G.; Kalam, N.; Ansari, S.H. Current concepts and prospects of herbal nutraceutical: A review. J. Adv. Pharm. Technol. Res. 2013, 4, 4–8.
  19. Kispotta, A.; Srivastava, M.K.; Dutta, M. Free radical scavenging activity of ethanolic extracts and determination of aloin from Aloe vera L. leaf extract. Int. J. Med. Aromat. Plants 2012, 2, 612–618.
  20. Souyoul, S.A.; Saussy, K.P.; Lupo, M.P. Nutraceuticals: A Review. Dermatol. Ther. 2018, 8, 5–16.
  21. Bailey, R.L.; Dodd, K.W.; Gahche, J.J.; Dwyer, J.T.; McDowell, M.A.; Yetley, E.A.; Sempos, C.A.; Burt, V.L.; Radimer, K.L.; Picciano, M.F. Total folate and folic acid intake from foods and dietary supplements in the United States: 2003–2006. Am. J. Clin. Nutr. 2010, 91, 231–237.
  22. Gupta, S.; Chauhan, D.; Mehla, K.; Sood, P.; Nair, A. An Overview of Nutraceuticals: Current Scenario. J. Basic Clin. Pharm. 2010, 1, 55–62.
  23. Areco, V.; Rivoira, M.A.; Rodriguez, V.; Marchionatti, A.M.; Carpentieri, A.; de Talamoni, N.T. Dietary and pharmacological compounds altering intestinal calcium absorption in humans and animals. Nutr. Res. Rev. 2015, 28, 83–99.
  24. Martini, M.; Altomonte, I.; Licitra, R.; Salari, F. Nutritional and Nutraceutical Quality of Donkey Milk. J. Equine Vet. Sci. 2018, 65, 33–37.
  25. Hossein-nezhad, A.; Holick, M.F. Vitamin D for Health: A Global Perspective. Mayo Clin. Proc. 2013, 88, 720–755.
  26. Keservani, R.K.; Kesharwani, R.K.; Vyas, N.; Jain, S.; Sharma, A.K. Nutraceutical and Functional Food as Future Food: A Review. Der Pharm. Lett. 2010, 2, 106–116.
  27. Prasanna, P.H.P.; Grandison, A.S.; Charalampopoulos, D. Bifidobacteria in milk products: An overview of physiological and biochemical properties, exopolysaccharide production, selection criteria of milk products and health benefits. Food Res. Int. 2014, 55, 247–262.
  28. Caetano, B.F.R.; De Moura, N.A.; Almeida, A.P.S.; Dias, M.C.; Sivieri, K.; Barbisan, L.F. Yacon (Smallanthus sonchifolius) as a Food Supplement: Health-Promoting Benefits of Fructooligosaccharides. Nutrients 2016, 8, 436.
  29. Al-Sheraji, S.H.; Ismail, A.; Manap, M.Y.; Mustafa, S.; Yusof, R.M.; Hassan, F.A. Prebiotics as Functional Foods: A review. J. Funct. Foods 2013, 5, 1542–1553.
  30. Shoaib, M.; Shehzad, A.; Omar, M.; Rakha, A.; Raza, H.; Sharif, H.R.; Shakeel, A.; Ansari, A.; Niazi, S. Inulin: Properties, health benefits and food applications. Carbohydr. Polym. 2016, 147, 444–454.
  31. Swaroopa, G.; Srinath, D. Nutraceuticals and their Health Benefits. Int. J. Pure Appl. Biosci. 2017, 5, 1151–1155.
  32. Sui, X.; Zhang, Y.; Zhou, W. Bread fortified with anthocyanin-rich extract from black rice as nutraceutical sources: Its quality attributes and in vitro digestibility. Food Chem. 2016, 196, 910–916.
  33. Skinner, M.A.; Loh, J.M.S.; Hunter, D.C.; Zhang, J. Gold kiwifruit (Actinidia chinensis ‘Hort16A’) for immune support. Proc. Nutr. Soc. 2011, 70, 276–280.
