Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 Tinley Hu -- 135 2026-11-05 04:40:37 |
2 format Tinley Hu -10 word(s) 125 2026-11-05 04:41:12 | |
3 format correct Catherine Yang Meta information modification 125 2026-11-05 09:03:14 |

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
No, upload directly Yes
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Hu, T. Behavioral Despair Assessments. Encyclopedia. Available online: https://encyclopedia.pub/entry/61900 (accessed on 09 November 2026).
Hu T. Behavioral Despair Assessments. Encyclopedia. Available at: https://encyclopedia.pub/entry/61900. Accessed November 09, 2026.
Hu, Tinley. "Behavioral Despair Assessments" Encyclopedia, https://encyclopedia.pub/entry/61900 (accessed November 09, 2026).
Hu, T. (2026, November 05). Behavioral Despair Assessments. In Encyclopedia. https://encyclopedia.pub/entry/61900
Hu, Tinley. "Behavioral Despair Assessments." Encyclopedia. Web. 05 November, 2026.

Behavioral Despair Assessments

Edit

Behavioural despair assessments are standardised paradigms in which brief, inescapable stress is used to elicit immobility, which is quantified as an index of passive coping. The forced swim test places a rodent in a cylinder of water from which it cannot escape and scores active swimming and climbing against passive immobility during a five-minute test that follows a longer pre-test exposure [1]. The tail suspension test suspends a mouse by the tail and records the duration of the immobile posture [2]. Reduced immobility is read as an antidepressant-like effect, provided that general locomotor activity is unchanged [1]. Construct and face validity for depressive-like states are weak, and immobility is held to reflect stress-coping strategy rather than depression [3].

behavioural despair forced swim test tail suspension test immobility stress coping
Help expand this entry Share your expertise by adding detailed content and references to improve this entry.
Add content

References

  1. David A Slattery; John F Cryan; Using the rat forced swim test to assess antidepressant-like activity in rodents. Nat. Protoc. 2012, 7, 1009-1014. [CrossRef]
  2. John F. Cryan; Cedric Mombereau; Annick Vassout; The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice. Neurosci. Biobehav. Rev. 2005, 29, 571-625. [CrossRef]
  3. Kathryn G. Commons; Aram B. Cholanians; Jessica A. Babb; Daniel G. Ehlinger; The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior. ACS Chem. Neurosci. 2017, 8, 955-960. [CrossRef]
More
©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Upload a video for this entry
Information
Subjects: Veterinary Sciences
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Tinley Hu
View Times: 3
Revisions: 3 times (View History)
Update Date: 05 Nov 2026
Table of Contents
    Notice
    You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
    OK
    Confirm
    Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
    Yes
    No
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    There is no comment~
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    ${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
    Submit
    Cancel
    Confirm
    Are you sure to Delete?
    Yes No
    Write an Entry
    Feedback