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Gao, H. Anticancer Agent. Encyclopedia. Available online: https://encyclopedia.pub/entry/61676 (accessed on 12 November 2026).
Gao H. Anticancer Agent. Encyclopedia. Available at: https://encyclopedia.pub/entry/61676. Accessed November 12, 2026.
Gao, Huanli. "Anticancer Agent" Encyclopedia, https://encyclopedia.pub/entry/61676 (accessed November 12, 2026).
Gao, H. (2026, October 29). Anticancer Agent. In Encyclopedia. https://encyclopedia.pub/entry/61676
Gao, Huanli. "Anticancer Agent." Encyclopedia. Web. 29 October, 2026.

Anticancer Agent

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An anticancer agent is a pharmacologically active substance intended to selectively inhibit, control, or eliminate malignant cells or to interfere with biological processes that are necessary for tumor maintenance and progression. The term encompasses conventional cytotoxic drugs, molecularly targeted agents, endocrine agents, immunotherapeutics, and other therapeutic substances whose primary pharmacological purpose is the treatment of cancer. Anticancer agents may act by damaging DNA, disrupting cell division, inhibiting oncogenic signaling, altering hormone-dependent growth, activating antitumor immunity, or affecting the tumor microenvironment [1][2][3][4]. Their defining feature is a demonstrable antineoplastic mechanism or therapeutic objective, rather than merely the ability to produce nonspecific cellular toxicity. Thus, an anticancer agent is distinct from a supportive-care medicine, which manages symptoms or treatment-related complications without directly exerting an antineoplastic effect, and from a preventive or diagnostic substance, which does not primarily treat established malignant disease.

antineoplastic drug cancer pharmacology cytotoxic therapy molecularly targeted therapy
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References

  1. Gregory Hannigan; Armelle A. Troussard; Shoukat Dedhar; Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat. Rev. Cancer 2005, 5, 51-63. [CrossRef]
  2. Douglas Hanahan; Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022, 12, 31-46. [CrossRef]
  3. Charles Sawyers; Targeted cancer therapy. Nature 2004, 432, 294-297. [CrossRef]
  4. Neil Vasan; José Baselga; David M. Hyman; A view on drug resistance in cancer. Nature 2019, 575, 299-309. [CrossRef]
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Subjects: Immunology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Huanli Gao
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Update Date: 29 Oct 2026
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