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De Jesús Gil, C. Candida Albicans in Psoriasis. Encyclopedia. Available online: https://encyclopedia.pub/entry/8608 (accessed on 15 November 2024).
De Jesús Gil C. Candida Albicans in Psoriasis. Encyclopedia. Available at: https://encyclopedia.pub/entry/8608. Accessed November 15, 2024.
De Jesús Gil, Carmen. "Candida Albicans in Psoriasis" Encyclopedia, https://encyclopedia.pub/entry/8608 (accessed November 15, 2024).
De Jesús Gil, C. (2021, April 12). Candida Albicans in Psoriasis. In Encyclopedia. https://encyclopedia.pub/entry/8608
De Jesús Gil, Carmen. "Candida Albicans in Psoriasis." Encyclopedia. Web. 12 April, 2021.
Candida Albicans in Psoriasis
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This entry is adapted from the peer-reviewed paper 10.3390/ijms22041519

Psoriasis is a T cell-mediated skin disease resulting from epithelial and immunological cells’ interactions, which affects around 2% of the population worldwide. Its onset is influenced by genetic and environmental factors, particularly infections among which Streptococcus pyogenes is the best characterized. However, the commensal fungus Candida albicans has been also associated to triggering psoriasis. Here we discuss what it is known about the link betweeen Candida and psoriasis pathogenesis.

psoriasis Candida albicans IL-17 plaque psoriasis

1. Introduction

Candida albicans infections have been associated to psoriasis flares over time[1]. However, the insights of this relationship is poorly characterized. Several studies have confirmed increased Candida albicans colonization of the oral[2][3][4][5][6] and gut[2][6] mucosa in psoriasis patients compared to healthy individuals, which have been confirmed by a recent meta-analysis too. Nonetheless, whereas some authors revealed an association between C. albicans existence at mucosal sites and psoriasis severity[2][4][6], others did not find such correlation[3][7][8]. Likewise, the presence of Candida albicans at cutaneous levels is still controversial. Most skin mycobiome studies have not revealed differences between psoriasis and healthy individuals’ Candida spp. levels[3][9][10][11][12][13][14][15]. However, Sarvtin T. and colleges found elevated C. albicans in lesional skin from the trunk compared to either adjacent normal skin or healthy controls’ skin[5]. Furthermore, Salem I. et al. recently reported the presence of higher C. albicans in non-lesional skin swabs[16].

Introduced in the early eighties, the role of the skin as a peripheral lymphoid organ has been dissected ever since[17]. The Cutaneous Lymphocyte-associated Antigen (CLA) identifies a subpopulation of memory T cells with skin tropism. It is expressed in more than 90% of cutaneous T cells whereas only in 15-20% of T cells in peripheral blood. Once in the skin, these cells can go back to systemic circulation though the lymphatic system, meaning that they recirculate back and forth between both tissue compartments. Of important note, the phenotype, antigen specificity and effector function of circulating CLA+ T lymphocytes reflect the mechanisms taking place at cutaneous levels, consequently they are consider good peripheral biomarkers for T cell mediated skin conditions such as psoriasis or atopic dermatitis[18][19]. Here we explore how this subset of skin tropic lymphocytes respond to C. albicans in coculture with autologous epidermals cells from psoriasis patients compared to healthy controls. 

2. Exploring C. albicans humoral and cellular responses in psoriasis

Currently, the evidence of microbes’ presence in psoriatic patients is focused on complex DNA-based technologies[20]. However, specific immunoglobulins assess environmental microorganism exposure and the isotypes observed in immunoglobulins can elucidate the mechanisms of antigen encounters[21]. Initial studies of anti-Candida antibody levels did not observe differences between patients with psoriasis and healthy individuals[9][22]. Recently, however, Liang YS et al. showed increased anti-whole cell antigen IgG and decreased anti-soluble antigen IgA and IgM in serum from psoriasis patients versus healthy individuals[23]. Whilst, Sarvtin MT et al. reported decreased anti-Candida IgM, IgA and IgG levels in psoriasis patients compared to controls[5]. As such, the humoral response against Candida albicans in psoriasis patients remains controversial.

To evaluate C. albicans exposure, we assessed fungus-specific IgA and IgG (including all subtypes) in plasmas from plaque and guttate psoriasis patients, as well as healthy controls. Significantly increased levels of anti-CA IgA and IgG were found in plaque psoriasis, with particularly higher disease severity, whereas similar antibody response was found in guttate psoriasis as to healthy controls. Importantly, active Candida infection was not observed in any subject, according to an ELISA diagnostic kit.

C. albicans T cell response in our ex vivo model of psoriasis in a small cohort of patients had been previously explored, showing primarily CD4+ T cell activity [24]. In this study, preferential CLA+ T cell response to C. albicans was confirmed, dominated by IL-17F production, in a larger cohort of psoriasis patients but also in control subjects. Even if similar CA-induced cytokine profile is observed, we found overall increased cytokine response in guttate versus plaque psoriasis patients. Interestingly, although C. albicans induction of IL-9 by CLA+ T cells was already shown in healthy donors[25], we observed significantly increased CA-induced IL-9 in psoriasis patients compared to controls.