  34. Karlsson, S.; Olausson, J.; Lundh, D.; Sögård, P.; Mandal, A.; Holmström, K.-O.; Stahel, A.; Bengtsson, J.; Larsson, D. Vitamin D and prostate cancer: The role of membrane initiated signaling pathways in prostate cancer progression. J. Steroid Biochem. Mol. Biol. 2010, 121, 413–416.
  35. Lassed, S.; Deus, C.M.; Djebbari, R.; Zama, D.; Oliveira, P.J.; Rizvanov, A.A.; Dahdouh, A.; Benayache, F.; Benayache, S. Protective Effect of Green Tea (Camellia sinensis (L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients. Evid. Based Complement Altern. Med. 2017, 2017.
  36. Yang, K.; Gao, Z.-Y.; Li, T.-Q.; Song, W.; Xiao, W.; Zheng, J.; Chen, H.; Chen, G.-H.; Zou, H.-Y. Anti-tumor activity and the mechanism of a green tea (Camellia sinensis) polysaccharide on prostate cancer. Int. J. Biol. Macromol. 2019, 122, 95–103.
  37. Johnson, J.J.; Mukhtar, H. Curcumin for chemoprevention of colon cancer. Cancer Lett. 2007, 255, 170–181.
  38. Umesalma, S.; Sudhandiran, G. Differential Inhibitory Effects of the Polyphenol Ellagic Acid on Inflammatory Mediators NF-κB, iNOS, COX-2, TNF-α, and IL-6 in 1,2-Dimethylhydrazine-Induced Rat Colon Carcinogenesis. Basic Clin. Pharmacol. Toxicol. 2010, 107, 650–655.
  39. Akrout, A.; Gonzalez, L.A.; El Jani, H.; Madrid, P.C. Antioxidant and antitumor activities of Artemisia campestris and Thymelaea hirsuta from southern Tunisia. Food Chem. Toxicol. 2011, 49, 342–347.
  40. Jayaprakasha, G.K.; Murthy, K.N.C.; Uckoo, R.M.; Patil, B.S. Chemical composition of volatile oil from Citrus limettioides and their inhibition of colon cancer cell proliferation. Ind. Crops Prod. 2013, 45, 200–207.
  41. Mondal, A.; Gandhi, A.; Fimognari, C.; Atanasov, A.G.; Bishayee, A. Alkaloids for cancer prevention and therapy: Current progress and future perspectives. Eur. J. Pharmacol. 2019, 858, 172472.
  42. Shoeb, M.; MacManus, S.M.; Jaspars, M.; Trevidu, J.; Nahar, L.; Kong-Thoo-Lin, P.; Sarkere, S.D. Montamine, a unique dimeric indole alkaloid, from the seeds of Centaurea montana (Asteraceae), and its in vitro cytotoxic activity against the CaCo2 colon cancer cells. Tetrahedron 2006, 62, 11172–11177.
  43. Zhou, J.; Feng, J.-H.; Fang, L. A novel monoterpenoid indole alkaloid with anticancer activity from Melodinus khasianus. Bioorg. Med. Chem. Lett. 2017, 27, 893–896.
  44. Chang, H.-F.; Yang, L.-L. Gamma-Mangostin, a Micronutrient of Mangosteen Fruit, Induces Apoptosis in Human Colon Cancer Cells. Molecules 2012, 17, 8010–8021.
  45. Prinz-langenohl, R.; Fohr, I.; Pietrzik, K. Beneficial role for folate in the prevention of colorectal and breast cancer. Eur. J. Nutr. 2001, 40, 98–105.
  46. Modem, S.; DiCarlo, S.E.; Reddy, T.R. Fresh Garlic Extract Induces Growth Arrest and Morphological Differentiation of MCF7 Breast Cancer Cells. Genes Cancer 2012, 3, 177–186.
  47. Talib, W.H. Consumption of garlic and lemon aqueous extracts combination reduces tumor burden by angiogenesis inhibition, apoptosis induction, and immune system modulation. Nutrition 2017, 43, 89–97.
