Colloidal drug delivery systems are dispersions of drug-associated particles or supramolecular assemblies within a continuous medium, commonly an aqueous phase ^[1][2]. Their dispersed components can contain lipids, polymers, or other materials that incorporate a therapeutic substance through encapsulation, partitioning, or association with a surface ^[2]. Liposomes are one structural class: phospholipid bilayers enclose an aqueous compartment, allowing different drug molecules to occupy the internal fluid or the membrane ^[1]. Particle composition, size distribution, and surface organization influence colloidal interactions and the disposition of the associated drug ^[2][3]. Loading methods determine both the amount incorporated and its location within the carrier ^[3]. Surface modification can change interactions with biological fluids, while carrier destabilization or permeation through its components can release the payload ^[3][4]. The colloidal particle and the drug therefore have related but distinct transport and clearance behaviours ^[2][4]. A preparation is characterized by the dispersed structures together with the molecular state and distribution of the drug they contain ^[1][2][3][4].