Considering the distinct exposure to C. albicans within psoriasis, we believed patients with high anti-CA IgA levels may carry pathophysiological peculiarities that could be responsible for their clinical course of disease. An extensive proteomic profile was performed in plasma from non-treated psoriasis patients. Interestingly, patients with high anti-CA IgA displayed generally increased proteins involved in antimicrobial humoral response, cell chemotaxis and inflammatory immune response. Based on their functions, several proteins were selected for further validation via ELISA in psoriasis and healthy samples, such as: RNASE3, azurocidin, CCL18 and CHI3L1. Increased CHI3L1, AZU1 and CCL18 levels were present in plasma from plaque psoriasis patients compared to guttate psoriasis and healthy subjects; whilst RNASE3 was similarly increased in plaque and guttate psoriasis as to controls. These proteins are associated to anti-candidal activity, are able to attract CLA+ T cells and have been described to be increased in periodontal disease lately. Notably, increased prevalence of periodontal disease has been reported in psoriasis patients[26]. Our data regarding plasma levels of these proteins in psoriasis support this link, although longitudinal follow-up studies are required to better establish a causal relationship.

3. Conclusions

In light of our findings, the association of C. albicans and psoriasis is reinforced. The presence of IgA against Candida albicans in plasma from plaque psoriasis patients without clinical signs of infection identifies subjects that have been exposed to this microbe, which preferentially activates skin-homing T cells to secrete IL-17 cytokines. We consider that C. albicans exposure may affect psoriasis evolution, and eventually response to therapies. Assessing anti-CA IgA levels may be beneficial to better evaluate and stratify psoriasis patients. However, the role of this commensal fungus in psoriasis pathogenesis remains to be fully understood and important questions persist. Th17 response is required for fighting against C. albicans infection, as demonstrated by defects in the IL-17/IL-17R axis that are associated to chronic mucocutaneous candidiasis[27]. Therefore, it could be hypothesized that our observation could be related to treatment approaches for psoriasis. Effective therapies in psoriasis reduce Th17 response, facilitating fungal colonization that subsequently promotes IL-17 response fueling psoriasis pathogenesis in a vicious circle. However, predisposing background to increased response to C. albicans cannot be ruled out. Single nucleotide polymorphisms (SNPs) on IL-23 and IL-17 related genes are described as psoriasis genetic risk markers [28]. Some of these SNPs could be associated to altered response to C. albicans in psoriasis patients, a matter that remains unexplored to our knowledge.