  48. Vijayakumar, S.; Malaikozhundan, B.; Saravanakumar, K.; Durán-Lara, E.F.; Wang, M.-H.; Vaseeharan, B. Garlic clove extract assisted silver nanoparticle—Antibacterial, antibiofilm, antihelminthic, anti-inflammatory, anticancer and ecotoxicity assessment. J. Photochem. Photobiol. B 2019, 198, 111558.
  49. Kronski, E.; Fiori, M.E.; Barbieri, O.; Astigiano, S.; Mirisola, V.; Killian, P.H.; Bruno, A.; Pagani, A.; Rovera, F.; Pfeffer, U.; et al. miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2. Mol. Oncol. 2014, 8, 581–595.
  50. Simboli-campbell, M.; Narvaez, C.J.; Vanweelden, K.; Tenniswood, M.; Welsh, J. Comparative effects of 1,25(OH)2D3 and EB1089 on cell cycle kinetics and apoptosis in MCF-7 breast cancer cells. Breast Cancer Res. Treat. 1997, 42, 31–41.
  51. Wang, Q.; Lee, D.; Sysounthone, V.; Chandraratna, R.A.S.; Christakos, S.; Korah, R.; Wieder, R. 1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects. Breast Cancer Res. Treat. 2001, 67, 157–168.
  52. Zhu, X.; Xiong, L.; Zhang, X.; Shi, N.; Zhang, Y.; Ke, J.; Sun, Z.; Chen, T. Lyophilized strawberries prevent 7,12-dimethylbenz[α]anthracene (DMBA)-induced oral squamous cell carcinogenesis in hamsters. J. Funct. Foods 2015, 15, 476–486.
  53. Petiwala, S.M.; Johnson, J.J. Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity. Cancer Lett. 2015, 367, 93–102.
  54. Vinothkumar, V.; Manoharan, S.; Sindhu, G.; Nirmal, M.R.; Vetrichelvi, V. Geraniol modulates cell proliferation, apoptosis, inflammation, and angiogenesis during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Mol. Cell Biochem. 2012, 369, 17–25.
  55. El-Abhar, H.S.; Hammad, L.N.A.; Gawad, H.S.A. Modulating effect of ginger extract on rats with ulcerative colitis. J. Ethnopharmacol. 2008, 118, 367–372.
  56. Lv, J.; Huang, H.; Yu, L.; Whent, M.; Niu, Y.; Shi, H.; Wang, T.T.Y.; Luthria, D.; Charles, D.; Yu, L.L. Phenolic composition and nutraceutical properties of organic and conventional cinnamon and peppermint. Food Chem. 2012, 132, 1442–1450.
  57. Hassanzadeh, P.; Arbabi, E.; Atyabi, F.; Dinarvand, R. The endocannabinoid system and NGF are involved in the mechanism of action of resveratrol: A multi-target nutraceutical with therapeutic potential in neuropsychiatric disorders. Psychopharmacology 2016, 233, 1087–1096.
  58. Cui, L.; Feng, L.; Zhang, Z.H.; Jia, X.B. The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation. Int. Immunopharmacol. 2014, 23, 294–303.
  59. Bitto, A.; Minutoli, L.; David, A.; Irrera, N.; Rinaldi, M.; Venuti, F.S.; Squadrito, F.; Altavilla, D. Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis. Crit. Care 2012, 16, R32.
  60. Liu, L.; Shang, Y.; Li, M.; Han, X.; Wang, J.; Wang, J. Curcumin ameliorates asthmatic airway inflammation by activating nuclear factor-E2-related factor 2/haem oxygenase (HO)-1 signalling pathway. Clin. Exp. Pharmacol. Physiol. 2015, 42, 520–529.
  61. Algandaby, M.M.; El-halawany, A.M.; Abdallah, H.M.; Alahdal, A.M.; Nagy, A.A.; Ashour, O.M.; Abdel-Naim, A.B. Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators. Naunyn Schmiedeberg Arch. Pharmacol. 2016, 389, 419–428.
  62. Zhang, T.; Su, J.; Guo, B.; Wang, K.; Li, X.; Liang, G. Apigenin protects blood–brain barrier and ameliorates early brain injury by inhibiting TLR4-mediated inflammatory pathway in subarachnoid hemorrhage rats. Int. Immunopharmacol. 2015, 28, 79–87.