References

  1. Lionel Fry; Barbara S. Baker; Triggering psoriasis: the role of infections and medications. Clinics in Dermatology 2007, 25, 606-615, 10.1016/j.clindermatol.2007.08.015.
  2. A. Waldman; A. Gilhar; L. Duek; I. Berdicevsky; Incidence of Candida in psoriasis--a study on the fungal flora of psoriatic patients.. Mycoses 2001, 44, 77-81, 10.1046/j.1439-0507.2001.00608.x.
  3. Vera Leibovici; Ronen Alkalay; Klilah Hershko; Arieh Ingber; Maria Westerman; Nurith Leviatan-Strauss; Malka Hochberg; Prevalence of Candida on the tongue and intertriginous areas of psoriatic and atopic dermatitis patients. Mycoses 2007, 51, 63-66, 10.1111/j.1439-0507.2007.01443.x.
  4. Bruna Lavinas Sayed Picciani; Bruna Michalski-Santos; Sueli Carneiro; Ana Luisa Sampaio; Joao Carlos Regazzi Avelleira; David Rubem Azulay; Jane Marcy Neffa Pinto; Eliane Pedra Dias; Oral candidiasis in patients with psoriasis: Correlation of oral examination and cytopathological evaluation with psoriasis disease severity and treatment. Journal of the American Academy of Dermatology 2013, 68, 986-991, 10.1016/j.jaad.2012.11.033.
  5. Mehdi Taheri Sarvtin; Tahereh Shokohi; Zohreh Hajheydari; Jamshid Yazdani; Mohammad T. Hedayati; Evaluation of candidal colonization and specific humoral responses againstCandida albicansin patients with psoriasis. International Journal of Dermatology 2014, 53, e555-e560, 10.1111/ijd.12562.
  6. Simin Lesan; Roja Toosi; Reza Aliakbarzadeh; Maryam Daneshpazhooh; Leila Mahmoudi; Soheil Tavakolpour; Hamidreza Mahmoudi; Oral Candida colonization and plaque type psoriasis: Is there any relationship?. Journal of Investigative and Clinical Dentistry 2018, 9, e12335, 10.1111/jicd.12335.
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  11. Tomasz Jagielski; Elżbieta Rup; Aleksandra Ziółkowska; Katarzyna Roeske; Anna B Macura; Jacek Bielecki; Distribution of Malassezia species on the skin of patients with atopic dermatitis, psoriasis, and healthy volunteers assessed by conventional and molecular identification methods. BMC Dermatology 2014, 14, 3-3, 10.1186/1471-5945-14-3.
  12. Akemi Takemoto; Otomi Cho; Yuka Morohoshi; Takashi Sugita; Masahiko Muto; Molecular characterization of the skin fungal microbiome in patients with psoriasis. The Journal of Dermatology 2014, 42, 166-170, 10.1111/1346-8138.12739.
  13. Luciana Campos Paulino; Chi-Hong Tseng; Bruce E. Strober; Martin J. Blaser; Molecular Analysis of Fungal Microbiota in Samples from Healthy Human Skin and Psoriatic Lesions. Journal of Clinical Microbiology 2006, 44, 2933-2941, 10.1128/jcm.00785-06.
  14. Luciana C. Paulino; Chi-Hong Tseng; Martin J. Blaser; Analysis of Malassezia microbiota in healthy superficial human skin and in psoriatic lesions by multiplex real-time PCR. FEMS Yeast Research 2008, 8, 460-471, 10.1111/j.1567-1364.2008.00359.x.
  15. Yuta Koike; Sayaka Kuwatsuka; Katsutaro Nishimoto; Daisuke Motooka; Hiroyuki Murota; Skin Mycobiome of Psoriasis Patients is Retained during Treatment with TNF and IL-17 Inhibitors. International Journal of Molecular Sciences 2020, 21, 3892, 10.3390/ijms21113892.
  16. I. Salem; K.P. Schrom; S. Chu; M. Retuerto; B. Richardson; S. Margvicius; M. Cameron; M. Ghannoum; T. McCormick; K. Cooper; et al. 362 Psoriatic fungal and bacterial microbiomes identify patient endotypes. Journal of Investigative Dermatology 2020, 140, S45, 10.1016/j.jid.2020.03.369.
  17. Gyohei Egawa; Kenji Kabashima; Skin as a Peripheral Lymphoid Organ: Revisiting the Concept of Skin-Associated Lymphoid Tissues. Journal of Investigative Dermatology 2011, 131, 2178-2185, 10.1038/jid.2011.198.
  18. Marta Ferrán; Ester R. Romeu; Catalina Rincon; Marc Sagristà; Ana M. Giménez Arnau; Antonio Celada; Ramon M. Pujol; Péter Hóllo; Hajnalka Jókai; Luis F. Santamaria-Babí; et al. Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases. Experimental Dermatology 2013, 22, 439-442, 10.1111/exd.12154.
  19. Carmen de Jesús-Gil; Lídia Sans-De SanNicolàs; Irene García-Jiménez; Marta Ferran; Antonio Celada; Anca Chiriac; Ramon M. Pujol; Luis F. Santamaria-Babí; The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders. Frontiers in Immunology 2021, 12, online , 10.3389/fimmu.2021.652613.
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  21. Sari H. Pakkanen; Jussi M. Kantele; Zina Moldoveanu; Spencer Hedges; Miikka Häkkinen; Jiri Mestecky; Anu Kantele; Expression of Homing Receptors on IgA1 and IgA2 Plasmablasts in Blood Reflects Differential Distribution of IgA1 and IgA2 in Various Body Fluids. Clinical and Vaccine Immunology 2010, 17, 393-401, 10.1128/cvi.00475-09.
  22. L. Squiquera; R. Galimberti; L. Morelli; L Plotkin; R Milicich; A. Kowalckzuk; J Leoni; Antibodies to proteins from Pityrosporum ovale in the sera from patients with psoriasis. Clinical and Experimental Dermatology 1994, 19, 289-293, 10.1111/j.1365-2230.1994.tb01197.x.
  23. Yun-Sheng Liang; Hai-Quan Wen; Rong Xiao; [Serum levels of antibodies for IgG, IgA, and IgM against the fungi antigen in psoriasis vulgaris].. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 2003, 28, 638-40.
  24. Ester Ruiz-Romeu; Marta Ferran; Carmen de Jesús-Gil; Pablo García; Marc Sagristà; J.M. Casanova; J.M. Fernández; Anca Chiriac; Péter Hóllo; Antonio Celada; et al.Ramon M. PujolLuis F. Santamaria-Babí Microbe-Dependent Induction of IL-9 by CLA+ T Cells in Psoriasis and Relationship with IL-17A. Journal of Investigative Dermatology 2018, 138, 580-587, 10.1016/j.jid.2017.08.048.
  25. Christoph Schlapbach; Ahmed Gehad; Chao Yang; Rei Watanabe; Emmanuella Guenova; Jessica E. Teague; Laura Campbell; Nikhil Yawalkar; Thomas S. Kupper; Rachael A. Clark; et al. Human TH9 Cells Are Skin-Tropic and Have Autocrine and Paracrine Proinflammatory Capacity. Science Translational Medicine 2014, 6, 219ra8-219ra8, 10.1126/scitranslmed.3007828.
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