  63. Zhai, W.; Zhang, Z.; Xu, N.; Guo, Y.; Qiu, C.; Li, C.; Deng, G.Z.; Guo, M.Y. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid. Based Complement Altern. Med. 2016, 2016.
  64. Sahu, B.D.; Tatireddy, S.; Koneru, M.; Borkar, R.M.; Kumar, J.M.; Kuncha, M.; Srinivas, R.; Sunder R, S.; Sistla, R. Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: Possible mechanism of nephroprotection. Toxicol. Appl. Pharmacol. 2014, 277, 8–20.
  65. Srinivasan, K. Antioxidant Potential of Spices and Their Active Constituents. Crit. Rev. Food Sci. Nutr. 2014, 54, 352–372.
  66. Danwilai, K.; Konmun, J.; Sripanidkulchai, B.; Subongkot, S. Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: A pilot study. Cancer Manag. Res. 2017, 9, 11–18.
  67. Cao, C.; Pathak, S.; Patil, K. Antioxidant Nutraceuticals: Preventive and Healthcare Applications, 1st ed.; Taylor & Francis Group: Milton, UK, 2018; p. 428.
  68. Tesoriere, L.; Allegra, M.; Butera, D.; Livrea, M.A. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: Potential health effects of betalains in humans. Am. J. Clin. Nutr. 2004, 80, 941–945.
  69. Krajka-Kuźniak, V.; Szaefer, H.; Ignatowicz, E.; Adamska, T.; Baer-Dubowska, W. Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats. Food Chem. Toxicol. 2012, 50, 2027–2033.
  70. Riccioni, G.; Gammone, M.A.; Currenti, W.; D’Orazio, N. Effectiveness and Safety of Dietetic Supplementation of a New Nutraceutical on Lipid Profile and Serum Inflammation Biomarkers in Hypercholesterolemic Patients. Molecules 2018, 23, 1168.
  71. Lyseng-Williamson, K.A. Ezetimibe/Simvastatin: A Guide to its Clinical Use in Hypercholesterolemia. Am. J. Cardiovasc. Drugs 2012, 12, 49–56.
  72. Cicero, A.F.G.; Colletti, A.; Bajraktari, G.; Descamps, O.; Djuric, D.M.; Ezhov, M.; Fras, Z.; Katsiki, N.; Langlois, M.; Latkovskis, G.; et al. Lipid lowering nutraceuticals in clinical practice: Position paper from an International Lipid Expert Panel. Arch. Med. Sci. 2017, 13, 965–1005.
  73. Amir Shaghaghi, M.; Harding, S.V.; Jones, P.J.H. Water dispersible plant sterol formulation shows improved effect on lipid profile compared to plant sterol esters. J. Funct. Foods 2014, 6, 280–289.
  74. Malina, D.M.T.; Fonseca, F.A.; Barbosa, S.A.; Kasmas, S.H.; Machado, V.A.; França, C.N.; Borges, N.C.; Moreno, R.A.; Izar, M.C. Additive effects of plant sterols supplementation in addition to different lipid-lowering regimens. J. Clin. Lipidol. 2015, 9, 542–552.
  75. Becker, D.J.; Gordon, R.Y.; Halbert, S.C.; French, B.; Morris, P.B.; Rader, D.J. Red yeast rice for dyslipidemia in statin-intolerant patients: A randomized trial. Ann. Intern. Med. 2009, 150, 830.
  76. Biagi, M.; Minoretti, P.; Bertona, M.; Emanuele, E. Effects of a nutraceutical combination of fermented red rice, liposomal berberine, and curcumin on lipid and inflammatory parameters in patients with mild-to-moderate hypercholesterolemia: An 8-week, open-label, single-arm pilot study. Arch. Med. Sci. Atheroscler. Dis. 2018, 3, e137–e141.
  77. Pirillo, A.; Catapano, A.L. Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies. Atherosclerosis 2015, 243, 449–461.
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Subjects: Agriculture, Dairy & Animal Science
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Erin Lim
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Entry Collection: Biopharmaceuticals Technology
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Update Date: 18 May 2021
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